JP2016530314A5 - - Google Patents
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- Publication number
- JP2016530314A5 JP2016530314A5 JP2016542073A JP2016542073A JP2016530314A5 JP 2016530314 A5 JP2016530314 A5 JP 2016530314A5 JP 2016542073 A JP2016542073 A JP 2016542073A JP 2016542073 A JP2016542073 A JP 2016542073A JP 2016530314 A5 JP2016530314 A5 JP 2016530314A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361877151P | 2013-09-12 | 2013-09-12 | |
| US61/877,151 | 2013-09-12 | ||
| US201462011784P | 2014-06-13 | 2014-06-13 | |
| US62/011,784 | 2014-06-13 | ||
| US201462031673P | 2014-07-31 | 2014-07-31 | |
| US62/031,673 | 2014-07-31 | ||
| PCT/US2014/055012 WO2015038655A1 (en) | 2013-09-12 | 2014-09-10 | Aza-pyridone compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530314A JP2016530314A (ja) | 2016-09-29 |
| JP2016530314A5 true JP2016530314A5 (https=) | 2017-10-26 |
| JP6448647B2 JP6448647B2 (ja) | 2019-01-09 |
Family
ID=52626171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542073A Expired - Fee Related JP6448647B2 (ja) | 2013-09-12 | 2014-09-10 | アザ−ピリドン化合物およびその用途 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US9328119B2 (https=) |
| EP (2) | EP3778603A1 (https=) |
| JP (1) | JP6448647B2 (https=) |
| KR (2) | KR102323515B1 (https=) |
| CN (1) | CN105764904B (https=) |
| AU (2) | AU2014318832B2 (https=) |
| BR (1) | BR112016005270B1 (https=) |
| CA (1) | CA2923075C (https=) |
| CL (1) | CL2016000539A1 (https=) |
| EA (1) | EA037949B1 (https=) |
| ES (1) | ES2821394T3 (https=) |
| IL (2) | IL244432B (https=) |
| MX (2) | MX377396B (https=) |
| PE (1) | PE20160661A1 (https=) |
| PH (1) | PH12016500486A1 (https=) |
| TW (1) | TWI652269B (https=) |
| UA (1) | UA121199C2 (https=) |
| WO (1) | WO2015038655A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS57869B1 (sr) | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2015038655A1 (en) * | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| ES2724581T3 (es) | 2013-09-12 | 2019-09-12 | Janssen Biopharma Inc | Compuestos de piridazinona y usos de los mismos |
| WO2016145103A1 (en) * | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| MX394421B (es) | 2015-04-28 | 2025-03-24 | Shionogi & Co | Derivados de piridona policiclica sustituida y profarmaco de los mismos |
| BR112017022550B1 (pt) | 2015-04-28 | 2021-02-23 | Shionogi & Co., Ltd | derivados policíclicos de piridona substituída |
| JP6857617B2 (ja) * | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤 |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| TW201726678A (zh) | 2015-10-30 | 2017-08-01 | 赫孚孟拉羅股份公司 | 嘧啶酮衍生物及其於治療、改善或預防病毒性疾病之用途 |
| AU2016374416A1 (en) | 2015-12-15 | 2018-06-14 | Shionogi & Co., Ltd. | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| WO2017156407A1 (en) * | 2016-03-10 | 2017-09-14 | Alios Biopharma, Inc. | Method of preparing aza-pyridone compounds |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
| RU2727962C1 (ru) | 2016-08-10 | 2020-07-28 | Сионоги Энд Ко., Лтд. | Фармацевтические композиции, содержащие замещенные полициклические пиридоновые производные и их пролекарство |
| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| EP4717317A2 (en) | 2017-06-20 | 2026-04-01 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| CN111848615B (zh) * | 2018-01-17 | 2022-05-17 | 江西彩石医药科技有限公司 | 吡啶酮衍生物及包含其的抗流感病毒药物组合物 |
| KR20230031990A (ko) | 2018-02-28 | 2023-03-07 | 노파르티스 아게 | 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7h-피롤로[1',2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 관련 화합물 |
| CN113286793B (zh) * | 2018-09-10 | 2024-04-05 | 共结晶制药公司 | 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂 |
| CN111909174B (zh) | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物的晶型及制备方法和应用 |
| EP4121031A4 (en) | 2020-03-20 | 2024-03-27 | Atux Iskay LLC | 3-DIARYLMETHYLENE AND THEIR USE |
| US20230290957A1 (en) | 2020-12-14 | 2023-09-14 | The School Corporation Kansai University | Electrode for electrochemical device and non-aqueous electrolyte secondary battery |
| CN117126044B (zh) * | 2023-04-12 | 2024-01-26 | 延边大学 | 一种微波辅助的甲基酮类化合物的合成方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPM354694A0 (en) * | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
| TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| CN100357284C (zh) * | 2003-09-11 | 2007-12-26 | 浙江海正药业股份有限公司 | 抗流感病毒化合物及其制备方法和用途 |
| WO2005087766A1 (en) * | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hiv integrase inhibitors |
| WO2005099688A2 (en) | 2004-04-07 | 2005-10-27 | Takeda Pharmaceutical Company Limited | Cyclic compounds |
| WO2005099699A1 (en) | 2004-04-07 | 2005-10-27 | Sepracor Inc. | Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension |
| WO2006028963A2 (en) | 2004-09-03 | 2006-03-16 | Celgene Corporation | Substituted heterocyclic compounds and uses thereof |
| AR057623A1 (es) | 2005-11-28 | 2007-12-05 | Omega Bio Pharma H K Ltd | Materiales y metodos para el tratamiento de las infecciones virales |
| ZA200805191B (en) * | 2005-11-28 | 2009-08-26 | Hk Omega Biopharma Ltd | Materials and methods for treating viral infections with a cysteamine compound |
| FR2909090B1 (fr) | 2006-11-23 | 2009-01-09 | Sanofi Aventis Sa | Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique. |
| KR20090097194A (ko) | 2006-12-22 | 2009-09-15 | 아벡사 리미티드 | 바이사이클 피리미디논 및 그 용도 |
| FR2921505B1 (fr) | 2007-09-25 | 2014-01-31 | Alstom Transport Sa | Dispositif de communication radioelectrique |
| JP2009096991A (ja) | 2007-09-27 | 2009-05-07 | Fujifilm Corp | 硬化性組成物、画像形成材料及び平版印刷版原版 |
| WO2009053799A1 (en) | 2007-10-24 | 2009-04-30 | Glenmark Pharmaceuticals, S.A. | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| EP2719700A1 (en) | 2008-01-09 | 2014-04-16 | Amura Therapeutics Limited | Tetrahydrofuro(3,2-b)pyrrol-3-one derivatives as inhibitors of cysteine proteinases |
| ES2467108T3 (es) | 2008-12-09 | 2014-06-11 | Gilead Sciences, Inc. | Moduladores de receptores tipo toll |
| WO2010080864A1 (en) | 2009-01-12 | 2010-07-15 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof |
| NZ594851A (en) | 2009-02-05 | 2013-10-25 | Takeda Pharmaceutical | Pyridazinone compounds |
| CA2750708A1 (en) | 2009-02-23 | 2010-08-26 | Merck Sharp & Dohme Corp. | Pyrazolo [4,3-c] cinnolin-3-one m1 receptor positive allosteric modulators |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
| TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| US8835461B2 (en) | 2009-03-26 | 2014-09-16 | Shionogi & Co., Ltd. | Substituted 3-hydroxy-4-pyridone derivative |
| WO2010138419A2 (en) * | 2009-05-23 | 2010-12-02 | Obio Pharmaceutical (H.K.) Ltd. | Materials and methods for treating viral infections |
| LT2444400T (lt) * | 2009-06-15 | 2018-06-11 | Shionogi & Co., Ltd. | Pakeistasis policiklinis karbamoilpiridono darinys |
| US8383638B2 (en) | 2009-12-21 | 2013-02-26 | Merck Sharp & Dohme | Aminobenzoquinazolinone M1 receptor positive allosteric modulators |
| PE20130010A1 (es) * | 2010-02-26 | 2013-02-05 | Japan Tobacco Inc | Derivado de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina como inhibidor de la integrasa del vih |
| CA2999435A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
| WO2012009194A1 (en) | 2010-07-12 | 2012-01-19 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| MX2013003139A (es) | 2010-09-24 | 2013-06-18 | Shionogi & Co | Profarmaco de derivado de carbamoilpiridona policiclica substituida. |
| HK1199028A1 (en) | 2011-09-30 | 2015-06-19 | Kineta, Inc. | Anti-viral compounds |
| CN104918942A (zh) | 2013-01-08 | 2015-09-16 | 萨维拉制药有限公司 | 嘧啶酮衍生物和它们用于治疗、改善或预防病毒疾病的用途 |
| ES2724581T3 (es) | 2013-09-12 | 2019-09-12 | Janssen Biopharma Inc | Compuestos de piridazinona y usos de los mismos |
| WO2015038655A1 (en) * | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| CR20160557A (es) | 2014-05-29 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2 |
| WO2016145103A1 (en) * | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| WO2017156407A1 (en) | 2016-03-10 | 2017-09-14 | Alios Biopharma, Inc. | Method of preparing aza-pyridone compounds |
| WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
-
2014
- 2014-09-10 WO PCT/US2014/055012 patent/WO2015038655A1/en not_active Ceased
- 2014-09-10 BR BR112016005270-6A patent/BR112016005270B1/pt not_active IP Right Cessation
- 2014-09-10 UA UAA201602294A patent/UA121199C2/uk unknown
- 2014-09-10 CN CN201480061771.XA patent/CN105764904B/zh not_active Expired - Fee Related
- 2014-09-10 EP EP20184298.6A patent/EP3778603A1/en not_active Withdrawn
- 2014-09-10 ES ES14844961T patent/ES2821394T3/es active Active
- 2014-09-10 MX MX2016003199A patent/MX377396B/es active IP Right Grant
- 2014-09-10 US US14/482,886 patent/US9328119B2/en active Active
- 2014-09-10 KR KR1020167009194A patent/KR102323515B1/ko not_active Expired - Fee Related
- 2014-09-10 PE PE2016000369A patent/PE20160661A1/es unknown
- 2014-09-10 JP JP2016542073A patent/JP6448647B2/ja not_active Expired - Fee Related
- 2014-09-10 KR KR1020217035836A patent/KR102468319B1/ko active Active
- 2014-09-10 EA EA201690372A patent/EA037949B1/ru unknown
- 2014-09-10 CA CA2923075A patent/CA2923075C/en active Active
- 2014-09-10 AU AU2014318832A patent/AU2014318832B2/en not_active Ceased
- 2014-09-10 EP EP14844961.4A patent/EP3030566B1/en active Active
- 2014-09-12 TW TW103131647A patent/TWI652269B/zh not_active IP Right Cessation
-
2016
- 2016-03-03 IL IL244432A patent/IL244432B/en active IP Right Grant
- 2016-03-09 CL CL2016000539A patent/CL2016000539A1/es unknown
- 2016-03-10 MX MX2020012132A patent/MX2020012132A/es unknown
- 2016-03-11 PH PH12016500486A patent/PH12016500486A1/en unknown
- 2016-04-28 US US15/141,387 patent/US10251882B2/en active Active
-
2019
- 2019-02-28 AU AU2019201403A patent/AU2019201403B2/en not_active Ceased
- 2019-03-01 US US16/290,690 patent/US10702523B2/en active Active
- 2019-08-09 US US16/537,396 patent/US10980805B2/en not_active Expired - Fee Related
-
2020
- 2020-04-30 IL IL274355A patent/IL274355B/en active IP Right Grant
-
2021
- 2021-02-25 US US17/185,750 patent/US20210186969A1/en not_active Abandoned
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