JP2016520053A5 - - Google Patents

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Publication number
JP2016520053A5
JP2016520053A5 JP2016512207A JP2016512207A JP2016520053A5 JP 2016520053 A5 JP2016520053 A5 JP 2016520053A5 JP 2016512207 A JP2016512207 A JP 2016512207A JP 2016512207 A JP2016512207 A JP 2016512207A JP 2016520053 A5 JP2016520053 A5 JP 2016520053A5
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JP
Japan
Prior art keywords
seq
tumstatin
amino acid
cd137l
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016512207A
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English (en)
Japanese (ja)
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JP2016520053A (ja
Filing date
Publication date
Priority claimed from CN201310163407.1A external-priority patent/CN103232543B/zh
Priority claimed from CN201310162738.3A external-priority patent/CN103214584B/zh
Application filed filed Critical
Priority claimed from PCT/CN2014/076768 external-priority patent/WO2014180288A1/zh
Publication of JP2016520053A publication Critical patent/JP2016520053A/ja
Publication of JP2016520053A5 publication Critical patent/JP2016520053A5/ja
Pending legal-status Critical Current

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JP2016512207A 2013-05-06 2014-05-05 腫瘍微小環境における血管再生の抑制及び適応免疫応答の活性化を有する二機能の融合タンパク質及びその遺伝子並びに使用 Pending JP2016520053A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201310163407.1A CN103232543B (zh) 2013-05-06 2013-05-06 具有Tumstatin活性的重组蛋白Tumstatin-CD137L4及其制备和应用
CN201310162738.3A CN103214584B (zh) 2013-05-06 2013-05-06 具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用
CN201310163407.1 2013-05-06
CN201310162738.3 2013-05-06
PCT/CN2014/076768 WO2014180288A1 (zh) 2013-05-06 2014-05-05 具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用

Publications (2)

Publication Number Publication Date
JP2016520053A JP2016520053A (ja) 2016-07-11
JP2016520053A5 true JP2016520053A5 (cg-RX-API-DMAC7.html) 2018-05-31

Family

ID=51866722

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016512207A Pending JP2016520053A (ja) 2013-05-06 2014-05-05 腫瘍微小環境における血管再生の抑制及び適応免疫応答の活性化を有する二機能の融合タンパク質及びその遺伝子並びに使用

Country Status (6)

Country Link
US (1) US10875903B2 (cg-RX-API-DMAC7.html)
EP (1) EP2995626B1 (cg-RX-API-DMAC7.html)
JP (1) JP2016520053A (cg-RX-API-DMAC7.html)
DK (1) DK2995626T3 (cg-RX-API-DMAC7.html)
ES (1) ES2686968T3 (cg-RX-API-DMAC7.html)
WO (1) WO2014180288A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
WO2018114748A1 (en) 2016-12-20 2018-06-28 F. Hoffmann-La Roche Ag Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists
IL267862B2 (en) 2017-01-05 2024-05-01 Kahr Medical Ltd A SIRPalpha-41BBL FUSION PROTEIN AND METHODS OF USE THEREOF
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
US11299530B2 (en) 2017-01-05 2022-04-12 Kahr Medical Ltd. SIRP alpha-CD70 fusion protein and methods of use thereof
HRP20230937T1 (hr) 2017-01-05 2023-11-24 Kahr Medical Ltd. Pd1-41bbl fuzijski protein i metode korištenja istog
CA3104778A1 (en) 2018-07-11 2020-01-16 Kahr Medical Ltd. Pd1-4-1bbl variant fusion protein and methods of use thereof
BR112021000360A2 (pt) 2018-07-11 2021-04-13 Kahr Medical Ltd. Proteína de fusão variante sirpalpha-4-1bbl e métodos de uso da mesma
CN116462769A (zh) * 2022-04-02 2023-07-21 广东东阳光药业有限公司 一种嵌合受体及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9673998A (en) * 1997-10-01 1999-04-23 G.D. Searle & Co. Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment
CN1309663A (zh) * 1998-06-17 2001-08-22 贝斯以色列护理医疗中心 抗血管生成蛋白及其应用
JP2006508635A (ja) * 2002-05-06 2006-03-16 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 治療用または診断用試薬を送達するためのターゲティングタンパク質
NZ553224A (en) * 2004-07-26 2009-05-31 Asterion Ltd Linkers
WO2009086132A2 (en) * 2007-12-20 2009-07-09 University Of Southern California Design of spacers to increase the expression of recombinant fusion proteins
CN101265482A (zh) 2008-04-25 2008-09-17 罗以勤 重组肿瘤抑素-肿瘤坏死因子分泌型真核表达载体及其制备方法和用途
PL219845B1 (pl) 2011-01-05 2015-07-31 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
EP2694550B1 (en) 2011-04-01 2019-11-27 Universität Stuttgart Recombinant tnf ligand family member polypeptides with antibody binding domain and uses thereof
PT2744831T (pt) * 2011-08-17 2018-03-05 Univ Colorado Regents Proteína de fusão de transferrina-tumstatina e métodos para a produzir e utilizar
CN103232543B (zh) 2013-05-06 2014-12-03 中国药科大学 具有Tumstatin活性的重组蛋白Tumstatin-CD137L4及其制备和应用
CN103214584B (zh) 2013-05-06 2014-07-09 中国药科大学 具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用

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