JP2016515119A5 - - Google Patents
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- JP2016515119A5 JP2016515119A5 JP2016502036A JP2016502036A JP2016515119A5 JP 2016515119 A5 JP2016515119 A5 JP 2016515119A5 JP 2016502036 A JP2016502036 A JP 2016502036A JP 2016502036 A JP2016502036 A JP 2016502036A JP 2016515119 A5 JP2016515119 A5 JP 2016515119A5
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- JP
- Japan
- Prior art keywords
- substituted
- ester
- pharmaceutically acceptable
- prodrug
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361783695P | 2013-03-14 | 2013-03-14 | |
| US61/783,695 | 2013-03-14 | ||
| PCT/US2014/026042 WO2014160203A2 (en) | 2013-03-14 | 2014-03-13 | Bmp inhibitors and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515119A JP2016515119A (ja) | 2016-05-26 |
| JP2016515119A5 true JP2016515119A5 (https=) | 2017-04-13 |
| JP6542192B2 JP6542192B2 (ja) | 2019-07-10 |
Family
ID=51625632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502036A Active JP6542192B2 (ja) | 2013-03-14 | 2014-03-13 | Ｂｍｐ阻害剤およびその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9682983B2 (https=) |
| EP (1) | EP2970311A4 (https=) |
| JP (1) | JP6542192B2 (https=) |
| WO (1) | WO2014160203A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5638961B2 (ja) | 2008-03-13 | 2014-12-10 | ザ ジェネラル ホスピタル コーポレイション | Ｂｍｐシグナル伝達経路のインヒビター |
| EP4066826B1 (en) | 2010-09-01 | 2024-03-06 | Thomas Jefferson University | Retinoic acid receptor gamma agonists for muscle repair and regeneration |
| KR102092988B1 (ko) | 2012-09-28 | 2020-03-25 | 벤더르빌트 유니버시티 | 선택성 bmp 저해제로써 융합된 헤테로 고리 화합물들 |
| US9682983B2 (en) | 2013-03-14 | 2017-06-20 | The Brigham And Women's Hospital, Inc. | BMP inhibitors and methods of use thereof |
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| WO2016011019A1 (en) * | 2014-07-15 | 2016-01-21 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| ES2849951T3 (es) | 2015-06-18 | 2021-08-24 | 89Bio Ltd | Derivados de piperidina 4-bencil y 4-benzoil sustituidos |
| EA201890086A1 (ru) * | 2015-06-18 | 2018-06-29 | Сефалон, Инк. | 1,4-замещенные производные пиперидина |
| SG11201810658PA (en) | 2016-06-08 | 2018-12-28 | Clementia Pharmaceuticals Inc | Methods for treating heterotopic ossification |
| US10710980B2 (en) | 2016-07-20 | 2020-07-14 | Novartis Ag | Aminopyridine derivatives and their use as selective ALK-2 inhibitors |
| MX379489B (es) | 2016-11-16 | 2025-03-11 | Clementia Pharmaceuticals Inc | Metodos para tratar la osteocondromatosis multiple (mo). |
| WO2018165569A1 (en) * | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Therapeutic compounds and methods |
| IL251949A0 (en) * | 2017-04-26 | 2017-07-31 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | Small organic molecules for use in the treatment of neuro-inflammatory diseases |
| WO2018200855A1 (en) | 2017-04-27 | 2018-11-01 | The Brigham And Women's Hospital, Inc. | Novel alk2 inhibitors and methods for inhibiting bmp signaling |
| US10875861B1 (en) | 2017-05-26 | 2020-12-29 | Rutgers, The State University Of New Jersey | Therapeutic compounds |
| WO2019178383A1 (en) | 2018-03-14 | 2019-09-19 | Vanderbilt University | Inhibition of bmp signaling, compounds, compositions and uses thereof |
| CN108586464A (zh) * | 2018-04-12 | 2018-09-28 | 苏州康润医药有限公司 | 一种3-溴吡唑并[1,5-α]嘧啶-6-甲酸的合成方法 |
| JP7504880B2 (ja) * | 2018-10-26 | 2024-06-24 | ケロス セラピューティクス インコーポレイテッド | Ａｌｋ２阻害剤の結晶形 |
| JP7541924B2 (ja) | 2018-10-31 | 2024-08-29 | 千寿製薬株式会社 | 網膜神経節細胞死抑制剤 |
| US12215106B2 (en) | 2018-11-27 | 2025-02-04 | Rutgers, The State University Of New Jersey | Pharmaceutical compounds and therapeutic methods |
| CA3124088A1 (en) | 2018-12-20 | 2020-06-25 | Incyte Corporation | Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2 |
| CN114761013A (zh) | 2019-09-27 | 2022-07-15 | 迪斯克医药公司 | 治疗骨髓纤维化和相关病症的方法 |
| US12508262B2 (en) | 2020-04-30 | 2025-12-30 | Keros Therapeutics, Inc. | Methods of using ALK2 inhibitors |
| WO2021231798A1 (en) | 2020-05-13 | 2021-11-18 | Disc Medicine, Inc. | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| CN115956081A (zh) | 2020-06-12 | 2023-04-11 | 因赛特公司 | 具有作为alk2抑制剂的活性的咪唑并哒嗪化合物 |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| CN121318983B (zh) * | 2025-12-15 | 2026-04-14 | 首都医科大学附属北京胸科医院 | 6-芳基取代的吡唑并[1,5-a]嘧啶类化合物及其制备和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7478298A (en) | 1997-05-16 | 1998-12-08 | Procter & Gamble Company, The | The use of a bone morphogenetic protein (bmp) receptor complex for screening |
| US6235741B1 (en) | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
| CA2291709A1 (en) | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6245759B1 (en) * | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US20020041880A1 (en) | 2000-07-05 | 2002-04-11 | Defeo-Jones Deborah | Method of treating cancer |
| AU2003298942A1 (en) | 2002-12-11 | 2004-06-30 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
| EP1632249A4 (en) | 2003-06-05 | 2007-12-26 | Nippon Shinyaku Co Ltd | OSTEOGENESIS PROMOTION AMPLIFIER AND SCREENING METHOD THEREFOR |
| ATE410169T1 (de) | 2004-03-29 | 2008-10-15 | Sod Conseils Rech Applic | Verwendung eines phenothiazin-derivats zur prävention und/oder behandlung von gerhörverlust |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| RU2285532C2 (ru) | 2004-10-28 | 2006-10-20 | Общество с ограниченной ответственностью "Научно-производственное объединение "Фарматрон" (НПО "Фарматрон") | Способ коррекции токсических поражений, вызванных доксорубицином |
| ATE482213T1 (de) * | 2004-11-04 | 2010-10-15 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine |
| CN101321760A (zh) | 2005-10-06 | 2008-12-10 | 先灵公司 | 作为蛋白激酶抑制剂的吡唑并嘧啶 |
| GB0601638D0 (en) | 2006-01-27 | 2006-03-08 | Merck Sharp & Dohme | Therapeutic treatment |
| ES2336625T3 (es) | 2006-03-22 | 2010-04-14 | Vertex Pharmaceuticals Incorporated | Inhibidores de la proteina quinasa c-met para el tratamiento de trastornos proliferativos. |
| BRPI0714409A2 (pt) | 2006-07-14 | 2013-03-12 | Novartis Ag | derivados de pirimidina como inibidores de alk-5 |
| EP1900727A1 (en) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Aminopyridine derivatives as kinase inhibitors |
| WO2008033408A2 (en) * | 2006-09-12 | 2008-03-20 | The General Hospital Corporation | Methods for identifying compounds that modulate cell signaling and methods employing such compounds |
| US8073681B2 (en) | 2006-10-16 | 2011-12-06 | Voicebox Technologies, Inc. | System and method for a cooperative conversational voice user interface |
| GB0625659D0 (en) | 2006-12-21 | 2007-01-31 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| PT2146721E (pt) | 2007-05-15 | 2013-07-18 | Otsuka Pharma Co Ltd | Métodos de utilização de antagonistas da vasopressina com agentes quimioterapeuticos de antraciclina para reduzir a cardiotoxicidade e/ou melhorar a sobrevivência |
| AU2008287542C1 (en) | 2007-06-01 | 2015-01-22 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
| ATE523508T1 (de) | 2007-10-25 | 2011-09-15 | Astrazeneca Ab | Für die behandlung von zellproliferativen erkrankungen geeignete pyridin- und pyrazinderivate |
| MX2010007604A (es) | 2008-01-11 | 2010-08-02 | Novartis Ag | Pirimidinas como inhibidores de cinasa. |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| WO2009099982A1 (en) | 2008-02-04 | 2009-08-13 | Osi Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
| JP5638961B2 (ja) * | 2008-03-13 | 2014-12-10 | ザ ジェネラル ホスピタル コーポレイション | Ｂｍｐシグナル伝達経路のインヒビター |
| US8278105B2 (en) | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| WO2010088735A1 (en) | 2009-02-05 | 2010-08-12 | Regenertech Pty Ltd | Method of producing progenitor cells from differentiated cells |
| EP2453882A1 (en) * | 2009-07-14 | 2012-05-23 | Beth Israel Deaconess Medical Center, Inc. | Methods of increasing liver proliferation |
| WO2012100229A2 (en) | 2011-01-21 | 2012-07-26 | The General Hospital Corporation | Compositions and methods for cardiovascular disease |
| WO2012115120A1 (ja) * | 2011-02-21 | 2012-08-30 | 国立大学法人 大阪大学 | ５－ｈｔ神経細胞の製造方法 |
| US9505763B2 (en) * | 2011-07-25 | 2016-11-29 | Vanderbilt University | Cancer treatment using BMP inhibitor |
| TWI462914B (zh) | 2011-09-15 | 2014-12-01 | Hoffmann La Roche | 新穎二氫喹啉－２－酮衍生物 |
| KR20130055216A (ko) | 2011-11-18 | 2013-05-28 | 롬엔드하스전자재료코리아유한회사 | 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자 |
| AU2014211856C1 (en) | 2013-02-02 | 2018-04-12 | Centaurus Biopharma Co., Ltd. | Substituted 2-aminopyridine protein kinase inhibitor |
| WO2014138088A1 (en) | 2013-03-04 | 2014-09-12 | The Brigham And Women's Hospital, Inc. | Bmp inhibitors and methods of use thereof |
| US9682983B2 (en) | 2013-03-14 | 2017-06-20 | The Brigham And Women's Hospital, Inc. | BMP inhibitors and methods of use thereof |
| WO2014151761A1 (en) | 2013-03-15 | 2014-09-25 | Ariad Pharmaceuticals, Inc. | Novel choline kinase inhibitors |
| WO2015148654A1 (en) | 2014-03-26 | 2015-10-01 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| WO2016011019A1 (en) | 2014-07-15 | 2016-01-21 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| US20170305883A1 (en) | 2014-10-01 | 2017-10-26 | The Brigham And Women's Hospital, Inc. | Compositions and Methods for Inhibiting BMP |
-
2014
- 2014-03-13 US US14/776,302 patent/US9682983B2/en active Active
- 2014-03-13 EP EP14775808.0A patent/EP2970311A4/en not_active Withdrawn
- 2014-03-13 JP JP2016502036A patent/JP6542192B2/ja active Active
- 2014-03-13 WO PCT/US2014/026042 patent/WO2014160203A2/en not_active Ceased
-
2017
- 2017-05-18 US US15/598,540 patent/US10017516B2/en active Active