WO2016080796A3 - 세스퀴테르펜 화합물을 포함하는, stat3 매개 질환의 예방 또는 치료용 약학적 조성물 및 이의 용도 - Google Patents

세스퀴테르펜 화합물을 포함하는, stat3 매개 질환의 예방 또는 치료용 약학적 조성물 및 이의 용도 Download PDF

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Publication number
WO2016080796A3
WO2016080796A3 PCT/KR2015/012504 KR2015012504W WO2016080796A3 WO 2016080796 A3 WO2016080796 A3 WO 2016080796A3 KR 2015012504 W KR2015012504 W KR 2015012504W WO 2016080796 A3 WO2016080796 A3 WO 2016080796A3
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WO
WIPO (PCT)
Prior art keywords
mediated diseases
preventing
pharmaceutical composition
sesquiterpene compound
stat3
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PCT/KR2015/012504
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English (en)
French (fr)
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WO2016080796A2 (ko
Inventor
노문철
이우송
오현미
정경숙
이소영
이승웅
박찬선
김상현
이철
Original Assignee
한국생명공학연구원
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Application filed by 한국생명공학연구원 filed Critical 한국생명공학연구원
Publication of WO2016080796A2 publication Critical patent/WO2016080796A2/ko
Publication of WO2016080796A3 publication Critical patent/WO2016080796A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

본 발명은 세스퀴테르펜 화합물을 포함하는 STAT3 매개 질환의 예방 또는 치료용 약학적 조성물 및 상기 조성물을 이용한 STAT3 매개 질환의 치료 방법에 관한 것이다. 또한, 본 발명은 세스퀴테르펜 화합물을 포함하는 STAT3 매개 질환의 예방 또는 개선용 식품 조성물, 의약외품 조성물, 사료 및 사료첨가제에 관한 것이다.
PCT/KR2015/012504 2014-11-19 2015-11-19 세스퀴테르펜 화합물을 포함하는, stat3 매개 질환의 예방 또는 치료용 약학적 조성물 및 이의 용도 WO2016080796A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20140161605 2014-11-19
KR10-2014-0161605 2014-11-19

Publications (2)

Publication Number Publication Date
WO2016080796A2 WO2016080796A2 (ko) 2016-05-26
WO2016080796A3 true WO2016080796A3 (ko) 2016-10-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/012504 WO2016080796A2 (ko) 2014-11-19 2015-11-19 세스퀴테르펜 화합물을 포함하는, stat3 매개 질환의 예방 또는 치료용 약학적 조성물 및 이의 용도

Country Status (2)

Country Link
KR (1) KR101741017B1 (ko)
WO (1) WO2016080796A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107805233B (zh) * 2017-10-30 2020-07-28 浙江工业大学 一种二聚倍半萜化合物及其制备方法与应用
KR102074575B1 (ko) * 2018-04-17 2020-02-06 원광대학교산학협력단 세스퀴테르펜 계열 대사체를 포함하는 항염증 조성물
CN111892563B (zh) * 2020-08-26 2022-12-09 河南中医药大学 化合物3β-acetoxyl-atractylenolide I、制备方法和用途
CN113831221B (zh) * 2021-09-18 2023-04-07 云南民族大学 一种倍半萜类化合物及其制备方法与应用
CN114956974B (zh) * 2022-06-02 2023-10-31 暨南大学 一类倍半萜聚酮化合物、药物组合物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040107185A (ko) * 2003-06-13 2004-12-20 이상국 알란토락톤 또는 이소알란토락톤을 포함하는 암 또는염증질환 예방 및 치료용 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040107185A (ko) * 2003-06-13 2004-12-20 이상국 알란토락톤 또는 이소알란토락톤을 포함하는 암 또는염증질환 예방 및 치료용 조성물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FU, XIU - QIONG: "Inhibition of STAT3 Signalling contributes to the Antimelanoma Action of Atractylenolide II.", EXPERIMENTAL DERMATOLOGY, vol. 23, no. 11, 24 July 2014 (2014-07-24), pages 855 - 857, XP055317353 *
LI, ER - WEI ET AL.: "New Eremophilenolides from Cacalia Pilgeriana.", PLANTA MEDICA, vol. 71, no. 12, 2005, pages 1140 - 1144, XP055317355 *
MATSUURA, BRYAN S. ET AL.: "Intercepting Wacker Intermediates with Arenes: C-H Functionalization and Dearomatization.", ORGANIC LETTERS, vol. 13, no. 23, 2011, pages 6320 - 6323, XP055317358 *
PANDEY, UMESH C. ET AL.: "Isoalantolactone Derivatives and Germacranolides from Blumea Densiflora.", PHYTOCHEMISTRY, vol. 24, no. 7, 1985, pages 1509 - 1514, XP026680004 *

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Publication number Publication date
KR101741017B1 (ko) 2017-05-30
KR20160060580A (ko) 2016-05-30
WO2016080796A2 (ko) 2016-05-26

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