JP2016531913A5 - - Google Patents

Info

Publication number

JP2016531913A5

JP2016531913A5 JP2016537782A JP2016537782A JP2016531913A5 JP 2016531913 A5 JP2016531913 A5 JP 2016531913A5 JP 2016537782 A JP2016537782 A JP 2016537782A JP 2016537782 A JP2016537782 A JP 2016537782A JP 2016531913 A5 JP2016531913 A5 JP 2016531913A5

Authority

JP

Japan

Prior art keywords

ketamine

tablet composition

gum

composition according

naket

Prior art date

2014-08-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 19
• 229960003299 ketamine Drugs 0.000 claims 19
• 239000007916 tablet composition Substances 0.000 claims 16
• 238000000034 method Methods 0.000 claims 6
• 239000002356 single layer Substances 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 4
• 229920000642 polymer Polymers 0.000 claims 4
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
• 239000000126 substance Substances 0.000 claims 3
• 230000001225 therapeutic effect Effects 0.000 claims 3
• 125000000129 anionic group Chemical group 0.000 claims 2
• 208000029028 brain injury Diseases 0.000 claims 2
• 239000011159 matrix material Substances 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 1
• BEQZHFIKTBVCAU-UHFFFAOYSA-N 2-amino-2-(2-chlorophenyl)-1-cyclohexanone Chemical compound C=1C=CC=C(Cl)C=1C1(N)CCCCC1=O BEQZHFIKTBVCAU-UHFFFAOYSA-N 0.000 claims 1
• 244000215068 Acacia senegal Species 0.000 claims 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
• 229920002101 Chitin Polymers 0.000 claims 1
• 208000020401 Depressive disease Diseases 0.000 claims 1
• 229920002907 Guar gum Polymers 0.000 claims 1
• 229920000084 Gum arabic Polymers 0.000 claims 1
• 229920000569 Gum karaya Polymers 0.000 claims 1
• 229920000161 Locust bean gum Polymers 0.000 claims 1
• 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 1
• 229920000954 Polyglycolide Polymers 0.000 claims 1
• 208000028017 Psychotic disease Diseases 0.000 claims 1
• 229920002125 Sokalan® Polymers 0.000 claims 1
• 229920002472 Starch Polymers 0.000 claims 1
• 241000934878 Sterculia Species 0.000 claims 1
• 229920001615 Tragacanth Polymers 0.000 claims 1
• 229910021536 Zeolite Inorganic materials 0.000 claims 1
• 235000010489 acacia gum Nutrition 0.000 claims 1
• 239000000205 acacia gum Substances 0.000 claims 1
• 235000010443 alginic acid Nutrition 0.000 claims 1
• 239000000783 alginic acid Substances 0.000 claims 1
• 229920000615 alginic acid Polymers 0.000 claims 1
• 229960001126 alginic acid Drugs 0.000 claims 1
• 150000004781 alginic acids Chemical class 0.000 claims 1
• 239000000305 astragalus gummifer gum Substances 0.000 claims 1
• 230000006931 brain damage Effects 0.000 claims 1
• 231100000874 brain damage Toxicity 0.000 claims 1
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
• 150000007942 carboxylates Chemical class 0.000 claims 1
• 235000010418 carrageenan Nutrition 0.000 claims 1
• 239000000679 carrageenan Substances 0.000 claims 1
• 229920001525 carrageenan Polymers 0.000 claims 1
• 229940113118 carrageenan Drugs 0.000 claims 1
• 239000003729 cation exchange resin Substances 0.000 claims 1
• 239000004927 clay Substances 0.000 claims 1
• HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims 1
• 235000010417 guar gum Nutrition 0.000 claims 1
• 239000000665 guar gum Substances 0.000 claims 1
• 229960002154 guar gum Drugs 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 235000010494 karaya gum Nutrition 0.000 claims 1
• 239000000231 karaya gum Substances 0.000 claims 1
• 229940039371 karaya gum Drugs 0.000 claims 1
• 235000010420 locust bean gum Nutrition 0.000 claims 1
• 239000000711 locust bean gum Substances 0.000 claims 1
• 239000002207 metabolite Substances 0.000 claims 1
• 230000001508 neuroinhibitory effect Effects 0.000 claims 1
• 230000007935 neutral effect Effects 0.000 claims 1
• 239000007935 oral tablet Substances 0.000 claims 1
• 229940096978 oral tablet Drugs 0.000 claims 1
• 229920001277 pectin Polymers 0.000 claims 1
• 239000001814 pectin Substances 0.000 claims 1
• 235000010987 pectin Nutrition 0.000 claims 1
• 229960000292 pectin Drugs 0.000 claims 1
• 230000036470 plasma concentration Effects 0.000 claims 1
• 229920000747 poly(lactic acid) Polymers 0.000 claims 1
• 239000004584 polyacrylic acid Substances 0.000 claims 1
• 239000004633 polyglycolic acid Substances 0.000 claims 1
• 239000004626 polylactic acid Substances 0.000 claims 1
• 229920000193 polymethacrylate Polymers 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000008107 starch Substances 0.000 claims 1
• 235000019698 starch Nutrition 0.000 claims 1
• 238000013268 sustained release Methods 0.000 claims 1
• 239000012730 sustained-release form Substances 0.000 claims 1
• 229920002994 synthetic fiber Polymers 0.000 claims 1
• 239000003826 tablet Substances 0.000 claims 1
• 231100000419 toxicity Toxicity 0.000 claims 1
• 230000001988 toxicity Effects 0.000 claims 1
• 229920001285 xanthan gum Polymers 0.000 claims 1
• 235000010493 xanthan gum Nutrition 0.000 claims 1
• 239000000230 xanthan gum Substances 0.000 claims 1
• 229940082509 xanthan gum Drugs 0.000 claims 1
• 239000010457 zeolite Substances 0.000 claims 1
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1