JP2017014254A5 - - Google Patents
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- Publication number
- JP2017014254A5 JP2017014254A5 JP2016159348A JP2016159348A JP2017014254A5 JP 2017014254 A5 JP2017014254 A5 JP 2017014254A5 JP 2016159348 A JP2016159348 A JP 2016159348A JP 2016159348 A JP2016159348 A JP 2016159348A JP 2017014254 A5 JP2017014254 A5 JP 2017014254A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cancer
- therapeutic agent
- agent according
- antagonistic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 16
- 239000007787 solid Substances 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 12
- 230000001472 cytotoxic effect Effects 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 11
- 230000003042 antagnostic effect Effects 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 5
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 4
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 4
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 4
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 4
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 4
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 4
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 4
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 4
- 230000001270 agonistic effect Effects 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 231100000433 cytotoxic Toxicity 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 239000002257 antimetastatic agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001483 mobilizing effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014032241 | 2014-02-21 | ||
| JP2014032241 | 2014-02-21 | ||
| JP2014120300 | 2014-06-11 | ||
| JP2014120300 | 2014-06-11 | ||
| JP2014178953 | 2014-09-03 | ||
| JP2014178953 | 2014-09-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504046A Division JP6029160B2 (ja) | 2014-02-21 | 2015-02-09 | 固形がんの治療剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019025193A Division JP7041439B2 (ja) | 2014-02-21 | 2019-02-15 | 固形がんの治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017014254A JP2017014254A (ja) | 2017-01-19 |
| JP2017014254A5 true JP2017014254A5 (https=) | 2018-03-22 |
| JP6578604B2 JP6578604B2 (ja) | 2019-09-25 |
Family
ID=53878157
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504046A Active JP6029160B2 (ja) | 2014-02-21 | 2015-02-09 | 固形がんの治療剤 |
| JP2016159348A Active JP6578604B2 (ja) | 2014-02-21 | 2016-08-15 | 固形がんの治療剤 |
| JP2019025193A Active JP7041439B2 (ja) | 2014-02-21 | 2019-02-15 | 固形がんの治療剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504046A Active JP6029160B2 (ja) | 2014-02-21 | 2015-02-09 | 固形がんの治療剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019025193A Active JP7041439B2 (ja) | 2014-02-21 | 2019-02-15 | 固形がんの治療剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20170165364A1 (https=) |
| EP (3) | EP3338801A1 (https=) |
| JP (3) | JP6029160B2 (https=) |
| ES (1) | ES2808728T3 (https=) |
| WO (1) | WO2015125652A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108601767A (zh) * | 2015-10-05 | 2018-09-28 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂和免疫肿瘤学药剂的组合疗法 |
| JP7078533B2 (ja) * | 2015-10-21 | 2022-05-31 | オーエスイー イムノセラピューティクス | 炎症促進性細胞へのマクロファージ分極を改変して癌を治療するための抗ＳＩＲＰａ化合物 |
| JP6992984B2 (ja) * | 2016-06-17 | 2022-02-04 | 国立大学法人大阪大学 | 腫瘍内静脈形成促進剤 |
| WO2018047917A1 (ja) * | 2016-09-09 | 2018-03-15 | 国立大学法人 東京大学 | Ｈｍｇタンパク質と抗ｃｄ４抗体又は免疫チェックポイント制御剤との組み合わせによる相乗的抗腫瘍効果 |
| SG10201912663YA (en) | 2016-10-11 | 2020-03-30 | Agenus Inc | Anti-lag-3 antibodies and methods of use thereof |
| PE20200859A1 (es) | 2017-06-02 | 2020-08-25 | Bayer Healthcare Llc | Combinacion farmaceutica que comprende regonafenib y nivolumab como anticancerigeno |
| JP7302793B2 (ja) * | 2018-03-08 | 2023-07-04 | 国立大学法人 東京大学 | Ｈｍｇｎ部分ペプチド及びこれを用いたがん療法 |
| GB201811291D0 (en) * | 2018-07-10 | 2018-08-29 | Univ Dublin City | A method of predicting response to treatment in cancer patients |
| CN110904045A (zh) * | 2018-09-17 | 2020-03-24 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| EP4011918A4 (en) * | 2019-08-08 | 2023-08-23 | ONO Pharmaceutical Co., Ltd. | DUAL SPECIFIC PROTEIN |
| US20240216401A1 (en) * | 2021-04-28 | 2024-07-04 | Obi Pharma, Inc. | Combination therapy by using akr1c3-activated compound with immune checkpoint inhibitor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002055100A2 (en) * | 2000-10-20 | 2002-07-18 | Genetics Institute, Llc | Method and composition for inhibition of tumor growth and enhancing an immune response |
| FI1897548T4 (fi) * | 2003-02-28 | 2024-09-03 | The Johns Hopkins University | T-solujen säätely |
| EP1460088A1 (en) * | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| RU2494107C2 (ru) * | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| BRPI0909048A2 (pt) * | 2008-03-13 | 2015-11-24 | Biotest Ag | composição farmacêutica, e, método de tratamento de uma doença autoimune |
| WO2010067671A1 (ja) * | 2008-12-12 | 2010-06-17 | 小野薬品工業株式会社 | 移植片対腫瘍効果を保存した免疫学的再構築促進剤または感染症予防剤 |
| WO2010074266A1 (ja) * | 2008-12-26 | 2010-07-01 | 協和発酵キリン株式会社 | 抗cd4抗体 |
| CA3083324A1 (en) * | 2010-03-05 | 2011-09-09 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| DK2699598T3 (en) * | 2011-04-19 | 2019-04-23 | Pfizer | COMBINATIONS OF ANTI-4-1BB ANTIBODIES AND ADCC-INducing ANTIBODIES FOR TREATMENT OF CANCER |
| JP6120848B2 (ja) * | 2011-08-15 | 2017-04-26 | メディミューン，エルエルシー | 抗ｂ７−ｈ４抗体およびその使用 |
| AR090263A1 (es) * | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| US20160108122A1 (en) * | 2013-05-23 | 2016-04-21 | Idac Theranostics, Inc. | Therapeutic or prophylactic agent for immunodeficiency virus infection |
| CA2937035A1 (en) * | 2014-02-05 | 2015-08-13 | Cedars-Sinai Medical Center | Methods and compositions for treating cancer and infectious diseases |
| JP6715491B2 (ja) * | 2014-06-11 | 2020-07-01 | Ｉｄａｃセラノスティクス株式会社 | 免疫チェックポイント制御剤の副作用低減方法 |
-
2015
- 2015-02-09 US US15/120,427 patent/US20170165364A1/en not_active Abandoned
- 2015-02-09 WO PCT/JP2015/053569 patent/WO2015125652A1/ja not_active Ceased
- 2015-02-09 JP JP2016504046A patent/JP6029160B2/ja active Active
- 2015-02-09 ES ES15751324T patent/ES2808728T3/es active Active
- 2015-02-09 EP EP18153990.9A patent/EP3338801A1/en not_active Withdrawn
- 2015-02-09 EP EP18153989.1A patent/EP3338800A1/en not_active Ceased
- 2015-02-09 EP EP15751324.3A patent/EP3132802B1/en not_active Not-in-force
-
2016
- 2016-08-15 JP JP2016159348A patent/JP6578604B2/ja active Active
-
2018
- 2018-12-27 US US16/234,292 patent/US20190125867A1/en not_active Abandoned
-
2019
- 2019-02-15 JP JP2019025193A patent/JP7041439B2/ja active Active
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