JP2014507142A5 - - Google Patents

Info

Publication number

JP2014507142A5

JP2014507142A5 JP2013553482A JP2013553482A JP2014507142A5 JP 2014507142 A5 JP2014507142 A5 JP 2014507142A5 JP 2013553482 A JP2013553482 A JP 2013553482A JP 2013553482 A JP2013553482 A JP 2013553482A JP 2014507142 A5 JP2014507142 A5 JP 2014507142A5

Authority

JP

Japan

Prior art keywords

oligopeptide

amino acid

acid sequence

composition

kcal

Prior art date

2012-02-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108010038807 Oligopeptides Proteins 0.000 claims 33
• 102000015636 Oligopeptides Human genes 0.000 claims 33
• 150000001413 amino acids Chemical group 0.000 claims 29
• 238000000034 method Methods 0.000 claims 19
• 239000000203 mixture Substances 0.000 claims 14
• 239000000427 antigen Substances 0.000 claims 13
• 102000036639 antigens Human genes 0.000 claims 13
• 108091007433 antigens Proteins 0.000 claims 13
• 230000002163 immunogen Effects 0.000 claims 13
• 235000001014 amino acid Nutrition 0.000 claims 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims 12
• 239000012634 fragment Substances 0.000 claims 11
• 102000004196 processed proteins & peptides Human genes 0.000 claims 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
• 230000001580 bacterial effect Effects 0.000 claims 8
• 150000001720 carbohydrates Chemical class 0.000 claims 8
• 235000014633 carbohydrates Nutrition 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 6
• 229920001184 polypeptide Polymers 0.000 claims 6
• 239000002671 adjuvant Substances 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 4
• 208000015181 infectious disease Diseases 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 102000040430 polynucleotide Human genes 0.000 claims 4
• 108091033319 polynucleotide Proteins 0.000 claims 4
• 239000002157 polynucleotide Substances 0.000 claims 4
• 241000894006 Bacteria Species 0.000 claims 3
• 241000124008 Mammalia Species 0.000 claims 3
• 241001465754 Metazoa Species 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 150000004676 glycans Chemical class 0.000 claims 3
• 239000013612 plasmid Substances 0.000 claims 3
• 229920001282 polysaccharide Polymers 0.000 claims 3
• 239000005017 polysaccharide Substances 0.000 claims 3
• 101710092462 Alpha-hemolysin Proteins 0.000 claims 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
• 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 2
• 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 2
• 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 claims 2
• 108010052285 Membrane Proteins Proteins 0.000 claims 2
• 102000018697 Membrane Proteins Human genes 0.000 claims 2
• 241000295644 Staphylococcaceae Species 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 241000251539 Vertebrata <Metazoa> Species 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 230000005875 antibody response Effects 0.000 claims 2
• 210000003719 b-lymphocyte Anatomy 0.000 claims 2
• 102000028861 calmodulin binding Human genes 0.000 claims 2
• 108091000084 calmodulin binding Proteins 0.000 claims 2
• 239000005090 green fluorescent protein Substances 0.000 claims 2
• 208000023504 respiratory system disease Diseases 0.000 claims 2
• 231100000617 superantigen Toxicity 0.000 claims 2
• -1 superantigens Proteins 0.000 claims 2
• 231100000765 toxin Toxicity 0.000 claims 2
• 239000003053 toxin Substances 0.000 claims 2
• 108700012359 toxins Proteins 0.000 claims 2
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
• 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 102000009027 Albumins Human genes 0.000 claims 1
• 108050001427 Avidin/streptavidin Proteins 0.000 claims 1
• 102000019034 Chemokines Human genes 0.000 claims 1
• 108010012236 Chemokines Proteins 0.000 claims 1
• 229920002101 Chitin Polymers 0.000 claims 1
• 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 239000004471 Glycine Substances 0.000 claims 1
• 101710179002 Hemolytic toxin Proteins 0.000 claims 1
• 241000238631 Hexapoda Species 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 1
• 241001195348 Nusa Species 0.000 claims 1
• 206010035664 Pneumonia Diseases 0.000 claims 1
• 101100408135 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) phnA gene Proteins 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 102000044159 Ubiquitin Human genes 0.000 claims 1
• 108090000848 Ubiquitin Proteins 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• OPGTXAUDXWCGFI-UHFFFAOYSA-N [1-[[6-[[3-(3-dodecanoyloxytetradecanoylamino)-6-(hydroxymethyl)-5-phosphonooxy-4-(3-tetradecanoyloxytetradecanoyloxy)oxan-2-yl]oxymethyl]-2,4,5-trihydroxyoxan-3-yl]amino]-1-oxotetradecan-3-yl] hexadecanoate Chemical compound OC1C(O)C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(O)OC1COC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)C(OP(O)(O)=O)C(CO)O1 OPGTXAUDXWCGFI-UHFFFAOYSA-N 0.000 claims 1
• 235000004279 alanine Nutrition 0.000 claims 1
• 229940037003 alum Drugs 0.000 claims 1
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 102000005936 beta-Galactosidase Human genes 0.000 claims 1
• 108010005774 beta-Galactosidase Proteins 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 229920002678 cellulose Polymers 0.000 claims 1
• 239000001913 cellulose Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 108010090623 galactose binding protein Proteins 0.000 claims 1
• 102000021529 galactose binding proteins Human genes 0.000 claims 1
• 150000002333 glycines Chemical class 0.000 claims 1
• 230000005745 host immune response Effects 0.000 claims 1
• 230000008348 humoral response Effects 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 230000015788 innate immune response Effects 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 238000010255 intramuscular injection Methods 0.000 claims 1
• 239000007927 intramuscular injection Substances 0.000 claims 1
• 239000007928 intraperitoneal injection Substances 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 101150066555 lacZ gene Proteins 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229950006780 n-acetylglucosamine Drugs 0.000 claims 1
• 238000006384 oligomerization reaction Methods 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 230000002685 pulmonary effect Effects 0.000 claims 1
• 210000003491 skin Anatomy 0.000 claims 1
• 210000004872 soft tissue Anatomy 0.000 claims 1
• 238000010254 subcutaneous injection Methods 0.000 claims 1
• 239000007929 subcutaneous injection Substances 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 230000009885 systemic effect Effects 0.000 claims 1
• 101150044170 trpE gene Proteins 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1