ES2721922T3 - Tratamiento o prevención del daño neuronal no inflamatorio por traumatismo cerebral e ictus utilizando mentol, linalool y/o icilina - Google Patents
Tratamiento o prevención del daño neuronal no inflamatorio por traumatismo cerebral e ictus utilizando mentol, linalool y/o icilina Download PDFInfo
- Publication number
- ES2721922T3 ES2721922T3 ES14726347T ES14726347T ES2721922T3 ES 2721922 T3 ES2721922 T3 ES 2721922T3 ES 14726347 T ES14726347 T ES 14726347T ES 14726347 T ES14726347 T ES 14726347T ES 2721922 T3 ES2721922 T3 ES 2721922T3
- Authority
- ES
- Spain
- Prior art keywords
- linalool
- stroke
- treatment
- icilin
- menthol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 title abstract 4
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 title abstract 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 title abstract 2
- 208000030886 Traumatic Brain injury Diseases 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 229930007744 linalool Natural products 0.000 title abstract 2
- 230000003961 neuronal insult Effects 0.000 title abstract 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 title 1
- RCEFMOGVOYEGJN-UHFFFAOYSA-N 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one Chemical compound OC1=CC=CC=C1N1C(=O)NC(C=2C=C(C=CC=2)[N+]([O-])=O)=CC1 RCEFMOGVOYEGJN-UHFFFAOYSA-N 0.000 title 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 title 1
- 229940041616 menthol Drugs 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una composición para su uso en el tratamiento del daño neuronal no inflamatorio por una afección seleccionada del grupo que consiste en traumatismo cerebral, un ictus y una combinación de los mismos, comprendiendo la composición una cantidad terapéuticamente eficaz de linalool.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361827232P | 2013-05-24 | 2013-05-24 | |
PCT/EP2014/060637 WO2014187945A1 (en) | 2013-05-24 | 2014-05-23 | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2721922T3 true ES2721922T3 (es) | 2019-08-06 |
Family
ID=50819728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14726347T Active ES2721922T3 (es) | 2013-05-24 | 2014-05-23 | Tratamiento o prevención del daño neuronal no inflamatorio por traumatismo cerebral e ictus utilizando mentol, linalool y/o icilina |
Country Status (10)
Country | Link |
---|---|
US (2) | US20160166570A1 (es) |
EP (1) | EP3003292B1 (es) |
JP (2) | JP2016520588A (es) |
CN (1) | CN105228601A (es) |
AU (2) | AU2014270341A1 (es) |
BR (1) | BR112015026484A2 (es) |
CA (1) | CA2908365C (es) |
ES (1) | ES2721922T3 (es) |
TR (1) | TR201906539T4 (es) |
WO (1) | WO2014187945A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2908365C (en) * | 2013-05-24 | 2023-02-28 | Nestec S.A. | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using linalool |
US20230133657A1 (en) * | 2020-03-24 | 2023-05-04 | China Medical University | The use of menthol for the preparation of a topical composition to improve neurodegenerative disease and stroke |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003090599A2 (en) * | 2002-04-25 | 2003-11-06 | Brainsgate Ltd. | Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head |
JP4742204B2 (ja) * | 2005-01-21 | 2011-08-10 | 財団法人ヒューマンサイエンス振興財団 | 脂肪細胞分化制御剤 |
JP2007291069A (ja) * | 2006-03-31 | 2007-11-08 | Daiichi Sankyo Healthcare Co Ltd | 抗酸化剤および/または消炎鎮痛剤組成物 |
GB0615136D0 (en) * | 2006-07-29 | 2006-09-06 | Univ Edinburgh | Induction of analgesia in neuropathic pain |
KR20090085237A (ko) * | 2008-02-04 | 2009-08-07 | 김병문 | 천연 진주가루를 함유한 뇌질환 예방 및 치료용 한약조성물 |
WO2011006073A1 (en) * | 2009-07-10 | 2011-01-13 | President And Fellows Of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
KR20120103317A (ko) * | 2011-03-10 | 2012-09-19 | 한국생명공학연구원 | 아실 코에이:콜레스테롤 아실트랜스퍼라제 저해활성을 갖는 고수씨 추출물 또는 이로부터 분리된 리나로올을 포함하는 조성물 |
LT2793883T (lt) * | 2011-12-19 | 2018-08-10 | DompƩ farmaceutici s.p.a. | Trpm8 antagonistai |
CN102512634A (zh) * | 2011-12-26 | 2012-06-27 | 神威药业(张家口)有限公司 | 复方麝香软胶囊及其制备方法 |
US20150320700A1 (en) * | 2012-05-07 | 2015-11-12 | The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Reserc Organizatio | Geranium oil and constituents thereof for treatment of neurodegenerative diseases |
CA2908365C (en) * | 2013-05-24 | 2023-02-28 | Nestec S.A. | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using linalool |
-
2014
- 2014-05-23 CA CA2908365A patent/CA2908365C/en active Active
- 2014-05-23 WO PCT/EP2014/060637 patent/WO2014187945A1/en active Application Filing
- 2014-05-23 TR TR2019/06539T patent/TR201906539T4/tr unknown
- 2014-05-23 US US14/892,287 patent/US20160166570A1/en not_active Abandoned
- 2014-05-23 BR BR112015026484A patent/BR112015026484A2/pt not_active Application Discontinuation
- 2014-05-23 CN CN201480029057.2A patent/CN105228601A/zh active Pending
- 2014-05-23 JP JP2016514431A patent/JP2016520588A/ja not_active Withdrawn
- 2014-05-23 EP EP14726347.9A patent/EP3003292B1/en active Active
- 2014-05-23 AU AU2014270341A patent/AU2014270341A1/en not_active Abandoned
- 2014-05-23 ES ES14726347T patent/ES2721922T3/es active Active
-
2017
- 2017-03-17 US US15/462,387 patent/US10799502B2/en active Active
-
2019
- 2019-08-26 AU AU2019222781A patent/AU2019222781B2/en active Active
- 2019-09-26 JP JP2019175366A patent/JP2020011985A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2019222781A1 (en) | 2019-09-12 |
US20170189403A1 (en) | 2017-07-06 |
CA2908365C (en) | 2023-02-28 |
AU2019222781B2 (en) | 2021-05-13 |
TR201906539T4 (tr) | 2019-05-21 |
CA2908365A1 (en) | 2014-11-27 |
US10799502B2 (en) | 2020-10-13 |
EP3003292A1 (en) | 2016-04-13 |
WO2014187945A1 (en) | 2014-11-27 |
US20160166570A1 (en) | 2016-06-16 |
JP2016520588A (ja) | 2016-07-14 |
JP2020011985A (ja) | 2020-01-23 |
AU2014270341A1 (en) | 2015-10-08 |
EP3003292B1 (en) | 2019-03-20 |
CN105228601A (zh) | 2016-01-06 |
BR112015026484A2 (pt) | 2017-07-25 |
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