JP2016535795A5 - - Google Patents
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- Publication number
- JP2016535795A5 JP2016535795A5 JP2016553270A JP2016553270A JP2016535795A5 JP 2016535795 A5 JP2016535795 A5 JP 2016535795A5 JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016535795 A5 JP2016535795 A5 JP 2016535795A5
- Authority
- JP
- Japan
- Prior art keywords
- chlorophenyl
- pharmaceutical composition
- oxopiperidin
- methylbutan
- isopropylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 8
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 6
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 6
- 201000001441 melanoma Diseases 0.000 claims 6
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 5
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 5
- -1 3-methyl-2-oxopiperidin-3-yl Chemical group 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 3
- 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 229960002465 dabrafenib Drugs 0.000 claims 2
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 2
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 2
- 229960004066 trametinib Drugs 0.000 claims 2
- DRLCSJFKKILATL-YWCVFVGNSA-N 2-[(3r,5r,6s)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2s)-3-methyl-1-propan-2-ylsulfonylbutan-2-yl]-2-oxopiperidin-3-yl]acetic acid Chemical compound C1([C@@H]2[C@H](N(C([C@@](C)(CC(O)=O)C2)=O)[C@H](CS(=O)(=O)C(C)C)C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 DRLCSJFKKILATL-YWCVFVGNSA-N 0.000 claims 1
- 102200055464 rs113488022 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902717P | 2013-11-11 | 2013-11-11 | |
| US61/902,717 | 2013-11-11 | ||
| PCT/US2014/065034 WO2015070224A2 (en) | 2013-11-11 | 2014-11-11 | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078325A Division JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016535795A JP2016535795A (ja) | 2016-11-17 |
| JP2016535795A5 true JP2016535795A5 (https=) | 2017-12-21 |
Family
ID=52001089
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553270A Ceased JP2016535795A (ja) | 2013-11-11 | 2014-11-11 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2019078325A Pending JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2020172367A Expired - Fee Related JP6972274B2 (ja) | 2013-11-11 | 2020-10-13 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2021178554A Pending JP2022009805A (ja) | 2013-11-11 | 2021-11-01 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2023003579A Pending JP2023033414A (ja) | 2013-11-11 | 2023-01-13 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078325A Pending JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2020172367A Expired - Fee Related JP6972274B2 (ja) | 2013-11-11 | 2020-10-13 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2021178554A Pending JP2022009805A (ja) | 2013-11-11 | 2021-11-01 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2023003579A Pending JP2023033414A (ja) | 2013-11-11 | 2023-01-13 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US20160287569A1 (https=) |
| EP (2) | EP3068393B9 (https=) |
| JP (5) | JP2016535795A (https=) |
| KR (3) | KR20220167335A (https=) |
| CN (2) | CN105934255A (https=) |
| AP (1) | AP2016009243A0 (https=) |
| AU (3) | AU2014346354A1 (https=) |
| BR (1) | BR112016010564A2 (https=) |
| CA (1) | CA2930244A1 (https=) |
| CL (1) | CL2016001131A1 (https=) |
| CY (1) | CY1125358T1 (https=) |
| DK (1) | DK3068393T5 (https=) |
| EA (2) | EA202092456A3 (https=) |
| ES (1) | ES2916721T3 (https=) |
| HR (1) | HRP20220718T1 (https=) |
| HU (1) | HUE059351T2 (https=) |
| IL (2) | IL245568B (https=) |
| LT (1) | LT3068393T (https=) |
| MA (1) | MA39094B1 (https=) |
| MX (6) | MX378969B (https=) |
| MY (1) | MY192088A (https=) |
| NZ (2) | NZ720766A (https=) |
| PH (1) | PH12016500871A1 (https=) |
| PL (1) | PL3068393T3 (https=) |
| PT (1) | PT3068393T (https=) |
| RS (1) | RS63348B9 (https=) |
| SG (1) | SG10201902429PA (https=) |
| SI (1) | SI3068393T1 (https=) |
| SM (1) | SMT202200241T1 (https=) |
| TN (1) | TN2016000176A1 (https=) |
| UA (1) | UA120750C2 (https=) |
| WO (1) | WO2015070224A2 (https=) |
| ZA (1) | ZA201603342B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| KR20170058446A (ko) | 2010-08-13 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| AR088392A1 (es) | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| AU2014236812B2 (en) | 2013-03-14 | 2018-03-01 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
| HRP20220718T1 (hr) * | 2013-11-11 | 2022-09-30 | Amgen Inc. | Kombinacijska terapija uključujući inhibitor mdm2 i jedan ili više dodatnih farmaceutski aktivnih sredstava za liječenje raka |
| SG11201702175YA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| JP6564449B2 (ja) | 2015-02-20 | 2019-08-21 | 第一三共株式会社 | がんの併用治療法 |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| EP3341023A1 (en) * | 2015-08-28 | 2018-07-04 | Novartis AG | Combination therapy using pi3k inhbitor and mdm2 inhibitor |
| RU2020142739A (ru) * | 2015-08-28 | 2021-01-15 | Новартис Аг | Ингибиторы mdm2 и их комбинации |
| WO2017200826A1 (en) * | 2016-05-16 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Assays and compounds for treatment of cancer |
| EP3458101B1 (en) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac antibody conjugates and methods of use |
| US20190240210A1 (en) * | 2016-10-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| IL308399B2 (en) * | 2018-04-30 | 2025-08-01 | Kartos Therapeutics Inc | Methods of treating cancer |
| CN112804994A (zh) * | 2018-05-25 | 2021-05-14 | 卡托斯医疗公司 | 治疗骨髓增殖性肿瘤的方法 |
| WO2020023502A1 (en) | 2018-07-23 | 2020-01-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN110963958B (zh) * | 2018-09-30 | 2025-10-10 | 上海长森药业有限公司 | 一种mdm2抑制剂，及其制备方法、药物组合物和应用 |
| EP3927344A4 (en) * | 2018-12-11 | 2023-01-18 | Kartos Therapeutics | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AN EYE CONDITION |
| CN111434353A (zh) * | 2019-02-02 | 2020-07-21 | 中国科学院上海营养与健康研究所 | Ras抑制剂筛选及疗效标志物 |
| US12194024B2 (en) | 2019-07-26 | 2025-01-14 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition of MDM2 inhibitor and use thereof for preventing and/or treating disease |
| TW202128156A (zh) * | 2019-11-14 | 2021-08-01 | 美商夸格智財控股有限公司 | 用於癌症治療之btk抑制劑及mdm2抑制劑之組合 |
| US20230218575A1 (en) * | 2020-06-15 | 2023-07-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Microsuspension of an mdm2 inhibitor and therapeautic applications thereof |
| WO2022036067A1 (en) * | 2020-08-12 | 2022-02-17 | Servier Pharmaceuticals, Llc | Combination therapies for use in treating cancer |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| CN115089585A (zh) * | 2022-08-05 | 2022-09-23 | 中国科学院大学宁波华美医院 | Mdm2抑制剂rg7112联合依托泊苷在治疗肺癌中的应用 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
| EP4719409A1 (en) * | 2023-06-05 | 2026-04-08 | Kartos Therapeutics, Inc. | Treatment of endometrial cancer with mdm2 inhibitors |
| WO2025098488A1 (zh) * | 2023-11-09 | 2025-05-15 | 深圳艾欣达伟医药科技有限公司 | 上调p53蛋白表达或激活p53功能的药物与DNA烷化剂联用治疗癌症 |
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| DZ3401A1 (fr) | 2000-07-19 | 2002-01-24 | Warner Lambert Co | Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques |
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| US20160002185A1 (en) | 2013-02-19 | 2016-01-07 | Amgen Inc. | Cis-morpholinone and other compounds as mdm2 inhibitors for the treatment of cancer |
| CA2902856C (en) | 2013-02-28 | 2021-02-16 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
| AU2014236812B2 (en) | 2013-03-14 | 2018-03-01 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
| CN105358530A (zh) * | 2013-06-10 | 2016-02-24 | 美国安进公司 | 制备mdm2抑制剂的方法及其结晶形式 |
| KR20160037233A (ko) | 2013-07-26 | 2016-04-05 | 베링거 인겔하임 인터내셔날 게엠베하 | 급성 골수성 백혈병 및 골수형성이상 증후군의 치료를 위한 데시타빈과 병용된 볼라세르티브 |
| HRP20220718T1 (hr) * | 2013-11-11 | 2022-09-30 | Amgen Inc. | Kombinacijska terapija uključujući inhibitor mdm2 i jedan ili više dodatnih farmaceutski aktivnih sredstava za liječenje raka |
-
2014
- 2014-11-11 HR HRP20220718TT patent/HRP20220718T1/hr unknown
- 2014-11-11 NZ NZ720766A patent/NZ720766A/en not_active IP Right Cessation
- 2014-11-11 BR BR112016010564A patent/BR112016010564A2/pt not_active IP Right Cessation
- 2014-11-11 MX MX2016006025A patent/MX378969B/es unknown
- 2014-11-11 DK DK14805743.3T patent/DK3068393T5/da active
- 2014-11-11 HU HUE14805743A patent/HUE059351T2/hu unknown
- 2014-11-11 SG SG10201902429PA patent/SG10201902429PA/en unknown
- 2014-11-11 KR KR1020227041845A patent/KR20220167335A/ko not_active Ceased
- 2014-11-11 SI SI201431961T patent/SI3068393T1/sl unknown
- 2014-11-11 SM SM20220241T patent/SMT202200241T1/it unknown
- 2014-11-11 AP AP2016009243A patent/AP2016009243A0/en unknown
- 2014-11-11 WO PCT/US2014/065034 patent/WO2015070224A2/en not_active Ceased
- 2014-11-11 LT LTEPPCT/US2014/065034T patent/LT3068393T/lt unknown
- 2014-11-11 MA MA39094A patent/MA39094B1/fr unknown
- 2014-11-11 RS RS20220533A patent/RS63348B9/sr unknown
- 2014-11-11 PL PL14805743.3T patent/PL3068393T3/pl unknown
- 2014-11-11 MX MX2020001550A patent/MX391859B/es unknown
- 2014-11-11 CA CA2930244A patent/CA2930244A1/en active Pending
- 2014-11-11 EA EA202092456A patent/EA202092456A3/ru unknown
- 2014-11-11 JP JP2016553270A patent/JP2016535795A/ja not_active Ceased
- 2014-11-11 KR KR1020217029928A patent/KR102473485B1/ko active Active
- 2014-11-11 MX MX2020013670A patent/MX2020013670A/es unknown
- 2014-11-11 US US15/035,438 patent/US20160287569A1/en not_active Abandoned
- 2014-11-11 PT PT148057433T patent/PT3068393T/pt unknown
- 2014-11-11 EP EP14805743.3A patent/EP3068393B9/en active Active
- 2014-11-11 AU AU2014346354A patent/AU2014346354A1/en not_active Abandoned
- 2014-11-11 MX MX2019009853A patent/MX393610B/es unknown
- 2014-11-11 NZ NZ758548A patent/NZ758548A/en not_active IP Right Cessation
- 2014-11-11 KR KR1020167015298A patent/KR102305351B1/ko not_active Expired - Fee Related
- 2014-11-11 EP EP22154212.9A patent/EP4039256A1/en not_active Withdrawn
- 2014-11-11 EA EA201690980A patent/EA036942B1/ru unknown
- 2014-11-11 UA UAA201606309A patent/UA120750C2/uk unknown
- 2014-11-11 MY MYPI2016000850A patent/MY192088A/en unknown
- 2014-11-11 TN TN2016000176A patent/TN2016000176A1/en unknown
- 2014-11-11 CN CN201480072891.XA patent/CN105934255A/zh active Pending
- 2014-11-11 CN CN202011275297.4A patent/CN112933236A/zh active Pending
- 2014-11-11 ES ES14805743T patent/ES2916721T3/es active Active
-
2016
- 2016-05-06 MX MX2022012320A patent/MX2022012320A/es unknown
- 2016-05-06 MX MX2022008175A patent/MX2022008175A/es unknown
- 2016-05-10 IL IL245568A patent/IL245568B/en unknown
- 2016-05-11 PH PH12016500871A patent/PH12016500871A1/en unknown
- 2016-05-11 CL CL2016001131A patent/CL2016001131A1/es unknown
- 2016-05-17 ZA ZA2016/03342A patent/ZA201603342B/en unknown
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2018
- 2018-12-21 US US16/229,150 patent/US10881648B2/en not_active Expired - Fee Related
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2019
- 2019-04-17 JP JP2019078325A patent/JP2019142916A/ja active Pending
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2020
- 2020-02-24 AU AU2020201321A patent/AU2020201321B2/en not_active Ceased
- 2020-10-13 JP JP2020172367A patent/JP6972274B2/ja not_active Expired - Fee Related
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2021
- 2021-08-16 IL IL285646A patent/IL285646A/en unknown
- 2021-09-09 US US17/470,136 patent/US20220280495A1/en not_active Abandoned
- 2021-11-01 JP JP2021178554A patent/JP2022009805A/ja active Pending
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2022
- 2022-03-03 AU AU2022201495A patent/AU2022201495A1/en not_active Abandoned
- 2022-06-08 CY CY20221100397T patent/CY1125358T1/el unknown
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2023
- 2023-01-13 JP JP2023003579A patent/JP2023033414A/ja active Pending
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