JP2016530315A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016530315A5 JP2016530315A5 JP2016542074A JP2016542074A JP2016530315A5 JP 2016530315 A5 JP2016530315 A5 JP 2016530315A5 JP 2016542074 A JP2016542074 A JP 2016542074A JP 2016542074 A JP2016542074 A JP 2016542074A JP 2016530315 A5 JP2016530315 A5 JP 2016530315A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- aryl
- heterocyclyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 48
- 150000001875 compounds Chemical class 0.000 claims 46
- 125000000623 heterocyclic group Chemical group 0.000 claims 39
- 125000003107 substituted aryl group Chemical group 0.000 claims 25
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 17
- 125000002947 alkylene group Chemical group 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
- 150000001412 amines Chemical class 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- -1 substituted Chemical class 0.000 claims 9
- 229940124530 sulfonamide Drugs 0.000 claims 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 239000011593 sulfur Substances 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000004474 heteroalkylene group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 4
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 4
- 101150065749 Churc1 gene Proteins 0.000 claims 4
- 102100038239 Protein Churchill Human genes 0.000 claims 4
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- 241000712461 unidentified influenza virus Species 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 1
- JGPXDNKSIXAZEQ-SBBZOCNPSA-N (2s,3s)-3-[[5-fluoro-2-(5-fluoro-1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Chemical compound C1=C(F)C=C2C(C=3N=C(C(=CN=3)F)N[C@H]3C4CCC(CC4)[C@@H]3C(=O)O)=CNC2=N1 JGPXDNKSIXAZEQ-SBBZOCNPSA-N 0.000 claims 1
- KLWQRKNCYXQRGD-CYBMUJFWSA-N (3r)-3-[[5-fluoro-2-(5-fluoro-1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-4,4-dimethylpentanoic acid Chemical compound C1=C(F)C(N[C@H](CC(O)=O)C(C)(C)C)=NC(C=2C3=CC(F)=CN=C3NC=2)=N1 KLWQRKNCYXQRGD-CYBMUJFWSA-N 0.000 claims 1
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 1
- 229940124895 FluMist Drugs 0.000 claims 1
- 229940124896 Fluarix Drugs 0.000 claims 1
- 229940124943 Flublok Drugs 0.000 claims 1
- 229940124946 Flucelvax Drugs 0.000 claims 1
- 229940124894 Fluzone Drugs 0.000 claims 1
- QNRRHYPPQFELSF-CNYIRLTGSA-N Laninamivir Chemical compound OC[C@@H](O)[C@@H](OC)[C@@H]1OC(C(O)=O)=C[C@H](N=C(N)N)[C@H]1NC(C)=O QNRRHYPPQFELSF-CNYIRLTGSA-N 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 208000009620 Orthomyxoviridae Infections Diseases 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 125000005631 S-sulfonamido group Chemical group 0.000 claims 1
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000005262 alkoxyamine group Chemical group 0.000 claims 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
- 229960003805 amantadine Drugs 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- CTPOHARTNNSRSR-APJZLKAGSA-N beraprost Chemical compound O([C@H]1C[C@@H](O)[C@@H]([C@@H]21)/C=C/[C@@H](O)C(C)CC#CC)C1=C2C=CC=C1CCCC(O)=O CTPOHARTNNSRSR-APJZLKAGSA-N 0.000 claims 1
- 229960002890 beraprost Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 108700020302 erbB-2 Genes Proteins 0.000 claims 1
- ZCGNOVWYSGBHAU-UHFFFAOYSA-N favipiravir Chemical compound NC(=O)C1=NC(F)=CNC1=O ZCGNOVWYSGBHAU-UHFFFAOYSA-N 0.000 claims 1
- 229950008454 favipiravir Drugs 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229950004244 laninamivir Drugs 0.000 claims 1
- 150000002886 octanoic acid esters Chemical class 0.000 claims 1
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 1
- 229960003752 oseltamivir Drugs 0.000 claims 1
- XRQDFNLINLXZLB-CKIKVBCHSA-N peramivir Chemical compound CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(O)=O)C[C@H]1NC(N)=N XRQDFNLINLXZLB-CKIKVBCHSA-N 0.000 claims 1
- 229960001084 peramivir Drugs 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229940121649 protein inhibitor Drugs 0.000 claims 1
- 239000012268 protein inhibitor Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- 229960000888 rimantadine Drugs 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 1
- 125000005423 trihalomethanesulfonamido group Chemical group 0.000 claims 1
- 125000005152 trihalomethanesulfonyl group Chemical group 0.000 claims 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims 1
- 229960001028 zanamivir Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361877171P | 2013-09-12 | 2013-09-12 | |
| US61/877,171 | 2013-09-12 | ||
| PCT/US2014/055018 WO2015038660A1 (en) | 2013-09-12 | 2014-09-10 | Pyridazinone compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530315A JP2016530315A (ja) | 2016-09-29 |
| JP2016530315A5 true JP2016530315A5 (https=) | 2017-11-02 |
| JP6360176B2 JP6360176B2 (ja) | 2018-07-18 |
Family
ID=52666233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542074A Expired - Fee Related JP6360176B2 (ja) | 2013-09-12 | 2014-09-10 | ピリダジノン化合物およびその用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10364226B2 (https=) |
| EP (1) | EP3030549B8 (https=) |
| JP (1) | JP6360176B2 (https=) |
| KR (1) | KR102286860B1 (https=) |
| CN (1) | CN105722831B (https=) |
| AU (1) | AU2014318837B2 (https=) |
| CA (1) | CA2922943A1 (https=) |
| DK (1) | DK3030549T3 (https=) |
| EA (1) | EA034868B1 (https=) |
| ES (1) | ES2724581T3 (https=) |
| HK (1) | HK1225382A1 (https=) |
| HR (1) | HRP20190822T1 (https=) |
| HU (1) | HUE043349T2 (https=) |
| IL (1) | IL244434B (https=) |
| LT (1) | LT3030549T (https=) |
| MX (1) | MX370085B (https=) |
| PH (1) | PH12016500492A1 (https=) |
| SI (1) | SI3030549T1 (https=) |
| WO (1) | WO2015038660A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2015038655A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| WO2016145103A1 (en) | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| BR112017022550B1 (pt) | 2015-04-28 | 2021-02-23 | Shionogi & Co., Ltd | derivados policíclicos de piridona substituída |
| AU2016374416A1 (en) | 2015-12-15 | 2018-06-14 | Shionogi & Co., Ltd. | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| WO2017156407A1 (en) | 2016-03-10 | 2017-09-14 | Alios Biopharma, Inc. | Method of preparing aza-pyridone compounds |
| RU2727962C1 (ru) | 2016-08-10 | 2020-07-28 | Сионоги Энд Ко., Лтд. | Фармацевтические композиции, содержащие замещенные полициклические пиридоновые производные и их пролекарство |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| KR20230031990A (ko) | 2018-02-28 | 2023-03-07 | 노파르티스 아게 | 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7h-피롤로[1',2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 관련 화합물 |
| MX2021004182A (es) * | 2018-10-10 | 2021-09-08 | Janssen Biopharma Inc | Inhibidores macrocíclicos de endonucleasa de la gripe. |
| WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| IL291665B2 (en) | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| JP2023502514A (ja) | 2019-11-26 | 2023-01-24 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | 疾患の処置のための受容体相互作用プロテインキナーゼｉの阻害剤 |
| WO2025244119A1 (ja) * | 2024-05-24 | 2025-11-27 | 住友化学株式会社 | ピリダジン誘導体及びそれを含有する組成物 |
| CN118546389B (zh) * | 2024-07-29 | 2024-10-15 | 陕西理工大学 | 哒嗪氢键骨架荧光传感材料及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4345934A (en) | 1977-03-10 | 1982-08-24 | Rohm And Haas Company | Method of producing hybrid cereal grain seeds by application of 1-aryl-1,4-dihydro-4-oxo(thio)-pyridazines |
| DK0482208T3 (da) | 1990-04-25 | 2000-09-18 | Nissan Chemical Ind Ltd | Pyridazinonderivat |
| AUPM354694A0 (en) | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| WO1998041511A1 (en) | 1997-03-14 | 1998-09-24 | Merck Frosst Canada & Co. | Pyridazinones as inhibitors of cyclooxygenase-2 |
| AU2002305926A1 (en) * | 2001-02-05 | 2002-10-08 | Exegenics Inc. | Cysteine protease inhibitors |
| AU2003209321A1 (en) | 2002-01-18 | 2003-07-30 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| FR2909090B1 (fr) * | 2006-11-23 | 2009-01-09 | Sanofi Aventis Sa | Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique. |
| FR2916443B1 (fr) | 2007-05-24 | 2012-08-03 | Sanofi Aventis | Nouveaux derives analogues de l'herbimycine a, compositions les contenant et utilisation. |
| NZ594851A (en) * | 2009-02-05 | 2013-10-25 | Takeda Pharmaceutical | Pyridazinone compounds |
| US9211044B2 (en) * | 2011-03-04 | 2015-12-15 | Omachron Intellectual Property Inc. | Compact surface cleaning apparatus |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| LT2444400T (lt) | 2009-06-15 | 2018-06-11 | Shionogi & Co., Ltd. | Pakeistasis policiklinis karbamoilpiridono darinys |
| CA2999435A1 (en) * | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
| US8883788B2 (en) * | 2010-08-04 | 2014-11-11 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
| MX2013003139A (es) | 2010-09-24 | 2013-06-18 | Shionogi & Co | Profarmaco de derivado de carbamoilpiridona policiclica substituida. |
| WO2015038655A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| WO2016145103A1 (en) | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| WO2017156407A1 (en) | 2016-03-10 | 2017-09-14 | Alios Biopharma, Inc. | Method of preparing aza-pyridone compounds |
| WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
-
2014
- 2014-09-10 ES ES14843298T patent/ES2724581T3/es active Active
- 2014-09-10 MX MX2016003135A patent/MX370085B/es active IP Right Grant
- 2014-09-10 SI SI201431180T patent/SI3030549T1/sl unknown
- 2014-09-10 JP JP2016542074A patent/JP6360176B2/ja not_active Expired - Fee Related
- 2014-09-10 CA CA2922943A patent/CA2922943A1/en not_active Abandoned
- 2014-09-10 US US15/021,073 patent/US10364226B2/en active Active
- 2014-09-10 DK DK14843298.2T patent/DK3030549T3/da active
- 2014-09-10 HR HRP20190822TT patent/HRP20190822T1/hr unknown
- 2014-09-10 EA EA201690371A patent/EA034868B1/ru not_active IP Right Cessation
- 2014-09-10 WO PCT/US2014/055018 patent/WO2015038660A1/en not_active Ceased
- 2014-09-10 EP EP14843298.2A patent/EP3030549B8/en active Active
- 2014-09-10 HK HK16113675.7A patent/HK1225382A1/zh unknown
- 2014-09-10 LT LTEP14843298.2T patent/LT3030549T/lt unknown
- 2014-09-10 KR KR1020167008927A patent/KR102286860B1/ko not_active Expired - Fee Related
- 2014-09-10 CN CN201480061772.4A patent/CN105722831B/zh not_active Expired - Fee Related
- 2014-09-10 AU AU2014318837A patent/AU2014318837B2/en not_active Ceased
- 2014-09-10 HU HUE14843298A patent/HUE043349T2/hu unknown
-
2016
- 2016-03-03 IL IL244434A patent/IL244434B/en active IP Right Grant
- 2016-03-11 PH PH12016500492A patent/PH12016500492A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016530315A5 (https=) | ||
| JP2016530314A5 (https=) | ||
| EA201491179A1 (ru) | 2',4'-дифтор-2'-метил замещенные нуклеозидные производные в качестве ингибиторов репликации рнк вируса гепатита с | |
| EA201190007A1 (ru) | Ингибиторы ns5a вгс | |
| EA200970156A1 (ru) | Пиридизиноновые производные | |
| PE20161475A1 (es) | Pirazolopiridinas y pirazolopirimidinas | |
| UA117800C2 (uk) | Похідні урацилу або тиміну для лікування гепатиту с | |
| PH12014501283A1 (en) | 4`-azido, 3``-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication | |
| EA201100580A1 (ru) | Имидазопиридазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
| PE20180232A1 (es) | Derivados de indol mono o disustituidos como inhibidores de la replicacion viral del dengue | |
| PY1153144A (es) | Inhibidores macrocíclicos de virus flaviviridae | |
| AR106252A2 (es) | Compuestos de pirrolo[2,3-d]pirimidina | |
| EA201391127A1 (ru) | C-17 и c-3 модифицированные тритерпеноиды с ингибиторной активностью созревания вич | |
| ECSP12011684A (es) | Inhibidores de los virus flaviviridae. | |
| CO6321265A2 (es) | Compuestos de 2-amido-3-metil pirrolo pirimidinona fenilo -sustituidos como inhibidores bace-1 composiciones y su uso | |
| BR112013020996A8 (pt) | derivados aminobutíricos substituídos como inibidores de neprilisina | |
| UY32490A (es) | Inhibidores de beta-secretasa | |
| EA201001724A1 (ru) | Производные изоксазола и их применение в качестве потенциирующих средств для метаботропных глутаматных рецепторов | |
| EA201490471A1 (ru) | Пиридазиноновые соединения и их применение в качестве ингибиторов daao | |
| EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
| CY1118567T1 (el) | Αναστολεις του ιου της ηπατιτιδας c | |
| NO20080865L (no) | Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer | |
| BR112013016595A2 (pt) | inibidores de neprilisina | |
| CO6561783A2 (es) | Inhibidores del virus flaviviridae | |
| BR112014010401A8 (pt) | Inibidores do vírus da hepatite c rod-like que contêm o fragmento {2-[4-(bifenil-4-il)-1h-imidazo-2-il] pirrolidina-1-carbonilmetil}amina |