JP2016515382A5 - - Google Patents
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- JP2016515382A5 JP2016515382A5 JP2016503223A JP2016503223A JP2016515382A5 JP 2016515382 A5 JP2016515382 A5 JP 2016515382A5 JP 2016503223 A JP2016503223 A JP 2016503223A JP 2016503223 A JP2016503223 A JP 2016503223A JP 2016515382 A5 JP2016515382 A5 JP 2016515382A5
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- Prior art keywords
- cells
- photoreceptor
- cell
- preparation
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091008695 photoreceptors Proteins 0.000 claims description 43
- 210000000130 stem cell Anatomy 0.000 claims description 18
- 239000002609 medium Substances 0.000 claims description 10
- 230000035899 viability Effects 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000005138 cryopreservation Methods 0.000 claims description 3
- 239000001963 growth medium Substances 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 47
- 238000002360 preparation method Methods 0.000 claims 33
- 239000002243 precursor Substances 0.000 claims 26
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 108010032788 PAX6 Transcription Factor Proteins 0.000 claims 10
- 102100037506 Paired box protein Pax-6 Human genes 0.000 claims 10
- 210000000608 photoreceptor cell Anatomy 0.000 claims 9
- 238000012258 culturing Methods 0.000 claims 8
- 230000002207 retinal effect Effects 0.000 claims 7
- 108020004999 messenger RNA Proteins 0.000 claims 6
- 101000854931 Homo sapiens Visual system homeobox 2 Proteins 0.000 claims 5
- 238000011529 RT qPCR Methods 0.000 claims 5
- 102100020676 Visual system homeobox 2 Human genes 0.000 claims 5
- 210000005155 neural progenitor cell Anatomy 0.000 claims 5
- 101100163882 Mus musculus Ascl1 gene Proteins 0.000 claims 4
- 230000001464 adherent effect Effects 0.000 claims 4
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 3
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 3
- 210000001671 embryonic stem cell Anatomy 0.000 claims 3
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 3
- 230000004031 neuronal differentiation Effects 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 2
- 102000010175 Opsin Human genes 0.000 claims 2
- 108050001704 Opsin Proteins 0.000 claims 2
- 108091008730 RAR-related orphan receptors β Proteins 0.000 claims 2
- 102000004330 Rhodopsin Human genes 0.000 claims 2
- 108090000820 Rhodopsin Proteins 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229930002330 retinoic acid Natural products 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 230000000392 somatic effect Effects 0.000 claims 2
- 229960001727 tretinoin Drugs 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 102000012286 Chitinases Human genes 0.000 claims 1
- 108010022172 Chitinases Proteins 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 102000009123 Fibrin Human genes 0.000 claims 1
- 108010073385 Fibrin Proteins 0.000 claims 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
- 102100020997 Fractalkine Human genes 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 102100027345 Homeobox protein SIX3 Human genes 0.000 claims 1
- 102100025448 Homeobox protein SIX6 Human genes 0.000 claims 1
- 101000854520 Homo sapiens Fractalkine Proteins 0.000 claims 1
- 101000651928 Homo sapiens Homeobox protein SIX3 Proteins 0.000 claims 1
- 101000835956 Homo sapiens Homeobox protein SIX6 Proteins 0.000 claims 1
- 101001020544 Homo sapiens LIM/homeobox protein Lhx2 Proteins 0.000 claims 1
- 101000666775 Homo sapiens T-box transcription factor TBX3 Proteins 0.000 claims 1
- 102100036132 LIM/homeobox protein Lhx2 Human genes 0.000 claims 1
- 102000008730 Nestin Human genes 0.000 claims 1
- 108010088225 Nestin Proteins 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 102100038409 T-box transcription factor TBX3 Human genes 0.000 claims 1
- 102000007000 Tenascin Human genes 0.000 claims 1
- 108010008125 Tenascin Proteins 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 210000000411 amacrine cell Anatomy 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 230000032677 cell aging Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000003436 cytoskeletal effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229950003499 fibrin Drugs 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000012744 immunostaining Methods 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000037356 lipid metabolism Effects 0.000 claims 1
- 108010082117 matrigel Proteins 0.000 claims 1
- 210000005055 nestin Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 230000000324 neuroprotective effect Effects 0.000 claims 1
- 230000000242 pagocytic effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000002510 pyrogen Substances 0.000 claims 1
- 230000022983 regulation of cell cycle Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361793168P | 2013-03-15 | 2013-03-15 | |
| US61/793,168 | 2013-03-15 | ||
| PCT/US2014/029790 WO2014145108A1 (en) | 2013-03-15 | 2014-03-14 | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019159491A Division JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515382A JP2016515382A (ja) | 2016-05-30 |
| JP2016515382A5 true JP2016515382A5 (cg-RX-API-DMAC7.html) | 2017-04-20 |
| JP6581966B2 JP6581966B2 (ja) | 2019-09-25 |
Family
ID=51537881
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503223A Active JP6581966B2 (ja) | 2013-03-15 | 2014-03-14 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2019159491A Active JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2021162946A Pending JP2022023092A (ja) | 2013-03-15 | 2021-10-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2023203590A Pending JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019159491A Active JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2021162946A Pending JP2022023092A (ja) | 2013-03-15 | 2021-10-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2023203590A Pending JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20160030490A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4292600A3 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6581966B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR20230058556A (cg-RX-API-DMAC7.html) |
| CN (2) | CN118995611A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2014233403B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3177943A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2970903T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2970720T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI2970903T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1222205A1 (cg-RX-API-DMAC7.html) |
| IL (5) | IL294897B2 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2970903T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014145108A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11241460B2 (en) | 2013-03-15 | 2022-02-08 | Astellas Institute For Regenerative Medicine | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| CN118995611A (zh) | 2013-03-15 | 2024-11-22 | 安斯泰来再生医药协会 | 由多能干细胞产生的光感受器和光感受器祖细胞 |
| SG10201907918VA (en) | 2015-03-23 | 2019-10-30 | Astellas Inst For Regenerative Medicine | Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors |
| US20160331867A1 (en) * | 2015-05-13 | 2016-11-17 | Taipei Veterans General Hospital | Multilayered retinal cell implant |
| KR102651291B1 (ko) | 2015-08-18 | 2024-03-26 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 임상 제제 |
| CN108350421A (zh) | 2015-09-08 | 2018-07-31 | 大日本住友制药株式会社 | 用于制备视网膜色素上皮细胞的方法 |
| CN105567635A (zh) * | 2016-02-21 | 2016-05-11 | 中国医科大学附属第一医院 | 一种改良的Neurobasal B27培养基、制备方法及应用 |
| US11920155B2 (en) | 2016-03-30 | 2024-03-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| WO2018149985A1 (en) * | 2017-02-17 | 2018-08-23 | Sorbonne Universite | Feeder-free methods for obtaining retinal progenitors, retinal pigmented epithelial cells and neural retinal cells |
| GB201703058D0 (en) * | 2017-02-24 | 2017-04-12 | Ucl Business Plc | Biomarkers |
| EP3594322A4 (en) | 2017-03-08 | 2021-01-27 | Sumitomo Dainippon Pharma Co., Ltd. | RETINAL PIGMENTARY EPITHELIAL CELL PRODUCTION PROCESS |
| CA3075877A1 (en) | 2017-09-14 | 2019-03-21 | Riken | Method for producing retinal tissues |
| CN111094548A (zh) * | 2017-09-14 | 2020-05-01 | 国立研究开发法人理化学研究所 | 基于背侧化信号转导物质或腹侧化信号转导物质的增加视锥细胞或视杆细胞的方法 |
| WO2019078781A1 (en) | 2017-10-17 | 2019-04-25 | National University Of Singapore | SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS |
| EP3781675A1 (en) | 2018-04-20 | 2021-02-24 | FUJIFILM Cellular Dynamics, Inc. | Method for differentiation of ocular cells and use thereof |
| CN108795864B (zh) * | 2018-05-24 | 2021-08-24 | 中山大学中山眼科中心 | 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法 |
| KR20210058872A (ko) * | 2018-09-07 | 2021-05-24 | 헤베셀 코포레이션 | 담체 무함유 3d 구체 현탁 배양에서 망막 뉴런 생성을 위한 방법 및 조성물 |
| JP7569089B2 (ja) * | 2018-09-19 | 2024-10-17 | リネージ セル セラピューティクス インコーポレイテッド | 動的懸濁培養において多能性幹細胞を分化させるための方法 |
| CN109486766B (zh) * | 2018-11-26 | 2021-05-07 | 中山大学 | 一种泪腺干细胞、泪腺干细胞的培养体系和培养方法 |
| CN113474451B (zh) | 2019-01-23 | 2025-06-10 | 阿斯特里亚斯生物疗法股份有限公司 | 来自人多能干细胞的背源性少突胶质祖细胞 |
| WO2021243256A1 (en) * | 2020-05-29 | 2021-12-02 | FUJIFILM Cellular Dynamics, Inc. | Retinal pigmented epithelium and photoreceptor dual cell aggregates and methods of use thereof |
| PH12022553083A1 (en) * | 2020-05-29 | 2024-03-25 | Fujifilm Cellular Dynamics Inc | Bilayer of retinal pigmented epithelium and photoreceptors and use thereof |
| WO2022134031A1 (zh) * | 2020-12-25 | 2022-06-30 | 武汉睿健医药科技有限公司 | 一种光感受器神经元细胞的化学诱导方法 |
| CN112608883B (zh) * | 2020-12-25 | 2023-02-24 | 武汉睿健医药科技有限公司 | 一种光感受器神经元细胞的化学诱导方法 |
| KR102525093B1 (ko) * | 2021-04-16 | 2023-04-27 | 가톨릭대학교 산학협력단 | 사람 신경능 유래 코 하비갑개 줄기세포를 유효성분으로 포함하는 망막변성질환 예방 또는 치료용 약학적 조성물 |
| CN113388582A (zh) * | 2021-06-21 | 2021-09-14 | 香港再生医学有限公司 | 促使iPSC分化为外周神经干细胞的方法及培养基和系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| EP4248752A3 (en) | 2004-01-23 | 2024-01-03 | President And Fellows Of Harvard College | Improved modalities for the treatment of degenerative diseases of the retina |
| CA2583473A1 (en) * | 2004-10-05 | 2007-04-04 | University Of Georgia Research Foundation, Inc. | Neuronal progenitors from feeder-free human embryonic stem cell culture |
| US7541186B2 (en) | 2006-02-22 | 2009-06-02 | University Of Washington | Method of generating human retinal progenitors from embryonic stem cells |
| WO2008045952A2 (en) * | 2006-10-10 | 2008-04-17 | The Regents Of The University Of Michigan | Photoreceptor precursor cells |
| US9133435B2 (en) * | 2007-01-18 | 2015-09-15 | Riken | Method for induction/differentiation into photoreceptor cell |
| WO2011028524A1 (en) * | 2009-08-24 | 2011-03-10 | Wisconsin Alumni Research Foundation | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| EP2486126B1 (en) | 2009-10-06 | 2017-12-06 | SNU R & DB Foundation | Method for differentiation into retinal cells from stem cells |
| CN111265551A (zh) | 2011-05-18 | 2020-06-12 | 加利福尼亚大学董事会 | 用于治疗视网膜疾病的组合物及方法 |
| US9458428B2 (en) * | 2012-06-05 | 2016-10-04 | The Regents Of The University Of California | Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells |
| US20160175361A1 (en) | 2014-03-14 | 2016-06-23 | Advanced Cell Technology, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| US20160175362A1 (en) | 2014-03-14 | 2016-06-23 | Ocata Therapeutics, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| CN118995611A (zh) | 2013-03-15 | 2024-11-22 | 安斯泰来再生医药协会 | 由多能干细胞产生的光感受器和光感受器祖细胞 |
-
2014
- 2014-03-14 CN CN202411157822.0A patent/CN118995611A/zh active Pending
- 2014-03-14 PT PT147648257T patent/PT2970903T/pt unknown
- 2014-03-14 KR KR1020237013967A patent/KR20230058556A/ko active Pending
- 2014-03-14 WO PCT/US2014/029790 patent/WO2014145108A1/en not_active Ceased
- 2014-03-14 KR KR1020157029814A patent/KR102263956B1/ko active Active
- 2014-03-14 IL IL294897A patent/IL294897B2/en unknown
- 2014-03-14 JP JP2016503223A patent/JP6581966B2/ja active Active
- 2014-03-14 KR KR1020217017223A patent/KR102527507B1/ko active Active
- 2014-03-14 US US14/774,771 patent/US20160030490A1/en not_active Abandoned
- 2014-03-14 AU AU2014233403A patent/AU2014233403B2/en active Active
- 2014-03-14 HK HK16110477.3A patent/HK1222205A1/zh unknown
- 2014-03-14 CA CA3177943A patent/CA3177943A1/en active Pending
- 2014-03-14 DK DK14764825.7T patent/DK2970903T3/da active
- 2014-03-14 IL IL307568A patent/IL307568A/en unknown
- 2014-03-14 ES ES14764825T patent/ES2970720T3/es active Active
- 2014-03-14 US US14/214,598 patent/US10307444B2/en active Active
- 2014-03-14 CN CN201480022584.0A patent/CN105378070A/zh active Pending
- 2014-03-14 CA CA2906815A patent/CA2906815A1/en active Pending
- 2014-03-14 EP EP23192245.1A patent/EP4292600A3/en active Pending
- 2014-03-14 FI FIEP14764825.7T patent/FI2970903T3/fi active
- 2014-03-14 EP EP14764825.7A patent/EP2970903B1/en active Active
-
2015
- 2015-09-03 IL IL241177A patent/IL241177B/en active IP Right Grant
-
2019
- 2019-02-25 US US16/284,565 patent/US20190290701A1/en not_active Abandoned
- 2019-03-27 US US16/367,045 patent/US20190321414A1/en not_active Abandoned
- 2019-05-21 IL IL266775A patent/IL266775B/en active IP Right Grant
- 2019-09-02 JP JP2019159491A patent/JP7245752B2/ja active Active
- 2019-10-24 AU AU2019253874A patent/AU2019253874A1/en not_active Abandoned
-
2020
- 2020-07-20 IL IL276173A patent/IL276173B2/en unknown
-
2021
- 2021-10-01 JP JP2021162946A patent/JP2022023092A/ja active Pending
-
2022
- 2022-03-22 AU AU2022201986A patent/AU2022201986B2/en active Active
- 2022-04-13 US US17/719,473 patent/US20220347228A1/en active Pending
-
2023
- 2023-12-01 JP JP2023203590A patent/JP2024053564A/ja active Pending
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