JP2016539105A5 - - Google Patents
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- JP2016539105A5 JP2016539105A5 JP2016527424A JP2016527424A JP2016539105A5 JP 2016539105 A5 JP2016539105 A5 JP 2016539105A5 JP 2016527424 A JP2016527424 A JP 2016527424A JP 2016527424 A JP2016527424 A JP 2016527424A JP 2016539105 A5 JP2016539105 A5 JP 2016539105A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cells
- composition according
- patient
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 57
- 210000004027 cell Anatomy 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 14
- 210000001808 exosome Anatomy 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 239000012049 topical pharmaceutical composition Substances 0.000 claims description 7
- 102000004127 Cytokines Human genes 0.000 claims description 6
- 108090000695 Cytokines Proteins 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 206010017533 Fungal infection Diseases 0.000 claims description 4
- 102000008070 Interferon-gamma Human genes 0.000 claims description 4
- 108010074328 Interferon-gamma Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 4
- 239000012228 culture supernatant Substances 0.000 claims description 4
- 230000002519 immonomodulatory effect Effects 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 229960003130 interferon gamma Drugs 0.000 claims description 4
- 238000002955 isolation Methods 0.000 claims description 4
- 229960000502 poloxamer Drugs 0.000 claims description 4
- 229920001983 poloxamer Polymers 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 208000035143 Bacterial infection Diseases 0.000 claims description 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 2
- 102000009109 Fc receptors Human genes 0.000 claims description 2
- 108010087819 Fc receptors Proteins 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 239000008365 aqueous carrier Substances 0.000 claims description 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 102000003675 cytokine receptors Human genes 0.000 claims description 2
- 108010057085 cytokine receptors Proteins 0.000 claims description 2
- 239000003405 delayed action preparation Substances 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 238000010254 subcutaneous injection Methods 0.000 claims description 2
- 239000007929 subcutaneous injection Substances 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- 230000002476 tumorcidal effect Effects 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361899066P | 2013-11-01 | 2013-11-01 | |
| US61/899,066 | 2013-11-01 | ||
| PCT/US2014/062695 WO2015066054A1 (en) | 2013-11-01 | 2014-10-28 | Tumoricidal and antimicrobial compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019186716A Division JP6870053B2 (ja) | 2013-11-01 | 2019-10-10 | 殺腫瘍性および抗菌性の組成物ならびに方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539105A JP2016539105A (ja) | 2016-12-15 |
| JP2016539105A5 true JP2016539105A5 (cg-RX-API-DMAC7.html) | 2017-12-07 |
| JP6603216B2 JP6603216B2 (ja) | 2019-11-06 |
Family
ID=53005034
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527424A Active JP6603216B2 (ja) | 2013-11-01 | 2014-10-28 | 殺腫瘍性および抗菌性の組成物ならびに方法 |
| JP2019186716A Active JP6870053B2 (ja) | 2013-11-01 | 2019-10-10 | 殺腫瘍性および抗菌性の組成物ならびに方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019186716A Active JP6870053B2 (ja) | 2013-11-01 | 2019-10-10 | 殺腫瘍性および抗菌性の組成物ならびに方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (10) | US10258649B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP3062800B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6603216B2 (cg-RX-API-DMAC7.html) |
| KR (5) | KR20220147705A (cg-RX-API-DMAC7.html) |
| CN (2) | CN105848662A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014342477B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2927977C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2935906T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015066054A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2927977C (en) | 2013-11-01 | 2024-03-05 | Nantkwest, Inc. | Tumoricidal and antimicrobial compositions and methods |
| CN107709552B (zh) * | 2015-06-10 | 2022-05-13 | 南克维斯特公司 | 用于治疗癌症的修饰的nk-92细胞 |
| WO2017100709A1 (en) * | 2015-12-09 | 2017-06-15 | Nant Holdings Ip, Llc | Compositions and methods for treatment of her2 positive metastatic breast cancer |
| WO2018015895A1 (en) * | 2016-07-19 | 2018-01-25 | National Institute Of Plant Genome Research | Novel protein against fungal pathogens |
| EP3519562A4 (en) * | 2016-09-29 | 2020-03-25 | Nantkwest, Inc. | NK-92 HLA CLASS I DEFICIENT CELLS WITH REDUCED IMMUNOGENICITY |
| CN108324735B (zh) * | 2017-01-20 | 2024-02-09 | 李莉 | 用于疾病治疗的胞外体制剂及其应用 |
| WO2018208702A1 (en) * | 2017-05-09 | 2018-11-15 | Saint Louis University | Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes |
| US20210040451A1 (en) * | 2018-01-31 | 2021-02-11 | Nantkwest, Inc. | Use of 5% human albumin in wash and harvest media |
| CN108815186A (zh) * | 2018-06-14 | 2018-11-16 | 上海鸣大生物科技有限公司 | 一种治疗hpv持续感染引起疾病的药物及制备方法与应用 |
| WO2021028787A1 (en) * | 2019-08-12 | 2021-02-18 | Advaccine (Suzhou) Biopharmaceuticals Co. Ltd. | Immune composition comprising respiratory syncytial virus (rsv) g polypeptide |
| WO2025221993A1 (en) | 2024-04-18 | 2025-10-23 | Immunitybio, Inc. | Compositions and methods for producing il-16 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8034332B2 (en) | 1997-04-30 | 2011-10-11 | Conkwest, Inc. | Interleukin-secreting natural killer cell lines and methods of use |
| WO1998049268A1 (en) * | 1997-04-30 | 1998-11-05 | Hans Klingemann | Natural killer cell lines and methods of use |
| JP2007522161A (ja) | 2004-02-13 | 2007-08-09 | コグニス・フランス・ソシエテ・パール・アクシオン・サンプリフィエ | カスタネア・サチバの葉抽出物を含有する化粧品組成物 |
| EP1781777A1 (en) | 2004-07-02 | 2007-05-09 | Avaris AB | Method for the genetic activation of cells and uses of said cells |
| DK3406631T3 (da) | 2004-07-10 | 2022-08-29 | The Institute For Cancer Res | Genetisk modificerede humane naturlige dræbercellelinjer |
| EP1888649A2 (en) | 2005-05-09 | 2008-02-20 | GlycArt Biotechnology AG | Antigen binding molecules having modified fc regions and altered binding to fc receptors |
| HUE026536T2 (en) * | 2008-02-22 | 2016-06-28 | Agency For Science Tech And Res (A Star) | Mesenchymal stem cell particles |
| US9347942B2 (en) * | 2010-07-28 | 2016-05-24 | Canvax Biotech Sl | Ultrasensitive cell based sensors and uses thereof |
| KR101298012B1 (ko) | 2011-02-08 | 2013-08-26 | (주)차바이오앤디오스텍 | 암세포로의 표적지향을 위한 자연살해 세포를 포함하는 림프구의 제조방법 및 이를 포함하는 약학 조성물 |
| US20150212064A1 (en) * | 2011-08-12 | 2015-07-30 | The Childrens's Hospital Of Philadelphia | Degranulation indicator and methods of use thereof |
| CA2927977C (en) | 2013-11-01 | 2024-03-05 | Nantkwest, Inc. | Tumoricidal and antimicrobial compositions and methods |
| EP3641790A1 (en) | 2017-06-20 | 2020-04-29 | Nantkwest, Inc. | Methods for treating merkel cell carcinoma (mcc) using nk-92 cells |
| US20200306302A1 (en) | 2017-08-04 | 2020-10-01 | Nantkwest, Inc. | Treating and inhibiting leukemia with nk-92 cells |
-
2014
- 2014-10-28 CA CA2927977A patent/CA2927977C/en active Active
- 2014-10-28 KR KR1020227036373A patent/KR20220147705A/ko not_active Ceased
- 2014-10-28 KR KR1020217037585A patent/KR102476640B1/ko active Active
- 2014-10-28 JP JP2016527424A patent/JP6603216B2/ja active Active
- 2014-10-28 KR KR1020237018562A patent/KR20230085215A/ko not_active Ceased
- 2014-10-28 US US15/032,518 patent/US10258649B2/en active Active
- 2014-10-28 WO PCT/US2014/062695 patent/WO2015066054A1/en not_active Ceased
- 2014-10-28 ES ES20159448T patent/ES2935906T3/es active Active
- 2014-10-28 EP EP14858835.3A patent/EP3062800B1/en active Active
- 2014-10-28 AU AU2014342477A patent/AU2014342477B2/en active Active
- 2014-10-28 EP EP20159448.8A patent/EP3701957B1/en active Active
- 2014-10-28 EP EP22197465.2A patent/EP4134085A1/en active Pending
- 2014-10-28 KR KR1020257021166A patent/KR20250099421A/ko active Pending
- 2014-10-28 KR KR1020167014198A patent/KR102329796B1/ko active Active
- 2014-10-28 CN CN201480068072.8A patent/CN105848662A/zh active Pending
- 2014-10-28 CN CN202510641320.3A patent/CN120501764A/zh active Pending
-
2018
- 2018-12-06 US US16/212,578 patent/US10646516B2/en active Active
-
2019
- 2019-02-28 US US16/289,512 patent/US10772912B2/en active Active
- 2019-02-28 US US16/289,526 patent/US11213547B2/en active Active
- 2019-02-28 US US16/289,494 patent/US10517895B2/en active Active
- 2019-10-10 US US16/598,418 patent/US11304977B2/en active Active
- 2019-10-10 JP JP2019186716A patent/JP6870053B2/ja active Active
-
2021
- 2021-11-30 US US17/539,155 patent/US11975027B2/en active Active
-
2022
- 2022-02-22 US US17/677,727 patent/US12064450B2/en active Active
-
2024
- 2024-07-17 US US18/775,316 patent/US20240366674A1/en active Pending
-
2025
- 2025-01-17 US US19/030,104 patent/US20250170181A1/en active Pending
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