JP2016513648A5 - - Google Patents
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- JP2016513648A5 JP2016513648A5 JP2016502055A JP2016502055A JP2016513648A5 JP 2016513648 A5 JP2016513648 A5 JP 2016513648A5 JP 2016502055 A JP2016502055 A JP 2016502055A JP 2016502055 A JP2016502055 A JP 2016502055A JP 2016513648 A5 JP2016513648 A5 JP 2016513648A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- alkoxy
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- -1 R 2 -S (O) m- Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000002098 pyridazinyl group Chemical group 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- ZNGWEEUXTBNKFR-UHFFFAOYSA-N 1,4-oxazepane Chemical compound C1CNCCOC1 ZNGWEEUXTBNKFR-UHFFFAOYSA-N 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 0 CCC=CS(N(*)*)(=O)=O Chemical compound CCC=CS(N(*)*)(=O)=O 0.000 description 42
- MGCZZUMCBWBPSY-IAZDBOIISA-N C/C=C(\C=C/C(c1c(C(N)=O)[s]c(N(CCCC2)CC2NCNC(C#CC)=O)n1)=C)/Oc1ccccc1 Chemical compound C/C=C(\C=C/C(c1c(C(N)=O)[s]c(N(CCCC2)CC2NCNC(C#CC)=O)n1)=C)/Oc1ccccc1 MGCZZUMCBWBPSY-IAZDBOIISA-N 0.000 description 1
- DWTCVFGAZGXNCC-QHHAFSJGSA-N C/C=C/C(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound C/C=C/C(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O DWTCVFGAZGXNCC-QHHAFSJGSA-N 0.000 description 1
- LBOWKGNCZZJHPW-UHFFFAOYSA-N C=CC(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound C=CC(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O LBOWKGNCZZJHPW-UHFFFAOYSA-N 0.000 description 1
- NISHYBDLQONLMX-UHFFFAOYSA-N C=CC(N(CC1)CCN1c1nc(-c(cc2)ccc2Br)c(C(N)=O)[s]1)=O Chemical compound C=CC(N(CC1)CCN1c1nc(-c(cc2)ccc2Br)c(C(N)=O)[s]1)=O NISHYBDLQONLMX-UHFFFAOYSA-N 0.000 description 1
- BKVQORVRXWTYJR-UHFFFAOYSA-N C=CC(N(CC1)CCN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound C=CC(N(CC1)CCN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O BKVQORVRXWTYJR-UHFFFAOYSA-N 0.000 description 1
- LKPJFZPDUXWTHQ-UHFFFAOYSA-N C=CC(N(CC1)CCN1c1nc(-c(cc2)cnc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound C=CC(N(CC1)CCN1c1nc(-c(cc2)cnc2Oc2ccccc2)c(C(N)=O)[s]1)=O LKPJFZPDUXWTHQ-UHFFFAOYSA-N 0.000 description 1
- ICJLDXFNSATXEI-UHFFFAOYSA-N C=CC(N(CC1)CCN1c1nc(-c2c[n](Cc3ccccc3)nc2)c(C(N)=O)[s]1)=O Chemical compound C=CC(N(CC1)CCN1c1nc(-c2c[n](Cc3ccccc3)nc2)c(C(N)=O)[s]1)=O ICJLDXFNSATXEI-UHFFFAOYSA-N 0.000 description 1
- BODIQTYTOZEGLQ-HDICACEKSA-N C=CC(N([C@H](CC1)C2)[C@@H]1CN2c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound C=CC(N([C@H](CC1)C2)[C@@H]1CN2c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O BODIQTYTOZEGLQ-HDICACEKSA-N 0.000 description 1
- DZJYMSKQVGPWDW-UHFFFAOYSA-N C=CC(N1CC(C2)(CN2c2nc(-c(cc3)ccc3Oc3ccccc3)c(C(N)=O)[s]2)CC1)=O Chemical compound C=CC(N1CC(C2)(CN2c2nc(-c(cc3)ccc3Oc3ccccc3)c(C(N)=O)[s]2)CC1)=O DZJYMSKQVGPWDW-UHFFFAOYSA-N 0.000 description 1
- QEMBDZBGVVIMDE-QGZVFWFLSA-N C=CC(NC[C@@H](CCC1)N1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound C=CC(NC[C@@H](CCC1)N1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O QEMBDZBGVVIMDE-QGZVFWFLSA-N 0.000 description 1
- IORHCEOOZXAEIB-UHFFFAOYSA-N CC#CC(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O IORHCEOOZXAEIB-UHFFFAOYSA-N 0.000 description 1
- SYHYHJNQHXVSGL-UHFFFAOYSA-N CC#CC(N(CC1)CCN1c1nc(-c(cc2)ccc2Br)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N(CC1)CCN1c1nc(-c(cc2)ccc2Br)c(C(N)=O)[s]1)=O SYHYHJNQHXVSGL-UHFFFAOYSA-N 0.000 description 1
- JHWLCLFZHPZTOM-UHFFFAOYSA-N CC#CC(N(CC1)CCN1c1nc(-c(cc2)ccc2S(C)(=O)=O)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N(CC1)CCN1c1nc(-c(cc2)ccc2S(C)(=O)=O)c(C(N)=O)[s]1)=O JHWLCLFZHPZTOM-UHFFFAOYSA-N 0.000 description 1
- XYUKSCVGRIEAJE-UHFFFAOYSA-N CC#CC(N(CC1)CCN1c1nc(-c(cc2)cnc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N(CC1)CCN1c1nc(-c(cc2)cnc2Oc2ccccc2)c(C(N)=O)[s]1)=O XYUKSCVGRIEAJE-UHFFFAOYSA-N 0.000 description 1
- VUSVLLABGJWKNK-UHFFFAOYSA-N CC#CC(N(CC1)CCN1c1nc(-c2c[n](Cc3ccccc3)nc2)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N(CC1)CCN1c1nc(-c2c[n](Cc3ccccc3)nc2)c(C(N)=O)[s]1)=O VUSVLLABGJWKNK-UHFFFAOYSA-N 0.000 description 1
- BRJHBECQGMZQNG-UHFFFAOYSA-N CC#CC(N(CC1)CCN1c1nc(-c2cccc(C(Nc3ccccc3)=O)c2)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N(CC1)CCN1c1nc(-c2cccc(C(Nc3ccccc3)=O)c2)c(C(N)=O)[s]1)=O BRJHBECQGMZQNG-UHFFFAOYSA-N 0.000 description 1
- QRNOTCBDCNPPHN-UHFFFAOYSA-N CC#CC(N(CC1)CCN1c1sc(C(N)=O)c(-c(nc2)ccc2Oc2ccccc2)[nH]1)=O Chemical compound CC#CC(N(CC1)CCN1c1sc(C(N)=O)c(-c(nc2)ccc2Oc2ccccc2)[nH]1)=O QRNOTCBDCNPPHN-UHFFFAOYSA-N 0.000 description 1
- YAWJKHVYPUJMMU-UHFFFAOYSA-N CC#CC(N(CCC1)C1(CC1)CCN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N(CCC1)C1(CC1)CCN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O YAWJKHVYPUJMMU-UHFFFAOYSA-N 0.000 description 1
- WUJCGJYECPHHBR-OUBYRJNXSA-N CC#CC(N(C[C@@H]1C2)[C@@H]2CN1c1nc(-c(cc2)ccc2Oc2cc(C3OCCN(C/C=C/C(N(C4)CC4(C4)CN4c4nc(-c(cc5)ccc5Oc5ccccc5)c(C(N)=O)[s]4)=O)C3)ccc2)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N(C[C@@H]1C2)[C@@H]2CN1c1nc(-c(cc2)ccc2Oc2cc(C3OCCN(C/C=C/C(N(C4)CC4(C4)CN4c4nc(-c(cc5)ccc5Oc5ccccc5)c(C(N)=O)[s]4)=O)C3)ccc2)c(C(N)=O)[s]1)=O WUJCGJYECPHHBR-OUBYRJNXSA-N 0.000 description 1
- ZIEKONTVPAHBEU-KDURUIRLSA-N CC#CC(N([C@H](CC1)C2)[C@@H]1CN2c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CC#CC(N([C@H](CC1)C2)[C@@H]1CN2c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O ZIEKONTVPAHBEU-KDURUIRLSA-N 0.000 description 1
- XORZTHRVENPVPF-GOSISDBHSA-N CC#CC(NC[C@@H](CCC1)N1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CC#CC(NC[C@@H](CCC1)N1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O XORZTHRVENPVPF-GOSISDBHSA-N 0.000 description 1
- POQLWCMSUQFCAB-UHFFFAOYSA-N CC(C)(C#CC(N(CC1)CCN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O)O Chemical compound CC(C)(C#CC(N(CC1)CCN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O)O POQLWCMSUQFCAB-UHFFFAOYSA-N 0.000 description 1
- MLLWIYAKXPQKTN-UHFFFAOYSA-N CC(C)C(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CC(C)C(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O MLLWIYAKXPQKTN-UHFFFAOYSA-N 0.000 description 1
- OFSIRYWHKYRECD-UHFFFAOYSA-N CC(C)N(CC1)CCC1(CCC1)N1C(C=C)=O Chemical compound CC(C)N(CC1)CCC1(CCC1)N1C(C=C)=O OFSIRYWHKYRECD-UHFFFAOYSA-N 0.000 description 1
- TUDKZYQJTCGAJJ-UHFFFAOYSA-N CC(C)c1c[n](Cc2ccccc2)nc1 Chemical compound CC(C)c1c[n](Cc2ccccc2)nc1 TUDKZYQJTCGAJJ-UHFFFAOYSA-N 0.000 description 1
- ZRHMROAHNFHRRL-UHFFFAOYSA-N CC(CN(CC1)c2nc(-c(cc3)ccc3Oc3ccccc3)c(C(N)=O)[s]2)N1C(C#CC)=O Chemical compound CC(CN(CC1)c2nc(-c(cc3)ccc3Oc3ccccc3)c(C(N)=O)[s]2)N1C(C#CC)=O ZRHMROAHNFHRRL-UHFFFAOYSA-N 0.000 description 1
- CEZQSZZFKOKBCY-UHFFFAOYSA-N CCC(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CCC(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O CEZQSZZFKOKBCY-UHFFFAOYSA-N 0.000 description 1
- OTCVAXWNLZTWCU-RMKNXTFCSA-N CN(C)C/C=C/C(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CN(C)C/C=C/C(N(C1)CC1(C1)CN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O OTCVAXWNLZTWCU-RMKNXTFCSA-N 0.000 description 1
- CRHPPKVBAJMZDF-OEMHODTASA-N CN(C)C/C=C/C(NC[C@H](CCC1)N1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CN(C)C/C=C/C(NC[C@H](CCC1)N1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O CRHPPKVBAJMZDF-OEMHODTASA-N 0.000 description 1
- BFSJAOSOHZGUNA-XQRVVYSFSA-N CN(C)CC/C=C\C(N(C1)CC11CN(C)CC1)=O Chemical compound CN(C)CC/C=C\C(N(C1)CC11CN(C)CC1)=O BFSJAOSOHZGUNA-XQRVVYSFSA-N 0.000 description 1
- UJGJSJXNPBRAKU-UHFFFAOYSA-N CN(C)CCC(N(CC1)CCN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O Chemical compound CN(C)CCC(N(CC1)CCN1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1)=O UJGJSJXNPBRAKU-UHFFFAOYSA-N 0.000 description 1
- NLCJUDKCZFWPQN-UHFFFAOYSA-N CN(C1)CC1(CC1)CN1C(C=C)=O Chemical compound CN(C1)CC1(CC1)CN1C(C=C)=O NLCJUDKCZFWPQN-UHFFFAOYSA-N 0.000 description 1
- IFVJBMXANYAMCR-UHFFFAOYSA-N CN1CC(C2)(CN2C(C=C)=O)CC1 Chemical compound CN1CC(C2)(CN2C(C=C)=O)CC1 IFVJBMXANYAMCR-UHFFFAOYSA-N 0.000 description 1
- BKNFUSSYXSBQCM-INIZCTEOSA-N C[C@@H](CN(CC1)C(C=C)=O)N1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1 Chemical compound C[C@@H](CN(CC1)C(C=C)=O)N1c1nc(-c(cc2)ccc2Oc2ccccc2)c(C(N)=O)[s]1 BKNFUSSYXSBQCM-INIZCTEOSA-N 0.000 description 1
- RPYDQYKXNFVDJJ-UHFFFAOYSA-N NC(c1c(-c(cc2)ccc2Oc2ccccc2)nc(N(CC2)CCN2C(C#CCN2CCOCC2)=O)[s]1)=O Chemical compound NC(c1c(-c(cc2)ccc2Oc2ccccc2)nc(N(CC2)CCN2C(C#CCN2CCOCC2)=O)[s]1)=O RPYDQYKXNFVDJJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782241P | 2013-03-14 | 2013-03-14 | |
| US61/782,241 | 2013-03-14 | ||
| PCT/US2014/026113 WO2014151620A1 (en) | 2013-03-14 | 2014-03-13 | 5-thiazolecarboxamide dervatives and their use as btk inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513648A JP2016513648A (ja) | 2016-05-16 |
| JP2016513648A5 true JP2016513648A5 (https=) | 2017-04-20 |
| JP6403751B2 JP6403751B2 (ja) | 2018-10-10 |
Family
ID=50549459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502055A Active JP6403751B2 (ja) | 2013-03-14 | 2014-03-13 | ５−チアゾールカルボキサミン誘導体及びｂｔｋ阻害剤としてのその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8895750B2 (https=) |
| EP (1) | EP2970163B1 (https=) |
| JP (1) | JP6403751B2 (https=) |
| WO (1) | WO2014151620A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6615752B2 (ja) * | 2013-09-30 | 2019-12-04 | グアンジョウ・イノケア・ファーマ・テク・カンパニー・リミテッド | Ｂｔｋの置換ニコチンイミド阻害剤およびそれらの調製、ならびにがん、炎症および自己免疫疾患の治療における使用 |
| PL3371165T3 (pl) * | 2015-11-04 | 2022-05-02 | Merck Patent Gmbh | Inhibitor btk do zastosowania w terapii rakowej |
| US9975882B2 (en) * | 2015-12-16 | 2018-05-22 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as BTK inhibitors |
| CN107226805A (zh) * | 2016-03-24 | 2017-10-03 | 北京天诚医药科技有限公司 | 芳香族酰胺类衍生物、其制备方法及其在医药上的应用 |
| CN107286150B (zh) * | 2016-04-11 | 2020-07-07 | 中国科学院上海有机化学研究所 | N-杂环类化合物、其中间体、制备方法、药物组合物和应用 |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007117692A2 (en) * | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
| BRPI0622054B8 (pt) | 2006-09-22 | 2021-05-25 | Oxford Amherst Llc | composto e composição farmacêutica |
| IL295053A (en) | 2007-03-28 | 2022-09-01 | Pharmacyclics Llc | Broton tyrosine kinase inhibitors |
| ES2445099T3 (es) | 2008-07-29 | 2014-02-28 | Université de Liège | Una prueba de marcador genético para braquispina y fertilidad en ganado vacuno |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| AU2010341229A1 (en) * | 2009-12-17 | 2012-08-02 | Merck Patent Gmbh | Sphingosine kinase inhibitors |
| BR112012030711B1 (pt) | 2010-05-31 | 2020-10-13 | Ono Pharmaceutical Co. Ltd | derivado de purinona |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| JP5985658B2 (ja) | 2012-01-31 | 2016-09-06 | ナンジン アルゲン ファルマ カンパニー リミテッドＮａｎｊｉｎｇ Ａｌｌｇｅｎ Ｐｈａｒｍａ Ｃｏ． Ｌｔｄ． | ブルトンチロシンキナーゼ阻害薬としての環状分子 |
| SG11201500499TA (en) | 2012-08-10 | 2015-03-30 | Boehringer Ingelheim Int | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| JP6178861B2 (ja) | 2012-11-02 | 2017-08-09 | ファイザー・インク | ブルトン型チロシンキナーゼ阻害剤 |
| CN103848810A (zh) | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
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2014
- 2014-03-13 JP JP2016502055A patent/JP6403751B2/ja active Active
- 2014-03-13 WO PCT/US2014/026113 patent/WO2014151620A1/en not_active Ceased
- 2014-03-13 US US14/209,280 patent/US8895750B2/en active Active
- 2014-03-13 EP EP14719465.8A patent/EP2970163B1/en active Active