|
EP2734621B1
(en)
|
2011-07-22 |
2019-09-04 |
President and Fellows of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
PL4289948T3
(pl)
|
2012-05-25 |
2025-06-02 |
The Regents Of The University Of California |
Sposoby i kompozycje do modyfikacji kierowanego na rna docelowego dna i do nakierowanej na rna modulacji transkrypcji
|
|
CN105142669B
(zh)
|
2012-12-06 |
2018-07-03 |
西格马-奥尔德里奇有限责任公司 |
基于crispr的基因组修饰和调控
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
IL289396B2
(en)
|
2013-03-15 |
2023-12-01 |
The General Hospital Coporation |
Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing
|
|
CA2908697C
(en)
|
2013-04-16 |
2023-12-12 |
Regeneron Pharmaceuticals, Inc. |
Targeted modification of rat genome
|
|
CN116083487A
(zh)
|
2013-05-15 |
2023-05-09 |
桑格摩生物治疗股份有限公司 |
用于治疗遗传病状的方法和组合物
|
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
CA2920899C
(en)
|
2013-08-28 |
2023-02-28 |
Sangamo Biosciences, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
|
EP3418379B1
(en)
|
2013-09-18 |
2020-12-09 |
Kymab Limited |
Methods, cells & organisms
|
|
JP2016536021A
(ja)
|
2013-11-07 |
2016-11-24 |
エディタス・メディシン，インコーポレイテッド |
ＣＲＩＳＰＲ関連方法および支配ｇＲＮＡのある組成物
|
|
SG10201700961TA
(en)
|
2013-12-11 |
2017-04-27 |
Regeneron Pharma |
Methods and compositions for the targeted modification of a genome
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
US10563207B2
(en)
|
2014-04-30 |
2020-02-18 |
Tsinghua University |
Modular construction of synthetic gene circuits in mammalian cells using TALE transcriptional repressors
|
|
WO2015165276A1
(zh)
*
|
2014-04-30 |
2015-11-05 |
清华大学 |
利用tale转录抑制子在哺乳动物细胞中模块化构建合成基因线路的试剂盒
|
|
EP3152319A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
KR102425438B1
(ko)
|
2014-06-23 |
2022-07-27 |
더 제너럴 하스피탈 코포레이션 |
서열결정에 의해 평가된 DSB의 게놈 전체에 걸친 비편향된 확인 (GUIDE-Seq)
|
|
US9816074B2
(en)
|
2014-07-25 |
2017-11-14 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
US9757420B2
(en)
|
2014-07-25 |
2017-09-12 |
Sangamo Therapeutics, Inc. |
Gene editing for HIV gene therapy
|
|
CA2956224A1
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
WO2016019144A2
(en)
|
2014-07-30 |
2016-02-04 |
Sangamo Biosciences, Inc. |
Gene correction of scid-related genes in hematopoietic stem and progenitor cells
|
|
EP3221457B1
(en)
|
2014-11-21 |
2019-03-20 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
WO2016114972A1
(en)
|
2015-01-12 |
2016-07-21 |
The Regents Of The University Of California |
Heterodimeric cas9 and methods of use thereof
|
|
EP3250689B1
(en)
|
2015-01-28 |
2020-11-04 |
The Regents of The University of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
WO2016141224A1
(en)
|
2015-03-03 |
2016-09-09 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
US20180080051A1
(en)
*
|
2015-03-31 |
2018-03-22 |
Exeligen Scientific, Inc. |
Cas 9 retroviral integrase and cas 9 recombinase systems for targeted incorporation of a dna sequence into a genome of a cell or organism
|
|
WO2016196655A1
(en)
|
2015-06-03 |
2016-12-08 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
|
WO2017040348A1
(en)
|
2015-08-28 |
2017-03-09 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017044843A1
(en)
|
2015-09-11 |
2017-03-16 |
The General Hospital Corporation |
Full interrogation of nuclease dsbs and sequencing (find-seq)
|
|
WO2017053729A1
(en)
|
2015-09-25 |
2017-03-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuclease-mediated genome editing of primary cells and enrichment thereof
|
|
US9850484B2
(en)
|
2015-09-30 |
2017-12-26 |
The General Hospital Corporation |
Comprehensive in vitro reporting of cleavage events by sequencing (Circle-seq)
|
|
EP4434589A3
(en)
|
2015-10-23 |
2025-05-14 |
President and Fellows of Harvard College |
Evolved cas9 proteins for gene editing
|
|
ES2895430T3
(es)
|
2016-01-15 |
2022-02-21 |
Univ Minnesota |
Métodos y composiciones para el tratamiento de enfermedad neurológica
|
|
JP7012650B2
(ja)
|
2016-02-02 |
2022-01-28 |
サンガモ セラピューティクス， インコーポレイテッド |
Ｄｎａ結合ドメインと切断ドメインとを連結するための組成物
|
|
US20190249172A1
(en)
|
2016-02-18 |
2019-08-15 |
The Regents Of The University Of California |
Methods and compositions for gene editing in stem cells
|
|
JP2019515654A
(ja)
|
2016-03-16 |
2019-06-13 |
ザ ジェイ． デヴィッド グラッドストーン インスティテューツ |
肥満及び／又は糖尿病を処置するための方法及び組成物、並びに候補処置薬剤を識別するための方法及び組成物
|
|
CN109475109B
(zh)
|
2016-05-20 |
2021-10-29 |
瑞泽恩制药公司 |
用于使用多个引导rna来破坏免疫耐受性的方法
|
|
RU2721125C1
(ru)
|
2016-07-29 |
2020-05-18 |
Регенерон Фармасьютикалз, Инк. |
Мыши, содержащие мутации, вследствие которых экспрессируется укороченный на с-конце фибриллин-1
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
JP2019532644A
(ja)
|
2016-09-30 |
2019-11-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Ｒｎａ誘導型核酸修飾酵素及びその使用方法
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
JP7042263B2
(ja)
|
2016-10-20 |
2022-03-25 |
サンガモ セラピューティクス， インコーポレイテッド |
ファブリー病の治療のための方法および組成物
|
|
EP3532106A4
(en)
|
2016-10-31 |
2020-06-24 |
Sangamo Therapeutics, Inc. |
GENERAL CORRECTION OF SCID-ASSOCIATED GENES IN HEMOTOPOIETIC STEM CELLS AND PROCUREMENT CELLS
|
|
WO2018085586A1
(en)
*
|
2016-11-02 |
2018-05-11 |
David Kiewlich |
Plasmid vectors for expression of large nucleic acid transgenes
|
|
CA3045134A1
(en)
|
2016-12-14 |
2018-06-21 |
Ligandal, Inc. |
Compositions and methods for nucleic acid and/or protein payload delivery
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
SG10202109874VA
(en)
|
2017-01-19 |
2021-10-28 |
Open Monoclonal Tech Inc |
Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
|
|
WO2018136758A1
(en)
|
2017-01-23 |
2018-07-26 |
Regeneron Pharmaceuticals, Inc. |
Hsd17b13 variants and uses thereof
|
|
US20190365818A1
(en)
*
|
2017-02-09 |
2019-12-05 |
Allen Institute |
Genetically-tagged stem cell lines and methods of use
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
CN110662556A
(zh)
|
2017-03-09 |
2020-01-07 |
哈佛大学的校长及成员们 |
癌症疫苗
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
WO2018176009A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
BR112019021719A2
(pt)
|
2017-04-21 |
2020-06-16 |
The General Hospital Corporation |
Variantes de cpf1 (cas12a) com especificidade para pam alterada
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
EP3630970A4
(en)
|
2017-05-25 |
2020-12-30 |
The General Hospital Corporation |
BASIC EDITORS WITH IMPROVED PRECISION AND SPECIFICITY
|
|
US11732274B2
(en)
|
2017-07-28 |
2023-08-22 |
President And Fellows Of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
|
|
WO2019032675A1
(en)
|
2017-08-08 |
2019-02-14 |
Sangamo Therapeutics, Inc. |
CELL TARGETING MEDIATED BY A CHIMERIC ANTIGEN RECEPTOR
|
|
EP3672612A4
(en)
|
2017-08-23 |
2021-09-29 |
The General Hospital Corporation |
GENETICALLY MODIFIED CRISPR-CAS9 NUCLEASES WITH MODIFIED PAM SPECIFICITY
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
US11725228B2
(en)
|
2017-10-11 |
2023-08-15 |
The General Hospital Corporation |
Methods for detecting site-specific and spurious genomic deamination induced by base editing technologies
|
|
KR20200121782A
(ko)
|
2017-10-16 |
2020-10-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
JP2021502085A
(ja)
|
2017-11-09 |
2021-01-28 |
サンガモ セラピューティクス， インコーポレイテッド |
サイトカイン誘導性ｓｈ２含有タンパク質（ｃｉｓｈ）遺伝子の遺伝子改変
|
|
US20220290186A1
(en)
*
|
2017-12-06 |
2022-09-15 |
Generation Bio Co. |
Gene editing using a modified closed-ended dna (cedna)
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019157239A1
(en)
*
|
2018-02-08 |
2019-08-15 |
David Kiewlich |
Plasmid vectors for expression of large nucleic acid transgenes
|
|
MX2020009579A
(es)
*
|
2018-03-15 |
2020-11-09 |
Intergalactic Therapeutics Inc |
Vectores de adn sintetico y metodos de uso.
|
|
WO2019204378A1
(en)
|
2018-04-17 |
2019-10-24 |
The General Hospital Corporation |
Sensitive in vitro assays for substrate preferences and sites of nucleic acid binding, modifying, and cleaving agents
|
|
WO2019204457A1
(en)
|
2018-04-18 |
2019-10-24 |
Sangamo Therapeutics, Inc. |
Zinc finger protein compositions for modulation of huntingtin (htt)
|
|
CN112088018A
(zh)
|
2018-05-07 |
2020-12-15 |
先锋国际良种公司 |
用于在植物细胞基因组中同源定向修复双链断裂的方法和组合物
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
CA3105658A1
(en)
|
2018-07-13 |
2020-01-16 |
The Regents Of The University Of California |
Retrotransposon-based delivery vehicle and methods of use thereof
|
|
WO2020041456A1
(en)
|
2018-08-22 |
2020-02-27 |
The Regents Of The University Of California |
Variant type v crispr/cas effector polypeptides and methods of use thereof
|
|
EP3867380A2
(en)
|
2018-10-18 |
2021-08-25 |
Intellia Therapeutics, Inc. |
Compositions and methods for expressing factor ix
|
|
WO2020084034A1
(en)
|
2018-10-26 |
2020-04-30 |
F. Hoffmann-La Roche Ag |
Multispecific antibody screening method using recombinase mediated cassette exchange
|
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
AU2019374883A1
(en)
|
2018-11-09 |
2021-05-20 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020163396A1
(en)
|
2019-02-04 |
2020-08-13 |
The General Hospital Corporation |
Adenine dna base editor variants with reduced off-target rna editing
|
|
EP3826664A4
(en)
|
2019-02-06 |
2022-10-26 |
Sangamo Therapeutics, Inc. |
Method for the treatment of mucopolysaccharidosis type i
|
|
US12460230B2
(en)
|
2019-02-10 |
2025-11-04 |
The J. David Gladstone Institutes |
Modified mitochondrion and methods of use thereof
|
|
EP3935156A4
(en)
|
2019-03-07 |
2022-12-28 |
The Regents of The University of California |
CRISPR-CAS EFFECTIVE POLYPEPTIDES AND METHODS OF USE THEREOF
|
|
MX2021011426A
(es)
|
2019-03-19 |
2022-03-11 |
Broad Inst Inc |
Metodos y composiciones para editar secuencias de nucleótidos.
|
|
SG11202110607WA
(en)
|
2019-04-01 |
2021-10-28 |
Tenaya Therapeutics Inc |
Adeno-associated virus with engineered capsid
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CA3137896A1
(en)
*
|
2019-04-24 |
2020-10-29 |
Seattle Children's Hospital D/B/A Seattle Children's Research Institute |
Wiskott-aldrich syndrome gene homing endonuclease variants, compositions, and methods of use
|
|
AU2020289581B2
(en)
|
2019-06-07 |
2024-11-21 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized albumin locus
|
|
AU2020302861A1
(en)
*
|
2019-06-26 |
2022-02-24 |
Virovek, Inc. |
Baculovirus expression system
|
|
MX2022001893A
(es)
*
|
2019-08-14 |
2022-04-26 |
Pairwise Plants Services Inc |
Alteracion de los rasgos de sabor en los cultivos de consumo mediante la desactivacion del sistema de mirosinasa/glucosinolato.
|
|
GB2700048B
(en)
|
2019-09-18 |
2026-03-04 |
Aldevron Llc |
synthetic dna vectors and method of use
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021151085A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Crispr-cas enzymes with enhanced on-target activity
|
|
US12312613B2
(en)
|
2020-01-24 |
2025-05-27 |
The General Hospital Corporation |
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
|
|
EP4097144A4
(en)
*
|
2020-01-28 |
2024-02-28 |
University of Southern California |
Genome engineering the human immunoglobulin locus to express recombinant binding domain molecules
|
|
JP2023515671A
(ja)
|
2020-03-04 |
2023-04-13 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
免疫療法に対する腫瘍細胞の感作のための方法及び組成物
|
|
WO2021226558A1
(en)
|
2020-05-08 |
2021-11-11 |
The Broad Institute, Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
CN115698304A
(zh)
|
2020-10-09 |
2023-02-03 |
特纳亚治疗股份有限公司 |
亲斑蛋白-2基因疗法的方法和组合物
|
|
EP4596697A3
(en)
|
2021-09-28 |
2025-08-27 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
CA3237482A1
(en)
|
2021-11-03 |
2023-05-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Precise genome editing using retrons
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
AU2023311964A1
(en)
|
2022-07-18 |
2025-01-30 |
Renagade Therapeutics Management Inc. |
Gene editing components, systems, and methods of use
|
|
US12171178B2
(en)
|
2022-07-18 |
2024-12-24 |
Pairwise Plants Services, Inc. |
Mustard green plants named ‘PWRG-1’, ‘PWRG-2,’ and ‘PWSGC’
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2025049959A2
(en)
|
2023-09-01 |
2025-03-06 |
Renagade Therapeutics Management Inc. |
Gene editing systems, compositions, and methods for treatment of vexas syndrome
|
|
WO2025081042A1
(en)
|
2023-10-12 |
2025-04-17 |
Renagade Therapeutics Management Inc. |
Nickase-retron template-based precision editing system and methods of use
|
|
WO2025155753A2
(en)
|
2024-01-17 |
2025-07-24 |
Renagade Therapeutics Management Inc. |
Improved gene editing system, guides, and methods
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2026006542A2
(en)
|
2024-06-26 |
2026-01-02 |
Yale University |
Compositions and methods for crispr/cas9 based reactivation of human angelman syndrome
|