PL3068393T3 - Terapia skojarzona obejmująca inhibitor mdm2 i jeden lub większą liczbę dodatkowych środków farmaceutycznie czynnych do leczenia nowotworów - Google Patents

Terapia skojarzona obejmująca inhibitor mdm2 i jeden lub większą liczbę dodatkowych środków farmaceutycznie czynnych do leczenia nowotworów

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Publication number
PL3068393T3
PL3068393T3 PL14805743.3T PL14805743T PL3068393T3 PL 3068393 T3 PL3068393 T3 PL 3068393T3 PL 14805743 T PL14805743 T PL 14805743T PL 3068393 T3 PL3068393 T3 PL 3068393T3
Authority
PL
Poland
Prior art keywords
cancers
treatment
active agents
pharmaceutically active
combination therapy
Prior art date
Application number
PL14805743.3T
Other languages
English (en)
Polish (pl)
Inventor
Sean Caenepeel
Jude CANON
Paul Hughes
Jonathan D. Oliner
Richard J. Rickles
Anne Y. SAIKI
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of PL3068393T3 publication Critical patent/PL3068393T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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  • Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PL14805743.3T 2013-11-11 2014-11-11 Terapia skojarzona obejmująca inhibitor mdm2 i jeden lub większą liczbę dodatkowych środków farmaceutycznie czynnych do leczenia nowotworów PL3068393T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361902717P 2013-11-11 2013-11-11
PCT/US2014/065034 WO2015070224A2 (en) 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Publications (1)

Publication Number Publication Date
PL3068393T3 true PL3068393T3 (pl) 2022-10-03

Family

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Application Number Title Priority Date Filing Date
PL14805743.3T PL3068393T3 (pl) 2013-11-11 2014-11-11 Terapia skojarzona obejmująca inhibitor mdm2 i jeden lub większą liczbę dodatkowych środków farmaceutycznie czynnych do leczenia nowotworów

Country Status (33)

Country Link
US (3) US20160287569A1 (https=)
EP (2) EP3068393B9 (https=)
JP (5) JP2016535795A (https=)
KR (3) KR20220167335A (https=)
CN (2) CN105934255A (https=)
AP (1) AP2016009243A0 (https=)
AU (3) AU2014346354A1 (https=)
BR (1) BR112016010564A2 (https=)
CA (1) CA2930244A1 (https=)
CL (1) CL2016001131A1 (https=)
CY (1) CY1125358T1 (https=)
DK (1) DK3068393T5 (https=)
EA (2) EA202092456A3 (https=)
ES (1) ES2916721T3 (https=)
HR (1) HRP20220718T1 (https=)
HU (1) HUE059351T2 (https=)
IL (2) IL245568B (https=)
LT (1) LT3068393T (https=)
MA (1) MA39094B1 (https=)
MX (6) MX378969B (https=)
MY (1) MY192088A (https=)
NZ (2) NZ720766A (https=)
PH (1) PH12016500871A1 (https=)
PL (1) PL3068393T3 (https=)
PT (1) PT3068393T (https=)
RS (1) RS63348B9 (https=)
SG (1) SG10201902429PA (https=)
SI (1) SI3068393T1 (https=)
SM (1) SMT202200241T1 (https=)
TN (1) TN2016000176A1 (https=)
UA (1) UA120750C2 (https=)
WO (1) WO2015070224A2 (https=)
ZA (1) ZA201603342B (https=)

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AU2008232709C1 (en) 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
KR20170058446A (ko) 2010-08-13 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
MX352672B (es) 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
AR088392A1 (es) 2011-10-18 2014-05-28 Aileron Therapeutics Inc Macrociclos peptidomimeticos
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
AU2014236812B2 (en) 2013-03-14 2018-03-01 Amgen Inc. Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
HRP20220718T1 (hr) * 2013-11-11 2022-09-30 Amgen Inc. Kombinacijska terapija uključujući inhibitor mdm2 i jedan ili više dodatnih farmaceutski aktivnih sredstava za liječenje raka
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
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