JP2017025021A - シラミ忌避剤 - Google Patents
シラミ忌避剤 Download PDFInfo
- Publication number
- JP2017025021A JP2017025021A JP2015144992A JP2015144992A JP2017025021A JP 2017025021 A JP2017025021 A JP 2017025021A JP 2015144992 A JP2015144992 A JP 2015144992A JP 2015144992 A JP2015144992 A JP 2015144992A JP 2017025021 A JP2017025021 A JP 2017025021A
- Authority
- JP
- Japan
- Prior art keywords
- lice
- repellent
- menthyl
- louse
- calculated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000005871 repellent Substances 0.000 title claims abstract description 42
- 230000002940 repellent Effects 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 20
- 150000002148 esters Chemical class 0.000 claims abstract description 19
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 241001674048 Phthiraptera Species 0.000 claims description 52
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 230000001846 repelling effect Effects 0.000 abstract description 34
- 230000002459 sustained effect Effects 0.000 abstract description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical group CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 26
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 15
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 13
- XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 description 13
- 208000028454 lice infestation Diseases 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 11
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 8
- 241000517307 Pediculus humanus Species 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 241000517324 Pediculidae Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- XEYZAKCJAFSLGZ-UHFFFAOYSA-N (5-methyl-2-propan-2-ylcyclohexyl) formate Chemical group CC(C)C1CCC(C)CC1OC=O XEYZAKCJAFSLGZ-UHFFFAOYSA-N 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VZRKEAFHFMSHCD-UHFFFAOYSA-N Ethyl 3-(N-butylacetamido)propionate Chemical compound CCCCN(C(C)=O)CCC(=O)OCC VZRKEAFHFMSHCD-UHFFFAOYSA-N 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- -1 polyalkylene glycol Chemical class 0.000 description 2
- 229920001515 polyalkylene glycol Polymers 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- PXLKJWMSFPYVNB-UHFFFAOYSA-N (1-methyl-4-propan-2-ylcyclohexyl) acetate Chemical compound CC(C)C1CCC(C)(OC(C)=O)CC1 PXLKJWMSFPYVNB-UHFFFAOYSA-N 0.000 description 1
- CDOOAUSHHFGWSA-OWOJBTEDSA-N (e)-1,3,3,3-tetrafluoroprop-1-ene Chemical compound F\C=C\C(F)(F)F CDOOAUSHHFGWSA-OWOJBTEDSA-N 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- ROBXZHNBBCHEIQ-UHFFFAOYSA-N ethyl 2-aminopropanoate Chemical compound CCOC(=O)C(C)N ROBXZHNBBCHEIQ-UHFFFAOYSA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000003915 liquefied petroleum gas Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
酢酸メンチルとアセトンとを混合して、適切な濃度の酢酸メンチルのアセトン溶液を調製した。次いで、ろ紙(アドバンテック東洋(株)製、品番:00021150)を直径が9cmの円形となるように切断し、得られた円形のろ紙をさらに半分に切断して、2枚の半円状のろ紙を得た。一方の半円状のろ紙に、調製した酢酸メンチルのアセトン溶液を滴下した(処理区)。具体的には、酢酸メンチルのアセトン溶液1mLを滴下し、半円状のろ紙の面積1cm2あたり、酢酸メンチルが5mgとなるようにアセトン溶液を滴下して風乾した。残りの半円状のろ紙には、アセトンを1mL滴下して風乾した(無処理区)。
忌避率(%)={(無処理区−処理区)/無処理区}×100
処理区2の酢酸メンチル量が、半円状のろ紙の面積1cm2あたり3mgとなるようにアセトン溶液を滴下した以外は、実施例1と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。結果を表1に示す。なお、表1には、後述の比較例1の忌避率を100とした場合の相対値を示す。
忌避成分として、酢酸メンチルの代わりにギ酸メンチルを用いた以外は、実施例1と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。結果を表1に示す。なお、表1には、後述の比較例1の忌避率を100とした場合の相対値を示す。
処理区2のギ酸メンチル量が、半円状のろ紙の面積1cm2あたり3mgとなるようにアセトン溶液を滴下した以外は、実施例3と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。結果を表1に示す。なお、表1には、後述の比較例1の忌避率を100とした場合の相対値を示す。
忌避成分として、酢酸メンチルの代わりにプロパン酸メンチルを用いた以外は、実施例1と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。結果を表1に示す。なお、表1には、後述の比較例1の忌避率を100とした場合の相対値を示す。
処理区2のプロパン酸メンチル量が、半円状のろ紙の面積1cm2あたり3mgとなるようにアセトン溶液を滴下した以外は、実施例5と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。結果を表1に示す。なお、表1には、後述の比較例1の忌避率を100とした場合の相対値を示す。
忌避成分として、酢酸メンチルの代わりにDEETを用いた以外は、実施例1と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。なお、表1には、算出した忌避率を「100」として記載している。
忌避成分として、酢酸メンチルの代わりに3−(N−n−ブチル−N−アセチル)アミノプロピオン酸エチルエステル(IR3535、メルク社製)を用いた以外は、実施例1と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。結果を表1に示す。なお、表1には、上記の比較例1の忌避率を100とした場合の相対値を示す。
忌避成分として、酢酸メンチルの代わりにオイゲノールを用いた以外は、実施例1と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。結果を表1に示す。なお、表1には、上記の比較例1の忌避率を100とした場合の相対値を示す。
忌避成分として、酢酸メンチルの代わりにα−ピネンを用いた以外は、実施例1と同様の手順で、忌避率を算出した。忌避率の3回の平均値を求めた。結果を表1に示す。なお、表1には、上記の比較例1の忌避率を100とした場合の相対値を示す。
2 処理区
3 無処理区
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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JP2015144992A JP6708377B2 (ja) | 2015-07-22 | 2015-07-22 | シラミ忌避剤 |
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JP2015144992A JP6708377B2 (ja) | 2015-07-22 | 2015-07-22 | シラミ忌避剤 |
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JP2020066876A Division JP7257354B2 (ja) | 2020-04-02 | 2020-04-02 | シラミ忌避方法 |
Publications (2)
Publication Number | Publication Date |
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JP2017025021A true JP2017025021A (ja) | 2017-02-02 |
JP6708377B2 JP6708377B2 (ja) | 2020-06-10 |
Family
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JP2015144992A Active JP6708377B2 (ja) | 2015-07-22 | 2015-07-22 | シラミ忌避剤 |
Country Status (1)
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JP (1) | JP6708377B2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021009888A1 (ja) * | 2019-07-18 | 2021-01-21 | 株式会社大阪製薬 | シラミ駆除剤 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5227163A (en) * | 1991-01-18 | 1993-07-13 | Clilco, Ltd. | Lice-repellant compositions |
JP2004511504A (ja) * | 2000-10-10 | 2004-04-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | 包装された頭皮用化粧組成物 |
JP2006122319A (ja) * | 2004-10-28 | 2006-05-18 | Daizo:Kk | 空間用エアゾール製品 |
JP2014201581A (ja) * | 2013-04-10 | 2014-10-27 | 株式会社大阪製薬 | 衛生害虫忌避剤 |
-
2015
- 2015-07-22 JP JP2015144992A patent/JP6708377B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5227163A (en) * | 1991-01-18 | 1993-07-13 | Clilco, Ltd. | Lice-repellant compositions |
JP2004511504A (ja) * | 2000-10-10 | 2004-04-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | 包装された頭皮用化粧組成物 |
JP2006122319A (ja) * | 2004-10-28 | 2006-05-18 | Daizo:Kk | 空間用エアゾール製品 |
JP2014201581A (ja) * | 2013-04-10 | 2014-10-27 | 株式会社大阪製薬 | 衛生害虫忌避剤 |
Non-Patent Citations (1)
Title |
---|
EDDY, G. W. ET AL: "Synergists with allethrin against the body louse", JOURNAL OF ECONOMIC ENTOMOLOGY, vol. 47, no. 3, JPN6020003085, 1954, pages 501 - 506, ISSN: 0004202687 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021009888A1 (ja) * | 2019-07-18 | 2021-01-21 | 株式会社大阪製薬 | シラミ駆除剤 |
JPWO2021009888A1 (ja) * | 2019-07-18 | 2021-01-21 | ||
JP7335642B2 (ja) | 2019-07-18 | 2023-08-30 | 株式会社大阪製薬 | シラミ駆除剤 |
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JP6708377B2 (ja) | 2020-06-10 |
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