JP2016515119A5 - - Google Patents
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- JP2016515119A5 JP2016515119A5 JP2016502036A JP2016502036A JP2016515119A5 JP 2016515119 A5 JP2016515119 A5 JP 2016515119A5 JP 2016502036 A JP2016502036 A JP 2016502036A JP 2016502036 A JP2016502036 A JP 2016502036A JP 2016515119 A5 JP2016515119 A5 JP 2016515119A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- ester
- pharmaceutically acceptable
- prodrug
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361783695P | 2013-03-14 | 2013-03-14 | |
| US61/783,695 | 2013-03-14 | ||
| PCT/US2014/026042 WO2014160203A2 (en) | 2013-03-14 | 2014-03-13 | Bmp inhibitors and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515119A JP2016515119A (ja) | 2016-05-26 |
| JP2016515119A5 true JP2016515119A5 (https=) | 2017-04-13 |
| JP6542192B2 JP6542192B2 (ja) | 2019-07-10 |
Family
ID=51625632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502036A Active JP6542192B2 (ja) | 2013-03-14 | 2014-03-13 | Ｂｍｐ阻害剤およびその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9682983B2 (https=) |
| EP (1) | EP2970311A4 (https=) |
| JP (1) | JP6542192B2 (https=) |
| WO (1) | WO2014160203A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5638961B2 (ja) | 2008-03-13 | 2014-12-10 | ザ ジェネラル ホスピタル コーポレイション | Ｂｍｐシグナル伝達経路のインヒビター |
| EP3721880B1 (en) | 2010-09-01 | 2022-02-02 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
| JP6430383B2 (ja) | 2012-09-28 | 2018-11-28 | ヴァンダービルト ユニバーシティーＶａｎｄｅｒｂｉｌｔ Ｕｎｉｖｅｒｓｉｔｙ | 選択的ｂｍｐ阻害剤としての縮合複素環化合物 |
| WO2014160203A2 (en) | 2013-03-14 | 2014-10-02 | The Brigham And Women's Hospital, Inc. | Bmp inhibitors and methods of use thereof |
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| US10513521B2 (en) | 2014-07-15 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting BMP |
| KR20180026459A (ko) | 2015-06-18 | 2018-03-12 | 세파론, 인코포레이티드 | 1,4-치환된 피페리딘 유도체 |
| WO2016205590A1 (en) | 2015-06-18 | 2016-12-22 | Cephalon, Inc. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| JP7023868B2 (ja) | 2016-06-08 | 2022-02-22 | クレメンティア ファーマシューティカルズ，インコーポレイテッド | 異所性骨化を治療するための方法 |
| MX388518B (es) | 2016-07-20 | 2025-03-19 | Novartis Ag | Derivados de aminopiridina y su uso como inhibidores selectivos de alk-2. |
| CA3043807A1 (en) | 2016-11-16 | 2018-05-24 | Clementia Pharmaceuticals Inc. | Methods for treating multiple osteochondroma (mo) |
| WO2018165569A1 (en) * | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Therapeutic compounds and methods |
| IL251949A0 (en) | 2017-04-26 | 2017-07-31 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | Small organic molecules for use in the treatment of neuro-inflammatory diseases |
| EP3615538B1 (en) * | 2017-04-27 | 2024-02-07 | The Brigham and Women's Hospital, Inc. | Novel alk2 inhibitors and methods for inhibiting bmp signaling |
| US10875861B1 (en) | 2017-05-26 | 2020-12-29 | Rutgers, The State University Of New Jersey | Therapeutic compounds |
| WO2019178383A1 (en) | 2018-03-14 | 2019-09-19 | Vanderbilt University | Inhibition of bmp signaling, compounds, compositions and uses thereof |
| CN108586464A (zh) * | 2018-04-12 | 2018-09-28 | 苏州康润医药有限公司 | 一种3-溴吡唑并[1,5-α]嘧啶-6-甲酸的合成方法 |
| EP3870181B1 (en) * | 2018-10-26 | 2024-08-14 | Keros Therapeutics, Inc. | Crystal forms of an alk2 inhibitor |
| US12427147B2 (en) | 2018-10-31 | 2025-09-30 | Senju Pharmaceutical Co., Ltd. | Retinal ganglion cell death inhibitor |
| EP3886848A4 (en) | 2018-11-27 | 2022-08-17 | Rutgers, The State University of New Jersey | PHARMACEUTICAL COMPOUNDS AND THERAPEUTIC METHODS |
| CA3124088A1 (en) * | 2018-12-20 | 2020-06-25 | Incyte Corporation | Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2 |
| US20220372135A1 (en) | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| US12508262B2 (en) | 2020-04-30 | 2025-12-30 | Keros Therapeutics, Inc. | Methods of using ALK2 inhibitors |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| CA3184811A1 (en) | 2020-06-12 | 2021-12-16 | Incyte Corporation | Imidazopyridazine compounds with activity as alk2 inhibitors |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| CN121318983B (zh) * | 2025-12-15 | 2026-04-14 | 首都医科大学附属北京胸科医院 | 6-芳基取代的吡唑并[1,5-a]嘧啶类化合物及其制备和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0981745A1 (en) | 1997-05-16 | 2000-03-01 | The Procter & Gamble Company | The use of a bone morphogenetic protein (bmp) receptor complex for screening |
| JP2002501532A (ja) * | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 新規血管形成阻害薬 |
| US6235741B1 (en) | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6245759B1 (en) * | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US20020041880A1 (en) | 2000-07-05 | 2002-04-11 | Defeo-Jones Deborah | Method of treating cancer |
| AU2003298942A1 (en) | 2002-12-11 | 2004-06-30 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
| JPWO2004108160A1 (ja) | 2003-06-05 | 2006-07-27 | 日本新薬株式会社 | 骨形成促進増強剤及びそのスクリーニング方法 |
| WO2005092345A1 (fr) | 2004-03-29 | 2005-10-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Utilisation d’un derive de la phenothiazine pour la prevention et/ou le traitement de la perte d’audition |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| RU2285532C2 (ru) | 2004-10-28 | 2006-10-20 | Общество с ограниченной ответственностью "Научно-производственное объединение "Фарматрон" (НПО "Фарматрон") | Способ коррекции токсических поражений, вызванных доксорубицином |
| PT1812440E (pt) * | 2004-11-04 | 2011-01-25 | Vertex Pharma | Pirazolo[1,5-a]pirimidinas úteis enquanto inibidores de proteínas cinases |
| JP5052518B2 (ja) | 2005-10-06 | 2012-10-17 | シェーリング コーポレイション | プロテインキナーゼインヒビターとしてのピラゾロピリミジン |
| GB0601638D0 (en) | 2006-01-27 | 2006-03-08 | Merck Sharp & Dohme | Therapeutic treatment |
| JP2009533327A (ja) | 2006-03-22 | 2009-09-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | 増殖性疾患を処置するためのｃ−ＭＥＴキナーゼ阻害剤 |
| PL2044056T3 (pl) | 2006-07-14 | 2013-01-31 | Novartis Ag | Pochodne pirymidyny jako inhibitory ALK-5 |
| EP1900727A1 (en) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Aminopyridine derivatives as kinase inhibitors |
| EP2062048A4 (en) * | 2006-09-12 | 2009-12-02 | Gen Hospital Corp | METHOD FOR IDENTIFYING CELL SIGNALING MODULATING COMPOUNDS AND METHOD FOR USING SUCH COMPOSITES |
| US8073681B2 (en) | 2006-10-16 | 2011-12-06 | Voicebox Technologies, Inc. | System and method for a cooperative conversational voice user interface |
| GB0625659D0 (en) | 2006-12-21 | 2007-01-31 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| AU2008254273B2 (en) | 2007-05-15 | 2013-03-28 | Otsuka Pharmaceutical Co., Ltd. | Methods for using vasopressin antagonists with anthracycline chemotherapy agents to reduce cardiotoxicity and/or improve survival |
| EP2581081A3 (en) | 2007-06-01 | 2013-07-31 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
| JP2011500778A (ja) | 2007-10-25 | 2011-01-06 | アストラゼネカ・アクチエボラーグ | ピリジン及びピラジン誘導体−０８３ |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| AU2009203693B2 (en) | 2008-01-11 | 2012-06-07 | Novartis Ag | Pyrimidines as kinase inhibitors |
| EP2265270A1 (en) | 2008-02-04 | 2010-12-29 | OSI Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
| JP5638961B2 (ja) * | 2008-03-13 | 2014-12-10 | ザ ジェネラル ホスピタル コーポレイション | Ｂｍｐシグナル伝達経路のインヒビター |
| US8278105B2 (en) | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| EP2393915A4 (en) * | 2009-02-05 | 2012-12-26 | Regenertech Pty Ltd | PROCESS FOR THE PREPARATION OF PRECURSOR CELLS FROM DIFFERENTIATED CELLS |
| JP2012533545A (ja) * | 2009-07-14 | 2012-12-27 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | 肝臓の増殖を増大させる方法 |
| WO2012100229A2 (en) * | 2011-01-21 | 2012-07-26 | The General Hospital Corporation | Compositions and methods for cardiovascular disease |
| WO2012115120A1 (ja) * | 2011-02-21 | 2012-08-30 | 国立大学法人 大阪大学 | ５－ｈｔ神経細胞の製造方法 |
| US9505763B2 (en) * | 2011-07-25 | 2016-11-29 | Vanderbilt University | Cancer treatment using BMP inhibitor |
| HRP20192323T1 (hr) | 2011-09-15 | 2020-03-20 | F. Hoffmann - La Roche Ag | Novi derivati dihidrokinolin-2-ona |
| KR20130055216A (ko) | 2011-11-18 | 2013-05-28 | 롬엔드하스전자재료코리아유한회사 | 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자 |
| RU2671212C2 (ru) | 2013-02-02 | 2018-10-30 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд | Замещенный 2-аминопиридин в качестве ингибитора протеинкиназы |
| EP2964651A4 (en) | 2013-03-04 | 2016-11-30 | Brigham & Womens Hospital | BMP HEMMER AND METHOD OF USE THEREOF |
| WO2014160203A2 (en) | 2013-03-14 | 2014-10-02 | The Brigham And Women's Hospital, Inc. | Bmp inhibitors and methods of use thereof |
| US9834521B2 (en) | 2013-03-15 | 2017-12-05 | Ariad Pharmaceuticals, Inc. | Choline kinase inhibitors |
| EP3122355A4 (en) | 2014-03-26 | 2017-08-09 | The Brigham and Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| US10513521B2 (en) | 2014-07-15 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting BMP |
| JP2017536411A (ja) | 2014-10-01 | 2017-12-07 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | Ｂｍｐ阻害用組成物及びｂｍｐ阻害方法 |
-
2014
- 2014-03-13 WO PCT/US2014/026042 patent/WO2014160203A2/en not_active Ceased
- 2014-03-13 US US14/776,302 patent/US9682983B2/en active Active
- 2014-03-13 EP EP14775808.0A patent/EP2970311A4/en not_active Withdrawn
- 2014-03-13 JP JP2016502036A patent/JP6542192B2/ja active Active
-
2017
- 2017-05-18 US US15/598,540 patent/US10017516B2/en active Active