CN105143221B - 用于治疗炎性障碍的化合物及其药物组合物 - Google Patents
用于治疗炎性障碍的化合物及其药物组合物 Download PDFInfo
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- CN105143221B CN105143221B CN201480014005.8A CN201480014005A CN105143221B CN 105143221 B CN105143221 B CN 105143221B CN 201480014005 A CN201480014005 A CN 201480014005A CN 105143221 B CN105143221 B CN 105143221B
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- Prior art keywords
- bases
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- ethyls
- amino
- imidazo
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- 0 CCC(CC(C)(C)CCC1)C(C)CCC(C)*1C(C(*)=C1*)=CN2C1=NC(*)[C@]2C=C(*)CC/C1=C\CC*/C(/c(ccc(F)c2)c2C#N)=C\S1 Chemical compound CCC(CC(C)(C)CCC1)C(C)CCC(C)*1C(C(*)=C1*)=CN2C1=NC(*)[C@]2C=C(*)CC/C1=C\CC*/C(/c(ccc(F)c2)c2C#N)=C\S1 0.000 description 14
- OEIWBEYFBKSWGX-UHFFFAOYSA-N CCC1=C(N(C)c2nc(-c(cc3)ccc3F)c[s]2)N(C=C(C=C2)N(CC3)CCC3=O)C2=C(C)C1 Chemical compound CCC1=C(N(C)c2nc(-c(cc3)ccc3F)c[s]2)N(C=C(C=C2)N(CC3)CCC3=O)C2=C(C)C1 OEIWBEYFBKSWGX-UHFFFAOYSA-N 0.000 description 1
- NSACLNWJFDGBHP-UHFFFAOYSA-N CCCNCCNC(C=C1)=CN2C1=NC(CC)C2(C)N(C)c1nc(-c(ccc(F)c2)c2C#N)c[s]1 Chemical compound CCCNCCNC(C=C1)=CN2C1=NC(CC)C2(C)N(C)c1nc(-c(ccc(F)c2)c2C#N)c[s]1 NSACLNWJFDGBHP-UHFFFAOYSA-N 0.000 description 1
- SJLCPEGUZIZCFP-UHFFFAOYSA-N CCc1c(N(C)c2nc(-c(cc3)ccc3F)c[s]2)[n](cc(cc2F)N3CCNCC3)c2n1 Chemical compound CCc1c(N(C)c2nc(-c(cc3)ccc3F)c[s]2)[n](cc(cc2F)N3CCNCC3)c2n1 SJLCPEGUZIZCFP-UHFFFAOYSA-N 0.000 description 1
- BFNXFBYTJYLROO-UHFFFAOYSA-N CCc1c(N(CC)c2nc(-c(cc3)ccc3F)c(C#N)[s]2)[n](cc(cc2C)[Br]=C)c2n1 Chemical compound CCc1c(N(CC)c2nc(-c(cc3)ccc3F)c(C#N)[s]2)[n](cc(cc2C)[Br]=C)c2n1 BFNXFBYTJYLROO-UHFFFAOYSA-N 0.000 description 1
- ITSMPHFOKYATMO-UHFFFAOYSA-N CN(c1c(CCC#N)nc2[n]1cc(C(CC1)CCN1S(C)=O)cc2)c1nc(-c(cc2)ccc2F)c[s]1 Chemical compound CN(c1c(CCC#N)nc2[n]1cc(C(CC1)CCN1S(C)=O)cc2)c1nc(-c(cc2)ccc2F)c[s]1 ITSMPHFOKYATMO-UHFFFAOYSA-N 0.000 description 1
- GGUKQCAXTMDKPC-UHFFFAOYSA-N CN(c1c(CCC#N)nc2[n]1cc(C1CCNCC1)cc2)c1nc(-c(cc2)ccc2F)c[s]1 Chemical compound CN(c1c(CCC#N)nc2[n]1cc(C1CCNCC1)cc2)c1nc(-c(cc2)ccc2F)c[s]1 GGUKQCAXTMDKPC-UHFFFAOYSA-N 0.000 description 1
- FRUCDTLYIYOMNQ-UHFFFAOYSA-N CN(c1cnc(CC2)[n]1C=C2C(CC1)CCN1S=O)c1nc(-c(cc2)ccc2F)c(CO)[s]1 Chemical compound CN(c1cnc(CC2)[n]1C=C2C(CC1)CCN1S=O)c1nc(-c(cc2)ccc2F)c(CO)[s]1 FRUCDTLYIYOMNQ-UHFFFAOYSA-N 0.000 description 1
- WWEINXQNCAWBPD-UHFFFAOYSA-N Nc1ncccc1F Chemical compound Nc1ncccc1F WWEINXQNCAWBPD-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781174P | 2013-03-14 | 2013-03-14 | |
| US61/781,174 | 2013-03-14 | ||
| PCT/EP2014/054440 WO2014139882A1 (en) | 2013-03-14 | 2014-03-07 | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105143221A CN105143221A (zh) | 2015-12-09 |
| CN105143221B true CN105143221B (zh) | 2017-06-09 |
Family
ID=50236198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480014005.8A Active CN105143221B (zh) | 2013-03-14 | 2014-03-07 | 用于治疗炎性障碍的化合物及其药物组合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US8993590B2 (enExample) |
| EP (3) | EP3269716B1 (enExample) |
| JP (2) | JP6339595B2 (enExample) |
| KR (2) | KR102231637B1 (enExample) |
| CN (1) | CN105143221B (enExample) |
| AR (1) | AR095280A1 (enExample) |
| AU (3) | AU2014231009B2 (enExample) |
| BR (1) | BR112015020998B1 (enExample) |
| CA (1) | CA2902103C (enExample) |
| CY (2) | CY1119352T1 (enExample) |
| DK (2) | DK3269716T3 (enExample) |
| ES (2) | ES2824723T3 (enExample) |
| HR (2) | HRP20171219T1 (enExample) |
| HU (2) | HUE051195T2 (enExample) |
| IL (2) | IL240531B (enExample) |
| LT (2) | LT2970255T (enExample) |
| MX (1) | MX358342B (enExample) |
| MY (1) | MY170260A (enExample) |
| NZ (1) | NZ711202A (enExample) |
| PH (1) | PH12015502055B1 (enExample) |
| PL (2) | PL2970255T3 (enExample) |
| PT (2) | PT2970255T (enExample) |
| RU (1) | RU2675818C2 (enExample) |
| SG (1) | SG11201507224RA (enExample) |
| SI (2) | SI2970255T1 (enExample) |
| TW (2) | TWI749290B (enExample) |
| UY (1) | UY35437A (enExample) |
| WO (1) | WO2014139882A1 (enExample) |
| ZA (1) | ZA201505909B (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012308570B2 (en) | 2011-09-14 | 2016-11-10 | Samumed, Llc | Indazole-3-carboxamides and their use as Wnt/b-catenin signaling pathway inhibitors |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| CA2902103C (en) | 2013-03-14 | 2021-09-21 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| EP3010922B1 (en) | 2013-06-19 | 2017-03-15 | Galapagos NV | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| US9943677B2 (en) | 2013-10-15 | 2018-04-17 | Radux Devices, LLC | Securing a medical device to a valve instrument |
| WO2016033440A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| CA2988306A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| JP6871919B2 (ja) | 2015-06-16 | 2021-05-19 | ナノファギックス エルエルシー | 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法 |
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