CA2916231C - Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof - Google Patents

Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof Download PDF

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Publication number
CA2916231C
CA2916231C CA2916231A CA2916231A CA2916231C CA 2916231 C CA2916231 C CA 2916231C CA 2916231 A CA2916231 A CA 2916231A CA 2916231 A CA2916231 A CA 2916231A CA 2916231 C CA2916231 C CA 2916231C
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Canada
Prior art keywords
seq
psm
amino acid
fusion protein
polypeptide
Prior art date
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Active
Application number
CA2916231A
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English (en)
French (fr)
Other versions
CA2916231A1 (en
Inventor
Mohammad Javad Aman
Rajan Prasad ADHIKARI
Sergey Shulenin
Frederick Wayne Holtsberg
Hatice KARAUZUM
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Abvacc Inc
Original Assignee
Abvacc Inc
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Publication date
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Application filed by Abvacc Inc filed Critical Abvacc Inc
Publication of CA2916231A1 publication Critical patent/CA2916231A1/en
Application granted granted Critical
Publication of CA2916231C publication Critical patent/CA2916231C/en
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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/085Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2916231A 2013-06-19 2014-06-18 Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof Active CA2916231C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361836959P 2013-06-19 2013-06-19
US61/836,959 2013-06-19
PCT/US2014/042999 WO2014205111A1 (en) 2013-06-19 2014-06-18 Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof

Publications (2)

Publication Number Publication Date
CA2916231A1 CA2916231A1 (en) 2014-12-24
CA2916231C true CA2916231C (en) 2024-02-06

Family

ID=52105236

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2916231A Active CA2916231C (en) 2013-06-19 2014-06-18 Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof

Country Status (7)

Country Link
US (2) US9815872B2 (enExample)
EP (1) EP3010535B1 (enExample)
JP (1) JP6632974B2 (enExample)
CA (1) CA2916231C (enExample)
DK (1) DK3010535T3 (enExample)
PT (1) PT3010535T (enExample)
WO (1) WO2014205111A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9815872B2 (en) 2013-06-19 2017-11-14 Integrated Biotherapeutics, Inc. Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof
US10717766B2 (en) 2016-08-22 2020-07-21 Technion Research & Development Foundation Limited Antimicrobial peptides and uses thereof
US20190271022A1 (en) * 2016-10-27 2019-09-05 Medimmune, Llc Signal Polypeptide For Improved Secretion Of Protein
CN107224575B (zh) * 2017-03-06 2018-11-09 浙江海隆生物科技有限公司 奶牛金黄色葡萄球菌乳房炎亚单位疫苗的组合物及其制备方法和应用
CN110996993B (zh) * 2017-07-27 2024-05-31 Ab疫苗公司 包含源自超抗原类毒素的融合肽的免疫原性组合物
US20230104241A1 (en) 2020-12-18 2023-04-06 Biomedizinische Forschung & Bio-Produkte AG Protective staphylococcal exotoxin vaccine
US12370235B2 (en) 2021-03-04 2025-07-29 University Of Saskatchewan Synthetic, non-natural antimicrobial peptides inspired by Staphylococcus auricularis delta toxin
GR1010289B (el) * 2021-04-27 2022-08-29 Integrated Biotherapeutic Vaccines, Inc., Τοξοειδη πεπτιδια που προερχονται απο διαλυτη σε φαινολη μοδουλινη, τοξινη δελτα, υπεραντιγονα και συντηξεις αυτων
CN113234125B (zh) * 2021-05-10 2022-12-06 华东理工大学 自组装多肽、多肽水凝胶及其制备方法和用途
WO2023227563A1 (en) 2022-05-23 2023-11-30 Biomedizinische Forschung & Bio-Produkte AG Protective staphylococcal exotoxin vaccine
WO2023247747A1 (en) 2022-06-23 2023-12-28 Biomedizinische Forschung & Bio-Produkte AG Protective staphylococcal exotoxin vaccine

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6593114B1 (en) * 1996-01-05 2003-07-15 Human Genome Sciences, Inc. Staphylococcus aureus polynucleotides and sequences
TW517061B (en) * 1996-03-29 2003-01-11 Pharmacia & Amp Upjohn Ab Modified/chimeric superantigens and their use
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6713284B2 (en) 1997-06-25 2004-03-30 The United States Of America As Represented By The Secretary Of The Army Bacterial superantigen vaccines
US7087235B2 (en) 1997-06-25 2006-08-08 The United States Of America As Represented By The Secretary Of The Army Fusion protein of streptococcal pyrogenic exotoxins
AU758019B2 (en) * 1998-07-10 2003-03-13 U.S. Medical Research Institute Of Infectious Diseases Anthrax vaccine
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
CA2517439C (en) * 2003-03-07 2013-07-23 Wyeth Holdings Corporation Polysaccharide - staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections
US20050008633A1 (en) 2003-05-19 2005-01-13 Advanced Inhalation Research Inc. Chemical and physical modulators of bioavailability of inhaled compositions
US7754225B2 (en) 2006-07-20 2010-07-13 Glaxosmithkline Biologicals S.A. Method of protecting against staphylococcal infection
WO2008154101A1 (en) * 2007-06-06 2008-12-18 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Psm peptides as vaccine targets against methicillin-resistant staphylococcus aureus
CA2697538C (en) * 2007-08-31 2019-02-12 University Of Chicago Methods and compositions related to immunizing against staphylococcal lung diseases and conditions
AU2012214677B2 (en) 2011-02-08 2016-11-10 Abvacc, Inc. Immunogenic composition comprising alpha-hemolysin oligopeptides
AU2012266880A1 (en) * 2011-03-16 2013-10-03 Regents Of The University Of Minnesota Compositions and methods for inducing immune responses against bacteria in the genus staphylococcus
CA2857666C (en) 2011-12-02 2020-08-11 Integrated Biotherapeutics, Inc. Immunogenic composition comprising panton-valentine leukocidin (pvl) derived polypeptides
US9815872B2 (en) 2013-06-19 2017-11-14 Integrated Biotherapeutics, Inc. Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof

Also Published As

Publication number Publication date
US9815872B2 (en) 2017-11-14
CA2916231A1 (en) 2014-12-24
DK3010535T3 (da) 2020-11-30
EP3010535B1 (en) 2019-08-14
JP2016522259A (ja) 2016-07-28
JP6632974B2 (ja) 2020-01-22
EP3010535A1 (en) 2016-04-27
WO2014205111A1 (en) 2014-12-24
PT3010535T (pt) 2020-07-03
EP3010535A4 (en) 2017-03-01
US10174085B2 (en) 2019-01-08
US20160185829A1 (en) 2016-06-30
US20180148482A1 (en) 2018-05-31

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