JP2016522259A5 - - Google Patents
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- JP2016522259A5 JP2016522259A5 JP2016521549A JP2016521549A JP2016522259A5 JP 2016522259 A5 JP2016522259 A5 JP 2016522259A5 JP 2016521549 A JP2016521549 A JP 2016521549A JP 2016521549 A JP2016521549 A JP 2016521549A JP 2016522259 A5 JP2016522259 A5 JP 2016522259A5
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- oligopeptide
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- amino acid
- peptide
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 claims description 9
- 208000015181 infectious disease Diseases 0.000 claims description 9
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- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 claims description 4
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- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
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- 108010090623 galactose binding protein Proteins 0.000 claims description 2
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- 101150066555 lacZ gene Proteins 0.000 claims description 2
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- 101150044170 trpE gene Proteins 0.000 claims description 2
- 101001023095 Anemonia sulcata Delta-actitoxin-Avd1a Proteins 0.000 claims 1
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- 101001028691 Carybdea rastonii Toxin CrTX-A Proteins 0.000 claims 1
- 101000685083 Centruroides infamatus Beta-toxin Cii1 Proteins 0.000 claims 1
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- 101001028688 Chironex fleckeri Toxin CfTX-1 Proteins 0.000 claims 1
- 101000644407 Cyriopagopus schmidti U6-theraphotoxin-Hs1a Proteins 0.000 claims 1
- 101000679608 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) Cysteine rich necrotrophic effector Tox1 Proteins 0.000 claims 1
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- 229920003259 poly(silylenemethylene) Polymers 0.000 description 12
- -1 X 15 Chemical compound 0.000 description 10
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- 239000005017 polysaccharide Substances 0.000 description 3
- 101710092462 Alpha-hemolysin Proteins 0.000 description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
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- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 229960000310 isoleucine Drugs 0.000 description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 239000004474 valine Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 101001047889 Staphylococcus aureus Delta-hemolysin Proteins 0.000 description 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 description 1
- 206010044250 Toxic shock syndrome staphylococcal Diseases 0.000 description 1
- 101710101607 Toxic shock syndrome toxin-1 Proteins 0.000 description 1
- OPGTXAUDXWCGFI-UHFFFAOYSA-N [1-[[6-[[3-(3-dodecanoyloxytetradecanoylamino)-6-(hydroxymethyl)-5-phosphonooxy-4-(3-tetradecanoyloxytetradecanoyloxy)oxan-2-yl]oxymethyl]-2,4,5-trihydroxyoxan-3-yl]amino]-1-oxotetradecan-3-yl] hexadecanoate Chemical compound OC1C(O)C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(O)OC1COC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)C(OP(O)(O)=O)C(CO)O1 OPGTXAUDXWCGFI-UHFFFAOYSA-N 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 230000008348 humoral response Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000017756 staphylococcal toxic-shock syndrome Diseases 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361836959P | 2013-06-19 | 2013-06-19 | |
| US61/836,959 | 2013-06-19 | ||
| PCT/US2014/042999 WO2014205111A1 (en) | 2013-06-19 | 2014-06-18 | Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016522259A JP2016522259A (ja) | 2016-07-28 |
| JP2016522259A5 true JP2016522259A5 (enExample) | 2017-07-27 |
| JP6632974B2 JP6632974B2 (ja) | 2020-01-22 |
Family
ID=52105236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521549A Active JP6632974B2 (ja) | 2013-06-19 | 2014-06-18 | フェノール可溶性モジュリン、δ毒素、スーパー抗原に由来するトキソイドペプチド、およびその融合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9815872B2 (enExample) |
| EP (1) | EP3010535B1 (enExample) |
| JP (1) | JP6632974B2 (enExample) |
| CA (1) | CA2916231C (enExample) |
| DK (1) | DK3010535T3 (enExample) |
| PT (1) | PT3010535T (enExample) |
| WO (1) | WO2014205111A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6632974B2 (ja) | 2013-06-19 | 2020-01-22 | インテグレイテッド バイオセラピューティクス，インコーポレイテッド | フェノール可溶性モジュリン、δ毒素、スーパー抗原に由来するトキソイドペプチド、およびその融合物 |
| EP3500288A4 (en) | 2016-08-22 | 2020-05-27 | Technion Research & Development Foundation Limited | ANTIMICROBIAL PEPTIDES AND USES THEREOF |
| JP2019532656A (ja) * | 2016-10-27 | 2019-11-14 | メディミューン，エルエルシー | タンパク質の改善された分泌のためのシグナルポリペプチド |
| CN107224575B (zh) * | 2017-03-06 | 2018-11-09 | 浙江海隆生物科技有限公司 | 奶牛金黄色葡萄球菌乳房炎亚单位疫苗的组合物及其制备方法和应用 |
| CA3069747A1 (en) * | 2017-07-27 | 2019-01-31 | Mohammad Javad Aman | Immunogenic composition comprising a fusion peptide derived from superantigen toxoids |
| JP2023512344A (ja) | 2020-12-18 | 2023-03-24 | ビオメディツィニッシュ・フォルシュング・ウント・ビオ－プロドゥクテ・アクチェンゲゼルシャフト | ブドウ球菌外毒素防御ワクチン |
| US12370235B2 (en) | 2021-03-04 | 2025-07-29 | University Of Saskatchewan | Synthetic, non-natural antimicrobial peptides inspired by Staphylococcus auricularis delta toxin |
| GR1010289B (el) * | 2021-04-27 | 2022-08-29 | Integrated Biotherapeutic Vaccines, Inc., | Τοξοειδη πεπτιδια που προερχονται απο διαλυτη σε φαινολη μοδουλινη, τοξινη δελτα, υπεραντιγονα και συντηξεις αυτων |
| CN113234125B (zh) * | 2021-05-10 | 2022-12-06 | 华东理工大学 | 自组装多肽、多肽水凝胶及其制备方法和用途 |
| WO2023227563A1 (en) | 2022-05-23 | 2023-11-30 | Biomedizinische Forschung & Bio-Produkte AG | Protective staphylococcal exotoxin vaccine |
| WO2023247747A1 (en) | 2022-06-23 | 2023-12-28 | Biomedizinische Forschung & Bio-Produkte AG | Protective staphylococcal exotoxin vaccine |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US6593114B1 (en) * | 1996-01-05 | 2003-07-15 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
| TW517061B (en) | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US7087235B2 (en) * | 1997-06-25 | 2006-08-08 | The United States Of America As Represented By The Secretary Of The Army | Fusion protein of streptococcal pyrogenic exotoxins |
| US6713284B2 (en) | 1997-06-25 | 2004-03-30 | The United States Of America As Represented By The Secretary Of The Army | Bacterial superantigen vaccines |
| DE69941454D1 (de) * | 1998-07-10 | 2009-11-05 | U S Medical Res Inst Of Infect | Impfstoff gegen staphylokokken-vergiftung |
| GB0118155D0 (en) * | 2001-07-25 | 2001-09-19 | Lorantis Ltd | Superantigen |
| US9296795B2 (en) * | 2003-03-07 | 2016-03-29 | Wyeth Holdings, Llc. | Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections |
| US20050008633A1 (en) | 2003-05-19 | 2005-01-13 | Advanced Inhalation Research Inc. | Chemical and physical modulators of bioavailability of inhaled compositions |
| US7754225B2 (en) | 2006-07-20 | 2010-07-13 | Glaxosmithkline Biologicals S.A. | Method of protecting against staphylococcal infection |
| WO2008154101A1 (en) * | 2007-06-06 | 2008-12-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Psm peptides as vaccine targets against methicillin-resistant staphylococcus aureus |
| AU2008292897B2 (en) * | 2007-08-31 | 2015-01-22 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
| CA2825770A1 (en) * | 2011-02-08 | 2012-08-16 | Integrated Biotherapeutics, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
| CN103561762A (zh) * | 2011-03-16 | 2014-02-05 | 明尼苏达大学董事会 | 诱导针对葡萄球菌属中细菌的免疫应答的组合物和方法 |
| JP6325452B2 (ja) * | 2011-12-02 | 2018-05-16 | インテグレイテッド バイオセラピューティクス，インコーポレイテッド | パントンバレンタインロイコシジン（ｐｖｌ）由来ポリペプチドを含む免疫原性組成物 |
| JP6632974B2 (ja) | 2013-06-19 | 2020-01-22 | インテグレイテッド バイオセラピューティクス，インコーポレイテッド | フェノール可溶性モジュリン、δ毒素、スーパー抗原に由来するトキソイドペプチド、およびその融合物 |
-
2014
- 2014-06-18 JP JP2016521549A patent/JP6632974B2/ja active Active
- 2014-06-18 PT PT148135122T patent/PT3010535T/pt unknown
- 2014-06-18 CA CA2916231A patent/CA2916231C/en active Active
- 2014-06-18 US US14/899,993 patent/US9815872B2/en active Active
- 2014-06-18 EP EP14813512.2A patent/EP3010535B1/en active Active
- 2014-06-18 DK DK14813512.2T patent/DK3010535T3/da active
- 2014-06-18 WO PCT/US2014/042999 patent/WO2014205111A1/en not_active Ceased
-
2017
- 2017-11-13 US US15/810,419 patent/US10174085B2/en active Active
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