JP2016528914A5 - - Google Patents
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- JP2016528914A5 JP2016528914A5 JP2016537848A JP2016537848A JP2016528914A5 JP 2016528914 A5 JP2016528914 A5 JP 2016528914A5 JP 2016537848 A JP2016537848 A JP 2016537848A JP 2016537848 A JP2016537848 A JP 2016537848A JP 2016528914 A5 JP2016528914 A5 JP 2016528914A5
- Authority
- JP
- Japan
- Prior art keywords
- activity profile
- panel
- subject
- genetic markers
- multikinase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000000694 effects Effects 0.000 claims description 70
- 230000002068 genetic effect Effects 0.000 claims description 36
- 229940124303 multikinase inhibitor Drugs 0.000 claims description 34
- 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 claims description 24
- 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 claims description 24
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 16
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 16
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 16
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims description 13
- 102100026656 Actin, alpha skeletal muscle Human genes 0.000 claims description 13
- 102000058080 Glucose Transporter Type 5 Human genes 0.000 claims description 13
- 101001066181 Homo sapiens 6-phosphogluconolactonase Proteins 0.000 claims description 13
- 101000834207 Homo sapiens Actin, alpha skeletal muscle Proteins 0.000 claims description 13
- 101001032345 Homo sapiens Interferon regulatory factor 8 Proteins 0.000 claims description 13
- 101001093919 Homo sapiens SEC14-like protein 2 Proteins 0.000 claims description 13
- 101000763474 Homo sapiens Transmembrane protein 140 Proteins 0.000 claims description 13
- 102100038069 Interferon regulatory factor 8 Human genes 0.000 claims description 13
- 102100035174 SEC14-like protein 2 Human genes 0.000 claims description 13
- 108091006301 SLC2A5 Proteins 0.000 claims description 13
- 102000004265 STAT2 Transcription Factor Human genes 0.000 claims description 13
- 108010081691 STAT2 Transcription Factor Proteins 0.000 claims description 13
- 102100027030 Transmembrane protein 140 Human genes 0.000 claims description 13
- 102100040215 UDP-glucuronosyltransferase 2A1 Human genes 0.000 claims description 13
- 101710199217 UDP-glucuronosyltransferase 2A1 Proteins 0.000 claims description 13
- 108091000080 Phosphotransferase Proteins 0.000 claims description 8
- 230000033115 angiogenesis Effects 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 8
- 102000020233 phosphotransferase Human genes 0.000 claims description 8
- 102000009929 raf Kinases Human genes 0.000 claims description 8
- 108010077182 raf Kinases Proteins 0.000 claims description 8
- 230000004043 responsiveness Effects 0.000 claims description 8
- 230000014509 gene expression Effects 0.000 claims description 4
- 239000003550 marker Substances 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 239000000523 sample Substances 0.000 claims description 3
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims description 2
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims description 2
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims description 2
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims description 2
- 239000002118 L01XE12 - Vandetanib Substances 0.000 claims description 2
- 239000002176 L01XE26 - Cabozantinib Substances 0.000 claims description 2
- 229960003005 axitinib Drugs 0.000 claims description 2
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims description 2
- 229960001292 cabozantinib Drugs 0.000 claims description 2
- ONIQOQHATWINJY-UHFFFAOYSA-N cabozantinib Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 ONIQOQHATWINJY-UHFFFAOYSA-N 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229960000639 pazopanib Drugs 0.000 claims description 2
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims description 2
- 230000004952 protein activity Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 229960003787 sorafenib Drugs 0.000 claims description 2
- 229960001796 sunitinib Drugs 0.000 claims description 2
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims description 2
- 229960000241 vandetanib Drugs 0.000 claims description 2
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 238000000034 method Methods 0.000 description 21
- 238000002493 microarray Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013082487 | 2013-08-28 | ||
| CNPCT/CN2013/082487 | 2013-08-28 | ||
| PCT/US2014/053142 WO2015031604A1 (en) | 2013-08-28 | 2014-08-28 | Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016528914A JP2016528914A (ja) | 2016-09-23 |
| JP2016528914A5 true JP2016528914A5 (cg-RX-API-DMAC7.html) | 2017-09-28 |
| JP6612232B2 JP6612232B2 (ja) | 2019-11-27 |
Family
ID=52587328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016537848A Active JP6612232B2 (ja) | 2013-08-28 | 2014-08-28 | 対象のマルチキナーゼ阻害剤に対する応答性を予測する遺伝子発現シグネチャ、及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11136625B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3039424B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6612232B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105659085B (cg-RX-API-DMAC7.html) |
| CY (1) | CY1123415T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3039424T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2813877T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3039424T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015031604A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2813877T3 (es) | 2013-08-28 | 2021-03-25 | Crown Bioscience Inc Taicang | Distintivos de expresión génica predictivos de la respuesta de un sujeto a un inhibidor multicinasa y métodos de uso de los mismos |
| JP6853789B2 (ja) * | 2015-12-24 | 2021-03-31 | 公益財団法人がん研究会 | マルチキナーゼ阻害剤の有効性と安全性を予測する検査方法、検査キット、及びバイオマーカー |
| WO2020085936A1 (ru) * | 2018-10-24 | 2020-04-30 | Общество С Ограниченной Ответственностью "Онкобокс" | Тест-классификатор клинического ответа на лечение сорафенибом индивидуальных пациентов с раком почки |
| CN113498341A (zh) * | 2019-01-02 | 2021-10-12 | 浙江冠科美博生物科技有限公司 | 使用多靶点激酶抑制剂结合蛋白激酶生物标志物的癌症治疗 |
| CN111521810B (zh) * | 2019-02-02 | 2024-06-21 | 中国科学院上海药物研究所 | 癌症患者根据脾酪氨酸激酶进行分层 |
| CN111693707A (zh) * | 2020-07-16 | 2020-09-22 | 首都医科大学附属北京朝阳医院 | Rock激酶活性在辅助诊断血管炎患者中的应用 |
| CN118345086B (zh) * | 2024-04-22 | 2024-10-11 | 西部(重庆)科学城种质创制大科学中心 | 柑橘溃疡病抗性Cs7g24050基因及其编码蛋白与应用 |
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| US20140322166A1 (en) * | 2011-12-12 | 2014-10-30 | Stc. Unm | Gene expression signatures for detection of underlying philadelphia chromosome-like (ph-like) events and therapeutic targeting in leukemia |
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| ES2813877T3 (es) | 2013-08-28 | 2021-03-25 | Crown Bioscience Inc Taicang | Distintivos de expresión génica predictivos de la respuesta de un sujeto a un inhibidor multicinasa y métodos de uso de los mismos |
-
2014
- 2014-08-28 ES ES14840944T patent/ES2813877T3/es active Active
- 2014-08-28 DK DK14840944.4T patent/DK3039424T3/da active
- 2014-08-28 JP JP2016537848A patent/JP6612232B2/ja active Active
- 2014-08-28 EP EP14840944.4A patent/EP3039424B1/en active Active
- 2014-08-28 WO PCT/US2014/053142 patent/WO2015031604A1/en not_active Ceased
- 2014-08-28 PT PT148409444T patent/PT3039424T/pt unknown
- 2014-08-28 CN CN201480057475.2A patent/CN105659085B/zh active Active
- 2014-08-28 US US14/915,121 patent/US11136625B2/en active Active
-
2020
- 2020-08-28 CY CY20201100811T patent/CY1123415T1/el unknown
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