JP2016540809A5 - - Google Patents
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- Publication number
- JP2016540809A5 JP2016540809A5 JP2016540677A JP2016540677A JP2016540809A5 JP 2016540809 A5 JP2016540809 A5 JP 2016540809A5 JP 2016540677 A JP2016540677 A JP 2016540677A JP 2016540677 A JP2016540677 A JP 2016540677A JP 2016540809 A5 JP2016540809 A5 JP 2016540809A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- pharmaceutical composition
- isoxazoline compound
- potable water
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 methoxyethyl Chemical group 0.000 claims 28
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000003651 drinking water Substances 0.000 claims 9
- 241001465754 Metazoa Species 0.000 claims 7
- 235000012206 bottled water Nutrition 0.000 claims 7
- 229920000136 polysorbate Polymers 0.000 claims 6
- 229950008882 polysorbate Drugs 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 5
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- 230000009545 invasion Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- XEUCQOBUZPQUMQ-UHFFFAOYSA-N Glycolone Chemical compound COC1=C(CC=C(C)C)C(=O)NC2=C1C=CC=C2OC XEUCQOBUZPQUMQ-UHFFFAOYSA-N 0.000 claims 2
- 235000020188 drinking water Nutrition 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 2
- 125000004970 halomethyl group Chemical group 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 2
- 244000045947 parasite Species 0.000 claims 2
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 claims 2
- 206010061217 Infestation Diseases 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 239000002518 antifoaming agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000006260 ethylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 claims 1
- 229920005555 halobutyl Polymers 0.000 claims 1
- 125000004968 halobutyl group Chemical group 0.000 claims 1
- 125000004969 haloethyl group Chemical group 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 244000144977 poultry Species 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004673 propylcarbonyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 201000001064 tick infestation Diseases 0.000 claims 1
- 0 CC(C1)=NOC1(*)C1=C*(*=*)C=CC=C1 Chemical compound CC(C1)=NOC1(*)C1=C*(*=*)C=CC=C1 0.000 description 6
- XNTFQMKXUFFUQO-UHFFFAOYSA-N C[n]1nccc1CN Chemical compound C[n]1nccc1CN XNTFQMKXUFFUQO-UHFFFAOYSA-N 0.000 description 1
- QYOJSNPPGRBNJR-UHFFFAOYSA-N NC(C1)CS1(=O)=O Chemical compound NC(C1)CS1(=O)=O QYOJSNPPGRBNJR-UHFFFAOYSA-N 0.000 description 1
- OZGWIFFWPCEUEE-UHFFFAOYSA-N NC(C1)CS1=O Chemical compound NC(C1)CS1=O OZGWIFFWPCEUEE-UHFFFAOYSA-N 0.000 description 1
- YFEQTUUFQKDATK-UHFFFAOYSA-N NCc1c[s]cn1 Chemical compound NCc1c[s]cn1 YFEQTUUFQKDATK-UHFFFAOYSA-N 0.000 description 1
- WOXFMYVTSLAQMO-UHFFFAOYSA-N NCc1ccccn1 Chemical compound NCc1ccccn1 WOXFMYVTSLAQMO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199006 | 2013-12-20 | ||
| EP13199006.1 | 2013-12-20 | ||
| PCT/EP2014/078634 WO2015091898A1 (en) | 2013-12-20 | 2014-12-19 | Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016540809A JP2016540809A (ja) | 2016-12-28 |
| JP2016540809A5 true JP2016540809A5 (cg-RX-API-DMAC7.html) | 2018-01-25 |
| JP6581586B2 JP6581586B2 (ja) | 2019-09-25 |
Family
ID=49880542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540677A Active JP6581586B2 (ja) | 2013-12-20 | 2014-12-19 | イソオキサゾリン組成物および動物における寄生虫侵襲の予防または処置におけるその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10456358B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4306168B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6581586B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN110327468B (cg-RX-API-DMAC7.html) |
| ES (2) | ES2971061T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE066811T2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX373872B (cg-RX-API-DMAC7.html) |
| PL (2) | PL4306168T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT4306168T (cg-RX-API-DMAC7.html) |
| RU (1) | RU2688919C1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015091898A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110327468B (zh) | 2013-12-20 | 2023-04-28 | 英特维特国际股份有限公司 | 异噁唑啉组合物及其在预防或治疗动物的寄生虫侵袭中的用途 |
| US20170232024A1 (en) | 2014-08-04 | 2017-08-17 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| FI4008329T3 (fi) * | 2014-12-22 | 2025-08-22 | Intervet Int Bv | Isoksatsoliiniyhdisteitä käytettäväksi hoidettaessa demodikoosia |
| CN107750159B (zh) | 2015-06-23 | 2021-10-29 | 英特维特国际股份有限公司 | 用于消毒的饮用水的含有维生素的异噁唑啉溶液 |
| WO2018039508A1 (en) * | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| US20200061026A1 (en) * | 2016-10-31 | 2020-02-27 | The Scripps Research Institute | Methods and compositions for preventing vector-borne disease transmission |
| DK3707128T3 (da) * | 2017-11-07 | 2024-03-18 | Intervet Int Bv | Injicerbare, farmaceutiske isoxazolinsammensætninger og anvendelse deraf mod parasitangreb |
| CA3081653A1 (en) * | 2017-11-07 | 2019-05-16 | Intervet International B.V. | Process for preparing large size isoxazoline particles |
| CN111655241B (zh) * | 2017-12-15 | 2024-10-15 | 塔苏斯制药有限公司 | 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法 |
| CN111526716B (zh) | 2017-12-20 | 2023-04-04 | 英特维特国际股份有限公司 | 用于水产养殖中的鱼外部寄生虫监测的方法和系统 |
| WO2019121851A1 (en) * | 2017-12-20 | 2019-06-27 | Intervet International B.V. | System for external fish parasite monitoring in aquaculture |
| WO2019121854A1 (en) | 2017-12-20 | 2019-06-27 | Intervet International B.V. | Method and system for external fish parasite monitoring in aquaculture |
| CA3084287A1 (en) * | 2017-12-20 | 2019-06-27 | Intervet International B.V. | System for external fish parasite monitoring in aquaculture |
| EP3726971A1 (en) * | 2017-12-20 | 2020-10-28 | Intervet International B.V. | System for external fish parasite monitoring in aquaculture |
| KR102142916B1 (ko) * | 2018-08-17 | 2020-08-10 | 부산대학교 산학협력단 | 상향식 방법을 통한 난용성 약물을 포함하는 나노현탁액의 제조방법 및 이로 제조된 나노현탁액 |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| US20220249445A1 (en) * | 2019-06-19 | 2022-08-11 | Tarsus Pharmaceuticals, Inc. | Isoxazoline parasiticide formulations and methods for treating blepharitis |
| KR20220053550A (ko) * | 2019-06-19 | 2022-04-29 | 타르서스 파마수티칼스, 아이엔씨. | 안검염을 치료하기 위한 이소옥사졸린 구충제 제형 및 방법 |
| MX2022007455A (es) | 2019-12-18 | 2022-08-15 | Elanco Tiergesundheit Ag | Derivados de isoxazolina como plaguicidas. |
| EP4185585A1 (en) | 2020-07-24 | 2023-05-31 | Elanco Us Inc. | Process for making an isoxazoline compound and intermediate thereof |
| CN114306231B (zh) * | 2021-12-29 | 2023-03-24 | 天津市中升挑战生物科技有限公司 | 一种氟雷拉纳杀虫剂及其制备方法和应用 |
| CN117064851A (zh) * | 2023-09-20 | 2023-11-17 | 中国农业大学 | 一种异噁唑啉类驱虫药制剂的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3727648A1 (de) | 1987-08-19 | 1989-03-02 | Bayer Ag | Neue avermectin derivate, verfahren zu ihrer herstellung und ihre verwendung |
| US6998131B2 (en) * | 1996-09-19 | 2006-02-14 | Merial Limited | Spot-on formulations for combating parasites |
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| WO2007053902A1 (en) * | 2005-11-10 | 2007-05-18 | Bomac Animal Health Pty Limited | Method of treating parasites |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| CA2971008A1 (en) * | 2007-06-27 | 2008-12-31 | E. I. Du Pont De Nemours And Company | Animal pest control method |
| TWI556741B (zh) * | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| CN102088856B (zh) * | 2008-07-09 | 2015-11-25 | 巴斯夫欧洲公司 | 包含异*唑啉化合物的杀虫活性混合物i |
| AU2009270255B2 (en) | 2008-07-09 | 2013-12-12 | Nissan Chemical Corporation | Process for production of isoxazoline-substituted benzoic acid amide compound |
| EP2364147A2 (en) * | 2008-11-19 | 2011-09-14 | Merial Limited | Compositions comprising 1-arylpyrazole alone or in combination with formamidine for the treatment of parasitic infection |
| CA2747060A1 (en) | 2008-12-18 | 2010-07-15 | Novartis Ag | Isoxazolines derivatives and their use as pesticide |
| AR074790A1 (es) | 2008-12-19 | 2011-02-09 | Novartis Ag | Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente. |
| AU2010278948B2 (en) | 2009-07-30 | 2015-04-23 | Boehringer Ingelheim Animal Health USA Inc. | Insecticidal 4-Amino-thieno(2,3-d)-pyrimidine compounds and methods of their use |
| AR081843A1 (es) | 2010-06-09 | 2012-10-24 | Syngenta Participations Ag | Mezclas pesticidas incluyendo derivados isoxazolina |
| DK178277B1 (da) * | 2010-06-18 | 2015-10-26 | Novartis Tiergesundheit Ag | Diaryloxazolinforbindelser til bekæmpelse af fiskelus |
| HUE058290T2 (hu) * | 2010-12-27 | 2022-07-28 | Intervet Int Bv | Topikális lokalizált izoxazolin formuláció, amely tartalmaz glikofurolt |
| US9173870B2 (en) | 2010-12-27 | 2015-11-03 | Intervet Inc. | Topical localized isoxazoline formulation |
| MX2013009211A (es) | 2011-02-10 | 2013-08-29 | Novartis Ag | Derivados de isoxazolina para controlar plagas de invertebrados. |
| WO2012120399A1 (en) | 2011-03-10 | 2012-09-13 | Pfizer Inc. | Spirocyclic isoxazoline derivatives as antiparasitic agents |
| WO2013026695A1 (en) | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
| WO2013026931A1 (en) | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
| SG11201400558YA (en) * | 2011-09-12 | 2014-04-28 | Merial Ltd | Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof |
| CN103842346A (zh) | 2011-10-03 | 2014-06-04 | 先正达参股股份有限公司 | 作为杀虫化合物的异噁唑啉衍生物 |
| ES2633611T5 (es) | 2012-04-04 | 2023-09-26 | Intervet Int Bv | Composiciones farmacéuticas orales sólidas de compuestos de isoxazolina |
| CA2924537C (en) | 2013-09-30 | 2018-01-16 | Todd P. Foster | Long-acting spiro-isoxazoline formulations |
| US10272071B2 (en) * | 2013-12-20 | 2019-04-30 | Intervet Inc. | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
| CN110327468B (zh) * | 2013-12-20 | 2023-04-28 | 英特维特国际股份有限公司 | 异噁唑啉组合物及其在预防或治疗动物的寄生虫侵袭中的用途 |
-
2014
- 2014-12-19 CN CN201910734505.3A patent/CN110327468B/zh active Active
- 2014-12-19 EP EP23206906.2A patent/EP4306168B1/en active Active
- 2014-12-19 PT PT232069062T patent/PT4306168T/pt unknown
- 2014-12-19 RU RU2016129474A patent/RU2688919C1/ru active
- 2014-12-19 MX MX2016008118A patent/MX373872B/es active IP Right Grant
- 2014-12-19 US US15/102,414 patent/US10456358B2/en active Active
- 2014-12-19 HU HUE14815365A patent/HUE066811T2/hu unknown
- 2014-12-19 WO PCT/EP2014/078634 patent/WO2015091898A1/en not_active Ceased
- 2014-12-19 PL PL23206906.2T patent/PL4306168T3/pl unknown
- 2014-12-19 PL PL14815365.3T patent/PL3082867T3/pl unknown
- 2014-12-19 EP EP14815365.3A patent/EP3082867B1/en active Active
- 2014-12-19 CN CN201480068585.9A patent/CN105813651B/zh active Active
- 2014-12-19 ES ES14815365T patent/ES2971061T3/es active Active
- 2014-12-19 ES ES23206906T patent/ES3036365T3/es active Active
- 2014-12-19 JP JP2016540677A patent/JP6581586B2/ja active Active
-
2019
- 2019-09-13 US US16/570,633 patent/US20200000720A1/en not_active Abandoned
-
2021
- 2021-07-30 US US17/390,296 patent/US11883530B2/en active Active
-
2023
- 2023-12-06 US US18/530,282 patent/US20240122849A1/en not_active Abandoned
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