JP2012525335A5 - - Google Patents

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Publication number
JP2012525335A5
JP2012525335A5 JP2012507474A JP2012507474A JP2012525335A5 JP 2012525335 A5 JP2012525335 A5 JP 2012525335A5 JP 2012507474 A JP2012507474 A JP 2012507474A JP 2012507474 A JP2012507474 A JP 2012507474A JP 2012525335 A5 JP2012525335 A5 JP 2012525335A5
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JP
Japan
Prior art keywords
alkyl
piperazin
benzamide
pyridin
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012507474A
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English (en)
Japanese (ja)
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JP5741574B2 (ja
JP2012525335A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/032477 external-priority patent/WO2010126851A1/en
Publication of JP2012525335A publication Critical patent/JP2012525335A/ja
Publication of JP2012525335A5 publication Critical patent/JP2012525335A5/ja
Application granted granted Critical
Publication of JP5741574B2 publication Critical patent/JP5741574B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012507474A 2009-04-27 2010-04-27 Ｃｘｃｒ３受容体アンタゴニスト Expired - Fee Related JP5741574B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17286909P 2009-04-27 2009-04-27
US61/172,869 2009-04-27
US31735110P 2010-03-25 2010-03-25
US61/317,351 2010-03-25
PCT/US2010/032477 WO2010126851A1 (en) 2009-04-27 2010-04-27 Cxcr3 receptor antagonists

Publications (3)

Publication Number Publication Date
JP2012525335A JP2012525335A (ja) 2012-10-22
JP2012525335A5 true JP2012525335A5 (https=) 2013-06-20
JP5741574B2 JP5741574B2 (ja) 2015-07-01

Family

ID=42272001

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012507474A Expired - Fee Related JP5741574B2 (ja) 2009-04-27 2010-04-27 Ｃｘｃｒ３受容体アンタゴニスト

Country Status (7)

Country Link
US (1) US8362249B2 (https=)
EP (1) EP2424858B1 (https=)
JP (1) JP5741574B2 (https=)
AR (1) AR076460A1 (https=)
TW (1) TW201103933A (https=)
UY (1) UY32574A (https=)
WO (1) WO2010126851A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2330894B8 (en) 2008-09-03 2017-04-19 BioMarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
EP2424840B1 (en) * 2009-04-27 2014-08-06 Boehringer Ingelheim International GmbH Cxcr3 receptor antagonists
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
US8952004B2 (en) 2010-01-07 2015-02-10 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
US9540395B2 (en) 2011-02-28 2017-01-10 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
EP2508511A1 (en) * 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
US9266876B2 (en) 2012-02-02 2016-02-23 Actelion Pharmaceuticals Ltd. 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
WO2014143666A1 (en) 2013-03-15 2014-09-18 Biomarin Pharmaceutical Inc. Hdac inhibitors
WO2014182673A1 (en) * 2013-05-07 2014-11-13 Arena Pharmaceuticals, Inc. Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
WO2014182688A1 (en) * 2013-05-07 2014-11-13 Arena Pharmaceuticals, Inc. Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
EP3016950B1 (en) 2013-07-02 2017-06-07 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
US9914740B2 (en) 2013-07-02 2018-03-13 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
EA030067B1 (ru) 2013-07-22 2018-06-29 Идорсиа Фармасьютиклз Лтд Производные 1-(пиперазин-1-ил)-2-([1,2,4]триазол-1-ил)этанона
AR099789A1 (es) * 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
RU2743074C2 (ru) 2014-08-01 2021-02-15 Нуэволюшон А/С Соединения, активные по отношению к бромодоменам
TWI689497B (zh) * 2014-09-04 2020-04-01 南北兄弟藥業投資有限公司 芳雜環類衍生物及其在藥物中的應用
JP6337218B2 (ja) 2015-01-15 2018-06-06 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｃｘｃｒ３受容体調節剤としてのヒドロキシアルキル−ピペラジン誘導体
AR103399A1 (es) * 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
US12024520B2 (en) 2018-08-29 2024-07-02 Acerta Pharma B.V. Processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)-pyrrolidin-2-yl]imidazo[1,5-a]-pyrazin-1-yl}N-(pyridin-2-yl)-benzamide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1531822T3 (da) * 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US20040192728A1 (en) * 2003-02-03 2004-09-30 Ellen Codd Quinoline-derived amide modulators of vanilloid VR1 receptor
BRPI0612112A8 (pt) * 2005-06-22 2017-12-26 Chemocentryx Inc composto, composição farmacêutica, e, método de tratar doenças ou condições mediadas por ccr1.
EP1988900A2 (en) * 2006-02-23 2008-11-12 Merck & Co., Inc. Pyridine, pyrimidine and pyrazine derivatives as cxcr3 receptor modulators
JP5182088B2 (ja) * 2006-04-19 2013-04-10 アステラス製薬株式会社 アゾールカルボキサミド誘導体
JP5286646B2 (ja) * 2006-04-19 2013-09-11 トヨタ自動車株式会社 スルホン基含有モノマーの重合方法
US20090099201A1 (en) * 2007-05-22 2009-04-16 David Robert Bolin Diacylglycerol Acyltransferase Inhibitors
JO2972B1 (en) * 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
EP2424840B1 (en) * 2009-04-27 2014-08-06 Boehringer Ingelheim International GmbH Cxcr3 receptor antagonists

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