JP2016522887A5 - - Google Patents
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- Publication number
- JP2016522887A5 JP2016522887A5 JP2016507962A JP2016507962A JP2016522887A5 JP 2016522887 A5 JP2016522887 A5 JP 2016522887A5 JP 2016507962 A JP2016507962 A JP 2016507962A JP 2016507962 A JP2016507962 A JP 2016507962A JP 2016522887 A5 JP2016522887 A5 JP 2016522887A5
- Authority
- JP
- Japan
- Prior art keywords
- ablation
- injector
- plume
- laser
- icp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002679 ablation Methods 0.000 claims 36
- 238000000608 laser ablation Methods 0.000 claims 21
- 238000009616 inductively coupled plasma Methods 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 239000007789 gas Substances 0.000 claims 16
- 238000004458 analytical method Methods 0.000 claims 10
- 238000005070 sampling Methods 0.000 claims 10
- 238000012083 mass cytometry Methods 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 5
- 239000012159 carrier gas Substances 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 230000007423 decrease Effects 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361812893P | 2013-04-17 | 2013-04-17 | |
| US61/812,893 | 2013-04-17 | ||
| PCT/CA2014/050387 WO2014169394A1 (en) | 2013-04-17 | 2014-04-17 | Sample analysis for mass cytometry |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016522887A JP2016522887A (ja) | 2016-08-04 |
| JP2016522887A5 true JP2016522887A5 (OSRAM) | 2017-06-01 |
| JP6230693B2 JP6230693B2 (ja) | 2017-11-15 |
Family
ID=51730644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507962A Active JP6230693B2 (ja) | 2013-04-17 | 2014-04-17 | マス・サイトメトリーのための試料分析 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US9589779B2 (OSRAM) |
| EP (2) | EP2987177B1 (OSRAM) |
| JP (1) | JP6230693B2 (OSRAM) |
| CN (1) | CN105190829B (OSRAM) |
| CA (2) | CA2895360C (OSRAM) |
| RU (1) | RU2637795C2 (OSRAM) |
| SG (2) | SG11201504874QA (OSRAM) |
| WO (1) | WO2014169394A1 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201507853QA (en) | 2013-03-22 | 2015-10-29 | Eth Zuerich | Laser ablation cell |
| CA2895360C (en) | 2013-04-17 | 2023-05-02 | Fluidigm Canada Inc. | Sample analysis for mass cytometry |
| CA2924284C (en) | 2013-09-13 | 2022-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry |
| GB201403625D0 (en) * | 2014-02-28 | 2014-04-16 | Asrepresented By The Sec Dep Of Health And Human Services The | Multiplexed imaging of tissue samples by mass cytometry |
| US11293872B2 (en) | 2014-09-18 | 2022-04-05 | Universiteit Gent | Laser ablation probe |
| EP4321852A3 (en) * | 2014-12-29 | 2024-05-29 | Fluidigm Canada Inc. | Mass cytometry apparatus and methods |
| EP3240885B1 (en) | 2014-12-31 | 2024-11-13 | Fluidigm Canada Inc. | Structured biological samples for analysis by mass cytometry |
| WO2016126988A1 (en) * | 2015-02-04 | 2016-08-11 | Fluidigm Canada Inc. | Laser enabled imaging mass cytometry |
| WO2016153819A1 (en) | 2015-03-25 | 2016-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis using secondary ion mass spectrometry |
| WO2016172215A1 (en) | 2015-04-23 | 2016-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method for multiplexed sample analysis by photoionizing secondary sputtered neutrals |
| US10622199B2 (en) * | 2016-08-02 | 2020-04-14 | Fluidigm Canada Inc. | Laser ablation system |
| CN110312486B (zh) * | 2016-12-22 | 2023-07-21 | 先进截骨工具 -Aot股份公司 | 激光设备和组织表征方法 |
| US11092519B1 (en) * | 2017-02-06 | 2021-08-17 | Elemental Scientific Lasers, Llc | System and method for automated sampling and analysis |
| JP7078382B2 (ja) * | 2017-11-22 | 2022-05-31 | 藤太郎 今坂 | 飛行時間型質量分析装置及び質量分析方法 |
| US11892428B2 (en) | 2018-04-18 | 2024-02-06 | S.T.Japan Inc. | Laser ablation device and analysis apparatus |
| CN119480607A (zh) | 2018-06-18 | 2025-02-18 | 富鲁达加拿大公司 | 用于分析生物样本的设备 |
| EP3850329A4 (en) | 2018-09-10 | 2022-06-22 | Fluidigm Canada Inc. | APPARATUS AND METHOD FOR AUTO-FOCUSING SAMPLE IMAGING |
| EP3850656A4 (en) * | 2018-09-10 | 2022-06-22 | Fluidigm Canada Inc. | APPARATUS AND METHOD FOR HIGH SPEED MODULATION SAMPLE IMAGING |
| KR102577694B1 (ko) * | 2018-09-11 | 2023-09-12 | 주식회사 엘지에너지솔루션 | 검출 감도 향상을 위한 레이저 탈착-dart-ms 시스템 및 이에 사용되는 인터페이스 유닛 |
| CN111954917B (zh) * | 2018-09-11 | 2023-11-07 | 株式会社 Lg新能源 | 接口单元 |
| US12345650B2 (en) | 2018-10-29 | 2025-07-01 | Standard Biotools Canada Inc. | Inductively coupled plasma torch with reverse vortex flow and method of operation |
| CN109668818B (zh) * | 2018-12-26 | 2024-07-12 | 宁波大学 | 基于激光烧蚀的细胞分析装置及方法 |
| US20210391161A1 (en) * | 2019-01-15 | 2021-12-16 | Fluidigm Canada Inc. | Direct ionization in imaging mass spectrometry operation |
| EP3712923A1 (en) * | 2019-03-18 | 2020-09-23 | ETH Zurich | Ion source for inductively coupled plasma mass spectrometry |
| CN114207775B (zh) | 2019-05-15 | 2023-06-06 | 上海宸安生物科技有限公司 | 用于质谱法的样品输送装置 |
| WO2020257258A1 (en) * | 2019-06-18 | 2020-12-24 | Fluidigm Corporation | Improved mass cytometry |
| EP4078140A4 (en) * | 2019-12-20 | 2024-06-26 | Standard Biotools Canada Inc. | PLASMA AND SAMPLING GEOMETRIES FOR IMAGING MASS CYTOMETRY |
| WO2021168213A1 (en) * | 2020-02-19 | 2021-08-26 | Elemental Scientific Lasers, Llc | Variable beam size via homqgenizer movement |
| EP3943197A1 (en) * | 2020-07-20 | 2022-01-26 | The Provost, Fellows, Scholars and other Members of Board of Trinity College Dublin | Jet deposition using laser-produced dry aerosol |
| EP4215025A4 (en) | 2020-09-18 | 2024-10-09 | Fluidigm Canada Inc. | INDUCTIVELY COUPLED PLASMA-BASED ATOMIC ANALYSIS SYSTEMS AND METHODS |
| US11443933B1 (en) * | 2020-10-30 | 2022-09-13 | Agilent Technologies, Inc. | Inductively coupled plasma mass spectrometry (ICP-MS) with ion trapping |
| JP2022131579A (ja) | 2021-02-26 | 2022-09-07 | キオクシア株式会社 | 分析装置および分析方法 |
| EP4308647A4 (en) | 2021-03-15 | 2025-01-22 | The Governing Council Of The University Of Toronto | METAL-MARKED POLYMER MICROBEADS WITH MARKING LEVEL CONTROL |
| CN113218846A (zh) * | 2021-03-18 | 2021-08-06 | 上海交通大学 | 一种面向于单细胞质谱流式分析的icp装置 |
| US20240203722A1 (en) * | 2021-04-14 | 2024-06-20 | Kimia Analytics Inc | A system to generate a high yield of negative ions for icp-ms |
| AT525093B1 (de) * | 2021-10-05 | 2022-12-15 | Univ Wien Tech | Vorrichtung zur Aufnahme eines Feststoff-Probenmaterials |
| WO2024224612A1 (ja) * | 2023-04-28 | 2024-10-31 | 株式会社 イアス | レーザーアブレーションicp分析方法及び分析装置 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4740692A (en) | 1985-06-13 | 1988-04-26 | Mitsubishi Denki Kabushiki Kaisha | Laser mass spectroscopic analyzer and method |
| DE4108462C2 (de) | 1991-03-13 | 1994-10-13 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtung zum Erzeugen von Ionen aus thermisch instabilen, nichtflüchtigen großen Molekülen |
| DE4200497A1 (de) | 1992-01-10 | 1993-07-15 | Bayer Ag | Verfahren und vorrichtung zur schnellen identifizierung von kunststoffen mit hilfe der massenspektrometrie |
| JP2870364B2 (ja) * | 1993-06-29 | 1999-03-17 | 日本鋼管株式会社 | レーザー気化分析方法及び装置 |
| US5526110A (en) | 1994-07-08 | 1996-06-11 | Iowa State University Research Foundation, Inc. | In situ calibration of inductively coupled plasma-atomic emission and mass spectroscopy |
| US5777324A (en) | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
| JPH11201945A (ja) * | 1998-01-09 | 1999-07-30 | Jeol Ltd | レーザーアブレーション装置 |
| US5965884A (en) * | 1998-06-04 | 1999-10-12 | The Regents Of The University Of California | Atmospheric pressure matrix assisted laser desorption |
| CA2460567C (en) * | 2001-09-17 | 2010-11-02 | Mds Inc. | Method and apparatus for cooling and focusing ions |
| US6683277B1 (en) | 2002-12-20 | 2004-01-27 | Osram Opto Semiconductors | Laser ablation nozzle assembly |
| EP1562042A3 (en) * | 2004-01-22 | 2007-02-21 | Ionalytics Corporation | Method and apparatus for FAIMS for In-Line analysis of multiple samples |
| JPWO2005095942A1 (ja) | 2004-03-30 | 2008-02-21 | 独立行政法人理化学研究所 | レーザーアブレーションを用いた生体試料の分析方法およびその装置 |
| US7180058B1 (en) | 2005-10-05 | 2007-02-20 | Thermo Finnigan Llc | LDI/MALDI source for enhanced spatial resolution |
| US8283624B2 (en) | 2006-08-15 | 2012-10-09 | Dvs Sciences Inc. | Apparatus and method for elemental analysis of particles by mass spectrometry |
| US9465036B2 (en) | 2006-11-02 | 2016-10-11 | Fluidigm Canada Inc. | Particles containing detectable elemental code |
| WO2008080224A1 (en) * | 2006-12-29 | 2008-07-10 | Tanner Scott D | Cell injector for flow cytometer having mass spectrometer detector and method for using same |
| US8174691B1 (en) * | 2007-03-15 | 2012-05-08 | Arkansas State University—Jonesboro | Detection of a component of interest with an ultraviolet laser and method of using the same |
| US9079268B2 (en) * | 2007-09-14 | 2015-07-14 | Robert C. Fry | Analytical laser ablation of solid samples for ICP, ICP-MS, and FAG-MS analysis |
| US8207494B2 (en) * | 2008-05-01 | 2012-06-26 | Indiana University Research And Technology Corporation | Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry |
| US9383260B1 (en) * | 2008-05-05 | 2016-07-05 | Applied Spectra, Inc. | Laser ablation analysis system |
| DE102008049833A1 (de) | 2008-10-01 | 2010-04-22 | Forschungszentrum Jülich GmbH | Verfahren und Vorrichtung zur Durchführung einer quantitativen ortsaufgelösten Lokal- und Verteilunganalyse chemischer Elemente und in-situ Charakterisierung der ablatierten Oberflächenregionen |
| EP2391877B1 (en) * | 2009-02-02 | 2019-05-15 | Light Matter Interaction Inc. | Soft ablative desorption method and system |
| DE102009016512B4 (de) * | 2009-04-08 | 2011-05-12 | Forschungszentrum Jülich GmbH | Verfahren und Vorrichtung zur Durchführung einer quantitativen ortsaufgelösten Lokal- und Verteilungsanalyse chemischer Elemente und in-situ Charakterisierung der ablatierten Oberflächenregionen |
| WO2011006156A2 (en) * | 2009-07-10 | 2011-01-13 | University Of Florida Research Foundation, Inc. | Method and apparatus to laser ablation-laser induced breakdown spectroscopy |
| DE202010010932U1 (de) * | 2010-04-19 | 2011-10-07 | Witec Wissenschaftliche Instrumente Und Technologie Gmbh | Vorrichtung zur Abbildung einer Probenoberfläche |
| US8519330B2 (en) * | 2010-10-01 | 2013-08-27 | Ut-Battelle, Llc | Systems and methods for laser assisted sample transfer to solution for chemical analysis |
| US8879064B2 (en) * | 2011-12-23 | 2014-11-04 | Electro Scientific Industries, Inc. | Apparatus and method for transporting an aerosol |
| US8598488B2 (en) * | 2011-12-23 | 2013-12-03 | Electro Scientific Industries, Inc. | Method and apparatus for adjusting radiation spot size |
| WO2014114803A2 (en) * | 2013-01-28 | 2014-07-31 | Westfälische Wilhelms-Universität Münster | Parallel elemental and molecular mass spectrometry analysis with laser ablation sampling |
| WO2014114808A2 (en) * | 2013-01-28 | 2014-07-31 | Westfälische Wilhelms-Universität Münster | Laser ablation atmospheric pressure ionization mass spectrometry |
| US20140227776A1 (en) * | 2013-02-14 | 2014-08-14 | Electro Scientific Industries, Inc. | Laser ablation cell and torch system for a compositional analysis system |
| US20140268134A1 (en) * | 2013-03-15 | 2014-09-18 | Electro Scientific Industries, Inc. | Laser sampling methods for reducing thermal effects |
| SG11201507853QA (en) * | 2013-03-22 | 2015-10-29 | Eth Zuerich | Laser ablation cell |
| CA2895360C (en) | 2013-04-17 | 2023-05-02 | Fluidigm Canada Inc. | Sample analysis for mass cytometry |
| WO2016126988A1 (en) * | 2015-02-04 | 2016-08-11 | Fluidigm Canada Inc. | Laser enabled imaging mass cytometry |
-
2014
- 2014-04-17 CA CA2895360A patent/CA2895360C/en active Active
- 2014-04-17 US US14/783,791 patent/US9589779B2/en active Active
- 2014-04-17 SG SG11201504874QA patent/SG11201504874QA/en unknown
- 2014-04-17 RU RU2015123440A patent/RU2637795C2/ru active
- 2014-04-17 EP EP14784995.4A patent/EP2987177B1/en active Active
- 2014-04-17 JP JP2016507962A patent/JP6230693B2/ja active Active
- 2014-04-17 SG SG10201808165YA patent/SG10201808165YA/en unknown
- 2014-04-17 CN CN201480009995.6A patent/CN105190829B/zh active Active
- 2014-04-17 EP EP20150581.5A patent/EP3690923A1/en active Pending
- 2014-04-17 CA CA3191952A patent/CA3191952A1/en active Pending
- 2014-04-17 WO PCT/CA2014/050387 patent/WO2014169394A1/en not_active Ceased
-
2017
- 2017-01-18 US US15/408,806 patent/US9952132B2/en active Active
-
2018
- 2018-04-18 US US15/956,403 patent/US10241023B2/en active Active
-
2019
- 2019-02-07 US US16/270,421 patent/US10705006B2/en active Active
-
2020
- 2020-06-08 US US16/895,009 patent/US11099116B2/en active Active
-
2021
- 2021-07-22 US US17/382,764 patent/US11630050B2/en active Active
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