JP6339595B2 - 炎症性障害の治療のための化合物及びその医薬組成物 - Google Patents

炎症性障害の治療のための化合物及びその医薬組成物 Download PDF

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JP6339595B2
JP6339595B2 JP2015562040A JP2015562040A JP6339595B2 JP 6339595 B2 JP6339595 B2 JP 6339595B2 JP 2015562040 A JP2015562040 A JP 2015562040A JP 2015562040 A JP2015562040 A JP 2015562040A JP 6339595 B2 JP6339595 B2 JP 6339595B2
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methyl
ethyl
pyridin
imidazo
fluorophenyl
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JP2016512208A5 (enExample
JP2016512208A (ja
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デスロイ ニコラス
デスロイ ニコラス
ヘクマン ベルトランド
ヘクマン ベルトランド
クリストフェ ザビエル ブリス レギナルド
クリストフェ ザビエル ブリス レギナルド
ジョンコウル アグネス
ジョンコウル アグネス
ペイクオト クリストフェ
ペイクオト クリストフェ
ボク ザビエル
ボク ザビエル
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Galapagos NV
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2015562040A 2013-03-14 2014-03-07 炎症性障害の治療のための化合物及びその医薬組成物 Active JP6339595B2 (ja)

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US201361781174P 2013-03-14 2013-03-14
US61/781,174 2013-03-14
PCT/EP2014/054440 WO2014139882A1 (en) 2013-03-14 2014-03-07 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

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US (7) US8993590B2 (enExample)
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KR (2) KR20210034098A (enExample)
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Cited By (1)

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JP2018135350A (ja) * 2013-03-14 2018-08-30 ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． 炎症性障害の治療のための化合物及びその医薬組成物

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PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
CN105339370B (zh) 2013-06-19 2017-09-15 加拉帕戈斯股份有限公司 用于治疗炎症性疾病的化合物和及其药物组合物
US9943677B2 (en) 2013-10-15 2018-04-17 Radux Devices, LLC Securing a medical device to a valve instrument
PL3197277T3 (pl) 2014-08-29 2022-04-04 Chdi Foundation, Inc. Sondy do obrazowania molekularnego białka huntingtyny
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