JP2016538271A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016538271A5 JP2016538271A5 JP2016526337A JP2016526337A JP2016538271A5 JP 2016538271 A5 JP2016538271 A5 JP 2016538271A5 JP 2016526337 A JP2016526337 A JP 2016526337A JP 2016526337 A JP2016526337 A JP 2016526337A JP 2016538271 A5 JP2016538271 A5 JP 2016538271A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- salt
- nicotinamide riboside
- weight
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 58
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 14
- 239000011618 nicotinamide riboside Substances 0.000 claims 14
- -1 nicotinamide riboside compound Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 6
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 6
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 claims 6
- 210000003491 skin Anatomy 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 3
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 3
- 229910002651 NO3 Inorganic materials 0.000 claims 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 3
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 3
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 3
- 229940072107 ascorbate Drugs 0.000 claims 3
- 235000010323 ascorbic acid Nutrition 0.000 claims 3
- 239000011668 ascorbic acid Substances 0.000 claims 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 3
- 150000003841 chloride salts Chemical class 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000001177 diphosphate Substances 0.000 claims 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 3
- 235000011180 diphosphates Nutrition 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 229940044170 formate Drugs 0.000 claims 3
- 229940050410 gluconate Drugs 0.000 claims 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 3
- 229940001447 lactate Drugs 0.000 claims 3
- 229940102396 methyl bromide Drugs 0.000 claims 3
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 3
- 230000005778 DNA damage Effects 0.000 claims 2
- 231100000277 DNA damage Toxicity 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- UPUOLJWYFICKJI-UHFFFAOYSA-N cyclobutane;pyrimidine Chemical class C1CCC1.C1=CN=CN=C1 UPUOLJWYFICKJI-UHFFFAOYSA-N 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 230000004792 oxidative damage Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361897713P | 2013-10-30 | 2013-10-30 | |
| US61/897,713 | 2013-10-30 | ||
| PCT/US2014/063260 WO2015066382A1 (en) | 2013-10-30 | 2014-10-30 | Nicotinamide riboside compositions for topical use in treating skin conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016538271A JP2016538271A (ja) | 2016-12-08 |
| JP2016538271A5 true JP2016538271A5 (cg-RX-API-DMAC7.html) | 2017-12-21 |
| JP6509844B2 JP6509844B2 (ja) | 2019-05-08 |
Family
ID=53005146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016526337A Active JP6509844B2 (ja) | 2013-10-30 | 2014-10-30 | 皮膚症状の治療において局所使用されるニコチンアミドリボシド組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10688118B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3063163B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6509844B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR20160067195A (cg-RX-API-DMAC7.html) |
| CN (2) | CN105873937A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014342185B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2928656C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2925879T3 (cg-RX-API-DMAC7.html) |
| MX (2) | MX394291B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ719328A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015066382A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201603314B (cg-RX-API-DMAC7.html) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10316054B2 (en) | 2014-06-02 | 2019-06-11 | Glaxosmithkline Intellectual Property (No. 2) Limited | Preparation and use of crystalline beta-D-nicotinamide riboside |
| JP6559713B2 (ja) | 2014-06-06 | 2019-08-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | ニコチンアミドリボシド類似体ならびにその医薬組成物および使用 |
| CN106715454B (zh) | 2014-07-24 | 2020-06-16 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| FI3268379T3 (fi) | 2015-03-09 | 2023-12-15 | Grace W R & Co | Nikotiiniamidiribosidin kiteinen muoto |
| BR112017019696A2 (pt) * | 2015-03-16 | 2018-09-04 | ChromaDex Inc. | composto e usos de um composto |
| JP2018515485A (ja) | 2015-05-01 | 2018-06-14 | ザ プロクター アンド ギャンブル カンパニー | 皮膚の外観を改善する方法及びニコチンアミドリボシドを使用したそのための組成物 |
| JP2018515486A (ja) | 2015-05-01 | 2018-06-14 | ザ プロクター アンド ギャンブル カンパニー | ニコチンアミドリボシドを用いた皮膚外観の改善方法及びそのための組成物 |
| JP6611099B2 (ja) * | 2015-05-01 | 2019-11-27 | ザ プロクター アンド ギャンブル カンパニー | 皮膚の健康を改善する方法及びそのための組成物 |
| AU2016274126A1 (en) * | 2015-06-10 | 2018-01-18 | Elysium Health, Inc. | Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders |
| US20180177703A1 (en) * | 2015-06-25 | 2018-06-28 | N.V. Perricone Llc | Niacinamide Mononucleotide Formulations For Skin Aging |
| US20160374908A1 (en) | 2015-06-29 | 2016-12-29 | The Procter & Gamble Company | Skin care composition and methods of using the same |
| WO2017004102A1 (en) | 2015-06-29 | 2017-01-05 | The Procter & Gamble Company | Multi-component skin care product comprising nicoinamide riboside in a multi-chambered container |
| US20160374918A1 (en) * | 2015-06-29 | 2016-12-29 | The Procter & Gamble Company | Encapsulated skin care agent |
| MX380159B (es) | 2016-01-11 | 2025-03-12 | Procter & Gamble | Metodo para tratar una afeccion cutanea y composiciones de este. |
| AU2017232930B2 (en) | 2016-03-16 | 2021-03-25 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| NZ747693A (en) * | 2016-04-20 | 2023-07-28 | Chromadex Inc | Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as nad+increasing precursors |
| CN109982706A (zh) * | 2016-08-22 | 2019-07-05 | 益力舒健康公司 | 用于治疗神经退行性病症的烟酰胺核苷和紫檀芪的组合物和方法 |
| WO2018089830A1 (en) | 2016-11-11 | 2018-05-17 | The Queen's University Of Belfast | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| BR112019010607B1 (pt) | 2016-11-29 | 2023-10-31 | University Of Iowa Research Foundation | Uso de precursores de nad e composição compreendendo os referidos precursores |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| WO2018113634A1 (en) | 2016-12-21 | 2018-06-28 | Unilever Plc | Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids |
| US11077039B2 (en) | 2016-12-21 | 2021-08-03 | Conopco, Inc. | Topical skin lightening additive and composition with amino acids and nicotinamide compounds |
| EA201991003A1 (ru) | 2016-12-21 | 2019-12-30 | Юнилевер Н.В. | Композиции для личной гигиены, содержащие малорастворимые соединения |
| US11337908B2 (en) | 2016-12-21 | 2022-05-24 | Conopco, Inc. | Personal care compositions with cystine |
| RU2651047C1 (ru) * | 2017-05-04 | 2018-04-18 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Лекарственная композиция цитопротекторного действия и способ ее получения |
| CN111093676A (zh) * | 2017-05-18 | 2020-05-01 | 益力舒健康公司 | 改善睡眠的方法和组合物 |
| EP3642214A2 (en) | 2017-06-19 | 2020-04-29 | Gangadhara Ganapati | Nicotinamide riboside derivatives and their uses |
| EP3641725A1 (en) | 2017-06-23 | 2020-04-29 | The Procter and Gamble Company | Composition and method for improving the appearance of skin |
| US11364187B2 (en) * | 2017-07-28 | 2022-06-21 | Centers For Age Control, Inc. | Compositions and methods for preventing and reversing aspects of aging |
| US11219590B2 (en) * | 2017-09-14 | 2022-01-11 | Megumi Tanaka | Anti-aging agent and anti-aging method |
| GB201716391D0 (en) * | 2017-10-06 | 2017-11-22 | Xobaderm Ltd | Kit for delivery of an active compound into a biological barrier |
| US11414407B2 (en) | 2017-12-22 | 2022-08-16 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| US11052100B2 (en) * | 2018-08-17 | 2021-07-06 | Bontac Bio-Engineering (Shenzhen) Co., Ltd | Stable nicotinamide riboside composition and preparation method thereof |
| KR102060374B1 (ko) * | 2018-12-14 | 2019-12-30 | 주식회사 휴메딕스 | 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체 |
| US11833167B2 (en) | 2018-12-17 | 2023-12-05 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| CA3148300A1 (en) * | 2019-07-19 | 2021-01-28 | Biosynth Ag | Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof |
| CN110638827A (zh) * | 2019-10-17 | 2020-01-03 | 泓博元生命科技（深圳）有限公司 | Nadh及其盐在制备皮肤色素抑制剂中的应用 |
| CN111166760A (zh) * | 2019-12-17 | 2020-05-19 | 浙江安赛新材料科技有限公司 | β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用 |
| KR102315139B1 (ko) | 2019-12-17 | 2021-10-20 | 주식회사 휴메딕스 | 지방아민 컨쥬게이션된 니코틴아미드 리보사이드 유도체 |
| CN111184732B (zh) * | 2020-03-04 | 2023-09-08 | 武汉华纳联合药业有限公司 | 一种复合组合物制剂及其制备方法和皮肤炎症中的应用 |
| CN111454311B (zh) | 2020-04-03 | 2021-10-19 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其组合物与制备方法 |
| FR3110410A1 (fr) * | 2020-05-20 | 2021-11-26 | Nuvamid Sa | Compositions cosmétiques anti-âge comprenant de la NMN |
| EP4153323A1 (fr) * | 2020-05-20 | 2023-03-29 | Nuvamid SA | Compositions cosmetiques anti-age comprenant du nmn |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| EP4157206A1 (en) | 2020-06-01 | 2023-04-05 | The Procter & Gamble Company | Method of improving penetration of a vitamin b3 compound into skin |
| CN111632049A (zh) * | 2020-06-09 | 2020-09-08 | 西北农林科技大学 | 一种通过综合矫正细胞活性氧簇代谢紊乱以缓解睾丸衰老损伤的复合配方 |
| WO2022047182A1 (en) * | 2020-08-28 | 2022-03-03 | University Of Washington | High dose nicotinamide adenine dinucleotide (nad) precursor regimens for reduction of inflammation in human patients with preexisting inflammation |
| US20240059727A1 (en) * | 2021-01-19 | 2024-02-22 | Biosynth Ag | Method of making nicotinamide ribofuranoside salts by salt metathesis, the crystalline form of its tosylate salt and the co-crystallized form of its chloride:iodide salt |
| US12150461B2 (en) * | 2021-05-04 | 2024-11-26 | Sovida Solutions Ltd. | Nicotinamide adenine dinucleotide (NAD) compositions, methods of manufacturing thereof, and methods of use thereof |
| CN114129509B (zh) * | 2021-12-03 | 2023-12-01 | 药酚享科技(北京)有限公司 | 一种保湿性nmn亲水凝胶剂及其制备方法 |
| CN116621898A (zh) * | 2022-04-13 | 2023-08-22 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途 |
| KR102784901B1 (ko) * | 2022-06-23 | 2025-03-21 | 제너럴바이오(주) | Nr, nmn 및 nad를 함유한 피부 주름 개선용 화장료 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200305174B (en) * | 2001-02-22 | 2004-09-23 | Unilever Plc | Skin composition for reducing skin oils and grease. |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| EP1723227A4 (en) | 2004-02-10 | 2007-09-19 | Dartmouth College | NICOTINAMIDRIBOSIDE KINASE COMPOSITIONS AND METHOD FOR THEIR USE |
| CN1964627B (zh) | 2004-06-04 | 2011-10-19 | 华盛顿大学 | 治疗神经病变的方法和组合物 |
| US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| WO2007008548A2 (en) * | 2005-07-07 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| CN101257897A (zh) * | 2005-07-07 | 2008-09-03 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
| EP3369738B1 (en) | 2005-11-18 | 2020-05-20 | Cornell Research Foundation, Inc. | Method for making nicotinoyl ribosides and nicotinamide beta-riboside |
| JP2010520897A (ja) * | 2007-03-12 | 2010-06-17 | ディーエスエム アイピー アセッツ ビー．ブイ． | 化粧品組成物 |
| US20090069444A1 (en) | 2007-09-07 | 2009-03-12 | The United States Of America, As Represented By Th E Secretary Of Agriculture | Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration |
| KR101807328B1 (ko) * | 2010-01-06 | 2017-12-08 | 가부시키가이샤 야쿠르트 혼샤 | 경구용 ｄｎａ 손상 수복 촉진제 및 엘라스타아제 활성 억제제 |
-
2014
- 2014-10-30 CN CN201480071722.4A patent/CN105873937A/zh active Pending
- 2014-10-30 CA CA2928656A patent/CA2928656C/en active Active
- 2014-10-30 NZ NZ719328A patent/NZ719328A/en unknown
- 2014-10-30 MX MX2021009652A patent/MX394291B/es unknown
- 2014-10-30 AU AU2014342185A patent/AU2014342185B2/en active Active
- 2014-10-30 KR KR1020167014302A patent/KR20160067195A/ko not_active Ceased
- 2014-10-30 KR KR1020217026414A patent/KR20210107895A/ko not_active Ceased
- 2014-10-30 JP JP2016526337A patent/JP6509844B2/ja active Active
- 2014-10-30 CN CN201910027571.7A patent/CN109985056A/zh active Pending
- 2014-10-30 US US15/033,285 patent/US10688118B2/en active Active
- 2014-10-30 MX MX2016005574A patent/MX385305B/es unknown
- 2014-10-30 WO PCT/US2014/063260 patent/WO2015066382A1/en not_active Ceased
- 2014-10-30 KR KR1020227022241A patent/KR20220098049A/ko not_active Ceased
- 2014-10-30 ES ES14857903T patent/ES2925879T3/es active Active
- 2014-10-30 EP EP14857903.0A patent/EP3063163B1/en active Active
-
2016
- 2016-05-16 ZA ZA2016/03314A patent/ZA201603314B/en unknown
-
2020
- 2020-06-03 US US16/891,824 patent/US11033568B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016538271A5 (cg-RX-API-DMAC7.html) | ||
| IN2014MN02288A (cg-RX-API-DMAC7.html) | ||
| MY180145A (en) | Cenicriviroc compositions and methods of making and using the same | |
| IN2014MN01755A (cg-RX-API-DMAC7.html) | ||
| MX377629B (es) | Composiciones farmacéuticas tópicas. | |
| JP2016536286A5 (cg-RX-API-DMAC7.html) | ||
| NZ726366A (en) | Syk inhibitors | |
| JP2016147915A5 (cg-RX-API-DMAC7.html) | ||
| MX338554B (es) | Compuestos de fenil carbamato para usarse en aliviar o tratar el dolor. | |
| HRP20171648T1 (hr) | Supstituirani piperidil-etil-pirimidin kao inhibitor grelin-o-acil-transferaze | |
| WO2011117377A3 (en) | Compositions comprising brimonidine for the treatment of erythema | |
| RU2015102772A (ru) | Бензодиазелипы для мелкоклеточного рака легкого | |
| WO2016004404A3 (en) | Gls1 inhibitors for treating disease | |
| RU2018135973A (ru) | Фармацевтическая комбинация, содержащая метроформин и дигидрокверценин, и ее применение для лечения рака | |
| ME02405B (me) | Spojevi pirazola као inhibitori sglt1 | |
| JP2013514328A5 (cg-RX-API-DMAC7.html) | ||
| JP2016515550A5 (cg-RX-API-DMAC7.html) | ||
| JP2014530204A5 (cg-RX-API-DMAC7.html) | ||
| JP2013525342A5 (cg-RX-API-DMAC7.html) | ||
| JP2017525738A5 (cg-RX-API-DMAC7.html) | ||
| WO2019004788A3 (ko) | 브라우쏘칼콘 a를 유효성분으로 포함하는 염증성 장질환 예방 또는 치료용 약학 조성물 | |
| PH12015502203A1 (en) | Phenyl derivative | |
| DK2004235T3 (da) | Sammensætning til kosmetisk eller farmaceutisk-dermatologisk anvendelse | |
| JP2011157392A5 (cg-RX-API-DMAC7.html) | ||
| MX2014011843A (es) | Compuestos para usarse en el tratamiento de neuroblastoma, sarcoma de ewing o rabdomiosarcoma. |