AR095631A1 - Composición farmacéutica que comprende un activador ampk y un agente de serotonergico y métodos de uso - Google Patents

Composición farmacéutica que comprende un activador ampk y un agente de serotonergico y métodos de uso

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Publication number
AR095631A1
AR095631A1 ARP140101258A ARP140101258A AR095631A1 AR 095631 A1 AR095631 A1 AR 095631A1 AR P140101258 A ARP140101258 A AR P140101258A AR P140101258 A ARP140101258 A AR P140101258A AR 095631 A1 AR095631 A1 AR 095631A1
Authority
AR
Argentina
Prior art keywords
serotonin
pharmaceutical composition
adiponectin
group
agent
Prior art date
Application number
ARP140101258A
Other languages
English (en)
Inventor
Chen Chien
Hung
Original Assignee
Chen Chien-Hung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51538303&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR095631(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chen Chien-Hung filed Critical Chen Chien-Hung
Publication of AR095631A1 publication Critical patent/AR095631A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

Una combinación de ciertos fármacos conocidos que tiene efectos sinérgicos en el tratamiento del síndrome metabólico y otras enfermedades. Composición farmacéutica que comprende: (1) una cantidad terapéuticamente eficaz de un primer agente que es un activador de AMPK, y (2) una cantidad terapéuticamente eficaz de un segundo agente que posee o conserva actividad de serotonina. Una composición preferida comprende clorhidrato de metformina y melatonina. Métodos para el uso de dichas composiciones para el tratamiento del síndrome metabólico, enfermedades hiperproliferativas que incluyen al cáncer, y otras enfermedades y condiciones. Reivindicación 2: La composición farmacéutica de la reivindicación 1 donde el activador de AMPK se selecciona entre el grupo que consiste en: (1) metformina; (2) fenformina; (3) buformina; (4) AICAR; (5) una tienopiridona; (6) resveratrol; (7) nootkatona; (8) tiazol; (9) adiponectina; (10) 2-desoxiglucosa; (11) AAPDs; (12) polipéptidos variantes de adiponectina; (13) catequinas; (14) ácido linoleico conjugado trans-10, cis-12; (15) un compuesto relacionado con coridalina que se selecciona entre el grupo que consiste en: coridalina, corlumidina, (+)-corlumidina, coripalmina, 14R-(+)-coripalmina, tetrahidropalmatina, 14R-(+)-tetrahidropalmatina, 14R,13S-(+)-coridalina, bicuculina, d-(+)-bicuculina, egenina, y +-egenina; (16) una ditioltiona; (17) un inhibidor o antagonista de la subunidad catalítica de la proteína quinasa dependiente de ADN (DNA-PKcs); (18) un ARN de interferencia pequeño (ARNip) que puede inhibir la expresión y/o traducción de DNA-PKcs; (19) un fibrato que se selecciona entre el grupo que consiste en: bezafibrato, ciprofibrato, fenofibrato, clofibrato, y gemfibrozil; (20) GW2974 (N4-(1-bencil-1H-indazol-5-il)-N6,N6-dimetil-pirido-[3,4-d]-pirimidina-4,6-diamina); (21) honokiol; (22) leptina; (23) LKB1 (serina/treonina quinasa 11); (24) obovatol (4,5-dialil-2,3-dihidroxibifenil éter); (25) una tiazolidinadiona que se selecciona entre el grupo que consiste en: pioglitazona y tiazolidinadionas relacionadas, que incluyen: rosiglitazona y maleato de rosiglitazona, (26) un péptido variante de adiponectina con una o más mutaciones en las posiciones de los aminoácidos 109 - 229 respecto de la adiponectina de tipo salvaje y con un incremento de la solubilidad de por lo menos tres veces en comparación con la adiponectina de tipo salvaje, (27) un compuesto butirato que se selecciona entre una sal butirato y un éster butirato, y (28) un derivado de quinoxalinadiona, y las sales, solvatos, análogos, congéneres, bioisósteros, productos de hidrólisis, metabolitos, precursores, y profármacos de los mismos. Reivindicación 3: La composición farmacéutica de la reivindicación 2 donde el activador de AMPK se selecciona entre el grupo que consiste en: metformina, fenformina, buformina, AICAR, tienopiridonas, resveratrol, nootkatona, tiazol, adiponectina, tiazolidinadionas, rosiglitazona, pioglitazona, ditioltionas, y las sales, solvatos, análogos, congéneres, bioisósteros, productos de hidrólisis, metabolitos, precursores, y profármacos de los mismos. Reivindicación 8: La composición farmacéutica de la reivindicación 7 donde el segundo agente es melatonina o una sal de la misma. Reivindicación 9: La composición farmacéutica de la reivindicación 1 donde el segundo agente es un compuesto serotoninérgico. Reivindicación 10: La composición farmacéutica de la reivindicación 9 donde el compuesto serotoninérgico se selecciona entre el grupo que consiste en: (a) inhibidores del transporte de serotonina; (b) moduladores del receptor de serotonina 2C; (c) inhibidores de reabsorción de serotonina, (d) inhibidores de reabsorción de serotonina y norepinefrina, (e) antagonistas de serotonina y dopamina, (f) inhibidores de la reabsorción de monoamina, (g) inhibidores de la aldosa reductasa a base de piridazinona, (h) estimulantes de los receptores de serotonina, (i) estimulantes de la síntesis de serotonina, (j) agonistas de serotonina, (k) antagonistas del receptor de serotonina 1A, y (I) metabolitos de serotonina.
ARP140101258A 2013-03-15 2014-03-17 Composición farmacéutica que comprende un activador ampk y un agente de serotonergico y métodos de uso AR095631A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361793407P 2013-03-15 2013-03-15

Publications (1)

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AR095631A1 true AR095631A1 (es) 2015-10-28

Family

ID=51538303

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140101258A AR095631A1 (es) 2013-03-15 2014-03-17 Composición farmacéutica que comprende un activador ampk y un agente de serotonergico y métodos de uso

Country Status (16)

Country Link
US (1) US20140350064A1 (es)
EP (1) EP2983473A4 (es)
JP (1) JP2016513734A (es)
KR (1) KR20160005341A (es)
CN (1) CN105636438A (es)
AR (1) AR095631A1 (es)
AU (1) AU2014227807B2 (es)
BR (1) BR112015023922A2 (es)
CA (1) CA2909633A1 (es)
CL (1) CL2015002680A1 (es)
HK (1) HK1222297A1 (es)
IL (1) IL241587B (es)
MX (1) MX2015012760A (es)
RU (1) RU2015143438A (es)
TW (1) TW201444552A (es)
WO (1) WO2014144130A2 (es)

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KR101663543B1 (ko) * 2015-07-29 2016-10-07 고려대학교 산학협력단 부스피론 유도체 및 이를 함유하는 약학 조성물
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KR101838625B1 (ko) * 2016-09-20 2018-03-14 김브라이언 아디포넥틴 수용체에 대한 작용제 펩타이드
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AU2014227807B2 (en) 2018-03-08
IL241587B (en) 2019-01-31
WO2014144130A2 (en) 2014-09-18
CA2909633A1 (en) 2014-09-18
BR112015023922A2 (pt) 2017-07-18
US20140350064A1 (en) 2014-11-27
RU2015143438A (ru) 2017-04-21
KR20160005341A (ko) 2016-01-14
WO2014144130A3 (en) 2015-02-05
EP2983473A2 (en) 2016-02-17
TW201444552A (zh) 2014-12-01
HK1222297A1 (zh) 2017-06-30
AU2014227807A1 (en) 2015-11-05
MX2015012760A (es) 2016-06-17
CN105636438A (zh) 2016-06-01
EP2983473A4 (en) 2016-11-23
JP2016513734A (ja) 2016-05-16
CL2015002680A1 (es) 2016-09-02

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