JP2016519079A5 - - Google Patents
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- JP2016519079A5 JP2016519079A5 JP2016503007A JP2016503007A JP2016519079A5 JP 2016519079 A5 JP2016519079 A5 JP 2016519079A5 JP 2016503007 A JP2016503007 A JP 2016503007A JP 2016503007 A JP2016503007 A JP 2016503007A JP 2016519079 A5 JP2016519079 A5 JP 2016519079A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogel
- cells
- capsule
- mammalian
- capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002775 capsule Substances 0.000 claims description 108
- 239000000017 hydrogel Substances 0.000 claims description 92
- 210000004027 cell Anatomy 0.000 claims description 50
- 239000010410 layer Substances 0.000 claims description 34
- 239000012792 core layer Substances 0.000 claims description 12
- 230000002503 metabolic effect Effects 0.000 claims description 12
- 210000003537 structural cell Anatomy 0.000 claims description 12
- 230000004888 barrier function Effects 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 10
- 238000002513 implantation Methods 0.000 claims description 10
- 229920001577 copolymer Polymers 0.000 claims description 8
- 150000004676 glycans Chemical class 0.000 claims description 8
- 210000004153 islets of langerhan Anatomy 0.000 claims description 8
- 210000004962 mammalian cell Anatomy 0.000 claims description 8
- 229920001282 polysaccharide Polymers 0.000 claims description 8
- 239000005017 polysaccharide Substances 0.000 claims description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 210000002955 secretory cell Anatomy 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 4
- 229920000936 Agarose Polymers 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 4
- 108010035532 Collagen Proteins 0.000 claims description 4
- 206010016654 Fibrosis Diseases 0.000 claims description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 4
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 230000000735 allogeneic effect Effects 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229940045110 chitosan Drugs 0.000 claims description 4
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 4
- 229920001436 collagen Polymers 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 4
- 230000004761 fibrosis Effects 0.000 claims description 4
- 230000003176 fibrotic effect Effects 0.000 claims description 4
- 229920002674 hyaluronan Polymers 0.000 claims description 4
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims description 4
- 229940099552 hyaluronan Drugs 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 4
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 4
- 239000011118 polyvinyl acetate Substances 0.000 claims description 4
- 239000002243 precursor Substances 0.000 claims description 4
- 238000005086 pumping Methods 0.000 claims description 4
- 230000001154 acute effect Effects 0.000 claims description 2
- 230000001028 anti-proliverative effect Effects 0.000 claims description 2
- 239000000560 biocompatible material Substances 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 239000011258 core-shell material Substances 0.000 claims description 2
- 239000000032 diagnostic agent Substances 0.000 claims description 2
- 229940039227 diagnostic agent Drugs 0.000 claims description 2
- 230000005684 electric field Effects 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- 239000002530 phenolic antioxidant Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 230000000069 prophylactic effect Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/831,250 US9555007B2 (en) | 2013-03-14 | 2013-03-14 | Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates |
| US13/831,250 | 2013-03-14 | ||
| PCT/US2014/029189 WO2014153126A1 (en) | 2013-03-14 | 2014-03-14 | Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204916A Division JP6881877B2 (ja) | 2013-03-14 | 2018-10-31 | 細胞の封入および細胞集合体のための多層ヒドロゲルカプセル |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519079A JP2016519079A (ja) | 2016-06-30 |
| JP2016519079A5 true JP2016519079A5 (enExample) | 2017-04-13 |
| JP6456355B2 JP6456355B2 (ja) | 2019-01-23 |
Family
ID=50513504
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503007A Active JP6456355B2 (ja) | 2013-03-14 | 2014-03-14 | 細胞の封入および細胞集合体のための多層ヒドロゲルカプセル |
| JP2018204916A Active JP6881877B2 (ja) | 2013-03-14 | 2018-10-31 | 細胞の封入および細胞集合体のための多層ヒドロゲルカプセル |
| JP2019073953A Pending JP2019104769A (ja) | 2013-03-14 | 2019-04-09 | 細胞の封入および細胞集合体のための多層ヒドロゲルカプセル |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204916A Active JP6881877B2 (ja) | 2013-03-14 | 2018-10-31 | 細胞の封入および細胞集合体のための多層ヒドロゲルカプセル |
| JP2019073953A Pending JP2019104769A (ja) | 2013-03-14 | 2019-04-09 | 細胞の封入および細胞集合体のための多層ヒドロゲルカプセル |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US9555007B2 (enExample) |
| EP (1) | EP2968115B1 (enExample) |
| JP (3) | JP6456355B2 (enExample) |
| AU (1) | AU2014236296B2 (enExample) |
| CA (2) | CA2906174C (enExample) |
| WO (1) | WO2014153126A1 (enExample) |
Families Citing this family (87)
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| US9555007B2 (en) | 2013-03-14 | 2017-01-31 | Massachusetts Institute Of Technology | Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates |
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| US11229607B2 (en) * | 2014-06-30 | 2022-01-25 | President And Fellows Of Harvard College | Hydrogel compositions comprising encapsulated cells and methods of use thereof |
| WO2016108234A1 (en) * | 2014-12-30 | 2016-07-07 | Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. | Liquid-core capsules comprising non-crosslinked alginate |
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| EP3261626A4 (en) * | 2015-02-27 | 2018-10-03 | Wayne State University | Methods and compositions relating to biocompatible implants |
| CA3018694C (en) | 2015-03-23 | 2025-12-30 | The Regents Of The University Of California | Thin film cell encapsulation devices |
| JP2018521717A (ja) * | 2015-05-17 | 2018-08-09 | マサチューセッツ インスティテュート オブ テクノロジー | 細胞および細胞凝集体を封入するための多層ヒドロゲルカプセル |
| US10918673B2 (en) | 2015-08-28 | 2021-02-16 | The Regents Of The University Of Michigan | Immunoisolation device |
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