CN105143221B - 用于治疗炎性障碍的化合物及其药物组合物 - Google Patents

用于治疗炎性障碍的化合物及其药物组合物 Download PDF

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CN105143221B
CN105143221B CN201480014005.8A CN201480014005A CN105143221B CN 105143221 B CN105143221 B CN 105143221B CN 201480014005 A CN201480014005 A CN 201480014005A CN 105143221 B CN105143221 B CN 105143221B
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methyl
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amino
imidazo
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CN105143221A (zh
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N·迪斯若瑞
B·海克曼
R·C·X·布莱斯
A·容古
C·佩肖托
X·博克
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Galapagos NV
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CN201480014005.8A 2013-03-14 2014-03-07 用于治疗炎性障碍的化合物及其药物组合物 Active CN105143221B (zh)

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US201361781174P 2013-03-14 2013-03-14
US61/781,174 2013-03-14
PCT/EP2014/054440 WO2014139882A1 (en) 2013-03-14 2014-03-07 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

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CN105143221B true CN105143221B (zh) 2017-06-09

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