JP2016514716A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016514716A5 JP2016514716A5 JP2016503643A JP2016503643A JP2016514716A5 JP 2016514716 A5 JP2016514716 A5 JP 2016514716A5 JP 2016503643 A JP2016503643 A JP 2016503643A JP 2016503643 A JP2016503643 A JP 2016503643A JP 2016514716 A5 JP2016514716 A5 JP 2016514716A5
- Authority
- JP
- Japan
- Prior art keywords
- globin
- hemoglobin
- serum
- formulation
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 108060003196 globin Proteins 0.000 claims 10
- 102000018146 globin Human genes 0.000 claims 10
- 108010054147 Hemoglobins Proteins 0.000 claims 8
- 102000001554 Hemoglobins Human genes 0.000 claims 8
- 210000002966 serum Anatomy 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 7
- 206010052428 Wound Diseases 0.000 claims 6
- 208000027418 Wounds and injury Diseases 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 210000001612 chondrocyte Anatomy 0.000 claims 4
- 230000035876 healing Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 210000002950 fibroblast Anatomy 0.000 claims 3
- 210000000963 osteoblast Anatomy 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920002201 Oxidized cellulose Polymers 0.000 claims 2
- 239000004826 Synthetic adhesive Substances 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 239000003146 anticoagulant agent Substances 0.000 claims 2
- 229940127219 anticoagulant drug Drugs 0.000 claims 2
- -1 bandages Substances 0.000 claims 2
- 239000000227 bioadhesive Substances 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000000919 ceramic Substances 0.000 claims 2
- 230000001112 coagulating effect Effects 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229940107304 oxidized cellulose Drugs 0.000 claims 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 239000008223 sterile water Substances 0.000 claims 2
- 230000017423 tissue regeneration Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 200000000007 Arterial disease Diseases 0.000 claims 1
- 206010063560 Excessive granulation tissue Diseases 0.000 claims 1
- 108010061951 Methemoglobin Proteins 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 208000002847 Surgical Wound Diseases 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 230000003190 augmentative effect Effects 0.000 claims 1
- 210000002449 bone cell Anatomy 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000002316 cosmetic surgery Methods 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000000630 fibrocyte Anatomy 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 210000001126 granulation tissue Anatomy 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 150000003278 haem Chemical group 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000001338 necrotic effect Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 230000003239 periodontal effect Effects 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 238000007493 shaping process Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000005070 sphincter Anatomy 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000037997 venous disease Diseases 0.000 claims 1
- 210000001260 vocal cord Anatomy 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305318.1 | 2013-03-18 | ||
| EP20130305318 EP2781224A1 (en) | 2013-03-18 | 2013-03-18 | Implantable preparations comrpsing globin insoluble at physiological pH and serum for regeneration of tissues and treatment of wounds. |
| PCT/EP2014/055449 WO2014147092A1 (en) | 2013-03-18 | 2014-03-18 | Implantable preparations for regeneration of tissues and treatment of wounds, their method of preparation, and method of treatment of patients with said implantable preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016514716A JP2016514716A (ja) | 2016-05-23 |
| JP2016514716A5 true JP2016514716A5 (enExample) | 2017-04-20 |
Family
ID=48139855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503643A Pending JP2016514716A (ja) | 2013-03-18 | 2014-03-18 | 組織の再生および創傷の治療のための植え込み型製剤、それらの製剤化方法、および該植え込み型製剤を用いる患者の治療方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10456500B2 (enExample) |
| EP (2) | EP2781224A1 (enExample) |
| JP (1) | JP2016514716A (enExample) |
| KR (1) | KR20150131378A (enExample) |
| WO (1) | WO2014147092A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2806914B1 (en) | 2012-01-23 | 2021-09-22 | Estar Technologies Ltd | A system and method for obtaining a cellular sample enriched with defined cells such as platelet rich plasma(prp) |
| EP2781224A1 (en) | 2013-03-18 | 2014-09-24 | Khorionyx | Implantable preparations comrpsing globin insoluble at physiological pH and serum for regeneration of tissues and treatment of wounds. |
| EP3258945B1 (en) * | 2015-02-16 | 2020-10-07 | Nayacure Therapeutics Ltd. | Modified blood clots |
| JP6875619B2 (ja) * | 2015-02-26 | 2021-05-26 | 株式会社細胞応用技術研究所 | 多血小板血漿の保存方法 |
| EP3305306A1 (en) * | 2016-10-04 | 2018-04-11 | Dr. Sarah Prinzessin von Isenburg | Compositions comprising adjustable concentrations of growth factors derived from blood serum and clot hypoxia-conditioned medium and methods of their production |
| JP6999927B2 (ja) * | 2017-11-13 | 2022-01-19 | 株式会社細胞応用技術研究所 | 多血小板血漿を製造する方法 |
| WO2020016758A1 (en) * | 2018-07-16 | 2020-01-23 | Systagenix Wound Management, Limited | Nitric oxide producing collagen/orc dressing |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6949625B2 (en) | 2003-05-12 | 2005-09-27 | Khorionyx | Injectable implant of insoluble globin |
| FR2854801B1 (fr) * | 2003-05-12 | 2006-09-01 | Khorionyx | Implant injectable de globine insoluble |
| FR2889449B1 (fr) | 2005-08-05 | 2011-06-10 | Khorionyx | Preparations implantables |
| DK2046407T3 (en) | 2006-08-02 | 2015-05-26 | Khorionyx | Implantable preparation that can be used especially for tissue supplementation and wound healing |
| FR2920666B1 (fr) | 2007-09-11 | 2010-11-26 | Khorionyx | Preparations implantables contenant de la globine, procede pour leur fabrication et utilisations |
| CN102438635B (zh) * | 2009-03-05 | 2014-09-17 | 马克罗柯尔有限公司 | 活化的白细胞组合物 |
| US20120183501A1 (en) | 2010-11-12 | 2012-07-19 | Jean-Louis Tayot | Novel method for treatment of skin wounds and preparations for implementation of same |
| JP6070693B2 (ja) * | 2012-03-30 | 2017-02-01 | 味の素株式会社 | 硫酸化化合物を含む幹細胞増殖用培地 |
| EP2781224A1 (en) | 2013-03-18 | 2014-09-24 | Khorionyx | Implantable preparations comrpsing globin insoluble at physiological pH and serum for regeneration of tissues and treatment of wounds. |
-
2013
- 2013-03-18 EP EP20130305318 patent/EP2781224A1/en not_active Withdrawn
-
2014
- 2014-03-18 EP EP14710898.9A patent/EP2976098B1/en not_active Not-in-force
- 2014-03-18 WO PCT/EP2014/055449 patent/WO2014147092A1/en not_active Ceased
- 2014-03-18 JP JP2016503643A patent/JP2016514716A/ja active Pending
- 2014-03-18 US US14/778,183 patent/US10456500B2/en not_active Expired - Fee Related
- 2014-03-18 KR KR1020157030039A patent/KR20150131378A/ko not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6892485B2 (ja) | トロンビン血清の調製、その利用およびその調製機器 | |
| JP2016514716A5 (enExample) | ||
| ES2791755T3 (es) | Nuevos dispositivo médico y composición para ingeniería tisular basados en A-PRP, máquinas y procesos de fabricación | |
| JP2018164757A (ja) | 単独でまたはヒアルロン酸と組み合わせて、多血小板血漿（ｐｒｐ）または骨髄遠心分離液（ｃｅｎｔｒａｔｅ）（ｂｍｃ）を調製するための新しい規格化および医療デバイス | |
| BRPI1005362B1 (pt) | método para preparar um curativo para ferida, e banco de curativos biológicos de feridas | |
| RU2015137965A (ru) | Сывороточная фракция обогащенного тромбоцитами фибрина | |
| US20200390930A1 (en) | Systems and methods for treating a wound with wound packing | |
| JP2016514716A (ja) | 組織の再生および創傷の治療のための植え込み型製剤、それらの製剤化方法、および該植え込み型製剤を用いる患者の治療方法 | |
| RU2543344C2 (ru) | Способ лечения трофических язв | |
| CN108434529A (zh) | 一种脂肪液化伤口用原位自体仿生修复材料及其制备方法和应用 | |
| JP7291972B2 (ja) | 血小板を含有する血液組成物から得られる組織製剤又は接着剤、及びそのような製剤を調製する方法 | |
| JP4642765B2 (ja) | 不溶性グロビンの注射可能埋め込み剤 | |
| AU2022242956B2 (en) | Wound treatment compositions and methods of stabilizing, protecting, and treating a wound | |
| CN107715167A (zh) | 作为骨蜡替代物的壳聚糖基止血糊剂及制备方法 | |
| OA21689A (en) | Wound treatments and methods of stabilizing, protecting, and treating a wound. | |
| JP2018145169A (ja) | 多血小板血漿をゲル化させるゲル化方法、及びゲル化方法に用いられるキット |