JP2016520588A5 - - Google Patents
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- Publication number
- JP2016520588A5 JP2016520588A5 JP2016514431A JP2016514431A JP2016520588A5 JP 2016520588 A5 JP2016520588 A5 JP 2016520588A5 JP 2016514431 A JP2016514431 A JP 2016514431A JP 2016514431 A JP2016514431 A JP 2016514431A JP 2016520588 A5 JP2016520588 A5 JP 2016520588A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- composition
- combinations
- stroke
- brain trauma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 12
- 235000013305 food Nutrition 0.000 claims 9
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 4
- 235000015872 dietary supplement Nutrition 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 230000001537 neural effect Effects 0.000 claims 3
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims 2
- RCEFMOGVOYEGJN-UHFFFAOYSA-N 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one Chemical compound OC1=CC=CC=C1N1C(=O)NC(C=2C=C(C=CC=2)[N+]([O-])=O)=CC1 RCEFMOGVOYEGJN-UHFFFAOYSA-N 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 229930007744 linalool Natural products 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 230000009223 neuronal apoptosis Effects 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Claims (11)
- メントール、リナロール、イシリン及びその組合せからなる群より選択される化合物の治療的有効量を含む、脳外傷、卒中及びその組合せからなる群より選択される状態からの非炎症性ニューロン傷害の処置用又は予防用組成物。
- 医薬、食品及び食品への栄養補助剤からなる群より選択される、請求項１に記載の組成物。
- 請求項１に記載の組成物であって、脳外傷、卒中及びその組合せからなる群より選択される状態からの非炎症性ニューロンアポトーシスの予防用組成物。
- 医薬、食品及び食品への栄養補助剤からなる群より選択される、請求項３に記載の組成物。
- 請求項１に記載の組成物であって、脳外傷、卒中及びその組合せからなる群より選択される状態からの非炎症性ニューロン壊死の予防用組成物。
- 医薬、食品及び食品への栄養補助剤からなる群より選択される、請求項５に記載の組成物。
- メントール、リナロール、イシリン及びその組合せからなる群より選択される化合物の治療的有効量を含む、脳外傷、卒中及びその組合せからなる群より選択される状態からの非炎症性ニューロン傷害に対する神経保護用組成物。
- 医薬である、請求項７に記載の組成物。
- 食品である、請求項７に記載の組成物。
- 食品がタンパク質、炭水化物、脂肪及びその組合せからなる群より選択される成分を含む、請求項９に記載の組成物。
- 食品への栄養補助剤である、請求項７に記載の組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361827232P | 2013-05-24 | 2013-05-24 | |
| US61/827,232 | 2013-05-24 | ||
| PCT/EP2014/060637 WO2014187945A1 (en) | 2013-05-24 | 2014-05-23 | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019175366A Division JP2020011985A (ja) | 2013-05-24 | 2019-09-26 | メントール、リナロール及び／又はイシリンを用いる脳外傷及び卒中からの非炎症性ニューロン傷害の処置又は予防 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016520588A JP2016520588A (ja) | 2016-07-14 |
| JP2016520588A5 true JP2016520588A5 (ja) | 2017-06-29 |
Family
ID=50819728
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514431A Withdrawn JP2016520588A (ja) | 2013-05-24 | 2014-05-23 | メントール、リナロール及び／又はイシリンを用いる脳外傷及び卒中からの非炎症性ニューロン傷害の処置又は予防 |
| JP2019175366A Withdrawn JP2020011985A (ja) | 2013-05-24 | 2019-09-26 | メントール、リナロール及び／又はイシリンを用いる脳外傷及び卒中からの非炎症性ニューロン傷害の処置又は予防 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019175366A Withdrawn JP2020011985A (ja) | 2013-05-24 | 2019-09-26 | メントール、リナロール及び／又はイシリンを用いる脳外傷及び卒中からの非炎症性ニューロン傷害の処置又は予防 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160166570A1 (ja) |
| EP (1) | EP3003292B1 (ja) |
| JP (2) | JP2016520588A (ja) |
| CN (1) | CN105228601A (ja) |
| AU (2) | AU2014270341A1 (ja) |
| BR (1) | BR112015026484A2 (ja) |
| CA (1) | CA2908365C (ja) |
| ES (1) | ES2721922T3 (ja) |
| TR (1) | TR201906539T4 (ja) |
| WO (1) | WO2014187945A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3003292B1 (en) * | 2013-05-24 | 2019-03-20 | Nestec S.A. | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin |
| WO2021189256A1 (zh) * | 2020-03-24 | 2021-09-30 | 中国医药大学 | 薄荷醇用于制备治疗神经退化症及中风的外用组合物的用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006500318A (ja) * | 2002-04-25 | 2006-01-05 | ブレインスゲート リミテッド | 着臭剤の頭内神経への神経興奮性および／または神経抑制性作用を用いてｂｂｂおよび脳循環の特性を加減する方法および装置 |
| JP4742204B2 (ja) * | 2005-01-21 | 2011-08-10 | 財団法人ヒューマンサイエンス振興財団 | 脂肪細胞分化制御剤 |
| JP2007291069A (ja) * | 2006-03-31 | 2007-11-08 | Daiichi Sankyo Healthcare Co Ltd | 抗酸化剤および／または消炎鎮痛剤組成物 |
| GB0615136D0 (en) * | 2006-07-29 | 2006-09-06 | Univ Edinburgh | Induction of analgesia in neuropathic pain |
| KR20090085237A (ko) * | 2008-02-04 | 2009-08-07 | 김병문 | 천연 진주가루를 함유한 뇌질환 예방 및 치료용 한약조성물 |
| CA3027255C (en) * | 2009-07-10 | 2022-06-21 | The General Hospital Corporation | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| KR20120103317A (ko) * | 2011-03-10 | 2012-09-19 | 한국생명공학연구원 | 아실 코에이:콜레스테롤 아실트랜스퍼라제 저해활성을 갖는 고수씨 추출물 또는 이로부터 분리된 리나로올을 포함하는 조성물 |
| ME03038B (me) * | 2011-12-19 | 2018-10-20 | Dompe Farm Spa | Antagonisti trpm8 |
| CN102512634A (zh) * | 2011-12-26 | 2012-06-27 | 神威药业（张家口）有限公司 | 复方麝香软胶囊及其制备方法 |
| US20150320700A1 (en) * | 2012-05-07 | 2015-11-12 | The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Reserc Organizatio | Geranium oil and constituents thereof for treatment of neurodegenerative diseases |
| EP3003292B1 (en) * | 2013-05-24 | 2019-03-20 | Nestec S.A. | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin |
-
2014
- 2014-05-23 EP EP14726347.9A patent/EP3003292B1/en active Active
- 2014-05-23 CN CN201480029057.2A patent/CN105228601A/zh active Pending
- 2014-05-23 AU AU2014270341A patent/AU2014270341A1/en not_active Abandoned
- 2014-05-23 ES ES14726347T patent/ES2721922T3/es active Active
- 2014-05-23 BR BR112015026484A patent/BR112015026484A2/pt not_active Application Discontinuation
- 2014-05-23 US US14/892,287 patent/US20160166570A1/en not_active Abandoned
- 2014-05-23 WO PCT/EP2014/060637 patent/WO2014187945A1/en active Application Filing
- 2014-05-23 JP JP2016514431A patent/JP2016520588A/ja not_active Withdrawn
- 2014-05-23 CA CA2908365A patent/CA2908365C/en active Active
- 2014-05-23 TR TR2019/06539T patent/TR201906539T4/tr unknown
-
2017
- 2017-03-17 US US15/462,387 patent/US10799502B2/en active Active
-
2019
- 2019-08-26 AU AU2019222781A patent/AU2019222781B2/en active Active
- 2019-09-26 JP JP2019175366A patent/JP2020011985A/ja not_active Withdrawn
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