JP2016520550A5 - - Google Patents
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- Publication number
- JP2016520550A5 JP2016520550A5 JP2016506654A JP2016506654A JP2016520550A5 JP 2016520550 A5 JP2016520550 A5 JP 2016520550A5 JP 2016506654 A JP2016506654 A JP 2016506654A JP 2016506654 A JP2016506654 A JP 2016506654A JP 2016520550 A5 JP2016520550 A5 JP 2016520550A5
- Authority
- JP
- Japan
- Prior art keywords
- mmp
- tissue
- inactive
- composition
- mmps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 184
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 184
- 239000000203 mixture Substances 0.000 claims 48
- 239000012634 fragment Substances 0.000 claims 36
- 210000001519 tissue Anatomy 0.000 claims 35
- 238000000034 method Methods 0.000 claims 31
- 102100026799 Matrix metalloproteinase-28 Human genes 0.000 claims 29
- 108010062466 Enzyme Precursors Proteins 0.000 claims 25
- 102000010911 Enzyme Precursors Human genes 0.000 claims 25
- 210000002808 connective tissue Anatomy 0.000 claims 18
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 16
- 101710151806 72 kDa type IV collagenase Proteins 0.000 claims 16
- 102100027995 Collagenase 3 Human genes 0.000 claims 16
- 108050005238 Collagenase 3 Proteins 0.000 claims 16
- 102000004055 Matrix metalloproteinase-19 Human genes 0.000 claims 16
- 108090000587 Matrix metalloproteinase-19 Proteins 0.000 claims 16
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 16
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 16
- 102100030411 Neutrophil collagenase Human genes 0.000 claims 16
- 101710118230 Neutrophil collagenase Proteins 0.000 claims 16
- 102100028847 Stromelysin-3 Human genes 0.000 claims 16
- 108050005271 Stromelysin-3 Proteins 0.000 claims 16
- 108090000440 matrix metalloproteinase 25 Proteins 0.000 claims 16
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 15
- 101000627861 Homo sapiens Matrix metalloproteinase-28 Proteins 0.000 claims 15
- 102100027998 Macrophage metalloelastase Human genes 0.000 claims 15
- 101710187853 Macrophage metalloelastase Proteins 0.000 claims 15
- 102100030417 Matrilysin Human genes 0.000 claims 15
- 108090000855 Matrilysin Proteins 0.000 claims 15
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 15
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 15
- 102100030201 Matrix metalloproteinase-15 Human genes 0.000 claims 15
- 108090000560 Matrix metalloproteinase-15 Proteins 0.000 claims 15
- 102100030219 Matrix metalloproteinase-17 Human genes 0.000 claims 15
- 108090000585 Matrix metalloproteinase-17 Proteins 0.000 claims 15
- 102100029693 Matrix metalloproteinase-20 Human genes 0.000 claims 15
- 108090000609 Matrix metalloproteinase-20 Proteins 0.000 claims 15
- 101710082411 Matrix metalloproteinase-21 Proteins 0.000 claims 15
- 102100024130 Matrix metalloproteinase-23 Human genes 0.000 claims 15
- 102100030416 Stromelysin-1 Human genes 0.000 claims 15
- 101710108790 Stromelysin-1 Proteins 0.000 claims 15
- 101000627854 Homo sapiens Matrix metalloproteinase-26 Proteins 0.000 claims 14
- 108010076557 Matrix Metalloproteinase 14 Proteins 0.000 claims 14
- 102100030216 Matrix metalloproteinase-14 Human genes 0.000 claims 14
- 102100024129 Matrix metalloproteinase-24 Human genes 0.000 claims 14
- 108050005214 Matrix metalloproteinase-24 Proteins 0.000 claims 14
- 102100024128 Matrix metalloproteinase-26 Human genes 0.000 claims 14
- 102100024132 Matrix metalloproteinase-27 Human genes 0.000 claims 14
- 108050005201 Matrix metalloproteinase-27 Proteins 0.000 claims 14
- 102100028848 Stromelysin-2 Human genes 0.000 claims 14
- 101710108792 Stromelysin-2 Proteins 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 102100030200 Matrix metalloproteinase-16 Human genes 0.000 claims 13
- 108090000561 Matrix metalloproteinase-16 Proteins 0.000 claims 13
- 210000004923 pancreatic tissue Anatomy 0.000 claims 13
- 101001011896 Homo sapiens Matrix metalloproteinase-19 Proteins 0.000 claims 12
- 102100030218 Matrix metalloproteinase-19 Human genes 0.000 claims 12
- 101001011890 Xenopus laevis Matrix metalloproteinase-18 Proteins 0.000 claims 12
- 229940002612 prodrug Drugs 0.000 claims 12
- 239000000651 prodrug Substances 0.000 claims 12
- 229940124761 MMP inhibitor Drugs 0.000 claims 11
- 239000012190 activator Substances 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 210000000130 stem cell Anatomy 0.000 claims 7
- 210000000577 adipose tissue Anatomy 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 6
- 210000004369 blood Anatomy 0.000 claims 6
- 239000008280 blood Substances 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 6
- 210000005013 brain tissue Anatomy 0.000 claims 6
- 230000002526 effect on cardiovascular system Effects 0.000 claims 6
- 239000012530 fluid Substances 0.000 claims 6
- 210000004379 membrane Anatomy 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- -1 MMP- 18 Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 3
- 208000006735 Periostitis Diseases 0.000 claims 3
- 210000002469 basement membrane Anatomy 0.000 claims 3
- 210000004204 blood vessel Anatomy 0.000 claims 3
- 210000001185 bone marrow Anatomy 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 3
- 238000013270 controlled release Methods 0.000 claims 3
- 210000001174 endocardium Anatomy 0.000 claims 3
- 210000003038 endothelium Anatomy 0.000 claims 3
- 210000000981 epithelium Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 210000002744 extracellular matrix Anatomy 0.000 claims 3
- 210000004700 fetal blood Anatomy 0.000 claims 3
- 210000005003 heart tissue Anatomy 0.000 claims 3
- 230000000968 intestinal effect Effects 0.000 claims 3
- 210000004153 islets of langerhan Anatomy 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 210000003563 lymphoid tissue Anatomy 0.000 claims 3
- 210000003205 muscle Anatomy 0.000 claims 3
- 210000000944 nerve tissue Anatomy 0.000 claims 3
- 210000001706 olfactory mucosa Anatomy 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 210000002394 ovarian follicle Anatomy 0.000 claims 3
- 210000003460 periosteum Anatomy 0.000 claims 3
- 210000002826 placenta Anatomy 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 210000003491 skin Anatomy 0.000 claims 3
- 210000000278 spinal cord Anatomy 0.000 claims 3
- 239000002299 complementary DNA Substances 0.000 claims 2
- 210000004207 dermis Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000816 peptidomimetic Substances 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 102000009123 Fibrin Human genes 0.000 claims 1
- 108010073385 Fibrin Proteins 0.000 claims 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 108010085895 Laminin Proteins 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000009849 deactivation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 229950003499 fibrin Drugs 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361808861P | 2013-04-05 | 2013-04-05 | |
| US61/808,861 | 2013-04-05 | ||
| PCT/US2014/033009 WO2014165780A2 (en) | 2013-04-05 | 2014-04-04 | Matrix metalloproteinases and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016520550A JP2016520550A (ja) | 2016-07-14 |
| JP2016520550A5 true JP2016520550A5 (https=) | 2017-05-25 |
Family
ID=51659357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016506654A Pending JP2016520550A (ja) | 2013-04-05 | 2014-04-04 | マトリクスメタロプロテイナーゼおよびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20160053250A1 (https=) |
| EP (2) | EP2981276A4 (https=) |
| JP (1) | JP2016520550A (https=) |
| KR (1) | KR20160006694A (https=) |
| CN (1) | CN105246500A (https=) |
| AU (1) | AU2014248002A1 (https=) |
| BR (1) | BR112015025390A2 (https=) |
| CA (1) | CA2908739A1 (https=) |
| CR (1) | CR20150603A (https=) |
| HK (1) | HK1221405A1 (https=) |
| MX (1) | MX2015014053A (https=) |
| PH (1) | PH12015502306A1 (https=) |
| RU (1) | RU2015147878A (https=) |
| SG (1) | SG11201508199QA (https=) |
| WO (1) | WO2014165780A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412916B (zh) * | 2014-09-19 | 2021-04-30 | 达森生物药业有限公司 | 治疗乳腺癌的组合物及其用途 |
| CN105477627B (zh) * | 2014-09-19 | 2021-04-30 | 山东蓝金生物工程有限公司 | 治疗前列腺癌的组合物及其用途 |
| CN105412917B (zh) * | 2014-09-19 | 2021-04-30 | 达森生物药业有限公司 | 治疗实体瘤的抗癌组合物及其用途 |
| CN105477628B (zh) * | 2014-09-19 | 2021-04-30 | 山东蓝金生物工程有限公司 | 抗癌组合物及其用途 |
| JPWO2017038473A1 (ja) * | 2015-08-28 | 2018-06-14 | 天野エンザイム株式会社 | エンドトキシン低減サーモリシン |
| CN105907840A (zh) * | 2016-03-29 | 2016-08-31 | 苏州大学 | 单细胞水平检测mmp酶活性的方法 |
| US10137179B2 (en) * | 2016-05-18 | 2018-11-27 | Hyalo Technologies, LLC | Composition and method of preparation of protease microparticulate slow release preparation |
| CN108451981B (zh) * | 2018-04-21 | 2019-07-23 | 江西汉氏联合干细胞科技有限公司 | 使用皮肤间充质干细胞治疗系统性硬化症 |
| US12569594B2 (en) | 2018-12-20 | 2026-03-10 | The Steadman Clinic And Steadman Philippon Research Institute | Decellularized tendon matrix methods and uses thereof |
| CN114377150B (zh) * | 2021-12-29 | 2023-10-13 | 中山大学南昌研究院 | 一种mmp酶敏感胎盘微环境和肿瘤微环境靶向载体及其制备方法和应用 |
| CN116549325B (zh) * | 2022-01-27 | 2025-07-29 | 南京大学 | 一种组合物、其制备方法、制剂及应用 |
| CN119530138B (zh) * | 2024-12-05 | 2026-01-30 | 中国肉类食品综合研究中心 | 一种用于工业化细胞解离的多酶制剂及其使用方法和应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5770691A (en) * | 1995-06-05 | 1998-06-23 | Regents Of The University Of Minnesota | Discriminatory substrates for MMP hydrolysis |
| ES2317657T3 (es) | 1996-09-19 | 2009-04-16 | The Regents Of The University Of Michigan | Polimeros que contienen polisacaridos tales como alginatos o alginatos modificados. |
| US6531154B1 (en) | 1997-06-10 | 2003-03-11 | Brown University Research Foundation | Modulated release from biocompatible polymers |
| US6248587B1 (en) | 1997-11-26 | 2001-06-19 | University Of Southern Cailfornia | Method for promoting mesenchymal stem and lineage-specific cell proliferation |
| WO1999055396A1 (en) | 1998-04-27 | 1999-11-04 | Surmodics, Inc. | Bioactive agent release coating |
| US6376742B1 (en) | 1999-02-17 | 2002-04-23 | Richard J. Zdrahala | In vivo tissue engineering with biodegradable polymers |
| WO2000051662A1 (en) | 1999-03-04 | 2000-09-08 | Tepha, Inc. | Bioabsorbable, biocompatible polymers for tissue engineering |
| KR100392501B1 (ko) | 2000-06-28 | 2003-07-22 | 동국제약 주식회사 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
| EP1611233B1 (en) * | 2003-04-08 | 2016-01-06 | Yeda Research And Development Co., Ltd. | Stem cells having increased sensitivity to sdf-1 and methods of generating and using same |
| SE0302559D0 (sv) * | 2003-09-25 | 2003-09-25 | Astrazeneca Ab | Method |
| JP2007508018A (ja) * | 2003-10-08 | 2007-04-05 | べト−ステム インコーポレイテッド | 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット |
| CA2633980A1 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
| WO2007117451A2 (en) * | 2006-03-31 | 2007-10-18 | The Regents Of The University Of Michigan | A pericellular collagenase directs the 3-dimensional development of white adipose tissue |
| MX2010003019A (es) * | 2007-09-19 | 2010-04-30 | Pluristem Ltd | Celulas adherentes de los tejidos adiposo y de placenta y uso de las mismas en la terapia. |
| US8222206B2 (en) * | 2008-03-04 | 2012-07-17 | Taiwan Advance Bio-Pharm Inc. | Method of enhancing the mobilization of hematopoietic stem cells using TAT-HOXB4H |
| JP5572291B2 (ja) * | 2008-04-07 | 2014-08-13 | 独立行政法人国立長寿医療研究センター | 歯髄及び／又は象牙質形成促進のための薬剤及びその利用 |
| US9435811B2 (en) * | 2008-09-30 | 2016-09-06 | Oriental Yeast Co., Ltd | Inducer of chondrocyte proliferation and differentiation |
| CA2794165A1 (en) * | 2010-03-24 | 2011-09-29 | Lifenet Health | Bmp-4 peptides & methods of use |
| EP2608809B1 (en) * | 2010-08-27 | 2019-05-22 | Gilead Biologics, Inc. | Antibodies to matrix metalloproteinase 9 |
-
2014
- 2014-04-04 MX MX2015014053A patent/MX2015014053A/es unknown
- 2014-04-04 RU RU2015147878A patent/RU2015147878A/ru not_active Application Discontinuation
- 2014-04-04 EP EP14779257.6A patent/EP2981276A4/en not_active Withdrawn
- 2014-04-04 EP EP17191200.9A patent/EP3290047A1/en not_active Withdrawn
- 2014-04-04 AU AU2014248002A patent/AU2014248002A1/en not_active Abandoned
- 2014-04-04 KR KR1020157031871A patent/KR20160006694A/ko not_active Withdrawn
- 2014-04-04 SG SG11201508199QA patent/SG11201508199QA/en unknown
- 2014-04-04 CA CA2908739A patent/CA2908739A1/en not_active Abandoned
- 2014-04-04 HK HK16109565.8A patent/HK1221405A1/zh unknown
- 2014-04-04 CN CN201480030453.7A patent/CN105246500A/zh active Pending
- 2014-04-04 BR BR112015025390A patent/BR112015025390A2/pt not_active Application Discontinuation
- 2014-04-04 JP JP2016506654A patent/JP2016520550A/ja active Pending
- 2014-04-04 WO PCT/US2014/033009 patent/WO2014165780A2/en not_active Ceased
- 2014-04-04 US US14/782,118 patent/US20160053250A1/en not_active Abandoned
-
2015
- 2015-10-05 PH PH12015502306A patent/PH12015502306A1/en unknown
- 2015-11-05 CR CR20150603A patent/CR20150603A/es unknown
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