|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4704362A
(en)
|
1977-11-08 |
1987-11-03 |
Genentech, Inc. |
Recombinant cloning vehicle microbial polypeptide expression
|
|
US4394448A
(en)
|
1978-02-24 |
1983-07-19 |
Szoka Jr Francis C |
Method of inserting DNA into living cells
|
|
US4391904A
(en)
|
1979-12-26 |
1983-07-05 |
Syva Company |
Test strip kits in immunoassays and compositions therein
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4554101A
(en)
|
1981-01-09 |
1985-11-19 |
New York Blood Center, Inc. |
Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
|
|
US4489710A
(en)
|
1981-06-23 |
1984-12-25 |
Xoma Corporation |
Composition and method for transplantation therapy
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
US4766075A
(en)
|
1982-07-14 |
1988-08-23 |
Genentech, Inc. |
Human tissue plasminogen activator
|
|
US5186941A
(en)
|
1983-05-06 |
1993-02-16 |
Vestar, Inc. |
Vesicle formulation for the controlled release of therapeutic agents
|
|
US4625014A
(en)
|
1984-07-10 |
1986-11-25 |
Dana-Farber Cancer Institute, Inc. |
Cell-delivery agent
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4801542A
(en)
|
1984-10-12 |
1989-01-31 |
Zymogenetics, Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
US4638045A
(en)
|
1985-02-19 |
1987-01-20 |
Massachusetts Institute Of Technology |
Non-peptide polyamino acid bioerodible polymers
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
US4935349A
(en)
|
1986-01-17 |
1990-06-19 |
Zymogenetics, Inc. |
Expression of higher eucaryotic genes in aspergillus
|
|
GB2188637B
(en)
|
1986-02-07 |
1990-11-14 |
Oncogen |
Vaccines against melanoma
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4873192A
(en)
|
1987-02-17 |
1989-10-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Process for site specific mutagenesis without phenotypic selection
|
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US4866042A
(en)
|
1987-11-18 |
1989-09-12 |
Neuwelt Edward A |
Method for the delivery of genetic material across the blood brain barrier
|
|
US5720937A
(en)
|
1988-01-12 |
1998-02-24 |
Genentech, Inc. |
In vivo tumor detection assay
|
|
JP3040121B2
(ja)
|
1988-01-12 |
2000-05-08 |
ジェネンテク，インコーポレイテッド |
増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
|
|
DE3815826A1
(de)
|
1988-05-09 |
1989-11-23 |
Henkel Kgaa |
Verfahren zur herstellung von vicinal diacyloxysubstituierten verbindungen
|
|
US5470829A
(en)
|
1988-11-17 |
1995-11-28 |
Prisell; Per |
Pharmaceutical preparation
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5089261A
(en)
|
1989-01-23 |
1992-02-18 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
ES2136595T5
(es)
|
1989-04-19 |
2004-04-01 |
Enzon, Inc. |
Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos.
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
IL90193A
(en)
|
1989-05-04 |
1993-02-21 |
Biomedical Polymers Int |
Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
|
|
US5672683A
(en)
|
1989-09-07 |
1997-09-30 |
Alkermes, Inc. |
Transferrin neuropharmaceutical agent fusion protein
|
|
US6018031A
(en)
|
1989-10-20 |
2000-01-25 |
Trustees Of Dartmouth College |
Binding agents specific for IgA receptor
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5312808A
(en)
|
1989-11-22 |
1994-05-17 |
Enzon, Inc. |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
|
|
US5650388A
(en)
|
1989-11-22 |
1997-07-22 |
Enzon, Inc. |
Fractionated polyalkylene oxide-conjugated hemoglobin solutions
|
|
NL194941C
(nl)
|
1990-02-15 |
2003-08-04 |
Cordis Corp |
Werkwijze voor het aanbrengen van een fysiologisch actieve verbinding op een substraatoppervlak.
|
|
US5275838A
(en)
|
1990-02-28 |
1994-01-04 |
Massachusetts Institute Of Technology |
Immobilized polyethylene oxide star molecules for bioapplications
|
|
US5171264A
(en)
|
1990-02-28 |
1992-12-15 |
Massachusetts Institute Of Technology |
Immobilized polyethylene oxide star molecules for bioapplications
|
|
US5219564A
(en)
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
US5965695A
(en)
|
1990-05-15 |
1999-10-12 |
Chiron Corporation |
Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
|
|
WO1992000748A1
(en)
|
1990-07-06 |
1992-01-23 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
FR2672053B1
(fr)
|
1991-01-30 |
1993-04-23 |
Atochem |
Polyether bloc amides, leur procede de synthese.
|
|
FR2673946B1
(fr)
|
1991-03-15 |
1993-05-28 |
Atochem |
Polyether bloc amides, leur procede de synthese.
|
|
JPH06506217A
(ja)
|
1991-03-18 |
1994-07-14 |
エンゾン，インコーポレーテッド |
ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
US5932211A
(en)
|
1991-11-12 |
1999-08-03 |
Women's And Children's Hospital |
Glycosylation variants of iduronate 2-sulfatase
|
|
ATE207080T1
(de)
|
1991-11-25 |
2001-11-15 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
AU660534B2
(en)
|
1992-02-13 |
1995-06-29 |
Novo Nordisk A/S |
Polyethylene or polypropylene glycol containing polymer
|
|
AU4553793A
(en)
|
1992-07-10 |
1994-01-31 |
University Of British Columbia, The |
Use of p97 and iron binding proteins as diagnostic and therapeutic agents
|
|
US20020119095A1
(en)
|
1992-07-10 |
2002-08-29 |
Reinhard Gabathuler |
Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours
|
|
US5981194A
(en)
|
1992-07-10 |
1999-11-09 |
University Of British Columbia |
Use of p97 and iron binding proteins as diagnostic and therapeutic agents
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
AU5006993A
(en)
|
1992-08-21 |
1994-03-15 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5614549A
(en)
|
1992-08-21 |
1997-03-25 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
ES2156149T3
(es)
|
1992-12-04 |
2001-06-16 |
Medical Res Council |
Proteinas de union multivalente y multiespecificas, su fabricacion y su uso.
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5321095A
(en)
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
|
ES2162863T3
(es)
|
1993-04-29 |
2002-01-16 |
Unilever Nv |
Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
|
|
AU7109494A
(en)
|
1993-06-16 |
1995-01-03 |
Enzon, Inc. |
Conjugated biodhesives
|
|
US5965566A
(en)
|
1993-10-20 |
1999-10-12 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5880131A
(en)
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5840900A
(en)
|
1993-10-20 |
1998-11-24 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5605976A
(en)
|
1995-05-15 |
1997-02-25 |
Enzon, Inc. |
Method of preparing polyalkylene oxide carboxylic acids
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5618528A
(en)
|
1994-02-28 |
1997-04-08 |
Sterling Winthrop Inc. |
Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
|
|
PT699237E
(pt)
|
1994-03-17 |
2003-07-31 |
Merck Patent Gmbh |
Fvs de cadeia anti-egfr e anticorpos anti-egfr
|
|
AU2826495A
(en)
|
1994-06-02 |
1996-01-04 |
Enzon, Inc. |
Method of solubilizing substantially water insoluble materials
|
|
US5730990A
(en)
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US6169073B1
(en)
|
1995-02-16 |
2001-01-02 |
Bayer Corporation |
Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function
|
|
US5756593A
(en)
|
1995-05-15 |
1998-05-26 |
Enzon, Inc. |
Method of preparing polyalkyene oxide carboxylic acids
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
CA2226299A1
(en)
|
1995-08-11 |
1997-02-27 |
Dendritech, Inc. |
Hyper comb-branched polymer conjugates
|
|
WO1997022371A1
(en)
|
1995-12-18 |
1997-06-26 |
Collagen Corporation |
Crosslinked polymer compositions and methods for their use
|
|
EP0964702B1
(en)
|
1996-08-02 |
2006-10-04 |
Ortho-McNeil Pharmaceutical, Inc. |
Polypeptides having a single covalently bound n-terminal water-soluble polymer
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
EP0979102A4
(en)
|
1997-04-30 |
2005-11-23 |
Enzon Inc |
DETAILED POLYPEPTIDE MODIFIED BY POLYALKYLENE OXIDE
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
US6011042A
(en)
|
1997-10-10 |
2000-01-04 |
Enzon, Inc. |
Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
|
|
US6111107A
(en)
|
1997-11-20 |
2000-08-29 |
Enzon, Inc. |
High yield method for stereoselective acylation of tertiary alcohols
|
|
TW492882B
(en)
|
1997-11-28 |
2002-07-01 |
Caleb Pharmaceuticals Inc |
Cholinergic antagonist plaster composition
|
|
WO1999030727A1
(en)
|
1997-12-17 |
1999-06-24 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
|
US6180095B1
(en)
|
1997-12-17 |
2001-01-30 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US5965119A
(en)
|
1997-12-30 |
1999-10-12 |
Enzon, Inc. |
Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
|
|
JP4078032B2
(ja)
|
1998-03-12 |
2008-04-23 |
ネクター セラピューティックス エイエル，コーポレイション |
近位の反応性基を持つポリ（エチレングリコール）誘導体
|
|
US6153655A
(en)
|
1998-04-17 |
2000-11-28 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
|
US6419934B1
(en)
|
1999-02-24 |
2002-07-16 |
Edward L. Tobinick |
TNF modulators for treating neurological disorders associated with viral infection
|
|
US6015557A
(en)
|
1999-02-24 |
2000-01-18 |
Tobinick; Edward L. |
Tumor necrosis factor antagonists for the treatment of neurological disorders
|
|
US6419944B2
(en)
|
1999-02-24 |
2002-07-16 |
Edward L. Tobinick |
Cytokine antagonists for the treatment of localized disorders
|
|
US6982089B2
(en)
|
1999-02-24 |
2006-01-03 |
Tact Ip, Llc |
Cytokine antagonists for neurological and neuropsychiatric disorders
|
|
US6177077B1
(en)
|
1999-02-24 |
2001-01-23 |
Edward L. Tobinick |
TNT inhibitors for the treatment of neurological disorders
|
|
US7214658B2
(en)
|
2004-07-06 |
2007-05-08 |
Tact Ip, Llc |
Method of delivering a TNF antagonist to the brain of a human by perispinal administration without direct intrathecal injection
|
|
US6537549B2
(en)
|
1999-02-24 |
2003-03-25 |
Edward L. Tobinick |
Cytokine antagonists for the treatment of localized disorders
|
|
US6507788B1
(en)
*
|
1999-02-25 |
2003-01-14 |
Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) |
Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function
|
|
US6387620B1
(en)
|
1999-07-28 |
2002-05-14 |
Gilead Sciences, Inc. |
Transcription-free selex
|
|
US6534300B1
(en)
|
1999-09-14 |
2003-03-18 |
Genzyme Glycobiology Research Institute, Inc. |
Methods for producing highly phosphorylated lysosomal hydrolases
|
|
DK1455839T3
(da)
|
1999-10-08 |
2013-05-06 |
Nektar Therapeutics |
Heterobifunktioneller poly(ethylenglycol)-derivater og fremgangsmåder til fremstilling heraf
|
|
JP2003525038A
(ja)
|
2000-02-08 |
2003-08-26 |
ユニバーシティー オブ ブリティッシュ コロンビア |
治療薬をスクリーニングするための組成物および方法
|
|
US6261595B1
(en)
|
2000-02-29 |
2001-07-17 |
Zars, Inc. |
Transdermal drug patch with attached pocket for controlled heating device
|
|
AU2001289284A1
(en)
|
2000-04-04 |
2001-10-15 |
Enanta Pharmaceuticals, Inc. |
Methods for identifying peptide aptamers capable of altering a cell phenotype
|
|
WO2001083722A2
(en)
|
2000-05-01 |
2001-11-08 |
Biomarin Pharmaceuticals |
Enzymes useful for treating and methods for treating mps-vi and cells lines for producing such enzymes recombinantly
|
|
AU2001283740A1
(en)
|
2000-08-17 |
2002-02-25 |
University Of British Columbia |
Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours
|
|
AU2001285020A1
(en)
|
2000-08-17 |
2002-02-25 |
Synapse Technologies, Inc. |
P97-active agent conjugates and their methods of use
|
|
US6376190B1
(en)
|
2000-09-22 |
2002-04-23 |
Somalogic, Inc. |
Modified SELEX processes without purified protein
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US7132511B2
(en)
|
2001-02-19 |
2006-11-07 |
Merck Patent Gmbh |
Modified anti-EGFR antibodies with reduced immunogenicity
|
|
US7595378B2
(en)
|
2001-06-13 |
2009-09-29 |
Genmab A/S |
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
|
|
CA2450285C
(en)
|
2001-06-13 |
2016-08-02 |
Genmab A/S |
Human monoclonal antibodies to epidermal growth factor receptor (egfr)
|
|
AU2002322720B2
(en)
|
2001-07-25 |
2008-11-13 |
Raptor Pharmaceutical Inc. |
Compositions and methods for modulating blood-brain barrier transport
|
|
US7179617B2
(en)
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
|
ES2411007T3
(es)
|
2001-10-10 |
2013-07-04 |
Novo Nordisk A/S |
Remodelación y glicoconjugación de péptidos
|
|
US20030072761A1
(en)
|
2001-10-16 |
2003-04-17 |
Lebowitz Jonathan |
Methods and compositions for targeting proteins across the blood brain barrier
|
|
WO2003057179A2
(en)
|
2002-01-11 |
2003-07-17 |
Biomarin Pharmaceutical, Inc. |
Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
|
|
US7244592B2
(en)
|
2002-03-07 |
2007-07-17 |
Dyax Corp. |
Ligand screening and discovery
|
|
WO2004060403A2
(en)
*
|
2003-01-06 |
2004-07-22 |
Angiochem Inc. |
Aprotinin and anglos as carriers across the blood-brain barrier
|
|
WO2004078215A2
(en)
|
2003-02-28 |
2004-09-16 |
The Board Of Trustees Of The University Of Illinois |
Use of antibody conjugated deoxycytidine kinase for adept
|
|
AU2003286870A1
(en)
|
2003-06-05 |
2005-01-04 |
Salk Institute For Biological Studies |
Targeting polypeptides to the central nervous system
|
|
US20050026823A1
(en)
|
2003-06-20 |
2005-02-03 |
Biomarin Pharmaceutical Inc. |
Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
|
|
CA2542099A1
(en)
|
2003-10-11 |
2005-04-21 |
Inex Pharmaceuticals Corporation |
Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
|
|
DE10355904A1
(de)
|
2003-11-29 |
2005-06-30 |
Merck Patent Gmbh |
Feste Formen von anti-EGFR-Antikörpern
|
|
US20080014188A1
(en)
|
2004-02-06 |
2008-01-17 |
Zankel Todd C |
Manufacture of Highly Phosphorylated Lysosomal Enzymes and Uses Thereof
|
|
MX2007002433A
(es)
*
|
2004-09-01 |
2007-05-04 |
Astrazeneca Ab |
Derivados de quinazolinona y su uso como inhibidores de b-raf.
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
US8236306B2
(en)
|
2004-12-18 |
2012-08-07 |
Edward Lewis Tobinick |
Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers
|
|
AU2005325801A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
US7842467B1
(en)
|
2005-05-12 |
2010-11-30 |
Celera Corporation |
Breast disease targets and uses thereof
|
|
DK1951759T3
(da)
|
2005-11-12 |
2010-05-10 |
Lilly Co Eli |
Anti-EGFR-antistoffer
|
|
CA2631184A1
(en)
|
2005-11-28 |
2007-05-31 |
Genmab A/S |
Recombinant monovalent antibodies and methods for production thereof
|
|
US7498142B2
(en)
|
2006-01-31 |
2009-03-03 |
Yeda Research And Development Co., Ltd. |
Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
|
|
US8759297B2
(en)
|
2006-08-18 |
2014-06-24 |
Armagen Technologies, Inc. |
Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
PL2308514T3
(pl)
|
2007-03-23 |
2013-11-29 |
To Bbb Holding B V |
Koniugaty do ukierunkowanego dostarczania leku poprzez barierę krew-mózg
|
|
US9365634B2
(en)
|
2007-05-29 |
2016-06-14 |
Angiochem Inc. |
Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
|
|
WO2009019314A1
(en)
|
2007-08-08 |
2009-02-12 |
Novozymes A/S |
Transferrin variants and conjugates
|
|
DK2644194T3
(en)
|
2008-03-18 |
2017-07-03 |
Genentech Inc |
Combinations of an anti-HER2 antibody-drug conjugate and docetaxel
|
|
EP2123258A1
(en)
*
|
2008-05-23 |
2009-11-25 |
Liplasome Pharma A/S |
Liposomes for drug delivery
|
|
EP2216341A1
(en)
*
|
2009-02-10 |
2010-08-11 |
Novozymes Biopharma UK Limited |
Transferrin variants and conjugates
|
|
EP2485761B1
(en)
|
2009-10-09 |
2019-02-27 |
Armagen, Inc. |
Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
|
|
CA2796722C
(en)
|
2010-04-19 |
2021-06-01 |
Nlife Therapeutics, S.L. |
Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
|
|
FR2959229B1
(fr)
|
2010-04-21 |
2013-01-18 |
Vect Horus |
Derives peptidiques, leur preparation et leurs utilisations
|
|
KR20230159646A
(ko)
|
2010-06-25 |
2023-11-21 |
샤이어 휴먼 지네틱 테라피즈 인크. |
이듀로네이트-2-설파타제의 cns 전달을 위한 방법들 및 조성물들
|
|
LT2588130T
(lt)
|
2010-06-25 |
2016-12-12 |
Shire Human Genetic Therapies, Inc. |
Terapinės priemonės pristatymas cns
|
|
US20130236442A1
(en)
|
2010-11-12 |
2013-09-12 |
Green Cross Corporation |
Iduronate-2-sulfatase and use thereof
|
|
CN103747807B
(zh)
|
2011-07-05 |
2016-12-07 |
比奥阿赛斯技术有限公司 |
P97‑抗体缀合物和使用方法
|
|
AU2012294673B2
(en)
|
2011-08-05 |
2015-11-26 |
Bioasis Technologies Inc. |
p97 fragments with transfer activity
|
|
WO2013164689A2
(en)
|
2012-05-02 |
2013-11-07 |
Lantto, Johan |
Humanized pan-her antibody compositions
|
|
US20140004097A1
(en)
|
2012-06-29 |
2014-01-02 |
Shire Human Genetic Therapies, Inc. |
Method of producing recombinant iduronate-2-sulfatase
|
|
CA3140358A1
(en)
|
2012-07-31 |
2014-02-06 |
Bioasis Technologies, Inc. |
Dephosphorylated lysosomal storage disease proteins and methods of use thereof
|
|
US8753426B2
(en)
|
2012-08-03 |
2014-06-17 |
Air Products And Chemicals, Inc. |
Polymers, polymer membranes and methods of producing the same
|
|
AU2013336582A1
(en)
|
2012-10-26 |
2015-06-11 |
Nlife Therapeutics, S.L. |
Compositions and methods for selective delivery of oligonucleotide molecules to cell types
|
|
GB201303308D0
(en)
|
2013-02-25 |
2013-04-10 |
Oxford Biotherapeutics Ltd |
Therapeutic and diagnostic target
|
|
AU2014243816B2
(en)
|
2013-03-13 |
2019-01-31 |
Bioasis Technologies Inc. |
Fragments of p97 and uses thereof
|
|
US20150093399A1
(en)
|
2013-08-28 |
2015-04-02 |
Bioasis Technologies, Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
|
US9209965B2
(en)
|
2014-01-14 |
2015-12-08 |
Microsemi Semiconductor Ulc |
Network interface with clock recovery module on line card
|
|
JP6603227B2
(ja)
|
2014-02-03 |
2019-11-06 |
バイオアシス テクノロジーズ インコーポレイテッド |
Ｐ９７融合タンパク質
|
|
DK3107562T3
(da)
|
2014-02-19 |
2019-12-16 |
Bioasis Technologies Inc |
P97-ids-fusionsproteiner
|
|
AU2015252906C1
(en)
|
2014-05-01 |
2020-09-17 |
Bioasis Technologies Inc. |
p97-polynucleotide conjugates
|
|
WO2017123928A1
(en)
|
2016-01-13 |
2017-07-20 |
Bioasis Technologies, Inc. |
Blood-brain barrier vector compounds and conjugates thereof
|