JP2017006122A5 - - Google Patents
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- Publication number
- JP2017006122A5 JP2017006122A5 JP2016116227A JP2016116227A JP2017006122A5 JP 2017006122 A5 JP2017006122 A5 JP 2017006122A5 JP 2016116227 A JP2016116227 A JP 2016116227A JP 2016116227 A JP2016116227 A JP 2016116227A JP 2017006122 A5 JP2017006122 A5 JP 2017006122A5
- Authority
- JP
- Japan
- Prior art keywords
- olfactory receptor
- sulfide compound
- receptor polypeptide
- response
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 102000012547 Olfactory receptors Human genes 0.000 claims 9
- 108050002069 Olfactory receptors Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- -1 sulfide compound Chemical class 0.000 claims 9
- 230000004044 response Effects 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 101000614009 Homo sapiens Olfactory receptor 4S2 Proteins 0.000 claims 4
- 102100040567 Olfactory receptor 4S2 Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 238000005259 measurement Methods 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000003571 reporter gene assay Methods 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16811685.3A EP3312289B1 (en) | 2015-06-17 | 2016-06-16 | Method for evaluating and selecting agent for suppressing odors of sulfide compounds |
| US15/737,079 US10585087B2 (en) | 2015-06-17 | 2016-06-16 | Method for evaluating and selecting agent for suppressing odors of sulfide compounds |
| PCT/JP2016/067894 WO2016204211A1 (ja) | 2015-06-17 | 2016-06-16 | スルフィド化合物の臭いの抑制剤の評価又は選択方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015121916 | 2015-06-17 | ||
| JP2015121916 | 2015-06-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017006122A JP2017006122A (ja) | 2017-01-12 |
| JP2017006122A5 true JP2017006122A5 (enExample) | 2017-02-16 |
| JP6122181B2 JP6122181B2 (ja) | 2017-04-26 |
Family
ID=57760389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016116227A Active JP6122181B2 (ja) | 2015-06-17 | 2016-06-10 | スルフィド化合物の臭いの抑制剤の評価又は選択方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US10585087B2 (enExample) |
| EP (1) | EP3312289B1 (enExample) |
| JP (1) | JP6122181B2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR122022021021B1 (pt) * | 2017-11-22 | 2023-11-07 | Firmenich S.A. | Uso de composições voláteis para limitar ou eliminar a percepção de mau odor |
| US11649510B2 (en) | 2017-12-27 | 2023-05-16 | Takasago International Corporation | Screening method for materials that suppress characteristic body odor of elderly people |
| JP7197298B2 (ja) * | 2018-07-17 | 2022-12-27 | 花王株式会社 | メチルメルカプタン臭抑制剤の評価及び／又は選択方法 |
| WO2022270481A1 (ja) | 2021-06-22 | 2022-12-29 | 花王株式会社 | 嗅覚受容体の発現方法及び応答測定方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001247366A1 (en) | 2000-03-13 | 2001-09-24 | Senomyx Inc. | Human olfactory receptors and genes encoding same |
| JP5006540B2 (ja) | 2004-12-27 | 2012-08-22 | ライオン株式会社 | 水徐溶性組成物、及びそれを用いた洗浄方法 |
| EP1864131B1 (en) | 2005-03-03 | 2011-09-28 | ChemCom S.A. | Natural ligand of g protein coupled receptor rcc356 and uses thereof |
| JP5329852B2 (ja) | 2008-06-25 | 2013-10-30 | 花王株式会社 | 廃棄物や排水口等から発生する悪臭を抑制する方法 |
| EP2806031B1 (en) | 2010-09-03 | 2016-11-02 | Kao Corporation | Method for searching for malodor control agent |
| JP5697383B2 (ja) * | 2010-09-03 | 2015-04-08 | 花王株式会社 | 悪臭抑制剤の探索方法 |
| US8637259B1 (en) * | 2011-02-09 | 2014-01-28 | Chemcom S.A. | Methods of identifying modulators of olfactory receptors involved in the perception of sweat carboxylic acids |
| JP5593271B2 (ja) | 2011-06-06 | 2014-09-17 | 花王株式会社 | 悪臭抑制剤の探索方法 |
| MX371282B (es) * | 2013-06-29 | 2020-01-24 | Firmenich & Cie | Metodos para identificar, aislar y usar receptores de odorizantes y aroma. |
| JP6588715B2 (ja) * | 2014-04-14 | 2019-10-09 | 花王株式会社 | 尿臭抑制剤の探索方法 |
-
2016
- 2016-06-10 JP JP2016116227A patent/JP6122181B2/ja active Active
- 2016-06-16 US US15/737,079 patent/US10585087B2/en active Active
- 2016-06-16 EP EP16811685.3A patent/EP3312289B1/en active Active
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