JP2016534790A - 薬剤送達デバイス - Google Patents
薬剤送達デバイス Download PDFInfo
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- JP2016534790A JP2016534790A JP2016526093A JP2016526093A JP2016534790A JP 2016534790 A JP2016534790 A JP 2016534790A JP 2016526093 A JP2016526093 A JP 2016526093A JP 2016526093 A JP2016526093 A JP 2016526093A JP 2016534790 A JP2016534790 A JP 2016534790A
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- XVVOERDUTLJJHN-IAEQDCLQSA-N lixisenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 XVVOERDUTLJJHN-IAEQDCLQSA-N 0.000 description 1
- 108010004367 lixisenatide Proteins 0.000 description 1
- 229960001093 lixisenatide Drugs 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 description 1
- 229960002333 nafarelin Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000013777 protein digestion Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
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Abstract
Description
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
Claims (20)
- 薬剤送達デバイス(1)であって:
本体(2)と;
該本体(2)内に摺動可能に配置された容器キャリア(7)と;
該容器キャリア(7)に摺動可能に連結されたスリーブ(6)とを含む前記薬剤送達デバイス。 - 容器キャリア(7)は、少なくとも1つの第1の脚部(7.2)を含み、該少なくとも1つの第1の脚部は、第1の突起(7.3)と、該第1の突起(7.3)の近位にある第2の突起(7.4)とを有する、請求項1に記載の薬剤送達デバイス(1)。
- スリーブ(6)は、第1の突起(7.3)および第2の突起(7.4)に当接するように適用されたカラー(6.1)を含む、請求項2に記載の薬剤送達デバイス(1)。
- 容器キャリア(7)は、径方向外方へ付勢された少なくとも1つの第2の脚部(7.5)を含む、請求項1〜3のいずれか1項に記載の薬剤送達デバイス(1)。
- 本体(2)は、少なくとも1つの第2の脚部(7.5)に軸方向に当接するように適用された少なくとも1つの軸方向の止め具を含む、請求項4に記載の薬剤送達デバイス(1)。
- 容器キャリア(7)は、径方向外方へ付勢された少なくとも1つの第3の脚部(7.6)を含む、請求項1〜5のいずれか1項に記載の薬剤送達デバイス(1)。
- スリーブ(6)は、該スリーブ(6)が本体(2)に対して後退位置にあるときに少なくとも1つの第3の脚部(7.6)に径方向に当接するように適用された少なくとも1つのスリーブ脚部(6.3)を含む、請求項6に記載の薬剤送達デバイス(1)。
- 少なくとも1つの第3の脚部(7.6)は、少なくとも1つのスリーブ脚部(6.3)に軸方向に当接してスリーブ(6)を本体(2)に対して伸長位置でロックするように適用される、請求項7に記載の薬剤送達デバイス(1)。
- 少なくとも1つの第1の脚部(7.2)、少なくとも1つの第2の脚部(7.5)、および少なくとも1つの第3の脚部(7.6)は、容器キャリア(7)の近位部分(7.1)の周辺部に連結され、少なくとも1つの第1の脚部(7.2)、少なくとも1つの第2の脚部(7.5)、および少なくとも1つの第3の脚部(7.6)は、近位部分(7.1)から遠位方向に延びる、請求項2、4、または6に記載の薬剤送達デバイス(1)。
- 本体(2)内に配置されたプランジャロッド(11)をさらに含む、請求項1〜9のいずれか1項に記載の薬剤送達デバイス(1)。
- プランジャロッド(11)は、本体(2)に固定される、請求項10に記載の薬剤送達デバイス(1)。
- スリーブ(6)を容器キャリア(7)に対して付勢するスリーブばね(12)をさらに含む、請求項1〜11のいずれか1項に記載の薬剤送達デバイス(1)。
- スリーブばね(12)は、スリーブ(6)を第1の突起(7.3)の方へ付勢する、請求項3または12に記載の薬剤送達デバイス(1)。
- キャリア(7)を本体(2)に対して付勢する容器ばね(13)をさらに含む、請求項1〜13のいずれか1項に記載の薬剤送達デバイス(1)。
- スリーブ(6)は、1つまたはそれ以上のスリーブ窓(6.2)を含む、請求項1〜14のいずれか1項に記載の薬剤送達デバイス(1)。
- 本体(2)に着脱可能に連結されたキャップ(3)をさらに含む、請求項1〜15のいずれか1項に記載の薬剤送達デバイス(1)。
- キャップ(3)は、観察窓(4)を含む、請求項16に記載の薬剤送達デバイス(1)。
- キャップ(3)は、デバイス(1)の所期の向きを示す1つまたはそれ以上の印(5)を含む、請求項16に記載の薬剤送達デバイス(1)。
- 薬剤を含む容器をさらに含む、請求項1〜18のいずれか1項に記載の薬剤送達デバイス(1)。
- 容器キャリア(7)の近位部分(7.1)は、容器を受けるように適用される、請求項9または16に記載の薬剤送達デバイス(1)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20130191199 EP2868338A1 (en) | 2013-10-31 | 2013-10-31 | Medicament delivery device |
EP13191199.2 | 2013-10-31 | ||
PCT/EP2014/072557 WO2015062915A1 (en) | 2013-10-31 | 2014-10-21 | Medicament delivery device |
Publications (2)
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JP2016534790A true JP2016534790A (ja) | 2016-11-10 |
JP6618466B2 JP6618466B2 (ja) | 2019-12-11 |
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JP2016526093A Active JP6618466B2 (ja) | 2013-10-31 | 2014-10-21 | 薬剤送達デバイス |
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US (1) | US10857295B2 (ja) |
EP (3) | EP2868338A1 (ja) |
JP (1) | JP6618466B2 (ja) |
DK (1) | DK3062849T3 (ja) |
WO (1) | WO2015062915A1 (ja) |
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Also Published As
Publication number | Publication date |
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WO2015062915A1 (en) | 2015-05-07 |
JP6618466B2 (ja) | 2019-12-11 |
DK3062849T3 (da) | 2023-09-25 |
EP2868338A1 (en) | 2015-05-06 |
EP3062849B1 (en) | 2023-04-26 |
EP3062849A1 (en) | 2016-09-07 |
US20160263325A1 (en) | 2016-09-15 |
EP4223334A1 (en) | 2023-08-09 |
US10857295B2 (en) | 2020-12-08 |
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