CN105705149A - 用于预防或治疗系统性红斑狼疮和/或狼疮性肾炎的方法 - Google Patents

用于预防或治疗系统性红斑狼疮和/或狼疮性肾炎的方法 Download PDF

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Publication number
CN105705149A
CN105705149A CN201480060987.4A CN201480060987A CN105705149A CN 105705149 A CN105705149 A CN 105705149A CN 201480060987 A CN201480060987 A CN 201480060987A CN 105705149 A CN105705149 A CN 105705149A
Authority
CN
China
Prior art keywords
compound
amino
lupus erythematosus
systemic lupus
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480060987.4A
Other languages
English (en)
Chinese (zh)
Inventor
河村透
藤谷靖志
泷泽正之
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of CN105705149A publication Critical patent/CN105705149A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480060987.4A 2013-10-03 2014-10-02 用于预防或治疗系统性红斑狼疮和/或狼疮性肾炎的方法 Pending CN105705149A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361886403P 2013-10-03 2013-10-03
US61/886,403 2013-10-03
PCT/US2014/058738 WO2015051067A1 (en) 2013-10-03 2014-10-02 Method for the prophylaxis or treatment of systemic lupus erythematosus and/or lupus nephritis

Publications (1)

Publication Number Publication Date
CN105705149A true CN105705149A (zh) 2016-06-22

Family

ID=51842818

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480060987.4A Pending CN105705149A (zh) 2013-10-03 2014-10-02 用于预防或治疗系统性红斑狼疮和/或狼疮性肾炎的方法

Country Status (10)

Country Link
US (2) US20160250238A1 (enExample)
EP (1) EP3052105A1 (enExample)
JP (1) JP2016531886A (enExample)
KR (1) KR20160058886A (enExample)
CN (1) CN105705149A (enExample)
BR (1) BR112016007237A2 (enExample)
CA (1) CA2925935A1 (enExample)
EA (1) EA201690686A1 (enExample)
MX (1) MX2016003979A (enExample)
WO (1) WO2015051067A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115515578A (zh) * 2020-05-07 2022-12-23 诺罗瑞韦有限公司 用于治疗抑郁症的环丝氨酸和己酮可可碱联合疗法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112423742B (zh) * 2018-06-27 2024-03-19 阿尔杰农制药股份有限公司 使用阿克他利预防或治疗肾纤维化或肾脏疾病

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090325903A1 (en) * 2008-06-17 2009-12-31 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
CN101772507A (zh) * 2007-08-06 2010-07-07 米伦纽姆医药公司 蛋白酶体抑制剂
WO2012119056A1 (en) * 2011-03-03 2012-09-07 Cephalon, Inc. Proteasome inhibitor delanzomib for use in the treatment of lupus
WO2012177835A1 (en) * 2011-06-22 2012-12-27 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
DE60239384D1 (de) 2001-01-25 2011-04-21 Us Of America Represented By The Secretary Dept Of Health And Human Services Formulierungen von borsäure-verbindungen
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
TW201103904A (en) 2009-06-11 2011-02-01 Hoffmann La Roche Janus kinase inhibitor compounds and methods
CA2794334C (en) 2010-03-31 2018-06-12 Millennium Pharmaceuticals, Inc. Derivatives of 1-amino-2-cyclopropylethylboronic acid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101772507A (zh) * 2007-08-06 2010-07-07 米伦纽姆医药公司 蛋白酶体抑制剂
US20090325903A1 (en) * 2008-06-17 2009-12-31 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
WO2012119056A1 (en) * 2011-03-03 2012-09-07 Cephalon, Inc. Proteasome inhibitor delanzomib for use in the treatment of lupus
WO2012177835A1 (en) * 2011-06-22 2012-12-27 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALEXEI F. KISSELEV等: "Proteasome Inhibitors: An Expanding Army Attacking a Unique Target", 《CHEM BIOL》 *
H. TRAVIS ICHIKAWA等: "Beneficial Effect of Novel Proteasome Inhibitors in Murine Lupus via Dual Inhibition of Type I Interferon and Autoantibody-Secreting Cells", 《ARTHRITIS & RHEUMATISM》 *
KIRSTEN NEUBERT等: "The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis", 《NATURE MEDICINE》 *
NADINE HAINZ等: "The Proteasome Inhibitor Bortezomib Prevents Lupus Nephritis in the NZB/W F1 Mouse Model by Preservation of Glomerular and Tubulointerstitial Architecture", 《NEPHRON EXP NEPHROL》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115515578A (zh) * 2020-05-07 2022-12-23 诺罗瑞韦有限公司 用于治疗抑郁症的环丝氨酸和己酮可可碱联合疗法

Also Published As

Publication number Publication date
WO2015051067A1 (en) 2015-04-09
EA201690686A1 (ru) 2016-08-31
JP2016531886A (ja) 2016-10-13
US20160250238A1 (en) 2016-09-01
EP3052105A1 (en) 2016-08-10
CA2925935A1 (en) 2015-04-09
US20180099000A1 (en) 2018-04-12
KR20160058886A (ko) 2016-05-25
MX2016003979A (es) 2016-06-15
BR112016007237A2 (pt) 2017-09-12

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Application publication date: 20160622

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