MX2014003408A - N-(3-(2-amino-6,6-difluor-4,4a,5,6,7,7a-hexahidro-ciclopenta-[e][ 1,3]oxazin-4-il)-fenil)-amidas como inhibidores de la beta-secretasa 1 (bace1). - Google Patents

N-(3-(2-amino-6,6-difluor-4,4a,5,6,7,7a-hexahidro-ciclopenta-[e][ 1,3]oxazin-4-il)-fenil)-amidas como inhibidores de la beta-secretasa 1 (bace1).

Info

Publication number
MX2014003408A
MX2014003408A MX2014003408A MX2014003408A MX2014003408A MX 2014003408 A MX2014003408 A MX 2014003408A MX 2014003408 A MX2014003408 A MX 2014003408A MX 2014003408 A MX2014003408 A MX 2014003408A MX 2014003408 A MX2014003408 A MX 2014003408A
Authority
MX
Mexico
Prior art keywords
oxazin
cyclopenta
hexahydro
difluoro
amides
Prior art date
Application number
MX2014003408A
Other languages
English (en)
Inventor
Thomas Woltering
Hans Hilpert
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014003408A publication Critical patent/MX2014003408A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención proporciona N- (3- (2-amino-6, 6-difluor-4,4a,5,6,7,7a-hexahidro-ciclopenta [e] [1,3] oxazin-4-il)-fenil)-amidas de la fórmula I (ver Fórmula) que tienen actividad inhibidora de la BACE1, su obtención, composiciones farmacéuticas que las contienen y su utilización como sustancias terapéuticamente activas. Los compuestos activos de la presente invención son útiles para el tratamiento terapéutico y/o profiláctico p.ej. de la enfermedad de Alzheimer.
MX2014003408A 2011-09-21 2012-09-18 N-(3-(2-amino-6,6-difluor-4,4a,5,6,7,7a-hexahidro-ciclopenta-[e][ 1,3]oxazin-4-il)-fenil)-amidas como inhibidores de la beta-secretasa 1 (bace1). MX2014003408A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11182172 2011-09-21
PCT/EP2012/068287 WO2013041499A1 (en) 2011-09-21 2012-09-18 N-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-phenyl)-amides as bace1 inhibitors

Publications (1)

Publication Number Publication Date
MX2014003408A true MX2014003408A (es) 2014-04-10

Family

ID=46852012

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003408A MX2014003408A (es) 2011-09-21 2012-09-18 N-(3-(2-amino-6,6-difluor-4,4a,5,6,7,7a-hexahidro-ciclopenta-[e][ 1,3]oxazin-4-il)-fenil)-amidas como inhibidores de la beta-secretasa 1 (bace1).

Country Status (11)

Country Link
US (2) US20130073953A1 (es)
EP (1) EP2758393A1 (es)
JP (1) JP2014526534A (es)
KR (1) KR20140069183A (es)
CN (1) CN103827110A (es)
AR (1) AR087915A1 (es)
BR (1) BR112014006763A2 (es)
CA (1) CA2844654A1 (es)
MX (1) MX2014003408A (es)
RU (1) RU2014113679A (es)
WO (1) WO2013041499A1 (es)

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WO2009151098A1 (ja) 2008-06-13 2009-12-17 塩野義製薬株式会社 βセクレターゼ阻害作用を有する含硫黄複素環誘導体
AU2010328975B2 (en) 2009-12-11 2015-01-22 Shionogi & Co. Ltd. Oxazine derivative
KR20100075786A (ko) * 2010-05-19 2010-07-05 세창인스트루먼트(주) 웹사이트 영역취합시스템 및 그 방법
CN103631475A (zh) * 2012-08-29 2014-03-12 腾讯科技（深圳）有限公司 切换窗口的方法和装置
US9540359B2 (en) 2012-10-24 2017-01-10 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity
CA2902212C (en) 2013-03-01 2020-10-13 Amgen Inc. Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
AP2015008716A0 (en) 2013-03-08 2015-09-30 Amgen Inc Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
WO2015023703A1 (en) 2013-08-12 2015-02-19 Pharmacyclics, Inc. Methods for the treatment of her2 amplified cancer
TW201623295A (zh) 2014-04-11 2016-07-01 塩野義製藥股份有限公司 具有ｂａｃｅ１抑制活性之二氫噻及二氫衍生物
CN105278824B (zh) * 2014-07-31 2018-06-26 维沃移动通信有限公司 一种终端设备的截屏方法及其终端设备
MX2017001794A (es) 2014-08-08 2017-06-29 Amgen Inc Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso.
MX2017012188A (es) 2015-03-20 2017-12-15 Hoffmann La Roche Inhibidores de beta-secretasa 1 (bace1).
WO2019208693A1 (en) 2018-04-27 2019-10-31 Shionogi & Co., Ltd. Tetrahydropyranooxazine derivatives having selective bace1 inhibitory activity
CN110109593B (zh) * 2019-04-29 2021-04-02 维沃移动通信有限公司 一种截屏方法及终端设备
TWI810101B (zh) * 2022-10-27 2023-07-21 南亞塑膠工業股份有限公司 碟鏈系統

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395145A (en) * 1966-08-17 1968-07-30 Warner Lambert Pharmaceutical 2-aryl-1-oxa-3-azaspiro [5, 5] undec-2-enes
US20080092077A1 (en) * 2006-09-14 2008-04-17 Cqgt, Llc Interactive streaming news headline display
CN102186841A (zh) * 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
WO2011071057A1 (ja) * 2009-12-09 2011-06-16 塩野義製薬株式会社 含硫黄複素環誘導体を含有するアルツハイマー症の治療用または予防用医薬組成物
US7964594B1 (en) * 2009-12-10 2011-06-21 Hoffmann-La Roche Inc. Amino oxazine derivatives
AU2010328975B2 (en) * 2009-12-11 2015-01-22 Shionogi & Co. Ltd. Oxazine derivative
UA103272C2 (uk) 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2

Also Published As

Publication number Publication date
EP2758393A1 (en) 2014-07-30
US8476264B2 (en) 2013-07-02
RU2014113679A (ru) 2015-10-27
CN103827110A (zh) 2014-05-28
KR20140069183A (ko) 2014-06-09
AR087915A1 (es) 2014-04-23
US20130073953A1 (en) 2013-03-21
CA2844654A1 (en) 2013-03-28
JP2014526534A (ja) 2014-10-06
WO2013041499A1 (en) 2013-03-28
BR112014006763A2 (pt) 2017-03-28
US20130072478A1 (en) 2013-03-21

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