JP2014508170A5 - - Google Patents
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- Publication number
- JP2014508170A5 JP2014508170A5 JP2013558126A JP2013558126A JP2014508170A5 JP 2014508170 A5 JP2014508170 A5 JP 2014508170A5 JP 2013558126 A JP2013558126 A JP 2013558126A JP 2013558126 A JP2013558126 A JP 2013558126A JP 2014508170 A5 JP2014508170 A5 JP 2014508170A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- pharmaceutically acceptable
- acceptable salt
- methyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 26
- 239000001257 hydrogen Substances 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 206010019233 Headaches Diseases 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 231100000869 headache Toxicity 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- -1 [1- (trifluoromethyl) cyclopropyl] methyl Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161453989P | 2011-03-18 | 2011-03-18 | |
| US61/453,989 | 2011-03-18 | ||
| PCT/US2012/028976 WO2012129014A1 (en) | 2011-03-18 | 2012-03-14 | Piperidine carboxamide spirohydantoin cgrp receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014508170A JP2014508170A (ja) | 2014-04-03 |
| JP2014508170A5 true JP2014508170A5 (enExample) | 2015-04-30 |
Family
ID=46879681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013558126A Pending JP2014508170A (ja) | 2011-03-18 | 2012-03-14 | ピペリジノンカルボキサミドスピロヒダントインｃｇｒｐ受容体アンタゴニスト |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140005214A1 (enExample) |
| EP (1) | EP2686324B1 (enExample) |
| JP (1) | JP2014508170A (enExample) |
| AU (1) | AU2012231293A1 (enExample) |
| CA (1) | CA2830348A1 (enExample) |
| WO (1) | WO2012129014A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012129013A1 (en) | 2011-03-18 | 2012-09-27 | Merck Sharp & Dohme Corp. | Piperidinone carboxamide spirohydantoin cgrp receptor antagonists |
| GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| CN119431222B (zh) * | 2024-11-04 | 2025-10-17 | 杭州澳赛诺生物科技有限公司 | 一种不对称合成乌布吉泮手性中间体的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2355B1 (en) * | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| AU2005208834B2 (en) * | 2004-01-29 | 2009-10-08 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| EP1791843B1 (en) * | 2004-09-08 | 2012-08-29 | Merck Sharp & Dohme Corp. | Monocyclic anilide spirolactam cgrp receptor antagonists |
| US7384930B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| WO2007133491A1 (en) * | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Substituted spirocyclic cgrp receptor antagonists |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| JP2011512410A (ja) * | 2008-02-19 | 2011-04-21 | メルク・シャープ・エンド・ドーム・コーポレイション | イミダゾベンゾアゼピンｃｇｒｐ受容体アンタゴニスト |
| AU2011326455A1 (en) * | 2010-11-12 | 2013-05-23 | Merck Sharp & Dohme Corp. | Piperidinone carboxamide indane CGRP receptor antagonists |
-
2012
- 2012-03-14 WO PCT/US2012/028976 patent/WO2012129014A1/en not_active Ceased
- 2012-03-14 JP JP2013558126A patent/JP2014508170A/ja active Pending
- 2012-03-14 US US14/005,595 patent/US20140005214A1/en not_active Abandoned
- 2012-03-14 AU AU2012231293A patent/AU2012231293A1/en not_active Abandoned
- 2012-03-14 CA CA2830348A patent/CA2830348A1/en not_active Abandoned
- 2012-03-14 EP EP12760168.0A patent/EP2686324B1/en active Active