JP2016512208A5 - - Google Patents
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- JP2016512208A5 JP2016512208A5 JP2015562040A JP2015562040A JP2016512208A5 JP 2016512208 A5 JP2016512208 A5 JP 2016512208A5 JP 2015562040 A JP2015562040 A JP 2015562040A JP 2015562040 A JP2015562040 A JP 2015562040A JP 2016512208 A5 JP2016512208 A5 JP 2016512208A5
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- JP
- Japan
- Prior art keywords
- fibrosis
- disease
- induced
- ipf
- liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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- LFTLOKWAGJYHHR-UHFFFAOYSA-N N-methylmorpholine N-oxide Chemical compound CN1(=O)CCOCC1 LFTLOKWAGJYHHR-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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- MCUXGRJXNJGKPY-UHFFFAOYSA-N 1-[6-bromo-3-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-methylamino]imidazo[1,2-a]pyridin-2-yl]-2-phenylethane-1,2-diol Chemical compound C=1C=CC=CC=1C(O)C(O)C=1N=C2C=CC(Br)=CN2C=1N(C)C(SC=1)=NC=1C1=CC=C(F)C=C1 MCUXGRJXNJGKPY-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- UHNYTFYKANFKII-UHFFFAOYSA-N 6-bromo-3-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-methylamino]imidazo[1,2-a]pyridine-2-carbaldehyde Chemical compound O=CC=1N=C2C=CC(Br)=CN2C=1N(C)C(SC=1)=NC=1C1=CC=C(F)C=C1 UHNYTFYKANFKII-UHFFFAOYSA-N 0.000 description 1
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781174P | 2013-03-14 | 2013-03-14 | |
| US61/781,174 | 2013-03-14 | ||
| PCT/EP2014/054440 WO2014139882A1 (en) | 2013-03-14 | 2014-03-07 | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018072964A Division JP6517976B2 (ja) | 2013-03-14 | 2018-04-05 | 炎症性障害の治療のための化合物及びその医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512208A JP2016512208A (ja) | 2016-04-25 |
| JP2016512208A5 true JP2016512208A5 (enExample) | 2017-04-06 |
| JP6339595B2 JP6339595B2 (ja) | 2018-06-06 |
Family
ID=50236198
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562040A Active JP6339595B2 (ja) | 2013-03-14 | 2014-03-07 | 炎症性障害の治療のための化合物及びその医薬組成物 |
| JP2018072964A Active JP6517976B2 (ja) | 2013-03-14 | 2018-04-05 | 炎症性障害の治療のための化合物及びその医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018072964A Active JP6517976B2 (ja) | 2013-03-14 | 2018-04-05 | 炎症性障害の治療のための化合物及びその医薬組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US8993590B2 (enExample) |
| EP (3) | EP3269716B1 (enExample) |
| JP (2) | JP6339595B2 (enExample) |
| KR (2) | KR20210034098A (enExample) |
| CN (1) | CN105143221B (enExample) |
| AR (1) | AR095280A1 (enExample) |
| AU (3) | AU2014231009B2 (enExample) |
| BR (1) | BR112015020998B1 (enExample) |
| CA (1) | CA2902103C (enExample) |
| CY (2) | CY1119352T1 (enExample) |
| DK (2) | DK2970255T3 (enExample) |
| ES (2) | ES2824723T3 (enExample) |
| HR (2) | HRP20171219T1 (enExample) |
| HU (2) | HUE035966T2 (enExample) |
| IL (2) | IL240531B (enExample) |
| LT (2) | LT2970255T (enExample) |
| MX (1) | MX358342B (enExample) |
| MY (1) | MY170260A (enExample) |
| NZ (1) | NZ711202A (enExample) |
| PH (1) | PH12015502055A1 (enExample) |
| PL (2) | PL2970255T3 (enExample) |
| PT (2) | PT3269716T (enExample) |
| RU (1) | RU2675818C2 (enExample) |
| SG (1) | SG11201507224RA (enExample) |
| SI (2) | SI3269716T1 (enExample) |
| TW (2) | TWI695002B (enExample) |
| UY (1) | UY35437A (enExample) |
| WO (1) | WO2014139882A1 (enExample) |
| ZA (1) | ZA201505909B (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE041576T2 (hu) | 2011-09-14 | 2019-05-28 | Samumed Llc | Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| WO2014139882A1 (en) | 2013-03-14 | 2014-09-18 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| CN105339370B (zh) | 2013-06-19 | 2017-09-15 | 加拉帕戈斯股份有限公司 | 用于治疗炎症性疾病的化合物和及其药物组合物 |
| US9943677B2 (en) | 2013-10-15 | 2018-04-17 | Radux Devices, LLC | Securing a medical device to a valve instrument |
| PL3197277T3 (pl) | 2014-08-29 | 2022-04-04 | Chdi Foundation, Inc. | Sondy do obrazowania molekularnego białka huntingtyny |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| US10118904B2 (en) | 2015-06-05 | 2018-11-06 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of Demyelinating Diseases |
| JP6871919B2 (ja) | 2015-06-16 | 2021-05-19 | ナノファギックス エルエルシー | 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法 |
| WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10206909B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017023980A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017023987A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| US10231956B2 (en) | 2015-08-03 | 2019-03-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10463651B2 (en) | 2015-08-03 | 2019-11-05 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof |
| WO2017023993A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10206908B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10383861B2 (en) | 2015-08-03 | 2019-08-20 | Sammumed, LLC | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10329309B2 (en) | 2015-08-03 | 2019-06-25 | Samumed, Llc | 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10285983B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof |
| US10604512B2 (en) | 2015-08-03 | 2020-03-31 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof |
| WO2017024025A1 (en) | 2015-08-03 | 2017-02-09 | Sunil Kumar Kc | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| US10195185B2 (en) | 2015-08-03 | 2019-02-05 | Samumed, Llc | 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017079759A1 (en) | 2015-11-06 | 2017-05-11 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-c]pyridines and their anti-inflammatory uses thereof |
| WO2017192228A1 (en) * | 2016-05-06 | 2017-11-09 | Albert Einstein College Of Medicine, Inc. | Pak1 inhibitors and uses thereof |
| MY199242A (en) | 2016-06-01 | 2023-10-22 | Samumed Llc | Process for preparing n-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide |
| BR112019008061A2 (pt) | 2016-10-21 | 2019-09-17 | Samumed Llc | métodos de uso de indazol-3-carboxamidas e seu uso como inibidores da via de sinalização de wnt/b-catenina |
| DE112017005364T5 (de) | 2016-10-24 | 2019-07-18 | Precision Combustion, Inc. | Regenerativer festoxidstapel |
| MA46696A (fr) | 2016-11-07 | 2019-09-11 | Samumed Llc | Formulations injectables à dose unique prêtes à l'emploi |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| GB201710851D0 (en) | 2017-07-06 | 2017-08-23 | Galápagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis |
| CN109384803B (zh) * | 2017-08-09 | 2021-08-31 | 广州市恒诺康医药科技有限公司 | Atx抑制剂及其制备方法和应用 |
| US20200253959A1 (en) | 2017-08-09 | 2020-08-13 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for use in the treatment of fibrotic diseases |
| US20210106582A1 (en) | 2017-11-15 | 2021-04-15 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for use in the treatment of fibrotic diseases |
| AU2019220064A1 (en) * | 2018-02-14 | 2020-10-01 | Suzhou Sinovent Pharmaceuticals Co., Ltd. | Heterocyclic compound, application thereof and pharmaceutical composition comprising same |
| JP7274767B2 (ja) * | 2018-05-24 | 2023-05-17 | ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司 | 芳香族複素環式化合物及びその医薬組成物 |
| WO2019228403A1 (en) | 2018-05-29 | 2019-12-05 | Fronthera U.S. Pharmaceuticals Llc | Autotaxin inhibitors and uses thereof |
| SG11202012524YA (en) | 2018-07-27 | 2021-01-28 | Mitsubishi Tanabe Pharma Corp | Novel 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same |
| GB201812861D0 (en) | 2018-08-08 | 2018-09-19 | Galapagos Nv | Methods of administering therapy |
| PL3873472T3 (pl) | 2018-10-29 | 2023-12-27 | Boehringer Ingelheim International Gmbh | Nowe pirydazyny |
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| GB201904375D0 (en) * | 2019-03-29 | 2019-05-15 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
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