JP2016531886A5 - - Google Patents
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- Publication number
- JP2016531886A5 JP2016531886A5 JP2016519782A JP2016519782A JP2016531886A5 JP 2016531886 A5 JP2016531886 A5 JP 2016531886A5 JP 2016519782 A JP2016519782 A JP 2016519782A JP 2016519782 A JP2016519782 A JP 2016519782A JP 2016531886 A5 JP2016531886 A5 JP 2016531886A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- methylbutyl
- dichlorobenzoyl
- acetyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 9
- -1 citrate ester Chemical class 0.000 claims description 9
- 230000002265 prevention Effects 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 3
- MXAYKZJJDUDWDS-LBPRGKRZSA-N ixazomib Chemical compound CC(C)C[C@@H](B(O)O)NC(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl MXAYKZJJDUDWDS-LBPRGKRZSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- BMTZTBHPQACQNX-UHFFFAOYSA-N O1BOC(CC1)C(=O)O Chemical compound O1BOC(CC1)C(=O)O BMTZTBHPQACQNX-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 3
- YTXSYWAKVMZICI-PVCZSOGJSA-N 4-(carboxymethyl)-2-[(1r)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Chemical compound N([C@@H](CC(C)C)B1OC(CC(O)=O)(CC(=O)O1)C(O)=O)C(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl YTXSYWAKVMZICI-PVCZSOGJSA-N 0.000 description 1
- CDFSNHZUTLZCTK-LBPRGKRZSA-N ClC1=C(C(=O)NCC(=O)N[C@@H](CC(C)C)[B])C=C(C=C1)Cl Chemical compound ClC1=C(C(=O)NCC(=O)N[C@@H](CC(C)C)[B])C=C(C=C1)Cl CDFSNHZUTLZCTK-LBPRGKRZSA-N 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361886403P | 2013-10-03 | 2013-10-03 | |
| US61/886,403 | 2013-10-03 | ||
| PCT/US2014/058738 WO2015051067A1 (en) | 2013-10-03 | 2014-10-02 | Method for the prophylaxis or treatment of systemic lupus erythematosus and/or lupus nephritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016531886A JP2016531886A (ja) | 2016-10-13 |
| JP2016531886A5 true JP2016531886A5 (enExample) | 2017-11-02 |
Family
ID=51842818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519782A Pending JP2016531886A (ja) | 2013-10-03 | 2014-10-02 | 全身性エリテマトーデス及び／または狼瘡腎炎の予防または治療のための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160250238A1 (enExample) |
| EP (1) | EP3052105A1 (enExample) |
| JP (1) | JP2016531886A (enExample) |
| KR (1) | KR20160058886A (enExample) |
| CN (1) | CN105705149A (enExample) |
| BR (1) | BR112016007237A2 (enExample) |
| CA (1) | CA2925935A1 (enExample) |
| EA (1) | EA201690686A1 (enExample) |
| MX (1) | MX2016003979A (enExample) |
| WO (1) | WO2015051067A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020000092A1 (en) * | 2018-06-27 | 2020-01-02 | Algernon Pharmaceuticals Inc. | The use of actarit in the prophylaxis or treatment of renal fibrosis or kidney disease |
| CN115515578A (zh) * | 2020-05-07 | 2022-12-23 | 诺罗瑞韦有限公司 | 用于治疗抑郁症的环丝氨酸和己酮可可碱联合疗法 |
| CN121041156A (zh) * | 2025-08-27 | 2025-12-02 | 复皙药业(上海)有限公司 | 含有替普瑞酮的具有祛红功效的膏霜及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| CA2435146C (en) | 2001-01-25 | 2011-03-29 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Formulation of boronic acid compounds |
| KR20140042933A (ko) * | 2007-08-06 | 2014-04-07 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아좀 억제제 |
| US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
| SI2318419T2 (sl) * | 2008-06-17 | 2025-10-30 | Takeda Pharmaceutical Company Limited | Spojine boronat estra in njihovi farmacevtski sestavki |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| TW201103904A (en) | 2009-06-11 | 2011-02-01 | Hoffmann La Roche | Janus kinase inhibitor compounds and methods |
| AU2011235227B2 (en) | 2010-03-31 | 2016-09-08 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
| TW201309303A (zh) * | 2011-03-03 | 2013-03-01 | Cephalon Inc | 用於治療狼瘡的蛋白酶體抑制劑 |
| WO2012177835A1 (en) * | 2011-06-22 | 2012-12-27 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
-
2014
- 2014-10-02 US US15/026,417 patent/US20160250238A1/en not_active Abandoned
- 2014-10-02 EA EA201690686A patent/EA201690686A1/ru unknown
- 2014-10-02 MX MX2016003979A patent/MX2016003979A/es unknown
- 2014-10-02 KR KR1020167010114A patent/KR20160058886A/ko not_active Withdrawn
- 2014-10-02 WO PCT/US2014/058738 patent/WO2015051067A1/en not_active Ceased
- 2014-10-02 CA CA2925935A patent/CA2925935A1/en not_active Abandoned
- 2014-10-02 CN CN201480060987.4A patent/CN105705149A/zh active Pending
- 2014-10-02 JP JP2016519782A patent/JP2016531886A/ja active Pending
- 2014-10-02 BR BR112016007237A patent/BR112016007237A2/pt not_active IP Right Cessation
- 2014-10-02 EP EP14790872.7A patent/EP3052105A1/en not_active Withdrawn
-
2017
- 2017-12-12 US US15/838,595 patent/US20180099000A1/en not_active Abandoned
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