JP2016513734A - Ampk活性化剤及びセロトニン作動薬を含む医薬組成物並びにそれらの使用方法 - Google Patents
Ampk活性化剤及びセロトニン作動薬を含む医薬組成物並びにそれらの使用方法 Download PDFInfo
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- JP2016513734A JP2016513734A JP2016502780A JP2016502780A JP2016513734A JP 2016513734 A JP2016513734 A JP 2016513734A JP 2016502780 A JP2016502780 A JP 2016502780A JP 2016502780 A JP2016502780 A JP 2016502780A JP 2016513734 A JP2016513734 A JP 2016513734A
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- acetamide
- fluorobenzyl
- piperidin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Pregnancy & Childbirth (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361793407P | 2013-03-15 | 2013-03-15 | |
| US61/793,407 | 2013-03-15 | ||
| PCT/US2014/028413 WO2014144130A2 (en) | 2013-03-15 | 2014-03-14 | Pharmaceutical composition comprising an ampk activator and a serotonergic agent and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016513734A true JP2016513734A (ja) | 2016-05-16 |
| JP2016513734A5 JP2016513734A5 (OSRAM) | 2017-03-30 |
Family
ID=51538303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502780A Pending JP2016513734A (ja) | 2013-03-15 | 2014-03-14 | Ampk活性化剤及びセロトニン作動薬を含む医薬組成物並びにそれらの使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20140350064A1 (OSRAM) |
| EP (1) | EP2983473A4 (OSRAM) |
| JP (1) | JP2016513734A (OSRAM) |
| KR (1) | KR20160005341A (OSRAM) |
| CN (1) | CN105636438A (OSRAM) |
| AR (1) | AR095631A1 (OSRAM) |
| AU (1) | AU2014227807B2 (OSRAM) |
| BR (1) | BR112015023922A2 (OSRAM) |
| CA (1) | CA2909633A1 (OSRAM) |
| CL (1) | CL2015002680A1 (OSRAM) |
| HK (1) | HK1222297A1 (OSRAM) |
| IL (1) | IL241587B (OSRAM) |
| MX (1) | MX2015012760A (OSRAM) |
| RU (1) | RU2015143438A (OSRAM) |
| TW (1) | TW201444552A (OSRAM) |
| WO (1) | WO2014144130A2 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023500493A (ja) * | 2019-10-31 | 2023-01-06 | ジェイディ・バイオサイエンス・インコーポレイテッド | 三環式化合物およびその薬学的使用 |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180071269A1 (en) * | 2015-08-12 | 2018-03-15 | Tianxin Wang | Therapeutical methods, formulations and nutraceutical formulations |
| ES2567105B1 (es) * | 2014-09-19 | 2017-02-10 | Consejo Superior De Investigaciones Científicas (Csic) | Derivados de indol para la prevención y/o tratamiento de diabetes ytrastornos metabólicos relacionados |
| WO2016126662A1 (en) * | 2015-02-03 | 2016-08-11 | Kardiatonos, Inc. | Compounds for the prevention and treatment of vascular disease |
| US10463649B2 (en) | 2015-06-08 | 2019-11-05 | Texas Tech University System | Inhibitors of Mc1-1 as drugs to overcome resistance to BRAF inhibitors and MEK inhibitors |
| KR101663543B1 (ko) * | 2015-07-29 | 2016-10-07 | 고려대학교 산학협력단 | 부스피론 유도체 및 이를 함유하는 약학 조성물 |
| WO2017018752A1 (ko) * | 2015-07-29 | 2017-02-02 | 고려대학교 산학협력단 | 부스피론 유도체 및 이를 함유하는 약학 조성물 |
| EP3328494A4 (en) | 2015-08-01 | 2019-04-03 | Stephen J. Petti | COMPOSITIONS AND METHODS FOR COMBINING PHARMACOLOGICAL TREATMENTS TO INDUCTION EXTENDED, Mild Acceptance of BODY CORE TEMPERATURE |
| CN105541665A (zh) * | 2016-02-18 | 2016-05-04 | 江苏大学 | 一种抗肿瘤药物化合物及制备方法和应用 |
| KR101838625B1 (ko) * | 2016-09-20 | 2018-03-14 | 김브라이언 | 아디포넥틴 수용체에 대한 작용제 펩타이드 |
| JP7034152B2 (ja) | 2016-10-05 | 2022-03-11 | ユニバーシティ オブ ピッツバーグ -オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 小分子ampk活性化剤 |
| US11337932B2 (en) | 2016-12-20 | 2022-05-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
| CN110087640A (zh) | 2016-12-20 | 2019-08-02 | 罗曼治疗系统股份公司 | 包含阿塞那平的透皮治疗系统 |
| JP2020525545A (ja) | 2017-06-26 | 2020-08-27 | エルテーエス ローマン テラピー−ジステーメ アーゲー | アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム |
| CN107252425A (zh) * | 2017-07-12 | 2017-10-17 | 上海华堇生物技术有限责任公司 | 去氢延胡索素的药物用途 |
| US11723894B2 (en) * | 2017-10-26 | 2023-08-15 | Terran Biosciences, Inc. | Combination product for the treatment of neurological and/or psychiatric disorders |
| US11103465B2 (en) | 2017-11-22 | 2021-08-31 | Ted's Brain Science, Inc. | Trans-resveratrol topical medication for the treatment of pain and method of manufacture thereof |
| US11208475B1 (en) * | 2018-01-30 | 2021-12-28 | Flagship Pioneering Innovations V, Inc. | Methods and compositions for treating inflammatory or autoimmune diseases or conditions using serotonin receptor activators |
| CN108159044A (zh) * | 2018-02-26 | 2018-06-15 | 华中科技大学 | 抗坏血酸与二甲双胍的复合制剂用于制备化疗药物的应用 |
| CN112704672A (zh) | 2018-06-20 | 2021-04-27 | 罗曼治疗系统股份公司 | 含有阿塞那平的透皮治疗系统 |
| US12329862B2 (en) | 2018-06-20 | 2025-06-17 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| CN108997172B (zh) * | 2018-08-08 | 2020-12-15 | 中国人民解放军总医院 | 抗肿瘤化合物 |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| CN109771424B (zh) * | 2019-03-11 | 2021-03-16 | 马慧 | 一种防治老年ⅱ型糖尿病性骨质疏松症的药物组合物及其应用 |
| CN109793727A (zh) * | 2019-03-13 | 2019-05-24 | 湖北科技学院 | 一种有效抗恶性肿瘤的药物组合物及其应用 |
| EP4027987A4 (en) | 2019-09-10 | 2023-11-29 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Methods and materials for increasing level of phosphorylated ampk protein |
| CN110559298A (zh) * | 2019-10-28 | 2019-12-13 | 中国药科大学 | 一种天然化合物Egenine用于制备抗肾纤维化药物的用途 |
| AU2021276656A1 (en) | 2020-05-19 | 2022-11-24 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| WO2022017440A1 (zh) * | 2020-07-22 | 2022-01-27 | 山东绿叶制药有限公司 | 5-ht 2a受体抑制剂或反向激动剂及其制备方法和应用 |
| TN2023000216A1 (en) | 2021-03-10 | 2025-04-03 | Jnana Therapeutics Inc | Small molecule inhibitors of mammalian slc6a19 function |
| EP4366731A4 (en) | 2021-07-07 | 2025-04-16 | Terran Biosciences, Inc. | N,N-DIMETHYLTRYPTAMINE AND RELATED PSYCHEDELICS AND USES THEREOF |
| EP4429672A4 (en) | 2021-11-12 | 2025-04-30 | Terran Biosciences Inc. | PSILOCYBIN AND O-ACETYLPSILOCIN, SALTS AND SOLID FORMS THEREOF |
| KR20250164150A (ko) * | 2022-12-05 | 2025-11-24 | 엔베다 테라퓨틱스, 인크. | 장 또는 복통 치료를 위한 누트카톤 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006001278A1 (ja) * | 2004-06-28 | 2006-01-05 | Kao Corporation | Ampk活性化剤 |
| JP2010516689A (ja) * | 2007-01-16 | 2010-05-20 | アイピントゥル,エルエルシー | メタボリック症候群治療用の新規組成物 |
| US20110281829A1 (en) * | 2010-04-28 | 2011-11-17 | Ipintl, Llc | Novel composition |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3174901A (en) * | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| US7754700B2 (en) * | 2006-04-24 | 2010-07-13 | Trager Seymour F | Composition and methods for alleviating symptoms of neurotoxicity |
| US20120183600A1 (en) * | 2007-01-16 | 2012-07-19 | Chien-Hung Chen | Novel composition for treating metabolic syndrome and other conditions |
| WO2011112167A1 (en) * | 2009-03-13 | 2011-09-15 | Reset Therapeutics, Inc. | Compositions and methods for diabetes treatment |
-
2014
- 2014-03-14 CA CA2909633A patent/CA2909633A1/en not_active Abandoned
- 2014-03-14 WO PCT/US2014/028413 patent/WO2014144130A2/en not_active Ceased
- 2014-03-14 HK HK16109576.5A patent/HK1222297A1/zh unknown
- 2014-03-14 BR BR112015023922A patent/BR112015023922A2/pt not_active IP Right Cessation
- 2014-03-14 US US14/212,734 patent/US20140350064A1/en not_active Abandoned
- 2014-03-14 AU AU2014227807A patent/AU2014227807B2/en not_active Ceased
- 2014-03-14 TW TW103109748A patent/TW201444552A/zh unknown
- 2014-03-14 MX MX2015012760A patent/MX2015012760A/es unknown
- 2014-03-14 JP JP2016502780A patent/JP2016513734A/ja active Pending
- 2014-03-14 CN CN201480028057.0A patent/CN105636438A/zh active Pending
- 2014-03-14 KR KR1020157029838A patent/KR20160005341A/ko not_active Withdrawn
- 2014-03-14 EP EP14763798.7A patent/EP2983473A4/en not_active Withdrawn
- 2014-03-14 RU RU2015143438A patent/RU2015143438A/ru unknown
- 2014-03-17 AR ARP140101258A patent/AR095631A1/es unknown
-
2015
- 2015-09-14 CL CL2015002680A patent/CL2015002680A1/es unknown
- 2015-09-16 IL IL241587A patent/IL241587B/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006001278A1 (ja) * | 2004-06-28 | 2006-01-05 | Kao Corporation | Ampk活性化剤 |
| JP2010516689A (ja) * | 2007-01-16 | 2010-05-20 | アイピントゥル,エルエルシー | メタボリック症候群治療用の新規組成物 |
| US20110281829A1 (en) * | 2010-04-28 | 2011-11-17 | Ipintl, Llc | Novel composition |
Non-Patent Citations (14)
| Title |
|---|
| ANISIMOV, V.N. ET AL.: ""Metformin extends life span of Her-2/neu transgenic mice and in combination with melatonin inhibits", CELL CYCLE, vol. 9, no. 1, JPN6017037382, 1 January 2010 (2010-01-01), pages 188 - 197, ISSN: 0003857251 * |
| BERGERON, R. ET AL.: "Effect of 5-Aminoimidazole-4-Carboxamide-1-b-D-Ribofuranoside Infusion on In Vivo Glucose and Lipid", DIABETES, vol. 50, no. 5, JPN6018031199, 2001, pages 1076 - 1082, ISSN: 0003857257 * |
| CARRUBA,M.O. ET AL.: "Effects of dextrofenfluramine and other anorectic drugs on experimentally induced hyperphagias", ADVANCES IN THE BIOSCIENCES(OXFORD), vol. 60, JPN6011067792, 1986, pages 353 - 60, ISSN: 0003857261 * |
| DAGON, Y. ET AL.: "Nutritional Status, Cognition, and Survival A NEW ROLE FOR LEPTIN AND AMP KINASE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 51, JPN6018031194, 2005, pages 42142 - 42148, ISSN: 0003857262 * |
| JENSEN,M.D.: "Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabol", OBESITY (SILVER SPRING), vol. Vol.14 Suppl 3, JPN7011004676, 2006, pages 143 - 149, ISSN: 0003857260 * |
| KADHIM, H. M. ET AL.: "Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly", JOURNAL OF PINEAL RESEARCH, vol. Vol. 41, Issue 2, JPN6018031193, 2006, pages 189 - 193, ISSN: 0003857255 * |
| KREJS,G.J.: "Metabolic benefits associated with sibutramine therapy", INT. J. OBES. RELAT. METAB. DISORD., vol. Vol.26 Suppl 4, JPN7011004675, 2002, pages 34 - 7, ISSN: 0003857259 * |
| KWON, K. J. ET AL.: "Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neu", JOURNAL OF CLINICAL NEUROLOGY, vol. 6, no. 3, JPN6018031191, 2010, pages 127 - 137, ISSN: 0003857254 * |
| KWON, K. J. ET AL.: "Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhi", JOURNAL OF PINEAL RESEARCH, vol. Vol. 50, Issue 2, JPN6018031189, 2011, pages 110 - 123, ISSN: 0003857253 * |
| MAN'CHEVA, T.A. ET AL.: ""Melatonin and Metformin Inhibit Skin Carcinogenesis and Lipid Peroxidation Induced by Benz(a)pyrene", BULL. EXP. BIOL. MED., vol. 151, no. 3, JPN6017037381, July 2011 (2011-07-01), pages 363 - 365, ISSN: 0003857250 * |
| SOLL, C. ET AL.: "Serotonin Promotes Tumor Growth in Human Hepatocellular Cancer", HEPATOLOGY, vol. Vol. 51, Issue 4, JPN6018031196, 2010, pages 1244 - 1254, ISSN: 0003857263 * |
| YAMAUCHI, T. ET AL: "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects", NATURE, vol. 423, no. 6941, JPN6018031198, 2003, pages 762 - 769, ISSN: 0003857256 * |
| ZAITONE, S. ET AL.: "Pentoxifylline and melatonin in combination with pioglitazone ameliorate experimental non-alcoholic", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. Vol. 662, Issue 1-3, JPN6018031187, 2011, pages 70 - 77, ISSN: 0003857252 * |
| ZHOU, G. ET AL.: "Role of AMP-activated protein kinase in mechanism of metformin action", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 108, no. 8, JPN6018031201, 2001, pages 1167 - 74, ISSN: 0003857258 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023500493A (ja) * | 2019-10-31 | 2023-01-06 | ジェイディ・バイオサイエンス・インコーポレイテッド | 三環式化合物およびその薬学的使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2983473A4 (en) | 2016-11-23 |
| HK1222297A1 (zh) | 2017-06-30 |
| BR112015023922A2 (pt) | 2017-07-18 |
| CA2909633A1 (en) | 2014-09-18 |
| WO2014144130A3 (en) | 2015-02-05 |
| AU2014227807A1 (en) | 2015-11-05 |
| CL2015002680A1 (es) | 2016-09-02 |
| AU2014227807B2 (en) | 2018-03-08 |
| KR20160005341A (ko) | 2016-01-14 |
| IL241587B (en) | 2019-01-31 |
| RU2015143438A (ru) | 2017-04-21 |
| WO2014144130A2 (en) | 2014-09-18 |
| MX2015012760A (es) | 2016-06-17 |
| CN105636438A (zh) | 2016-06-01 |
| TW201444552A (zh) | 2014-12-01 |
| AR095631A1 (es) | 2015-10-28 |
| EP2983473A2 (en) | 2016-02-17 |
| US20140350064A1 (en) | 2014-11-27 |
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