JP2014530204A5 - - Google Patents
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- Publication number
- JP2014530204A5 JP2014530204A5 JP2014532014A JP2014532014A JP2014530204A5 JP 2014530204 A5 JP2014530204 A5 JP 2014530204A5 JP 2014532014 A JP2014532014 A JP 2014532014A JP 2014532014 A JP2014532014 A JP 2014532014A JP 2014530204 A5 JP2014530204 A5 JP 2014530204A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- formula
- solvate
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 12
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 239000012453 solvate Substances 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 6
- 229960005489 paracetamol Drugs 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
- 206010061218 Inflammation Diseases 0.000 claims description 3
- 208000028389 Nerve injury Diseases 0.000 claims description 3
- 208000002193 Pain Diseases 0.000 claims description 3
- 206010037660 Pyrexia Diseases 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- 230000008764 nerve damage Effects 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 239000002504 physiological saline solution Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 description 4
- YZUYJZRZPQMZPL-UHFFFAOYSA-N CC(Nc(cc1)ccc1OC(SCCS(O)(=O)=O)=O)=O Chemical compound CC(Nc(cc1)ccc1OC(SCCS(O)(=O)=O)=O)=O YZUYJZRZPQMZPL-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 208000037906 ischaemic injury Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161538075P | 2011-09-22 | 2011-09-22 | |
| US61/538,075 | 2011-09-22 | ||
| PCT/US2012/056625 WO2013044064A1 (en) | 2011-09-22 | 2012-09-21 | Acetaminophen conjugates, compositions and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016204398A Division JP2017019859A (ja) | 2011-09-22 | 2016-10-18 | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530204A JP2014530204A (ja) | 2014-11-17 |
| JP2014530204A5 true JP2014530204A5 (cg-RX-API-DMAC7.html) | 2015-11-12 |
| JP6029670B2 JP6029670B2 (ja) | 2016-11-24 |
Family
ID=47914904
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014532014A Expired - Fee Related JP6029670B2 (ja) | 2011-09-22 | 2012-09-21 | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
| JP2016204398A Withdrawn JP2017019859A (ja) | 2011-09-22 | 2016-10-18 | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
| JP2018067394A Withdrawn JP2018131447A (ja) | 2011-09-22 | 2018-03-30 | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
| JP2020081769A Withdrawn JP2020122010A (ja) | 2011-09-22 | 2020-05-07 | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016204398A Withdrawn JP2017019859A (ja) | 2011-09-22 | 2016-10-18 | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
| JP2018067394A Withdrawn JP2018131447A (ja) | 2011-09-22 | 2018-03-30 | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
| JP2020081769A Withdrawn JP2020122010A (ja) | 2011-09-22 | 2020-05-07 | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9024055B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2758133A4 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6029670B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012312136B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2849731C (cg-RX-API-DMAC7.html) |
| HK (1) | HK1200392A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013044064A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009143297A1 (en) | 2008-05-20 | 2009-11-26 | Neurogesx, Inc. | Carbonate prodrugs and methods of using the same |
| CN105254662A (zh) | 2008-05-20 | 2016-01-20 | 阿索尔达治疗公司 | 水溶性对乙酰氨基酚类似物 |
| JP7156154B2 (ja) * | 2019-04-18 | 2022-10-19 | 株式会社島津製作所 | 培地処理システム及び培地処理方法 |
| US20220313630A1 (en) * | 2019-06-04 | 2022-10-06 | Lennham Pharmaceuticals, Inc. | Deuterated forms of acetaminophen and uses thereof |
| CN113248596B (zh) * | 2021-04-15 | 2022-12-16 | 华南农业大学 | 一种可同时检测对乙酰氨基酚和非那西丁的人工抗原、抗体及其制备方法和应用 |
| CN116239486B (zh) * | 2023-03-16 | 2025-07-08 | 梯尔希（南京）药物研发有限公司 | 一种对乙酰氨基酚杂质的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2444043A1 (fr) | 1978-12-15 | 1980-07-11 | Bottu | Nouveau derive du paracetamol, son procede de preparation et son utilisation en therapeutique |
| US5985856A (en) | 1997-12-31 | 1999-11-16 | University Of Kansas | Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| MX2009006007A (es) | 2006-12-05 | 2009-07-17 | Neurogesx Inc | Profarmacos y metodos para hacer y usar los mismos. |
| WO2009143297A1 (en) | 2008-05-20 | 2009-11-26 | Neurogesx, Inc. | Carbonate prodrugs and methods of using the same |
| CN105254662A (zh) | 2008-05-20 | 2016-01-20 | 阿索尔达治疗公司 | 水溶性对乙酰氨基酚类似物 |
| CA2724788C (en) | 2008-05-20 | 2016-12-06 | Neurogesx, Inc. | Hepatoprotectant acetaminophen mutual prodrugs |
| US8569466B2 (en) | 2008-09-10 | 2013-10-29 | Nnochiri Ekwuribe | Aromatic carboxylic acid derivatives for treatment and prophylaxis of gastrointestinal diseases including colon cancers |
| EP2408443A1 (en) | 2009-03-16 | 2012-01-25 | Genmedica Therapeutics SL | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
-
2012
- 2012-09-21 US US14/346,689 patent/US9024055B2/en not_active Expired - Fee Related
- 2012-09-21 JP JP2014532014A patent/JP6029670B2/ja not_active Expired - Fee Related
- 2012-09-21 AU AU2012312136A patent/AU2012312136B2/en not_active Ceased
- 2012-09-21 EP EP12833512.2A patent/EP2758133A4/en not_active Withdrawn
- 2012-09-21 WO PCT/US2012/056625 patent/WO2013044064A1/en not_active Ceased
- 2012-09-21 CA CA2849731A patent/CA2849731C/en not_active Expired - Fee Related
- 2012-09-21 HK HK15101054.4A patent/HK1200392A1/xx unknown
-
2016
- 2016-10-18 JP JP2016204398A patent/JP2017019859A/ja not_active Withdrawn
-
2018
- 2018-03-30 JP JP2018067394A patent/JP2018131447A/ja not_active Withdrawn
-
2020
- 2020-05-07 JP JP2020081769A patent/JP2020122010A/ja not_active Withdrawn