JP2016510019A5 - - Google Patents
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- Publication number
- JP2016510019A5 JP2016510019A5 JP2015559576A JP2015559576A JP2016510019A5 JP 2016510019 A5 JP2016510019 A5 JP 2016510019A5 JP 2015559576 A JP2015559576 A JP 2015559576A JP 2015559576 A JP2015559576 A JP 2015559576A JP 2016510019 A5 JP2016510019 A5 JP 2016510019A5
- Authority
- JP
- Japan
- Prior art keywords
- phenylephrine
- guaifenesin
- iii
- polyvinylpyrrolidone
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 13
- 229960001802 phenylephrine Drugs 0.000 claims 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 12
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims 8
- 229960002146 guaifenesin Drugs 0.000 claims 8
- 239000007788 liquid Substances 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 230000015556 catabolic process Effects 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770988P | 2013-02-28 | 2013-02-28 | |
| US61/770,988 | 2013-02-28 | ||
| PCT/IB2014/058978 WO2014132163A1 (en) | 2013-02-28 | 2014-02-13 | Enhanced stability of novel liquid compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016247717A Division JP2017078084A (ja) | 2013-02-28 | 2016-12-21 | 安定性を増強した新規な液体組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510019A JP2016510019A (ja) | 2016-04-04 |
| JP2016510019A5 true JP2016510019A5 (enExample) | 2016-06-16 |
| JP6067892B2 JP6067892B2 (ja) | 2017-01-25 |
Family
ID=50193557
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015559576A Active JP6067892B2 (ja) | 2013-02-28 | 2014-02-13 | 安定性を増強した新規な液体組成物 |
| JP2016247717A Pending JP2017078084A (ja) | 2013-02-28 | 2016-12-21 | 安定性を増強した新規な液体組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016247717A Pending JP2017078084A (ja) | 2013-02-28 | 2016-12-21 | 安定性を増強した新規な液体組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9308166B2 (enExample) |
| EP (1) | EP2961377B1 (enExample) |
| JP (2) | JP6067892B2 (enExample) |
| KR (3) | KR102218334B1 (enExample) |
| CN (2) | CN108187054B (enExample) |
| AU (2) | AU2014222418B2 (enExample) |
| BR (1) | BR112015018838B1 (enExample) |
| CA (1) | CA2898408C (enExample) |
| ES (1) | ES2792082T3 (enExample) |
| HK (1) | HK1255605A1 (enExample) |
| IL (2) | IL240080A (enExample) |
| MX (1) | MX345183B (enExample) |
| NZ (2) | NZ739588A (enExample) |
| PH (1) | PH12015501753B1 (enExample) |
| PL (1) | PL2961377T3 (enExample) |
| RU (1) | RU2015137145A (enExample) |
| SG (1) | SG11201505607SA (enExample) |
| TW (1) | TWI531385B (enExample) |
| WO (1) | WO2014132163A1 (enExample) |
| ZA (1) | ZA201505058B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6067892B2 (ja) * | 2013-02-28 | 2017-01-25 | ファイザー・インク | 安定性を増強した新規な液体組成物 |
| EP3302423B1 (en) | 2015-06-04 | 2022-05-25 | Crititech, Inc. | Particle production system and particle collection device |
| US20180263916A1 (en) | 2015-09-28 | 2018-09-20 | Puracap Pharmaceutical Llc | Soft gelatin capsules containing a mixture of analgesics and decongestants, expectorants, antitussives and/or antihistamines |
| US9549907B1 (en) | 2015-11-13 | 2017-01-24 | Sovereign Pharmaceuticals, Llc | Immediate release oral guaifenesin solution |
| WO2017176628A1 (en) * | 2016-04-04 | 2017-10-12 | Crititech, Inc. | Methods for solid tumor treatment |
| CA3032750C (en) * | 2016-09-01 | 2021-04-13 | The Procter & Gamble Company | Medication with improved taste and sensory experience |
| WO2018183082A1 (en) | 2017-03-27 | 2018-10-04 | Paracap Pharmaceutical Llc | Formulations containing expectorants or decongestants |
| BR112019023948A2 (pt) | 2017-06-09 | 2020-06-09 | Crititech Inc | tratamento de cistos epiteliais por injeção intracística de partículas antineoplásicas |
| EP3615004B1 (en) | 2017-06-14 | 2025-02-19 | Crititech, Inc. | Methods for treating lung disorders |
| JP7792750B2 (ja) | 2017-10-03 | 2025-12-26 | クリティテック・インコーポレイテッド | 癌の治療のための免疫療法剤の全身送達と組み合わせた抗腫瘍粒子の局所送達 |
| US10861033B2 (en) | 2018-01-29 | 2020-12-08 | Florida Power & Light Company | Crowd sourcing of object observations |
| US11911517B2 (en) | 2018-05-16 | 2024-02-27 | Bayer Healthcare Llc | High concentration suspension formulation for cold and flu soft gel capsule medications |
| CN109044968B (zh) * | 2018-10-18 | 2020-12-01 | 云南大唐汉方制药股份有限公司 | 氨酚右美肾素口服液及其制备方法 |
| CN109125257B (zh) * | 2018-10-18 | 2020-12-01 | 云南大唐汉方制药股份有限公司 | 氨酚愈创肾素口服液及其制备方法 |
| CN109045003B (zh) * | 2018-10-18 | 2020-12-01 | 云南大唐汉方制药股份有限公司 | 氨酚拉明肾素口服液及其制备方法 |
| TWI850346B (zh) * | 2019-03-11 | 2024-08-01 | 美商Ｒ Ｐ 先靈爾科技公司 | 於軟凝膠中改善api穩定性 |
| JP7654561B2 (ja) | 2019-04-11 | 2025-04-01 | アール．ピー． シェーラー テクノロジーズ エルエルシー | 浸透性が低いタンパク質、ペプチド、及び小分子の経口送達用の製剤 |
| CN110279695B (zh) * | 2019-08-07 | 2022-04-08 | 北京博智绿洲医药科技有限公司 | 一种治疗流涕、鼻塞等感冒症状的药物组合物及其制备方法和用途 |
| CN110302149A (zh) * | 2019-08-07 | 2019-10-08 | 北京博达绿洲医药科技研究有限公司 | 一种适合4-11岁儿童服用抗感冒药物及其制备方法 |
| CN110507607A (zh) * | 2019-09-27 | 2019-11-29 | 葵花药业集团北京药物研究院有限公司 | 苯海拉明肾素口服液及其制备方法和用途 |
| AU2020410965B2 (en) * | 2019-12-23 | 2025-12-11 | Farmalíder, S.A | Liquid composition comprising ibuprofen and phenylephrine |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA821577B (en) | 1981-04-06 | 1983-03-30 | Boots Co Plc | Therapeutic agents |
| US5288479A (en) * | 1989-01-17 | 1994-02-22 | Sterling Drug, Inc. | Extrudable elastic oral pharmaceutical gel compositions and metered dose dispensers containing them and method of making and method of use thereof |
| US5196436A (en) * | 1990-10-31 | 1993-03-23 | The Procter & Gamble Company | Dextromethorphan antitussive compositions |
| US5141961A (en) | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
| US5505961A (en) * | 1993-08-05 | 1996-04-09 | R. P. Scherer Corporation | Gelatin capsules containing a highly concentrated acetaminophen solution |
| US5484606A (en) | 1994-01-24 | 1996-01-16 | The Procter & Gamble Company | Process for reducing the precipitation of difficulty soluble pharmaceutical actives |
| JPH09508128A (ja) * | 1994-01-24 | 1997-08-19 | ザ、プロクター、エンド、ギャンブル、カンパニー | 難溶性医薬活性剤の溶解方法 |
| US5510389A (en) | 1994-03-02 | 1996-04-23 | The Procter & Gamble Company | Concentrated acetaminophen solution compositions |
| WO1997002273A1 (en) * | 1995-07-05 | 1997-01-23 | The Procter & Gamble Company | Warming compounds |
| US20050095288A1 (en) * | 2003-11-03 | 2005-05-05 | Andrx Labs, Llc | Decongestant and expectorant tablets |
| US8318210B2 (en) * | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| US20080014261A1 (en) * | 2006-07-12 | 2008-01-17 | Giordano John A | Non-narcotic biphasic release compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| US20080014274A1 (en) * | 2006-07-14 | 2008-01-17 | Wyeth | Enhanced stability phenylephrine liquid compositions |
| US20080085892A1 (en) * | 2006-08-31 | 2008-04-10 | Sangeetha Kandeepan | Liquid dosage form of acetaminophen |
| MX2009013019A (es) * | 2007-05-30 | 2010-04-01 | Neos Therapeutics Lp | Modificacion de liberacion de farmaco en suspensiones de sistemas de resina ionica. |
| JP6067892B2 (ja) * | 2013-02-28 | 2017-01-25 | ファイザー・インク | 安定性を増強した新規な液体組成物 |
-
2014
- 2014-02-13 JP JP2015559576A patent/JP6067892B2/ja active Active
- 2014-02-13 BR BR112015018838-9A patent/BR112015018838B1/pt active IP Right Grant
- 2014-02-13 MX MX2015011207A patent/MX345183B/es active IP Right Grant
- 2014-02-13 EP EP14707845.5A patent/EP2961377B1/en active Active
- 2014-02-13 SG SG11201505607SA patent/SG11201505607SA/en unknown
- 2014-02-13 KR KR1020197035664A patent/KR102218334B1/ko active Active
- 2014-02-13 CN CN201810111842.2A patent/CN108187054B/zh active Active
- 2014-02-13 CA CA2898408A patent/CA2898408C/en active Active
- 2014-02-13 KR KR1020167035270A patent/KR20160148723A/ko not_active Ceased
- 2014-02-13 NZ NZ739588A patent/NZ739588A/en unknown
- 2014-02-13 KR KR1020157023250A patent/KR101695580B1/ko active Active
- 2014-02-13 AU AU2014222418A patent/AU2014222418B2/en active Active
- 2014-02-13 PL PL14707845T patent/PL2961377T3/pl unknown
- 2014-02-13 WO PCT/IB2014/058978 patent/WO2014132163A1/en not_active Ceased
- 2014-02-13 RU RU2015137145A patent/RU2015137145A/ru unknown
- 2014-02-13 PH PH1/2015/501753A patent/PH12015501753B1/en unknown
- 2014-02-13 ES ES14707845T patent/ES2792082T3/es active Active
- 2014-02-13 NZ NZ709958A patent/NZ709958A/en unknown
- 2014-02-13 CN CN201480011120.XA patent/CN105007891B/zh active Active
- 2014-02-27 US US14/192,720 patent/US9308166B2/en active Active
- 2014-02-27 TW TW103106882A patent/TWI531385B/zh active
-
2015
- 2015-07-14 ZA ZA2015/05058A patent/ZA201505058B/en unknown
- 2015-07-21 IL IL240080A patent/IL240080A/en active IP Right Grant
-
2016
- 2016-02-04 US US15/015,483 patent/US9744133B2/en active Active
- 2016-07-27 IL IL246985A patent/IL246985B/en active IP Right Grant
- 2016-07-28 AU AU2016208390A patent/AU2016208390B2/en active Active
- 2016-12-21 JP JP2016247717A patent/JP2017078084A/ja active Pending
-
2017
- 2017-07-24 US US15/657,677 patent/US20170319479A1/en not_active Abandoned
-
2018
- 2018-11-19 HK HK18114735.1A patent/HK1255605A1/zh unknown
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