AR100437A1 - Composiciones para el cuidado bucal - Google Patents
Composiciones para el cuidado bucalInfo
- Publication number
- AR100437A1 AR100437A1 ARP150101492A ARP150101492A AR100437A1 AR 100437 A1 AR100437 A1 AR 100437A1 AR P150101492 A ARP150101492 A AR P150101492A AR P150101492 A ARP150101492 A AR P150101492A AR 100437 A1 AR100437 A1 AR 100437A1
- Authority
- AR
- Argentina
- Prior art keywords
- weight
- oral care
- zinc
- composition
- peg
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 11
- 229920001223 polyethylene glycol Polymers 0.000 abstract 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 4
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 2
- 239000000679 carrageenan Substances 0.000 abstract 2
- 229920001525 carrageenan Polymers 0.000 abstract 2
- 235000010418 carrageenan Nutrition 0.000 abstract 2
- 229940113118 carrageenan Drugs 0.000 abstract 2
- 239000003906 humectant Substances 0.000 abstract 2
- 210000000214 mouth Anatomy 0.000 abstract 2
- 239000002562 thickening agent Substances 0.000 abstract 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 abstract 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 229910001432 tin ion Inorganic materials 0.000 abstract 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 235000006076 zinc citrate Nutrition 0.000 abstract 1
- 239000011746 zinc citrate Substances 0.000 abstract 1
- 229940068475 zinc citrate Drugs 0.000 abstract 1
- 235000011478 zinc gluconate Nutrition 0.000 abstract 1
- 239000011670 zinc gluconate Substances 0.000 abstract 1
- 229960000306 zinc gluconate Drugs 0.000 abstract 1
- 229940050168 zinc lactate Drugs 0.000 abstract 1
- 235000000193 zinc lactate Nutrition 0.000 abstract 1
- 239000011576 zinc lactate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Composiciones para el cuidado bucal que tienen estabilidad mejorada debido a la eliminación de iones estañosos y a la inclusión de polietilenglicoles de bajo peso molecular (PEG). Las composiciones contienen una fuente de iones de zinc y PEG, y tienen un peso molecular promedio de 300 Da a 8000 Da; se usan para tratar la cavidad bucal y comprenden administrar una composición para el cuidado bucal en la cavidad bucal de acuerdo con la presente. Reivindicación 1: Una composición para el cuidado bucal que comprende: a) de 0,01% a 5% en peso de una fuente de ión de zinc; b) de 0,01% a 5% en peso de una composición saborizante; c) de 30% a 75% en peso del contenido total de agua; d) de 0,1% a 3% en peso de un primer humectante que comprende polietilenglicoles (PEG) que tienen un peso molecular promedio dentro del intervalo de 300 Da a 8.000 Da; y e) de 0,01% a 5% en peso de un sistema espesante que comprende una combinación de carboximetilcelulosa (CMC), hidroxietilcelulosa (HEC) y carragenina; caracterizada porque la composición para el cuidado bucal está prácticamente libre de iones estañosos. Reivindicación 3: La composición para el cuidado bucal de acuerdo con la reivindicación 1, caracterizada además porque el sistema espesante comprende: (i) de 0,2% a 2,5% en peso de carboximetilcelulosa (CMC); (ii) de 0,1% a 1,0% en peso de hidroxietilcelulosa (HEC); y (iii) de 0,2% a 2,5% en peso de carragenina. Reivindicación 5: La composición para el cuidado bucal de acuerdo con la reivindicación 4, caracterizada además porque el humectante secundario comprende de 40% a 55% en peso de sorbitol. Reivindicación 10: La composición para el cuidado bucal de acuerdo con la reivindicación 1, caracterizada además porque, la fuente de ión de zinc se selecciona del grupo que consiste en citrato de zinc, gluconato de zinc, lactato de zinc y mezclas de estos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/077427 WO2015172323A1 (en) | 2014-05-14 | 2014-05-14 | Oral care compositions having improved stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100437A1 true AR100437A1 (es) | 2016-10-05 |
Family
ID=54479146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101492A AR100437A1 (es) | 2014-05-14 | 2015-05-13 | Composiciones para el cuidado bucal |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9498416B2 (es) |
| EP (1) | EP3148500B1 (es) |
| JP (1) | JP2017514881A (es) |
| CN (1) | CN106255487B (es) |
| AR (1) | AR100437A1 (es) |
| AU (1) | AU2014393953B2 (es) |
| BR (1) | BR112016024176B1 (es) |
| CA (1) | CA2946053C (es) |
| MX (1) | MX362471B (es) |
| RU (1) | RU2670742C9 (es) |
| WO (1) | WO2015172323A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015172348A1 (en) | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Dentifrice compositions having dental plaque mitigation or improved fluoride uptake |
| RU2747237C2 (ru) * | 2016-07-06 | 2021-04-29 | Маккормик Энд Компани, Инкорпорейтед | Природные инкапсулированные ароматизирующие продукты |
| CN109475153A (zh) * | 2016-07-06 | 2019-03-15 | 麦克考米克有限公司 | 预测调味品性能的方法 |
| USD825741S1 (en) | 2016-12-15 | 2018-08-14 | Water Pik, Inc. | Oral irrigator handle |
| CN110505867A (zh) | 2017-02-02 | 2019-11-26 | 洁碧有限公司 | 用于牙齿清洁的包括研磨剂的片剂 |
| AU2018236429B2 (en) | 2017-03-16 | 2023-02-02 | Water Pik, Inc. | Oral irrigator handle for use with oral agent |
| USD868243S1 (en) | 2018-03-16 | 2019-11-26 | Water Pik, Inc. | Oral irrigator tip |
| JP7310357B2 (ja) * | 2018-07-06 | 2023-07-19 | ライオン株式会社 | 口腔用組成物 |
| WO2021059215A2 (en) | 2019-09-25 | 2021-04-01 | Church & Dwight Co., Inc. | Oral care composition |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3538230A (en) * | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| US3689637A (en) * | 1969-07-11 | 1972-09-05 | Lever Brothers Ltd | Dentifrice composition |
| CA1191083A (en) * | 1981-12-02 | 1985-07-30 | Jeffrey W. Rockliffe | Polymer articles |
| GB8411731D0 (en) * | 1984-05-09 | 1984-06-13 | Unilever Plc | Oral compositions |
| US4971788A (en) * | 1989-01-27 | 1990-11-20 | Medicontrol Corporation | Oral cavity and dental microemulsion products |
| US6117415A (en) * | 1999-06-17 | 2000-09-12 | Alpharx Inc. | Toothpaste comprising bioadhesive submicron emulsion for improved delivery of antibacterial and anticaries agents |
| CA2431002A1 (en) * | 2000-12-05 | 2002-06-13 | Colgate-Palmolive Company | Zinc containing dentifrice of reduced astringency |
| US7648363B2 (en) * | 2001-10-01 | 2010-01-19 | Lion Corporation | Method of whitening teeth, tooth whitening composition and tooth whitening set |
| US20080230298A1 (en) * | 2003-09-18 | 2008-09-25 | Robert Michael Buch | Method of Applying Oral Compositions |
| US20060134020A1 (en) * | 2004-12-21 | 2006-06-22 | Robinson Richard S | Anti-caries oral care composition with a chelating agent |
| JP2009520829A (ja) * | 2005-12-20 | 2009-05-28 | ザ プロクター アンド ギャンブル カンパニー | 亜鉛およびフィチン酸塩を含む口腔ケア組成物 |
| US8007771B2 (en) * | 2006-07-07 | 2011-08-30 | The Procter & Gamble Company | Flavors for oral compositions |
| JP5485160B2 (ja) * | 2007-11-09 | 2014-05-07 | ザ プロクター アンド ギャンブル カンパニー | 口腔用スズ組成物 |
| CN101910391B (zh) * | 2008-01-04 | 2013-04-17 | 宝洁公司 | 包含糖基水解酶和包含有益剂递送颗粒的衣物洗涤剂组合物 |
| CA2744386C (en) * | 2008-11-25 | 2013-10-01 | The Procter & Gamble Company | Improved cleaning oral care compositions |
| TW201110996A (en) * | 2009-06-03 | 2011-04-01 | Colgate Palmolive Co | Borinic compositions |
| WO2011031807A2 (en) * | 2009-09-11 | 2011-03-17 | The Procter & Gamble Company | Methods and compositions for hydrophobic modification of oral cavity surfaces |
| US20130084254A1 (en) * | 2010-06-17 | 2013-04-04 | Coralie Claudine Alonso | Oral care compositions |
| CN102946847B (zh) * | 2010-06-23 | 2016-08-24 | 荷兰联合利华有限公司 | 非水性口腔护理组合物 |
| CN102526102A (zh) * | 2010-12-26 | 2012-07-04 | 李朝晖 | 一种能治疗口腔炎症、牙周炎、口腔溃疡的漱口液 |
| CN103607993B (zh) * | 2011-04-04 | 2016-11-09 | 荷兰联合利华有限公司 | 口腔护理组合物 |
| AU2012302149B2 (en) * | 2011-09-01 | 2015-08-13 | The Procter & Gamble Company | Oral care compositions with improved rheology |
| BR112014014319A2 (pt) * | 2011-12-20 | 2017-06-13 | Colgate Palmolive Co | composições de cuidado oral |
| US20130344120A1 (en) | 2012-06-21 | 2013-12-26 | Douglas Craig Scott | Mouth Rinse Emulsions |
-
2014
- 2014-05-14 WO PCT/CN2014/077427 patent/WO2015172323A1/en active Application Filing
- 2014-05-14 EP EP14892208.1A patent/EP3148500B1/en active Active
- 2014-05-14 MX MX2016014937A patent/MX362471B/es active IP Right Grant
- 2014-05-14 AU AU2014393953A patent/AU2014393953B2/en not_active Ceased
- 2014-05-14 JP JP2016567252A patent/JP2017514881A/ja active Pending
- 2014-05-14 BR BR112016024176-2A patent/BR112016024176B1/pt not_active IP Right Cessation
- 2014-05-14 CN CN201480078612.0A patent/CN106255487B/zh not_active Expired - Fee Related
- 2014-05-14 RU RU2016140717A patent/RU2670742C9/ru active
- 2014-05-14 CA CA2946053A patent/CA2946053C/en active Active
-
2015
- 2015-03-02 US US14/635,196 patent/US9498416B2/en active Active
- 2015-05-13 AR ARP150101492A patent/AR100437A1/es unknown
-
2016
- 2016-10-17 US US15/294,855 patent/US10206864B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MX362471B (es) | 2019-01-16 |
| BR112016024176B1 (pt) | 2020-12-08 |
| AU2014393953B2 (en) | 2017-11-30 |
| EP3148500A4 (en) | 2018-02-07 |
| US20170027848A1 (en) | 2017-02-02 |
| RU2016140717A3 (es) | 2018-06-15 |
| CN106255487A (zh) | 2016-12-21 |
| EP3148500B1 (en) | 2020-10-28 |
| RU2016140717A (ru) | 2018-06-15 |
| RU2670742C2 (ru) | 2018-10-25 |
| US10206864B2 (en) | 2019-02-19 |
| MX2016014937A (es) | 2017-08-10 |
| CA2946053A1 (en) | 2015-11-19 |
| WO2015172323A1 (en) | 2015-11-19 |
| RU2670742C9 (ru) | 2018-12-19 |
| BR112016024176A2 (pt) | 2017-08-15 |
| AU2014393953A1 (en) | 2016-11-03 |
| US9498416B2 (en) | 2016-11-22 |
| CN106255487B (zh) | 2020-06-16 |
| JP2017514881A (ja) | 2017-06-08 |
| CA2946053C (en) | 2019-01-08 |
| US20150328132A1 (en) | 2015-11-19 |
| EP3148500A1 (en) | 2017-04-05 |
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