RU2015137145A - Новые жидкие композиции с повышенной стабильностью - Google Patents
Новые жидкие композиции с повышенной стабильностью Download PDFInfo
- Publication number
- RU2015137145A RU2015137145A RU2015137145A RU2015137145A RU2015137145A RU 2015137145 A RU2015137145 A RU 2015137145A RU 2015137145 A RU2015137145 A RU 2015137145A RU 2015137145 A RU2015137145 A RU 2015137145A RU 2015137145 A RU2015137145 A RU 2015137145A
- Authority
- RU
- Russia
- Prior art keywords
- phenylephrine
- composition
- approximately
- weight
- composition according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 30
- 239000007788 liquid Substances 0.000 title claims 8
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 22
- 229960001802 phenylephrine Drugs 0.000 claims 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 15
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000008177 pharmaceutical agent Substances 0.000 claims 4
- 239000008346 aqueous phase Substances 0.000 claims 3
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 3
- 239000002244 precipitate Substances 0.000 claims 3
- 238000001556 precipitation Methods 0.000 claims 3
- 239000000047 product Substances 0.000 claims 3
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical group C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims 2
- 239000003434 antitussive agent Substances 0.000 claims 2
- 229940124584 antitussives Drugs 0.000 claims 2
- 229960001985 dextromethorphan Drugs 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 239000007857 degradation product Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770988P | 2013-02-28 | 2013-02-28 | |
| US61/770,988 | 2013-02-28 | ||
| PCT/IB2014/058978 WO2014132163A1 (en) | 2013-02-28 | 2014-02-13 | Enhanced stability of novel liquid compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015137145A true RU2015137145A (ru) | 2017-04-03 |
Family
ID=50193557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015137145A RU2015137145A (ru) | 2013-02-28 | 2014-02-13 | Новые жидкие композиции с повышенной стабильностью |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9308166B2 (enExample) |
| EP (1) | EP2961377B1 (enExample) |
| JP (2) | JP6067892B2 (enExample) |
| KR (3) | KR101695580B1 (enExample) |
| CN (2) | CN105007891B (enExample) |
| AU (2) | AU2014222418B2 (enExample) |
| BR (1) | BR112015018838B1 (enExample) |
| CA (1) | CA2898408C (enExample) |
| ES (1) | ES2792082T3 (enExample) |
| HK (1) | HK1255605A1 (enExample) |
| IL (2) | IL240080A (enExample) |
| MX (1) | MX345183B (enExample) |
| NZ (2) | NZ709958A (enExample) |
| PH (1) | PH12015501753B1 (enExample) |
| PL (1) | PL2961377T3 (enExample) |
| RU (1) | RU2015137145A (enExample) |
| SG (1) | SG11201505607SA (enExample) |
| TW (1) | TWI531385B (enExample) |
| WO (1) | WO2014132163A1 (enExample) |
| ZA (1) | ZA201505058B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015018838B1 (pt) * | 2013-02-28 | 2020-12-15 | Pfizer Inc. | Composição oral líquida com estabilidade melhorada e seu processo para a preparação |
| EP3302431B1 (en) | 2015-06-04 | 2020-11-11 | Crititech, Inc. | Taxane particles and their use |
| WO2017058836A1 (en) | 2015-09-28 | 2017-04-06 | Puracap Pharmaceutical Llc | Soft gelatin capsules containing a mixture of analgesics and decongestants, expectorants, antitussives and/or antihistamines |
| US9549907B1 (en) * | 2015-11-13 | 2017-01-24 | Sovereign Pharmaceuticals, Llc | Immediate release oral guaifenesin solution |
| JP6970683B2 (ja) | 2016-04-04 | 2021-11-24 | クリティテック・インコーポレイテッド | 固形腫瘍治療のための方法 |
| CA3032750C (en) * | 2016-09-01 | 2021-04-13 | The Procter & Gamble Company | Medication with improved taste and sensory experience |
| CN110809465B (zh) | 2017-03-27 | 2022-10-25 | 帕拉卡普制药有限公司 | 含有祛痰剂或减充血剂的制剂 |
| AU2018279634A1 (en) | 2017-06-09 | 2019-10-31 | Crititech, Inc. | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| BR112019022720A2 (pt) | 2017-06-14 | 2020-05-12 | Crititech, Inc. | Métodos para tratar distúrbios pulmonares |
| KR20200064112A (ko) | 2017-10-03 | 2020-06-05 | 크리티테크, 인크. | 암의 치료를 위한 면역치료제의 전신 전달과 조합된 항신생물성 입자의 국소 전달 |
| US10861033B2 (en) | 2018-01-29 | 2020-12-08 | Florida Power & Light Company | Crowd sourcing of object observations |
| EP3793535A1 (en) | 2018-05-16 | 2021-03-24 | Bayer Healthcare LLC | High concentration suspension formulation for cold and flu soft gel capsule medications |
| CN109044968B (zh) * | 2018-10-18 | 2020-12-01 | 云南大唐汉方制药股份有限公司 | 氨酚右美肾素口服液及其制备方法 |
| CN109125257B (zh) * | 2018-10-18 | 2020-12-01 | 云南大唐汉方制药股份有限公司 | 氨酚愈创肾素口服液及其制备方法 |
| CN109045003B (zh) * | 2018-10-18 | 2020-12-01 | 云南大唐汉方制药股份有限公司 | 氨酚拉明肾素口服液及其制备方法 |
| TWI850346B (zh) * | 2019-03-11 | 2024-08-01 | 美商Ｒ Ｐ 先靈爾科技公司 | 於軟凝膠中改善api穩定性 |
| EA202192792A1 (ru) | 2019-04-11 | 2022-01-11 | Ар.Пи. ШЕРЕР ТЕКНОЛОДЖИЗ, ЭлЭлСи | Композиция для пероральной доставки белков, пептидов и малых молекул со слабой проницаемостью |
| CN110302149A (zh) * | 2019-08-07 | 2019-10-08 | 北京博达绿洲医药科技研究有限公司 | 一种适合4-11岁儿童服用抗感冒药物及其制备方法 |
| CN110279695B (zh) * | 2019-08-07 | 2022-04-08 | 北京博智绿洲医药科技有限公司 | 一种治疗流涕、鼻塞等感冒症状的药物组合物及其制备方法和用途 |
| CN110507607A (zh) * | 2019-09-27 | 2019-11-29 | 葵花药业集团北京药物研究院有限公司 | 苯海拉明肾素口服液及其制备方法和用途 |
| PT4081187T (pt) * | 2019-12-23 | 2024-02-14 | Nutra Essential Otc S L | Composição líquida compreendendo ibuprofeno e fenilefrina |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA821577B (en) | 1981-04-06 | 1983-03-30 | Boots Co Plc | Therapeutic agents |
| US5288479A (en) * | 1989-01-17 | 1994-02-22 | Sterling Drug, Inc. | Extrudable elastic oral pharmaceutical gel compositions and metered dose dispensers containing them and method of making and method of use thereof |
| US5196436A (en) * | 1990-10-31 | 1993-03-23 | The Procter & Gamble Company | Dextromethorphan antitussive compositions |
| US5141961A (en) * | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
| US5505961A (en) * | 1993-08-05 | 1996-04-09 | R. P. Scherer Corporation | Gelatin capsules containing a highly concentrated acetaminophen solution |
| SK96196A3 (en) * | 1994-01-24 | 1997-03-05 | Procter & Gamble | Process for solubilizing difficultly soluble pharmaceutical actives |
| US5484606A (en) | 1994-01-24 | 1996-01-16 | The Procter & Gamble Company | Process for reducing the precipitation of difficulty soluble pharmaceutical actives |
| US5510389A (en) | 1994-03-02 | 1996-04-23 | The Procter & Gamble Company | Concentrated acetaminophen solution compositions |
| EP0837862A1 (en) * | 1995-07-05 | 1998-04-29 | The Procter & Gamble Company | Warming compounds |
| US20050095288A1 (en) * | 2003-11-03 | 2005-05-05 | Andrx Labs, Llc | Decongestant and expectorant tablets |
| US8318210B2 (en) * | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| US20080014261A1 (en) * | 2006-07-12 | 2008-01-17 | Giordano John A | Non-narcotic biphasic release compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| US20080014274A1 (en) * | 2006-07-14 | 2008-01-17 | Wyeth | Enhanced stability phenylephrine liquid compositions |
| US20080085892A1 (en) * | 2006-08-31 | 2008-04-10 | Sangeetha Kandeepan | Liquid dosage form of acetaminophen |
| WO2008151071A1 (en) * | 2007-05-30 | 2008-12-11 | Neos Therapeutics, Lp | Modifying drug release in suspensions of ionic resin systems |
| BR112015018838B1 (pt) * | 2013-02-28 | 2020-12-15 | Pfizer Inc. | Composição oral líquida com estabilidade melhorada e seu processo para a preparação |
-
2014
- 2014-02-13 BR BR112015018838-9A patent/BR112015018838B1/pt active IP Right Grant
- 2014-02-13 KR KR1020157023250A patent/KR101695580B1/ko active Active
- 2014-02-13 ES ES14707845T patent/ES2792082T3/es active Active
- 2014-02-13 MX MX2015011207A patent/MX345183B/es active IP Right Grant
- 2014-02-13 SG SG11201505607SA patent/SG11201505607SA/en unknown
- 2014-02-13 NZ NZ709958A patent/NZ709958A/en unknown
- 2014-02-13 PL PL14707845T patent/PL2961377T3/pl unknown
- 2014-02-13 RU RU2015137145A patent/RU2015137145A/ru unknown
- 2014-02-13 CA CA2898408A patent/CA2898408C/en active Active
- 2014-02-13 NZ NZ739588A patent/NZ739588A/en unknown
- 2014-02-13 CN CN201480011120.XA patent/CN105007891B/zh active Active
- 2014-02-13 AU AU2014222418A patent/AU2014222418B2/en active Active
- 2014-02-13 CN CN201810111842.2A patent/CN108187054B/zh active Active
- 2014-02-13 WO PCT/IB2014/058978 patent/WO2014132163A1/en not_active Ceased
- 2014-02-13 PH PH1/2015/501753A patent/PH12015501753B1/en unknown
- 2014-02-13 KR KR1020197035664A patent/KR102218334B1/ko active Active
- 2014-02-13 KR KR1020167035270A patent/KR20160148723A/ko not_active Ceased
- 2014-02-13 EP EP14707845.5A patent/EP2961377B1/en active Active
- 2014-02-13 JP JP2015559576A patent/JP6067892B2/ja active Active
- 2014-02-27 TW TW103106882A patent/TWI531385B/zh active
- 2014-02-27 US US14/192,720 patent/US9308166B2/en active Active
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2015
- 2015-07-14 ZA ZA2015/05058A patent/ZA201505058B/en unknown
- 2015-07-21 IL IL240080A patent/IL240080A/en active IP Right Grant
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2016
- 2016-02-04 US US15/015,483 patent/US9744133B2/en active Active
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- 2016-07-28 AU AU2016208390A patent/AU2016208390B2/en active Active
- 2016-12-21 JP JP2016247717A patent/JP2017078084A/ja active Pending
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2017
- 2017-07-24 US US15/657,677 patent/US20170319479A1/en not_active Abandoned
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2018
- 2018-11-19 HK HK18114735.1A patent/HK1255605A1/zh unknown
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