CY1123415T1 - Υπογραφες εκφρασης γονιδιων προγνωστικες της αποκρισης υποκειμενου σε αναστολεα πολυκινασης και μεθοδοι χρησεως αυτων - Google Patents

Υπογραφες εκφρασης γονιδιων προγνωστικες της αποκρισης υποκειμενου σε αναστολεα πολυκινασης και μεθοδοι χρησεως αυτων

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Publication number
CY1123415T1
CY1123415T1 CY20201100811T CY201100811T CY1123415T1 CY 1123415 T1 CY1123415 T1 CY 1123415T1 CY 20201100811 T CY20201100811 T CY 20201100811T CY 201100811 T CY201100811 T CY 201100811T CY 1123415 T1 CY1123415 T1 CY 1123415T1
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CY
Cyprus
Prior art keywords
polykinase
methods
gene expression
inhibitors
expression signatures
Prior art date
Application number
CY20201100811T
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English (en)
Inventor
Sheng Guo
Dawei Chen
Juan Zhang
Jie Cai
Henry Qixiang LI
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Crown Bioscience, Inc. (Taicang)
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Publication date
Application filed by Crown Bioscience, Inc. (Taicang) filed Critical Crown Bioscience, Inc. (Taicang)
Publication of CY1123415T1 publication Critical patent/CY1123415T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Γνωστοποιείται η υπογραφή της έκφρασης γονιδίων προγνωστική της απόκρισης ασθενών με καρκίνο στον αναστολέα πολυκινάσης. Επίσης, γνωστοποιούνται μέθοδοι προγνωστικές της αποτελεσματικότητας του αναστολέα, πολυκινάσης στη θεραπευτική αντιμετώπιση του καρκίνου σε έναν ασθενή. Επίσης, γνωστοποιούνται μέθοδοι για τη διάκριση των αποκρινόμενων από τους μη αποκρινόμενους σε έναν αναστολέα πολυκινάσης στη θεραπευτική αντιμετώπιση του καρκίνου. Επίσης, γνωστοποιούνται μέθοδοι θεραπευτικής αγωγής ενός καρκινοπαθούς με έναν αναστολέα πολυκινάσης.
CY20201100811T 2013-08-28 2020-08-28 Υπογραφες εκφρασης γονιδιων προγνωστικες της αποκρισης υποκειμενου σε αναστολεα πολυκινασης και μεθοδοι χρησεως αυτων CY1123415T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013082487 2013-08-28
PCT/US2014/053142 WO2015031604A1 (en) 2013-08-28 2014-08-28 Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same

Publications (1)

Publication Number Publication Date
CY1123415T1 true CY1123415T1 (el) 2021-12-31

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CY20201100811T CY1123415T1 (el) 2013-08-28 2020-08-28 Υπογραφες εκφρασης γονιδιων προγνωστικες της αποκρισης υποκειμενου σε αναστολεα πολυκινασης και μεθοδοι χρησεως αυτων

Country Status (9)

Country Link
US (1) US11136625B2 (el)
EP (1) EP3039424B1 (el)
JP (1) JP6612232B2 (el)
CN (1) CN105659085B (el)
CY (1) CY1123415T1 (el)
DK (1) DK3039424T3 (el)
ES (1) ES2813877T3 (el)
PT (1) PT3039424T (el)
WO (1) WO2015031604A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3039424B1 (en) 2013-08-28 2020-07-29 Crown Bioscience, Inc. (Taicang) Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same
JP6853789B2 (ja) * 2015-12-24 2021-03-31 公益財団法人がん研究会 マルチキナーゼ阻害剤の有効性と安全性を予測する検査方法、検査キット、及びバイオマーカー
RU2747746C2 (ru) * 2018-10-24 2021-05-13 Общество с ограниченной ответственностью «Онкобокс» Тест-классификатор клинического ответа на лечение сорафенибом индивидуальных пациентов с раком почки
CN113498341A (zh) * 2019-01-02 2021-10-12 浙江冠科美博生物科技有限公司 使用多靶点激酶抑制剂结合蛋白激酶生物标志物的癌症治疗
CN111521810B (zh) * 2019-02-02 2024-06-21 中国科学院上海药物研究所 癌症患者根据脾酪氨酸激酶进行分层
CN111693707A (zh) * 2020-07-16 2020-09-22 首都医科大学附属北京朝阳医院 Rock激酶活性在辅助诊断血管炎患者中的应用

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix Inc N D Ges D Staat Verfahren zur Herstellung von Polymerarrays
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
ME00275B (me) 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US20020065296A1 (en) 1999-01-13 2002-05-30 Bayer Corporation Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
US7141581B2 (en) 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
MXPA02004366A (es) 1999-11-05 2002-11-07 Astrazeneca Ab Derivados de quinazolina como inhibidores vegf.
JP5004392B2 (ja) 1999-12-22 2012-08-22 スージェン， インク． インドリノン化合物を用いてｃ−ｋｉｔチロシン蛋白質キナーゼ機能を調節する方法
SK287142B6 (sk) 2000-02-15 2010-01-07 Sugen, Inc. Inhibítory proteínkináz na báze pyrolom substituovaného 2-indolinónu, farmaceutický prípravok s ich obsahom a ich použitie
HU230574B1 (hu) 2000-12-21 2023-11-28 Novartis Ag Pirimidinamin-származékok és ezeket tartalmazó gyógyászati készítmények, mint angiogenézis modulátorok
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2003047579A1 (en) 2001-12-03 2003-06-12 Bayer Pharmaceuticals Corporation Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
SE0104164L (sv) 2001-12-11 2003-06-12 Ericsson Telefon Ab L M Högspännings-mos-transistor
NO317200B1 (no) 2002-08-09 2004-09-13 Best Practice Deployment As System for trafikkopplaering i et kjoretoy
KR20050046751A (ko) * 2002-09-27 2005-05-18 오리디스 비오메드 포르슝스-운트 엔트비크룽스 게엠베하 폴리펩티드 및 이들을 암호화하는 핵산 및 간질환 및 상피세포암을 예방, 진단 또는 치료하기 위한 이들의 용도
AU2004256425A1 (en) * 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2537812C (en) 2003-09-26 2013-01-22 Exelixis, Inc. C-met modulators and method of use
GB0411378D0 (en) 2004-05-21 2004-06-23 Astrazeneca Ab Pharmaceutical compositions
CA2612021A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP1946115A4 (en) * 2005-10-21 2009-12-02 Bayer Healthcare Llc METHOD FOR PREDICTING AND FORECASTING CANCER AND MONITORING CANCER THERAPY
US8329408B2 (en) 2005-10-31 2012-12-11 Bayer Healthcare Llc Methods for prognosis and monitoring cancer therapy
CA2627873A1 (en) 2005-10-31 2007-05-10 Scott Wilhelm Treatment of cancer with sorafenib
JP2009543797A (ja) 2006-07-10 2009-12-10 エラン ファーマ インターナショナル，リミティド ナノ粒子ソラフェニブ製剤
KR20090071603A (ko) * 2006-09-19 2009-07-01 노파르티스 아게 Ｒａｆ 억제제에 대한 표적 조절, 효능, 진단 및/또는 예후의 바이오마커
JP5484327B2 (ja) 2007-07-25 2014-05-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 癌の処置において使用するための多キナーゼインヒビター
US20090062347A1 (en) 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched axitinib
US20090062368A1 (en) 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched sunitinib
US8445687B2 (en) 2007-09-10 2013-05-21 Cipla Limited Process for the preparation of a RAF kinase inhibitor and intermediates for use in the process
CL2008002885A1 (es) 2007-09-26 2010-07-02 Chugai Pharmaceutical Co Ltd Anticuerpo anti-receptor de interleucina-6 (il-6); y composicion farmaceutica que lo comprende
WO2009054004A2 (en) 2007-10-22 2009-04-30 Natco Pharma Limited Process for the preparation of sorafenib
US20100256392A1 (en) 2007-11-21 2010-10-07 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
EP2220072A2 (en) 2007-11-21 2010-08-25 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
AU2009215377A1 (en) 2008-02-21 2009-08-27 Generics [Uk] Limited Novel polymorphs and processes for their preparation
WO2009106825A1 (en) 2008-02-27 2009-09-03 Cipla Limited Polymorphs of sorafenib and salts thereof
EP2142507A1 (en) 2008-03-06 2010-01-13 Sicor, Inc. Process for the preparation of sorafenib and salts thereof
EP2098521A1 (en) 2008-03-06 2009-09-09 Ratiopharm GmbH Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation
WO2009124037A1 (en) 2008-03-31 2009-10-08 Teva Pharmaceutical Industries Ltd. Processes for preparing sunitinib and salts thereof
US8501962B2 (en) 2008-06-23 2013-08-06 Natco Pharma Limited Process for the preparation of high purity sunitinib and its pharmaceutically acceptable salt
US8618309B2 (en) 2008-07-24 2013-12-31 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs
WO2010036796A1 (en) 2008-09-26 2010-04-01 Concert Pharmaceuticals, Inc. Pyridineamine derivatives
KR20100051769A (ko) 2008-09-30 2010-05-18 테바 파마슈티컬 인더스트리즈 리미티드 수니티닙 베이스 및 ｌ-말산의 비정질 조성물
US20110257035A1 (en) * 2008-10-21 2011-10-20 Bayer Healthcare Llc Identification of signature genes associated with hepatocellular carcinoma
EP2181991A1 (en) 2008-10-28 2010-05-05 LEK Pharmaceuticals D.D. Novel salts of sunitinib
EP2186809A1 (en) 2008-11-13 2010-05-19 LEK Pharmaceuticals D.D. New crystal form of sunitinib malate
WO2010059742A1 (en) * 2008-11-18 2010-05-27 Collabrx, Inc. Individualized cancer treatment
WO2010135608A1 (en) 2009-05-20 2010-11-25 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
WO2011004200A1 (en) 2009-07-10 2011-01-13 Generics [Uk] Limited Novel pyrrole derivatives
EA201190337A1 (ru) 2009-07-16 2012-06-29 Глаксо Вэллкам Мэньюфэкчуринг Пти Лтд. Способ лечения
US20120232102A1 (en) 2009-09-30 2012-09-13 Chun-Fang Xu Methods Of Administration And Treatment
JP2013505968A (ja) 2009-10-01 2013-02-21 シーエスエル、リミテッド フィラデルフィア染色体陽性白血病の治療方法
US20120245051A1 (en) 2009-10-13 2012-09-27 Rimm David L Objective, quantitative method to predict histological subtype in non-small cell lung cancer
JP2013508396A (ja) 2009-10-23 2013-03-07 グラクソ ウェルカム マニュファクチュアリング ピーティーイー リミテッド 組成物および方法
TW201201808A (en) 2010-01-06 2012-01-16 Glaxo Wellcome Mfg Pte Ltd Treatment method
WO2011100325A2 (en) 2010-02-09 2011-08-18 Sicor Inc. Polymorphs of sunitinib salts
WO2011104555A2 (en) 2010-02-25 2011-09-01 Generics [Uk] Limited Novel process
WO2011128699A2 (en) 2010-04-16 2011-10-20 Generics [Uk] Limited Novel process
UY33367A (es) 2010-05-05 2011-10-31 Glaxo Wellcome Mfg Pte Ltd Composiciones farmacéuticas y métodos para su elaboración
WO2011146458A1 (en) 2010-05-18 2011-11-24 Glaxo Wellcome Manufacturing Pte Ltd Method of administration and treatment
CN103328465B (zh) 2010-11-01 2015-05-27 神隆(昆山)生化科技有限公司 使用2-甲硅烷氧基-吡咯类制备3-((吡咯-2-基)亚甲基)-2-吡咯酮类的方法
WO2012073254A1 (en) 2010-11-29 2012-06-07 Hetero Research Foundation A process for the preparation of pazopanib using novel intermediate
US10220020B2 (en) 2010-12-23 2019-03-05 Nektar Therapeutics Polymer-des-ethyl sunitinib conjugates
WO2012103060A1 (en) 2011-01-27 2012-08-02 Glaxo Wellcome Manufacturing Pte Ltd Method of administration and treatment
WO2012116040A1 (en) * 2011-02-22 2012-08-30 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
CN102283836B (zh) 2011-06-27 2013-01-09 苏州大学附属第一医院 索拉非尼在制备治疗动脉瘤性自发性蛛网膜下腔出血后发生的早期脑损伤的药物中的应用
CA2840491A1 (en) 2011-06-28 2013-01-03 Bayer Healthcare Llc Topical ophthalmological pharmaceutical composition containing sorafenib
EP2742154A4 (en) * 2011-08-08 2015-08-12 Caris Life Sciences Switzerland Holdings Gmbh BIOMARKER COMPOSITIONS AND METHODS
US20140248372A1 (en) 2011-09-19 2014-09-04 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
TW201328725A (zh) 2011-09-30 2013-07-16 Pfizer Ｎ－甲基－２－［３－（（ｅ）－２－吡啶－２－基－乙烯基）－１ｈ－吲唑－６－基硫烷基］苯甲醯胺之藥學組成物
US20140322166A1 (en) * 2011-12-12 2014-10-30 Stc. Unm Gene expression signatures for detection of underlying philadelphia chromosome-like (ph-like) events and therapeutic targeting in leukemia
WO2013138522A2 (en) * 2012-03-16 2013-09-19 Genelux Corporation Methods for assessing effectiveness and monitoring oncolytic virus treatment
EP3039424B1 (en) 2013-08-28 2020-07-29 Crown Bioscience, Inc. (Taicang) Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same

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CN105659085A (zh) 2016-06-08
US11136625B2 (en) 2021-10-05
EP3039424A4 (en) 2017-03-29
JP2016528914A (ja) 2016-09-23
US20160208328A1 (en) 2016-07-21
PT3039424T (pt) 2020-09-03
CN105659085B (zh) 2018-12-07
ES2813877T3 (es) 2021-03-25
DK3039424T3 (da) 2020-08-31
EP3039424A1 (en) 2016-07-06
EP3039424B1 (en) 2020-07-29
JP6612232B2 (ja) 2019-11-27
WO2015031604A1 (en) 2015-03-05

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