JP2016514709A5 - - Google Patents
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- Publication number
- JP2016514709A5 JP2016514709A5 JP2016503521A JP2016503521A JP2016514709A5 JP 2016514709 A5 JP2016514709 A5 JP 2016514709A5 JP 2016503521 A JP2016503521 A JP 2016503521A JP 2016503521 A JP2016503521 A JP 2016503521A JP 2016514709 A5 JP2016514709 A5 JP 2016514709A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- dihydro
- amino
- pyrazolo
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2013/072873 | 2013-03-19 | ||
| PCT/CN2013/072873 WO2014146249A1 (en) | 2013-03-19 | 2013-03-19 | Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors |
| PCT/CN2014/000297 WO2014146491A1 (en) | 2013-03-19 | 2014-03-19 | Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016514709A JP2016514709A (ja) | 2016-05-23 |
| JP2016514709A5 true JP2016514709A5 (enExample) | 2017-04-06 |
Family
ID=51579271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503521A Pending JP2016514709A (ja) | 2013-03-19 | 2014-03-19 | ヤヌスキナーゼ阻害剤としてのジェミナル置換シアノエチルピラゾロピリドン |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9957264B2 (enExample) |
| EP (1) | EP2976339B1 (enExample) |
| JP (1) | JP2016514709A (enExample) |
| AU (1) | AU2014234907B2 (enExample) |
| BR (1) | BR112015023858A2 (enExample) |
| CA (1) | CA2901765A1 (enExample) |
| RU (1) | RU2664533C2 (enExample) |
| WO (2) | WO2014146249A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014146246A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
| WO2016061751A1 (en) | 2014-10-22 | 2016-04-28 | Merck Sharp & Dohme Corp. | Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors |
| US10851116B2 (en) * | 2017-01-20 | 2020-12-01 | Leo Pharma A/S | Bicyclic amines as novel JAK kinase inhibitors |
| CN111499641B (zh) * | 2019-01-30 | 2021-06-04 | 格格巫（珠海）生物科技有限公司 | 一种jak抑制剂及其制备方法 |
| EP3982954A4 (en) * | 2019-06-14 | 2024-01-03 | The Trustees of Columbia University in the City of New York | NT5C2 INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA |
| MX2022013838A (es) | 2020-05-04 | 2023-02-22 | Amgen Inc | Compuestos heterociclicos como agonistas del receptor de activacion expresado en las celulas mieloides 2 y metodos de uso. |
| TW202208355A (zh) * | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
| JP7023026B1 (ja) | 2021-05-18 | 2022-02-21 | 株式会社アイビー化粧品 | Ｊａｋ阻害剤 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| JP5287253B2 (ja) * | 2007-01-12 | 2013-09-11 | アステラス製薬株式会社 | 縮合ピリジン化合物 |
| CN101910152B (zh) * | 2007-11-16 | 2014-08-06 | 因塞特公司 | 作为janus激酶抑制剂的4-吡唑基-n-芳基嘧啶-2-胺和4-吡唑基-n-杂芳基嘧啶-2-胺 |
| MX2010010012A (es) * | 2008-03-11 | 2010-10-20 | Incyte Corp | Derivados de azetidina y ciclobutano como inhibidores de jak. |
| TW201111385A (en) * | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
| PH12015502575A1 (en) * | 2010-03-10 | 2017-04-24 | Incyte Corp | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| NZ603446A (en) * | 2010-04-14 | 2014-05-30 | Array Biopharma Inc | 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases |
| EP2611809A1 (en) * | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | Azolopyridine and azolopyrimidine compounds and methods of use thereof |
| CA2817785A1 (en) * | 2010-11-19 | 2012-05-24 | Toby Blench | Pyrazolopyridines and pyrazolopyridines and their use as tyk2 inhibitors |
| EP2694060A4 (en) * | 2011-04-01 | 2014-09-10 | Univ Utah Res Found | SUBSTITUTED 3- (1H-BENZO- {D} -IMIDAZOL-2-YL-) 1H-INDAZOL ANALOGUE AS PDK1 KINASE INHIBITOR |
| UA111854C2 (uk) * | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| ES2633793T3 (es) * | 2011-09-22 | 2017-09-25 | Merck Sharp & Dohme Corp. | Pirazol carboxamidas como inhibidores de quinasa Janus |
| EP2857400A4 (en) | 2012-06-01 | 2015-12-09 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| EP2863914B1 (en) * | 2012-06-20 | 2018-10-03 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as syk inhibitors |
-
2013
- 2013-03-19 WO PCT/CN2013/072873 patent/WO2014146249A1/en not_active Ceased
-
2014
- 2014-03-19 RU RU2015144485A patent/RU2664533C2/ru not_active IP Right Cessation
- 2014-03-19 BR BR112015023858A patent/BR112015023858A2/pt not_active Application Discontinuation
- 2014-03-19 JP JP2016503521A patent/JP2016514709A/ja active Pending
- 2014-03-19 WO PCT/CN2014/000297 patent/WO2014146491A1/en not_active Ceased
- 2014-03-19 AU AU2014234907A patent/AU2014234907B2/en not_active Ceased
- 2014-03-19 CA CA2901765A patent/CA2901765A1/en not_active Abandoned
- 2014-03-19 US US14/778,046 patent/US9957264B2/en active Active
- 2014-03-19 EP EP14770170.0A patent/EP2976339B1/en active Active
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