JP2016536002A5 - - Google Patents
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- JP2016536002A5 JP2016536002A5 JP2016540449A JP2016540449A JP2016536002A5 JP 2016536002 A5 JP2016536002 A5 JP 2016536002A5 JP 2016540449 A JP2016540449 A JP 2016540449A JP 2016540449 A JP2016540449 A JP 2016540449A JP 2016536002 A5 JP2016536002 A5 JP 2016536002A5
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- tl1a
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- disease
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- 238000000034 method Methods 0.000 claims description 105
- 230000014509 gene expression Effects 0.000 claims description 81
- 108090000623 proteins and genes Proteins 0.000 claims description 62
- 239000000523 sample Substances 0.000 claims description 45
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- 108090000138 Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims description 38
- 201000010099 disease Diseases 0.000 claims description 37
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 37
- 238000002560 therapeutic procedure Methods 0.000 claims description 28
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- 101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 claims description 12
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims description 12
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- FOCAHLGSDWHSAH-UHFFFAOYSA-N difluoromethanethione Chemical compound FC(F)=S FOCAHLGSDWHSAH-UHFFFAOYSA-N 0.000 claims description 12
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- 108700003785 Baculoviral IAP Repeat-Containing 3 Proteins 0.000 claims description 6
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- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 claims description 6
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- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims description 6
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- 101000943584 Homo sapiens Glutathione-specific gamma-glutamylcyclotransferase 1 Proteins 0.000 claims description 6
- 101001066163 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 gamma Proteins 0.000 claims description 6
- 101001001336 Homo sapiens Guanylate-binding protein 1 Proteins 0.000 claims description 6
- 101001058851 Homo sapiens Guanylate-binding protein 4 Proteins 0.000 claims description 6
- 101001058850 Homo sapiens Guanylate-binding protein 5 Proteins 0.000 claims description 6
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- 101000979338 Homo sapiens Nuclear factor NF-kappa-B p100 subunit Proteins 0.000 claims description 6
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- 101000982054 Homo sapiens Unconventional myosin-Ib Proteins 0.000 claims description 6
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- 102100036981 Interferon regulatory factor 1 Human genes 0.000 claims description 6
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- 102100030703 Interleukin-22 Human genes 0.000 claims description 6
- 102100036679 Interleukin-26 Human genes 0.000 claims description 6
- 102100026388 L-amino-acid oxidase Human genes 0.000 claims description 6
- 101710142669 Leucine zipper putative tumor suppressor 1 Proteins 0.000 claims description 6
- 101001089108 Lotus tetragonolobus Anti-H(O) lectin Proteins 0.000 claims description 6
- 102100026238 Lymphotoxin-alpha Human genes 0.000 claims description 6
- 102100033984 Minor histocompatibility protein HMSD variant form Human genes 0.000 claims description 6
- 102100023059 Nuclear factor NF-kappa-B p100 subunit Human genes 0.000 claims description 6
- 101100379220 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) API2 gene Proteins 0.000 claims description 6
- 102100029462 Sodium-dependent lysophosphatidylcholine symporter 1 Human genes 0.000 claims description 6
- 102000003715 TNF receptor-associated factor 4 Human genes 0.000 claims description 6
- 108090000008 TNF receptor-associated factor 4 Proteins 0.000 claims description 6
- 102100029451 TRAF-type zinc finger domain-containing protein 1 Human genes 0.000 claims description 6
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 6
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- 102100026776 Unconventional myosin-Ib Human genes 0.000 claims description 6
- 108091007416 X-inactive specific transcript Proteins 0.000 claims description 6
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- 108091033319 polynucleotide Proteins 0.000 claims description 6
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- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 238000002965 ELISA Methods 0.000 claims description 4
- 206010016654 Fibrosis Diseases 0.000 claims description 4
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 4
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 4
- 101000864800 Homo sapiens Serine/threonine-protein kinase Sgk1 Proteins 0.000 claims description 4
- 101000708741 Homo sapiens Transcription factor RelB Proteins 0.000 claims description 4
- 108010065805 Interleukin-12 Proteins 0.000 claims description 4
- 102000013462 Interleukin-12 Human genes 0.000 claims description 4
- 102000003810 Interleukin-18 Human genes 0.000 claims description 4
- 108090000171 Interleukin-18 Proteins 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 4
- 208000001738 Nervous System Trauma Diseases 0.000 claims description 4
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 4
- 206010035664 Pneumonia Diseases 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 101150015877 RGT1 gene Proteins 0.000 claims description 4
- 102100030070 Serine/threonine-protein kinase Sgk1 Human genes 0.000 claims description 4
- 102100032727 Transcription factor RelB Human genes 0.000 claims description 4
- 206010052779 Transplant rejections Diseases 0.000 claims description 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 4
- 230000000172 allergic effect Effects 0.000 claims description 4
- 239000005557 antagonist Substances 0.000 claims description 4
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- 210000003169 central nervous system Anatomy 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
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- 206010025135 lupus erythematosus Diseases 0.000 claims description 4
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- 208000028412 nervous system injury Diseases 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 claims description 4
- 238000003757 reverse transcription PCR Methods 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 102100037965 60S ribosomal protein L21 Human genes 0.000 claims description 2
- 102100030346 Antigen peptide transporter 1 Human genes 0.000 claims description 2
- 101000661708 Homo sapiens 60S ribosomal protein L21 Proteins 0.000 claims description 2
- 101000739577 Homo sapiens Selenocysteine-specific elongation factor Proteins 0.000 claims description 2
- 108010023335 Member 2 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims description 2
- 238000000636 Northern blotting Methods 0.000 claims description 2
- 238000003559 RNA-seq method Methods 0.000 claims description 2
- 238000011529 RT qPCR Methods 0.000 claims description 2
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims description 2
- 102100037498 Selenocysteine-specific elongation factor Human genes 0.000 claims description 2
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
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- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 238000003127 radioimmunoassay Methods 0.000 claims description 2
- 238000003753 real-time PCR Methods 0.000 claims description 2
- 235000002020 sage Nutrition 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- -1 DR3 nucleic acid Chemical class 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 description 1
- 206010042953 Systemic sclerosis Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874487P | 2013-09-06 | 2013-09-06 | |
| US61/874,487 | 2013-09-06 | ||
| PCT/US2014/054425 WO2015035261A1 (en) | 2013-09-06 | 2014-09-05 | Systems, devices and methods for anti-tl1a therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016536002A JP2016536002A (ja) | 2016-11-24 |
| JP2016536002A5 true JP2016536002A5 (https=) | 2017-09-21 |
Family
ID=52628988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540449A Withdrawn JP2016536002A (ja) | 2013-09-06 | 2014-09-05 | 抗ｔｌ１ａ療法のためのシステム、デバイス、及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20160208329A1 (https=) |
| EP (1) | EP3041580A4 (https=) |
| JP (1) | JP2016536002A (https=) |
| KR (1) | KR20160052585A (https=) |
| CN (1) | CN105636648A (https=) |
| AU (1) | AU2014317991A1 (https=) |
| CA (1) | CA2922381A1 (https=) |
| IL (1) | IL244427A0 (https=) |
| MX (1) | MX2016002879A (https=) |
| WO (1) | WO2015035261A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| KR101982899B1 (ko) | 2011-09-30 | 2019-05-27 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | ＴＬ1ａ에 대한 항체 및 그의 용도 |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| JP6692748B2 (ja) * | 2013-09-26 | 2020-05-13 | ナショナル ユニヴァーシティー オブ シンガポール | リゾホスファチジルコリンの足場を利用する組成物及び方法 |
| US20170246259A1 (en) * | 2014-09-10 | 2017-08-31 | Georgetown University | Compositions and Methods of Using Interleukin-4 Induced Gene 1 (IL-4I1) |
| JP2018522533A (ja) * | 2015-05-15 | 2018-08-16 | シーダーズ—シナイ メディカル センター | 炎症性腸疾患を処置するためのモデル、方法および組成物 |
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| KR20240095481A (ko) * | 2016-03-17 | 2024-06-25 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| US10345302B2 (en) * | 2017-02-19 | 2019-07-09 | Sheng-He Huang | Circulating astrocytes and MFSD2A as biomarkers |
| CN106885902B (zh) * | 2017-03-03 | 2018-02-27 | 四川大学华西第二医院 | 以ncam‑1为检测指标的金标试剂盒及其制备方法和应用 |
| CN109954000B (zh) * | 2017-12-22 | 2021-02-23 | 中国农业大学 | 驴乳在制备食品或者药物中的用途、治疗溃疡性结肠炎的食品和药物 |
| WO2020112890A1 (en) | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Rnaset2 compositions and methods of treatment therewith |
| US12448651B2 (en) | 2018-12-12 | 2025-10-21 | Hadasit Medical Research Services And Development Ltd. | Markers of disease prognosis in multiple sclerosis |
| CA3180632A1 (en) * | 2020-06-03 | 2021-12-09 | Cedars-Sinai Medical Center | Methods and systems for measuring post-operative disease recurrence |
| BR112022025667A2 (pt) * | 2020-06-26 | 2023-03-07 | Pfizer | Métodos de tratamento da doença inflamatória intestinal com anticorpos tl1a |
| CN111979311A (zh) * | 2020-08-31 | 2020-11-24 | 西北大学 | 肌球蛋白1b作为动脉粥样硬化诊断和治疗靶标的应用 |
| CN112730850B (zh) * | 2021-01-22 | 2022-11-01 | 广州医科大学附属肿瘤医院 | 一种肾纤维化生物标志物及其应用 |
| CN115785277B (zh) * | 2022-09-09 | 2023-06-20 | 上海百英生物科技股份有限公司 | 一种抗IL4i1纳米抗体的制备及其应用 |
| CN121843714A (zh) | 2023-08-11 | 2026-04-10 | 派拉冈医疗公司 | Tl1a结合抗体及使用方法 |
| KR20250092108A (ko) * | 2023-12-12 | 2025-06-23 | 의료법인 성광의료재단 | 면역치료요법의 치료 반응 예측을 위한 바이오마커 및 이를 이용한 유전자 예측 모델 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6607879B1 (en) * | 1998-02-09 | 2003-08-19 | Incyte Corporation | Compositions for the detection of blood cell and immunological response gene expression |
| WO2005018571A2 (en) * | 2003-08-20 | 2005-03-03 | University Of Miami | Compositions and methods for treating inflammatory lung disease |
| AU2006284922B2 (en) * | 2005-08-30 | 2012-01-19 | University Of Miami | Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists and immunotoxins |
| US20090186034A1 (en) * | 2006-12-19 | 2009-07-23 | Genetech, Inc. | Gene expression markers for inflammatory bowel disease |
| US9896511B2 (en) * | 2007-01-10 | 2018-02-20 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies |
| US20110217310A1 (en) * | 2007-01-10 | 2011-09-08 | Siegel Richard M | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology |
| US20100190162A1 (en) * | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| US8362218B2 (en) * | 2009-04-17 | 2013-01-29 | New York University School Of Medicine | Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof |
| WO2010144358A1 (en) * | 2009-06-08 | 2010-12-16 | Singulex, Inc. | Highly sensitive biomarker panels |
| WO2012161856A1 (en) * | 2011-05-20 | 2012-11-29 | Government Of The United States, As Represented By The Secretary, Department Of Health And Human Services | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof |
-
2014
- 2014-09-05 MX MX2016002879A patent/MX2016002879A/es unknown
- 2014-09-05 US US14/915,544 patent/US20160208329A1/en not_active Abandoned
- 2014-09-05 EP EP14842590.3A patent/EP3041580A4/en not_active Withdrawn
- 2014-09-05 AU AU2014317991A patent/AU2014317991A1/en not_active Abandoned
- 2014-09-05 CN CN201480057198.5A patent/CN105636648A/zh active Pending
- 2014-09-05 CA CA2922381A patent/CA2922381A1/en not_active Abandoned
- 2014-09-05 WO PCT/US2014/054425 patent/WO2015035261A1/en not_active Ceased
- 2014-09-05 JP JP2016540449A patent/JP2016536002A/ja not_active Withdrawn
- 2014-09-05 KR KR1020167007354A patent/KR20160052585A/ko not_active Withdrawn
-
2016
- 2016-03-03 IL IL244427A patent/IL244427A0/en unknown
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