JP2016531593A5 - - Google Patents
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- Publication number
- JP2016531593A5 JP2016531593A5 JP2016544355A JP2016544355A JP2016531593A5 JP 2016531593 A5 JP2016531593 A5 JP 2016531593A5 JP 2016544355 A JP2016544355 A JP 2016544355A JP 2016544355 A JP2016544355 A JP 2016544355A JP 2016531593 A5 JP2016531593 A5 JP 2016531593A5
- Authority
- JP
- Japan
- Prior art keywords
- deoxyuridine
- aptamer
- carboxamide
- composition
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091023037 Aptamer Proteins 0.000 claims 43
- 239000000203 mixture Substances 0.000 claims 30
- 238000000034 method Methods 0.000 claims 22
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 18
- 238000012986 modification Methods 0.000 claims 17
- 230000004048 modification Effects 0.000 claims 17
- 150000003857 carboxamides Chemical class 0.000 claims 11
- -1 (N-benzylcarboxamide) -2′-deoxyuridine Chemical compound 0.000 claims 6
- 230000015572 biosynthetic process Effects 0.000 claims 4
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 claims 3
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 claims 2
- 125000004924 2-naphthylethyl group Chemical group C1=C(C=CC2=CC=CC=C12)CC* 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 125000005518 carboxamido group Chemical group 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- 230000036963 noncompetitive effect Effects 0.000 claims 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361881629P | 2013-09-24 | 2013-09-24 | |
| US61/881,629 | 2013-09-24 | ||
| PCT/US2014/057143 WO2015048084A1 (en) | 2013-09-24 | 2014-09-24 | Multiaptamer target detection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531593A JP2016531593A (ja) | 2016-10-13 |
| JP2016531593A5 true JP2016531593A5 (enExample) | 2017-11-02 |
| JP6506768B2 JP6506768B2 (ja) | 2019-04-24 |
Family
ID=52744404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544355A Active JP6506768B2 (ja) | 2013-09-24 | 2014-09-24 | 多重アプタマー標的の検出 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9926566B2 (enExample) |
| EP (1) | EP3049523B1 (enExample) |
| JP (1) | JP6506768B2 (enExample) |
| KR (1) | KR102348283B1 (enExample) |
| CN (2) | CN114703193A (enExample) |
| AU (1) | AU2014326975B2 (enExample) |
| BR (1) | BR112016005957A2 (enExample) |
| CA (1) | CA2924987C (enExample) |
| HK (1) | HK1218765A1 (enExample) |
| IL (1) | IL244284B (enExample) |
| MX (1) | MX361451B (enExample) |
| SG (1) | SG11201602063UA (enExample) |
| WO (1) | WO2015048084A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201602063UA (en) | 2013-09-24 | 2016-04-28 | Somalogic Inc | Multiaptamer target detection |
| AU2015353767B2 (en) | 2014-11-24 | 2021-09-09 | Somalogic Operating Co., Inc. | Nucleic acid compounds for binding growth differentiation factor 11 |
| PT3387152T (pt) * | 2015-12-08 | 2022-04-19 | Twinstrand Biosciences Inc | Adaptadores, métodos e composições melhorados para sequenciamento duplex |
| EP3430022B1 (en) | 2016-03-14 | 2020-03-11 | Somalogic, Inc. | Compounds and methods for the synthesis of 5-(n-protected-tryptaminocarboxyamide)-2'-deoxyuridine phosphoramidite for incorporation into a nucleic acid sequence |
| JP2019521680A (ja) * | 2016-06-17 | 2019-08-08 | プロクシミティー バイオサイエンシズ，エルエルシー | アプタマーペアを選択する方法 |
| EP3913058B1 (en) | 2016-07-01 | 2025-01-01 | SomaLogic Operating Co., Inc. | Oligonucleotides comprising modified nucleosides |
| EP3548652B1 (en) | 2016-12-01 | 2024-04-03 | Nautilus Subsidiary, Inc. | Methods of assaying proteins |
| WO2019103131A1 (ja) * | 2017-11-24 | 2019-05-31 | 国立大学法人 東京大学 | アプタマーの結合部位判別方法、アプタマーペアおよび目的物質からなる三元錯体の解離定数等の測定方法並びに最適なアプタマーペアの選択方法 |
| CA3086915A1 (en) | 2017-12-29 | 2019-07-04 | Sujal M. Patel | Decoding approaches for protein identification |
| JP7526102B2 (ja) * | 2018-06-22 | 2024-07-31 | ソマロジック・オペレイティング・カンパニー・インコーポレイテッド | 改良されたプロテオミクスマルチプレックスアッセイ |
| EP4165549A1 (en) | 2020-06-11 | 2023-04-19 | Nautilus Biotechnology, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
| CA3203106A1 (en) | 2021-01-20 | 2022-07-28 | Parag Mallick | Systems and methods for biomolecule quantitation |
| WO2022159663A1 (en) | 2021-01-21 | 2022-07-28 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| EP4399528A1 (en) | 2021-09-09 | 2024-07-17 | Nautilus Subsidiary, Inc. | Characterization and localization of protein modifications |
| US20230090454A1 (en) | 2021-09-22 | 2023-03-23 | Nautilus Biotechnology, Inc. | Methods and systems for determining polypeptide interactions |
| US20230149883A1 (en) | 2021-11-03 | 2023-05-18 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| WO2023192917A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
| WO2023212490A1 (en) | 2022-04-25 | 2023-11-02 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| EP4544077A1 (en) | 2022-06-21 | 2025-04-30 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| US20240094215A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| EP4619766A1 (en) | 2022-11-15 | 2025-09-24 | Nautilus Subsidiary, Inc. | Standard polypeptides |
| EP4630816A1 (en) | 2022-12-09 | 2025-10-15 | Nautilus Subsidiary, Inc. | A method comprising performing on a single-analyte array at least 50 cycles of a process |
| US20240201182A1 (en) | 2022-12-15 | 2024-06-20 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| US20240241110A1 (en) | 2023-01-12 | 2024-07-18 | Nautilus Subsidiary, Inc. | Characterization of glycans and glycoconjugates |
| WO2024206122A1 (en) | 2023-03-24 | 2024-10-03 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| WO2024216233A1 (en) | 2023-04-13 | 2024-10-17 | Nautilus Subsidiary, Inc. | Artificial proteins for displaying epitopes |
| WO2024243237A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| US20250189519A1 (en) | 2023-12-11 | 2025-06-12 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| WO2025137166A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| US20250298016A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| WO2025212338A1 (en) | 2024-04-01 | 2025-10-09 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020037506A1 (en) * | 2000-04-18 | 2002-03-28 | Yun Lin | Aptamer based two-site binding assay |
| CA2425208C (en) * | 2000-09-26 | 2013-04-09 | Duke University | Rna aptamers and methods for identifying the same |
| US20070071744A1 (en) | 2002-06-07 | 2007-03-29 | Gotz Munch | Agents which bind to epitopes of glycoprotein VI |
| US7595160B2 (en) | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
| US7795009B2 (en) * | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| WO2007056250A2 (en) | 2005-11-04 | 2007-05-18 | U.S. Genomics, Inc. | Heterogeneous assay of analytes in solution using polymers |
| US8658670B2 (en) | 2006-09-26 | 2014-02-25 | Crestone, Inc. | Methods and compounds for treatment of clostridium based infection |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| MX344253B (es) | 2007-07-17 | 2016-12-09 | Somalogic Inc | Metodo para generar aptameros con constantes de disociacion mejoradas. |
| WO2009037264A2 (en) | 2007-09-17 | 2009-03-26 | Da Volterra | Colonic delivery of antimicrobial agents |
| US8569252B2 (en) | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
| US20110256535A1 (en) | 2010-02-11 | 2011-10-20 | Intelligent Medical Devices, Inc. | Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantification, monitoring, screening and sequencing of clostridium difficile genes encoding toxin b, and/or toxin a and/or binary toxin |
| GB201002627D0 (en) | 2010-02-16 | 2010-03-31 | Loxbridge Res Llp | Aptamer based analyte detection method |
| BR112012025872B8 (pt) * | 2010-04-12 | 2021-05-25 | Somalogic Inc | primidinas modificadas na posição-5 |
| US8785132B2 (en) * | 2010-04-23 | 2014-07-22 | Postech Academy-Industry Foundation | Aptamer sandwich assays |
| US20150031585A1 (en) | 2011-03-10 | 2015-01-29 | Somalogic, Inc. | Multiaptamer Target Detection |
| EP2683729B1 (en) | 2011-03-10 | 2017-05-03 | Somalogic, Inc. | Aptamers for clostridium difficile diagnostics |
| US20120277419A1 (en) * | 2011-04-26 | 2012-11-01 | Douglas Brooks | Method for manufacturing pegylated oligonucleotides |
| JP6652781B2 (ja) * | 2011-09-30 | 2020-02-26 | ソマロジック・インコーポレーテッド | 心血管系リスクイベントの予測およびその使用 |
| WO2013102096A1 (en) | 2011-12-30 | 2013-07-04 | Quest Diagnostics Investments Incorporated | Aptamers and diagnostic methods for detecting the egf receptor |
| SG11201602063UA (en) | 2013-09-24 | 2016-04-28 | Somalogic Inc | Multiaptamer target detection |
-
2014
- 2014-09-24 SG SG11201602063UA patent/SG11201602063UA/en unknown
- 2014-09-24 MX MX2016003320A patent/MX361451B/es active IP Right Grant
- 2014-09-24 EP EP14847780.5A patent/EP3049523B1/en active Active
- 2014-09-24 CN CN202210264586.7A patent/CN114703193A/zh active Pending
- 2014-09-24 US US15/023,182 patent/US9926566B2/en active Active
- 2014-09-24 CA CA2924987A patent/CA2924987C/en active Active
- 2014-09-24 WO PCT/US2014/057143 patent/WO2015048084A1/en not_active Ceased
- 2014-09-24 JP JP2016544355A patent/JP6506768B2/ja active Active
- 2014-09-24 HK HK16106780.3A patent/HK1218765A1/zh unknown
- 2014-09-24 AU AU2014326975A patent/AU2014326975B2/en active Active
- 2014-09-24 CN CN201480051210.1A patent/CN105555957A/zh active Pending
- 2014-09-24 BR BR112016005957A patent/BR112016005957A2/pt not_active IP Right Cessation
- 2014-09-24 KR KR1020167006262A patent/KR102348283B1/ko active Active
-
2016
- 2016-02-25 IL IL244284A patent/IL244284B/en active IP Right Grant
-
2018
- 2018-02-13 US US15/895,723 patent/US10392621B2/en active Active
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