JP2016515119A5 - - Google Patents
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- JP2016515119A5 JP2016515119A5 JP2016502036A JP2016502036A JP2016515119A5 JP 2016515119 A5 JP2016515119 A5 JP 2016515119A5 JP 2016502036 A JP2016502036 A JP 2016502036A JP 2016502036 A JP2016502036 A JP 2016502036A JP 2016515119 A5 JP2016515119 A5 JP 2016515119A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- ester
- pharmaceutically acceptable
- prodrug
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361783695P | 2013-03-14 | 2013-03-14 | |
| US61/783,695 | 2013-03-14 | ||
| PCT/US2014/026042 WO2014160203A2 (en) | 2013-03-14 | 2014-03-13 | Bmp inhibitors and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515119A JP2016515119A (ja) | 2016-05-26 |
| JP2016515119A5 true JP2016515119A5 (enExample) | 2017-04-13 |
| JP6542192B2 JP6542192B2 (ja) | 2019-07-10 |
Family
ID=51625632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502036A Active JP6542192B2 (ja) | 2013-03-14 | 2014-03-13 | Ｂｍｐ阻害剤およびその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9682983B2 (enExample) |
| EP (1) | EP2970311A4 (enExample) |
| JP (1) | JP6542192B2 (enExample) |
| WO (1) | WO2014160203A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2265603B1 (en) | 2008-03-13 | 2014-05-07 | The General Hospital Corporation | Inhibitors of the bmp signaling pathway |
| CN111773213B (zh) | 2010-09-01 | 2023-02-24 | 托马斯杰弗逊大学 | 用于肌肉修复和再生的组合物和方法 |
| JP6430383B2 (ja) * | 2012-09-28 | 2018-11-28 | ヴァンダービルト ユニバーシティーＶａｎｄｅｒｂｉｌｔ Ｕｎｉｖｅｒｓｉｔｙ | 選択的ｂｍｐ阻害剤としての縮合複素環化合物 |
| JP6542192B2 (ja) | 2013-03-14 | 2019-07-10 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | Ｂｍｐ阻害剤およびその使用方法 |
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| US10513521B2 (en) | 2014-07-15 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting BMP |
| PE20180572A1 (es) | 2015-06-18 | 2018-04-04 | Cephalon Inc | Derivados de piperidina 1,4-sustituidos |
| EP3310773B1 (en) | 2015-06-18 | 2020-12-02 | 89Bio Ltd. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| ES2963348T3 (es) | 2016-06-08 | 2024-03-26 | Clementia Pharmaceuticals Inc | Métodos para tratar la osificación heterotópica |
| KR102359707B1 (ko) | 2016-07-20 | 2022-02-09 | 노파르티스 아게 | 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도 |
| JP7018957B2 (ja) | 2016-11-16 | 2022-02-14 | クレメンティア ファーマシューティカルズ インコーポレイテッド | 多発性骨軟骨腫（ｍｏ）を処置するための方法 |
| WO2018165569A1 (en) * | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Therapeutic compounds and methods |
| IL251949A0 (en) | 2017-04-26 | 2017-07-31 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | Small organic molecules for use in the treatment of neuro-inflammatory diseases |
| JP7175917B2 (ja) * | 2017-04-27 | 2022-11-21 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 新規のａｌｋ２阻害剤及びｂｍｐシグナル伝達の阻害方法 |
| US10875861B1 (en) | 2017-05-26 | 2020-12-29 | Rutgers, The State University Of New Jersey | Therapeutic compounds |
| WO2019178383A1 (en) | 2018-03-14 | 2019-09-19 | Vanderbilt University | Inhibition of bmp signaling, compounds, compositions and uses thereof |
| CN108586464A (zh) * | 2018-04-12 | 2018-09-28 | 苏州康润医药有限公司 | 一种3-溴吡唑并[1,5-α]嘧啶-6-甲酸的合成方法 |
| CA3117695A1 (en) * | 2018-10-26 | 2020-04-30 | Keros Therapeutics, Inc. | Crystal forms of an alk2 inhibitor |
| WO2020090705A1 (ja) | 2018-10-31 | 2020-05-07 | 千寿製薬株式会社 | 網膜神経節細胞死抑制剤 |
| EP3886848A4 (en) | 2018-11-27 | 2022-08-17 | Rutgers, The State University of New Jersey | PHARMACEUTICAL COMPOUNDS AND THERAPEUTIC METHODS |
| JP7414827B2 (ja) * | 2018-12-20 | 2024-01-16 | インサイト・コーポレイション | アクチビン受容体様キナーゼ－２の阻害剤としてのイミダゾピリダジン及びイミダゾピリジン化合物 |
| CA3156007A1 (en) | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS |
| US12508262B2 (en) | 2020-04-30 | 2025-12-30 | Keros Therapeutics, Inc. | Methods of using ALK2 inhibitors |
| ES3075793T3 (en) | 2020-05-13 | 2026-08-07 | Disc Medicine Inc | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| AU2021273014A1 (en) | 2020-05-13 | 2022-11-17 | AbbVie Deutschland GmbH & Co. KG | Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease |
| US11840546B2 (en) | 2020-06-12 | 2023-12-12 | Incyte Corporation | Imidazopyridazine compounds and uses thereof |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| CN117659069A (zh) * | 2023-12-05 | 2024-03-08 | 南通敏言生物医药科技有限公司 | 一种2-甲基-5-(4,4,5,5-四甲基-1,3,2-二氧硼杂环戊烷-2-基)喹啉的合成方法 |
| WO2026132379A1 (en) * | 2024-12-19 | 2026-06-25 | Coultreon Biopharma Bv | Compounds and pharmaceutical compositions thereof for the treatment of diseases |
| CN121318983B (zh) * | 2025-12-15 | 2026-04-14 | 首都医科大学附属北京胸科医院 | 6-芳基取代的吡唑并[1,5-a]嘧啶类化合物及其制备和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002510198A (ja) | 1997-05-16 | 2002-04-02 | ザ プロクター アンド ギャンブル カンパニー | スクリーニングのための骨形態形成タンパク質（ｂｍｐ）受容体複合体の使用 |
| CA2291709A1 (en) * | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| US6235741B1 (en) | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6245759B1 (en) * | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US20020041880A1 (en) | 2000-07-05 | 2002-04-11 | Defeo-Jones Deborah | Method of treating cancer |
| AU2003298942A1 (en) | 2002-12-11 | 2004-06-30 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
| US7276525B2 (en) | 2003-06-05 | 2007-10-02 | Nippon Shinyaku Co. Ltd. | Osteogenesis-promotion enhancer and method of screening the same |
| PL1732567T3 (pl) | 2004-03-29 | 2009-04-30 | Soc De Conseils De Recherches Et Dapplications Scientifiques S C R A S Sas | Zastosowanie pochodnej fenotiazyny do zapobiegania i/lub leczenia utraty słuchu |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| RU2285532C2 (ru) | 2004-10-28 | 2006-10-20 | Общество с ограниченной ответственностью "Научно-производственное объединение "Фарматрон" (НПО "Фарматрон") | Способ коррекции токсических поражений, вызванных доксорубицином |
| DE602005023763D1 (de) * | 2004-11-04 | 2010-11-04 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine |
| PE20070543A1 (es) | 2005-10-06 | 2007-06-14 | Schering Corp | Pirazolopirimidinas como inhibidores de protein quinasas |
| GB0601638D0 (en) | 2006-01-27 | 2006-03-08 | Merck Sharp & Dohme | Therapeutic treatment |
| KR20090007347A (ko) | 2006-03-22 | 2009-01-16 | 버텍스 파마슈티칼스 인코포레이티드 | 증식성 장애의 치료를 위한 ｃ-ＭＥＴ 단백질 키나제 억제제 |
| CA2657227A1 (en) | 2006-07-14 | 2008-01-17 | Novartis Ag | Pyrimidine derivatives as alk-5 inhibitors |
| EP1900727A1 (en) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Aminopyridine derivatives as kinase inhibitors |
| EP2270229A1 (en) * | 2006-09-12 | 2011-01-05 | The General Hospital Corporation | Inhibitors of bone morphogenetic protein (BMP) signalling for therapeutical purposes |
| US8073681B2 (en) | 2006-10-16 | 2011-12-06 | Voicebox Technologies, Inc. | System and method for a cooperative conversational voice user interface |
| GB0625659D0 (en) | 2006-12-21 | 2007-01-31 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| UA99914C2 (ru) | 2007-05-15 | 2012-10-25 | Оцука Фармас'Ютікел Ко., Лтд. | Способ применения антагонистов вазопресина со средствами антрациклиновой химиотерапии для снижения кардиотоксичности |
| WO2009023059A2 (en) | 2007-06-01 | 2009-02-19 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
| EP2215085B1 (en) | 2007-10-25 | 2011-09-07 | AstraZeneca AB | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| JP5584138B2 (ja) | 2008-01-11 | 2014-09-03 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
| JP2011511005A (ja) | 2008-02-04 | 2011-04-07 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | ２−アミノピリジン系キナーゼ阻害薬 |
| EP2265603B1 (en) | 2008-03-13 | 2014-05-07 | The General Hospital Corporation | Inhibitors of the bmp signaling pathway |
| US8278105B2 (en) * | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| WO2010088735A1 (en) | 2009-02-05 | 2010-08-12 | Regenertech Pty Ltd | Method of producing progenitor cells from differentiated cells |
| JP2012533545A (ja) * | 2009-07-14 | 2012-12-27 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | 肝臓の増殖を増大させる方法 |
| JP2014504604A (ja) | 2011-01-21 | 2014-02-24 | ザ ジェネラル ホスピタル コーポレイション | 心血管疾患のための組成物および方法 |
| WO2012115120A1 (ja) * | 2011-02-21 | 2012-08-30 | 国立大学法人 大阪大学 | ５－ｈｔ神経細胞の製造方法 |
| US9505763B2 (en) * | 2011-07-25 | 2016-11-29 | Vanderbilt University | Cancer treatment using BMP inhibitor |
| HRP20192323T1 (hr) | 2011-09-15 | 2020-03-20 | F. Hoffmann - La Roche Ag | Novi derivati dihidrokinolin-2-ona |
| KR20130055216A (ko) | 2011-11-18 | 2013-05-28 | 롬엔드하스전자재료코리아유한회사 | 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자 |
| AU2014211856C1 (en) | 2013-02-02 | 2018-04-12 | Centaurus Biopharma Co., Ltd. | Substituted 2-aminopyridine protein kinase inhibitor |
| EP2964651A4 (en) | 2013-03-04 | 2016-11-30 | Brigham & Womens Hospital | BMP HEMMER AND METHOD OF USE THEREOF |
| JP6542192B2 (ja) | 2013-03-14 | 2019-07-10 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | Ｂｍｐ阻害剤およびその使用方法 |
| WO2014151761A1 (en) | 2013-03-15 | 2014-09-25 | Ariad Pharmaceuticals, Inc. | Novel choline kinase inhibitors |
| WO2015148654A1 (en) | 2014-03-26 | 2015-10-01 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| US10513521B2 (en) | 2014-07-15 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting BMP |
| EP3201187A4 (en) | 2014-10-01 | 2018-04-11 | The Brigham and Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
-
2014
- 2014-03-13 JP JP2016502036A patent/JP6542192B2/ja active Active
- 2014-03-13 EP EP14775808.0A patent/EP2970311A4/en not_active Withdrawn
- 2014-03-13 WO PCT/US2014/026042 patent/WO2014160203A2/en not_active Ceased
- 2014-03-13 US US14/776,302 patent/US9682983B2/en active Active
-
2017
- 2017-05-18 US US15/598,540 patent/US10017516B2/en active Active