WO2016072692A3 - 네크록스를 유효성분으로 함유하는 점막염 예방 또는 치료용 조성물 - Google Patents

네크록스를 유효성분으로 함유하는 점막염 예방 또는 치료용 조성물 Download PDF

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Publication number
WO2016072692A3
WO2016072692A3 PCT/KR2015/011691 KR2015011691W WO2016072692A3 WO 2016072692 A3 WO2016072692 A3 WO 2016072692A3 KR 2015011691 W KR2015011691 W KR 2015011691W WO 2016072692 A3 WO2016072692 A3 WO 2016072692A3
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WO
WIPO (PCT)
Prior art keywords
necrox
preventing
composition
treating mucositis
effective ingredient
Prior art date
Application number
PCT/KR2015/011691
Other languages
English (en)
French (fr)
Other versions
WO2016072692A2 (ko
Inventor
조석구
임건일
임정연
김나연
남영선
이은솔
Original Assignee
가톨릭대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020150152916A external-priority patent/KR101718380B1/ko
Application filed by 가톨릭대학교 산학협력단 filed Critical 가톨릭대학교 산학협력단
Priority to JP2017543688A priority Critical patent/JP6464277B2/ja
Priority to CN201580059511.3A priority patent/CN107073009B/zh
Priority to PL15857570T priority patent/PL3216452T3/pl
Priority to EP15857570.4A priority patent/EP3216452B1/en
Priority to US15/523,197 priority patent/US10272092B2/en
Priority to ES15857570T priority patent/ES2842431T3/es
Publication of WO2016072692A2 publication Critical patent/WO2016072692A2/ko
Publication of WO2016072692A3 publication Critical patent/WO2016072692A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 네크록스를 함유하는 점막염 예방 및 치료용 조성물에 관한 것으로, 상기 네크록스는 방사선 또는 화학 치료 요법에 의한 질병의 사망률을 네크록스 투여 그룹에서 연장시켰으며, 장 기능을 보호하는 효과를 나타내고, 방사선 또는 항암 치료에 의한 장점막의 파괴를 억제하였으며, 장에 존재하는 세포 증식 효과도 확인함으로써 상기 네크록스를 함유하는 점막염 예방 및 치료용 약학 조성물, 항암보조제 또는 식품 조성물로 활용할 수 있다.
PCT/KR2015/011691 2014-11-03 2015-11-03 네크록스를 유효성분으로 함유하는 점막염 예방 또는 치료용 조성물 WO2016072692A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2017543688A JP6464277B2 (ja) 2014-11-03 2015-11-03 ネクロックスを有効成分として含有する粘膜炎予防又は治療用組成物
CN201580059511.3A CN107073009B (zh) 2014-11-03 2015-11-03 含有NecroX作为有效成分的用于预防或治疗粘膜炎的组合物
PL15857570T PL3216452T3 (pl) 2014-11-03 2015-11-03 Kompozycja do zapobiegania lub leczenia zapalenia błony śluzowej zawierająca jako skuteczny składnik NecroX
EP15857570.4A EP3216452B1 (en) 2014-11-03 2015-11-03 Composition for preventing or treating mucositis comprising necrox as effective ingredient
US15/523,197 US10272092B2 (en) 2014-11-03 2015-11-03 Composition for preventing or treating mucositis comprising NecroX as effective ingredient
ES15857570T ES2842431T3 (es) 2014-11-03 2015-11-03 Composición para prevenir o tratar mucositis que comprende NecroX como ingrediente eficaz

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20140151255 2014-11-03
KR10-2014-0151255 2014-11-03
KR1020150152916A KR101718380B1 (ko) 2014-11-03 2015-11-02 네크록스를 유효성분으로 함유하는 점막염 예방 또는 치료용 조성물
KR10-2015-0152916 2015-11-02

Publications (2)

Publication Number Publication Date
WO2016072692A2 WO2016072692A2 (ko) 2016-05-12
WO2016072692A3 true WO2016072692A3 (ko) 2016-06-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/011691 WO2016072692A2 (ko) 2014-11-03 2015-11-03 네크록스를 유효성분으로 함유하는 점막염 예방 또는 치료용 조성물

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WO (1) WO2016072692A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4201407A1 (en) 2020-08-19 2023-06-28 MitoImmune Therapeutics Inc. Mitochondria-targeted antioxidant as agent for treating pathologic inflammation caused by mabc-r infection
KR20220141252A (ko) 2021-04-12 2022-10-19 주식회사 미토이뮨테라퓨틱스 5-[(1,1-디옥시도-4-티오몰포리닐)메틸]-2-페닐-n-(테트라하이드로-2h-피란-4-일)-1h-인돌-7-아민 황산염 및 이의 신규 결정형
EP4324830A1 (en) 2021-04-12 2024-02-21 MitoImmune Therapeutics Inc. Novel crystal form of 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-n-(tetrahydro-2h-pyran-4-yl)-1h-indole-7-amine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130038585A (ko) * 2011-10-10 2013-04-18 전북대학교산학협력단 네크록스-5를 유효성분으로 함유하는 기관지 천식의 예방 또는 치료용 조성물
KR20130088720A (ko) * 2012-01-31 2013-08-08 인제대학교 산학협력단 ＮｅｃｒｏＸ를 함유하는 암 전이 억제용 조성물
KR101304772B1 (ko) * 2011-04-11 2013-09-05 인제대학교 산학협력단 ＮｅｃｒｏＸ―５를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물
KR20130140402A (ko) * 2012-06-14 2013-12-24 부산대학교 산학협력단 염증성 질환의 예방 또는 치료용 약학 조성물 및 건강기능식품
KR20140018698A (ko) * 2012-08-03 2014-02-13 주식회사 엘지생명과학 네크록스-5를 유효성분으로 포함하는 급성 폐 손상 및 급성 호흡 곤란 증후군의 예방 또는 치료용 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101304772B1 (ko) * 2011-04-11 2013-09-05 인제대학교 산학협력단 ＮｅｃｒｏＸ―５를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물
KR20130038585A (ko) * 2011-10-10 2013-04-18 전북대학교산학협력단 네크록스-5를 유효성분으로 함유하는 기관지 천식의 예방 또는 치료용 조성물
KR20130088720A (ko) * 2012-01-31 2013-08-08 인제대학교 산학협력단 ＮｅｃｒｏＸ를 함유하는 암 전이 억제용 조성물
KR20130140402A (ko) * 2012-06-14 2013-12-24 부산대학교 산학협력단 염증성 질환의 예방 또는 치료용 약학 조성물 및 건강기능식품
KR20140018698A (ko) * 2012-08-03 2014-02-13 주식회사 엘지생명과학 네크록스-5를 유효성분으로 포함하는 급성 폐 손상 및 급성 호흡 곤란 증후군의 예방 또는 치료용 조성물

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