JP2016539925A - Ｔｌｒ４リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 - Google Patents

Ｔｌｒ４リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 Download PDF

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JP2016539925A
JP2016539925A JP2016525584A JP2016525584A JP2016539925A JP 2016539925 A JP2016539925 A JP 2016539925A JP 2016525584 A JP2016525584 A JP 2016525584A JP 2016525584 A JP2016525584 A JP 2016525584A JP 2016539925 A JP2016539925 A JP 2016539925A
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tlr4
seq
antibody
citrullinated
acid sequence
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JP2016539925A5 (cg-RX-API-DMAC7.html
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ミン， クリスティーナ デ
ミン， クリスティーナ デ
リミン シャン，
リミン シャン，
エマニュエル モネ，
エマニュエル モネ，
グレッグ エルソン，
グレッグ エルソン，
エリック ハッテラー，
エリック ハッテラー，
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ノビミューン エスアー
ノビミューン エスアー
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JP2016525584A 2013-10-22 2014-10-22 Ｔｌｒ４リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 Pending JP2016539925A (ja)

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US201361894042P 2013-10-22 2013-10-22
US61/894,042 2013-10-22
PCT/EP2014/072606 WO2015059168A1 (en) 2013-10-22 2014-10-22 Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of tlr4 ligands and other biomarkers

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JP2018246722A Withdrawn JP2019048895A (ja) 2013-10-22 2018-12-28 Ｔｌｒ４リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物
JP2020177986A Pending JP2021006592A (ja) 2013-10-22 2020-10-23 Ｔｌｒ４リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物

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JP2020177986A Pending JP2021006592A (ja) 2013-10-22 2020-10-23 Ｔｌｒ４リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023523096A (ja) * 2020-04-20 2023-06-01 エデサ バイオテック リサーチ インコーポレイテッド 急性呼吸促迫症候群を治療するための組成物および方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE037613T2 (hu) * 2012-03-29 2018-09-28 Novimmune Sa Anti-TLR4 antitestek és azok felhasználása
CA2928317A1 (en) 2013-10-22 2015-04-30 Novimmune S.A. Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of tlr4 ligands and other biomarkers
AU2016303033A1 (en) * 2015-08-06 2018-03-01 Novimmune Sa Methods and compositions for identifying patient populations for diagnosis and treatment of TLR4-dependent disorders
CN110073217A (zh) 2016-10-04 2019-07-30 豪夫迈·罗氏有限公司 用于鉴定合成分类器的系统和方法
WO2018146129A1 (en) 2017-02-07 2018-08-16 Orthogenics As Biomarkers for diagnosing implant related risk of implant revision due to aseptic loosening
WO2020225549A1 (en) * 2019-05-06 2020-11-12 The Francis Crick Institute Limited Method for preventing inflammation
CN115397851B (zh) * 2019-12-20 2025-12-12 哈德森医学研究院 Cxcl10结合蛋白及其用途
CN113358872B (zh) * 2021-06-03 2022-10-21 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于评估肿瘤免疫治疗疗效的标志物组及系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005065015A2 (en) * 2003-12-10 2005-07-21 Novimmune Sa Neutralizing antibodies and methods of use thereof
US20080050366A1 (en) * 2003-12-10 2008-02-28 Greg Elson Neutralizing antibodies and methods of use thereof
JP2008523048A (ja) * 2004-12-10 2008-07-03 ノビミューン エスアー ｔｏｌｌ様レセプターを標的とする併用療法およびその使用
WO2012096917A1 (en) * 2011-01-10 2012-07-19 Novimmune S.A. Anti-tlr4 antibodies and methods of use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US7312320B2 (en) 2003-12-10 2007-12-25 Novimmune Sa Neutralizing antibodies and methods of use thereof
AU2005272598B2 (en) 2004-08-12 2011-11-17 Helsinn Therapeutics (U.S.), Inc. Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues
SI1919979T1 (sl) * 2005-08-25 2014-02-28 Creabilis Therapeutics S.P.A. Polimerni konjugati K-252A in njihovi derivati
KR101379693B1 (ko) 2005-08-25 2014-04-10 크리어빌리스 쎄라퓨틱스 에스.피.에이. Ｋ-252ａ 및 그의 유도체의 중합체 컨쥬게이트
US20070148704A1 (en) 2005-10-06 2007-06-28 Ursula Klause Anti-CCPand antinuclear antibodies in diagnosis of rheumatoid arthritis
US7712333B2 (en) 2006-03-29 2010-05-11 Asahi Glass Company, Limited Method for smoothing a surface of a glass substrate for a reflective mask blank used in EUV lithography
AU2008350535B2 (en) * 2007-05-14 2013-08-22 Novimmune S.A. Fc receptor-binding polypeptides with modified effector functions
US8202650B2 (en) 2007-07-24 2012-06-19 Panasonic Corporation Negative electrode material for nickel-metal hydride battery and treatment method thereof, and nickel-metal hydride battery
WO2009138494A2 (en) 2008-05-15 2009-11-19 Ablynx N.V. Amino acid sequences directed against toll-like receptors and polypeptides comprising the same for the treatment of diseases related to toll-like receptors
US9140701B2 (en) * 2009-08-18 2015-09-22 The Board Of Trustees Of The Leland Stanford Junior University Fibrinogen immune complexes to diagnose and guide therapy in rheumatoid arthritis
CN104800844A (zh) 2010-11-05 2015-07-29 诺华有限公司 使用il-17拮抗剂治疗类风湿性关节炎的方法
US20140378531A1 (en) * 2012-02-01 2014-12-25 New York University Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
US20160159922A1 (en) 2013-07-24 2016-06-09 Vilara Ab Novel Antibodies for the Diagnosis and Treatment of Rheumatoid Arthritis
CA2928317A1 (en) 2013-10-22 2015-04-30 Novimmune S.A. Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of tlr4 ligands and other biomarkers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005065015A2 (en) * 2003-12-10 2005-07-21 Novimmune Sa Neutralizing antibodies and methods of use thereof
US20080050366A1 (en) * 2003-12-10 2008-02-28 Greg Elson Neutralizing antibodies and methods of use thereof
JP2008523048A (ja) * 2004-12-10 2008-07-03 ノビミューン エスアー ｔｏｌｌ様レセプターを標的とする併用療法およびその使用
WO2012096917A1 (en) * 2011-01-10 2012-07-19 Novimmune S.A. Anti-tlr4 antibodies and methods of use thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ARTHRITIS RESEARCH & THERAPY, vol. 14, JPN6018025582, 2012, pages 260, ISSN: 0004010037 *
ARTHRITIS RESEARCH & THERAPY, vol. 8, JPN6018025585, 2006, pages 69, ISSN: 0004010038 *
ARTHRITIS&RHEUMATISM, vol. 56, no. 9, JPN6018025574, 2007, pages 2957 - 2967, ISSN: 0004010033 *
ARTHRITIS&RHEUMATISM, vol. 63, no. 1, JPN6018025578, 2011, pages 53 - 62, ISSN: 0004010035 *
RHEUMATOLOGY, vol. 52, JPN6018025580, April 2013 (2013-04-01), pages 1739 - 1747, ISSN: 0004010036 *
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 118, JPN6018025576, 2008, pages 205 - 216, ISSN: 0004010034 *
薬学用語解説 関節リウマチ, JPN6018025570, 2009, pages 30 - 6, ISSN: 0004010031 *
関節リウマチ（ＲＡ）に対するトシリズマブ使用ガイドライン, JPN6018025571, June 2013 (2013-06-01), pages 30 - 6, ISSN: 0004010032 *

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JP2023523096A (ja) * 2020-04-20 2023-06-01 エデサ バイオテック リサーチ インコーポレイテッド 急性呼吸促迫症候群を治療するための組成物および方法

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